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VTGPDWVQHVIWWQVYPLGFVGAYPLPQSSEPPQPEHHRLRRLVDWFDHAIELGASGIALGPIFTSRTHG YDTTDHYRIDPRLGDDADFDHLIAQAHRRGLRVLLDGVFNHVGVDFPRYRAAIDSDDHAAARWFRGSRGR FHTFEGHDGLITLNHDNPEVVDYTVDVMAHWLGRGADGWRLDAAYAVPETFWAATLPRVRDRYPQAWFVG ELIHGDYAAVVRAAGFDSATQYELWKAIWSSLNDGNFYELDWALQRHNAFLGRFSPLTFIGNHDVTRIAS QLNNPAHLAHALVLLLTVGGVPSVYAGDELGFRGVKEERFGGDDAVRPEFGSPPIPLDDFGTEVWRLHQY LIGLRRRHPWLHAATTTALLLQNRHYVYETRSGDEALLIVLNIGDEPLRVSLDELGGRRGRVIGGSAAPP PEVLDTVVVEPQGWRILSPI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2842 | - | - | 100% (440) | alpha-amylase 3 |
| M. avium 104 | MAV_5186 | treS | 1e-17 | 32.55% (212) | trehalose synthase |
| M. avium 104 | MAV_1700 | - | 6e-17 | 24.87% (386) | alpha-amylase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2498 | aglA | 1e-19 | 26.04% (384) | alpha-glucosidase AglA |
| M. gilvum PYR-GCK | Mflv_3333 | - | 0.0 | 68.11% (439) | alpha amylase, catalytic region |
| M. tuberculosis H37Rv | Rv2471 | aglA | 2e-19 | 26.04% (384) | alpha-glucosidase AglA |
| M. leprae Br4923 | MLBr_02045 | - | 1e-33 | 75.29% (85) | hypothetical protein MLBr_02045 |
| M. abscessus ATCC 19977 | MAB_1565c | - | 2e-16 | 24.94% (385) | Alpha-amylase family protein |
| M. marinum M | MMAR_2753 | treS_1 | 0.0 | 74.36% (433) | trehalose synthase TreS_1 |
| M. smegmatis MC2 155 | MSMEG_3576 | - | 0.0 | 69.48% (439) | alpha-amylase 3 |
| M. thermoresistible (build 8) | TH_2297 | - | 0.0 | 67.79% (444) | alpha-amylase 3 |
| M. ulcerans Agy99 | MUL_3001 | treS_1 | 0.0 | 74.26% (439) | trehalose synthase TreS_1 |
| M. vanbaalenii PYR-1 | Mvan_3059 | - | 0.0 | 70.16% (439) | alpha amylase, catalytic region |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2842|M.avium_104 -------------------------MTGPDWVQHVIWWQVYPLGFVGAYP
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MMAR_2753|M.marinum_M -------------------------------MQHAIWWQVYPLGFVGAFP
MUL_3001|M.ulcerans_Agy99 -------------------------MSKPTWVQHAIWWQVYPLGFVGAFP
Mflv_3333|M.gilvum_PYR-GCK -------------------------MSDPAWVEHVLWWQVYPLGFVGVHP
Mvan_3059|M.vanbaalenii_PYR-1 -------------------------MTEPDWVDHVVWWQVYPLGFVGAYP
MSMEG_3576|M.smegmatis_MC2_155 -------------------------MTMPDWVTHAIWWQIYPLGFVGAHP
TH_2297|M.thermoresistible__bu -------------------------VTGPDWVRHTIWWQIYPLGFVGAHP
Mb2498|M.bovis_AF2122/97 MDQHQRPDPMGPGSPRASARRPEPDPMGEPWWSRAVFYQVYPRSFADSNG
Rv2471|M.tuberculosis_H37Rv MDQHQRPDPMGPGSPRASARRPEPDPMGEPWWSRAVFYQVYPRSFADSNG
MAB_1565c|M.abscessus_ATCC_199 ---------------MTAAYLGQHD---DPWWSRAVFYQIYPRSFGDSDG
MAV_2842|M.avium_104 LPQSSE-PPQPEHHRLRRLVDWFDHAIELGASGIALGPIFTS--RTHGYD
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MMAR_2753|M.marinum_M ---ANQ-PPDPGEHRLRRLVGWFDHAVELGASGVALGPIFDS--RTHGYD
MUL_3001|M.ulcerans_Agy99 ---ANQ-PPNPGEHRLRRLVGWFDHAVELGASGVALGPIFDS--RTHGYD
Mflv_3333|M.gilvum_PYR-GCK ---ADT-APEPGEHRLRRIVDWLDYAVELGASGVALGPVFHS--RTHGYD
Mvan_3059|M.vanbaalenii_PYR-1 ---ADP-PPPPGEHRLRRIVDWLDYAIELGASGLALGPVFAS--RTHGYD
MSMEG_3576|M.smegmatis_MC2_155 -ADP---PPGPEEHRLRRIVEWLDHAVELGASGLALGPVFAS--RTHGYD
TH_2297|M.thermoresistible__bu WTDPTTGPPGPDEHRLRRVLDWLDHVVDLGASGLALGPVFAS--RSHGYD
Mb2498|M.bovis_AF2122/97 ----------DGVGDLDGLASRLDHLQQLGVDAIWINPVTVSPMADHGYD
Rv2471|M.tuberculosis_H37Rv ----------DGVGDLDGLASRLDHLQQLGVDAIWINPVTVSPMADHGYD
MAB_1565c|M.abscessus_ATCC_199 ----------DGVGDIDGISAKLGYLDLLGVEGIWLNPVTRSPMADHGYD
MAV_2842|M.avium_104 TTDHYRIDPRLGDDADFDHLIAQAHRRGLRVLLDGVFNHVGVDFPRYRAA
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MMAR_2753|M.marinum_M TTDHFRIDPRLGDEGDFDHLVAEAHRRGLRVLLDGVFNHVGMDFHRYRHA
MUL_3001|M.ulcerans_Agy99 TTDHFRIDPRLGDEGDFDHLVAEAHRRGLRVLLDGVFNHVGVDFHSYRHA
Mflv_3333|M.gilvum_PYR-GCK TIDHYRVDPRLGDDSDFDHLIEESHSRGLRVLLDGVFNHVGTEFPRYREA
Mvan_3059|M.vanbaalenii_PYR-1 TTDHYRIDPRLGEDGDFDHLVAEARDRGLRILLDGVFNHVGTDFPRYRDA
MSMEG_3576|M.smegmatis_MC2_155 TTDHLRIDPRLGDDADFDHVVAEAHRRGLRVLLDGVFNHVGTDFARYRQA
TH_2297|M.thermoresistible__bu TTDHYRIDPRLGTDADFDELVEQAHRRGLRVLLDGVFHHVGTDFARYRDA
Mb2498|M.bovis_AF2122/97 VADPRDIDPLFGGMPAFERLVAAAHRQGIKVTMDVVPNHTSSAHPWFQAA
Rv2471|M.tuberculosis_H37Rv VADPRDIDPLFGGMPAFERLVAAAHRQGIKVTMDVVPNHTSSAHPWFQAA
MAB_1565c|M.abscessus_ATCC_199 VSNPREIDPLFGGSIAMHRLIASAHRHNIKVIMDLVPNHTSSEHPWFLEA
MAV_2842|M.avium_104 IDSD----------------------------DHAAARWFRGSR-----G
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MMAR_2753|M.marinum_M AD------------------------------DPSSAGWFRGRA-----G
MUL_3001|M.ulcerans_Agy99 AD------------------------------DPSSAGWFRGRA-----G
Mflv_3333|M.gilvum_PYR-GCK VD-------------------------------GGDRSWFATRG-----D
Mvan_3059|M.vanbaalenii_PYR-1 AA-------------------------------GGDSAWFRRRG-----G
MSMEG_3576|M.smegmatis_MC2_155 LGGD-----------------------------ADSAAWFRHRD-----G
TH_2297|M.thermoresistible__bu AAG-------------------------------GSSGWFRRRG-----D
Mb2498|M.bovis_AF2122/97 LADLPGSPARDRYFFRDGRGPDGSLPPNNWESVFGGPAWTRVREPDGNPG
Rv2471|M.tuberculosis_H37Rv LADLPGSPARDRYFFRDGRGPDGSLPPNNWESVFGGPAWTRVREPDGNPG
MAB_1565c|M.abscessus_ATCC_199 LQSPPGSDARERYIFRDGKGAHGELPPNNWPSVFGGPAWTRVTEADGTPG
MAV_2842|M.avium_104 RFHTFEGHDGLITLNHDNPEVVDYTVDVMAHWLGRGADGWRLDAAYAVPE
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MMAR_2753|M.marinum_M NFRTFEGHSELITLNHANPEVADYVVDVMAHWLQRGADGWRLDAAYAVPQ
MUL_3001|M.ulcerans_Agy99 NFRTFEGHSGLITLNHANPEVADYVVDVMAHWLQRGADGWRLDAAYAVPQ
Mflv_3333|M.gilvum_PYR-GCK DFATFEGHEGLITLDHDNADVVDYTVDVMSHWLARGADGWRLDAAYAVPD
Mvan_3059|M.vanbaalenii_PYR-1 DFATFEGHGDLIALDHRSAEVVDYTVDVMSHWLGRGADGWRLDAAYAVPD
MSMEG_3576|M.smegmatis_MC2_155 KFEVFEGHGELIALNHDNPEVVNYTAGVMRHWLGRGADGWRLDAAYAVPD
TH_2297|M.thermoresistible__bu RFETFEGHDELIALDHDNPEVAAYTVDVLRHWLNRGADGWRLDAAYAVPD
Mb2498|M.bovis_AF2122/97 QWYLHLFDTEQPDLNSDNPEILDDFEKTLRFWLDRGVDGFRIDVAHGMAK
Rv2471|M.tuberculosis_H37Rv QWYLHLFDTEQPDLNWDNPEILDDFEKTLRFWLDRGVDGFRIDVAHGMAK
MAB_1565c|M.abscessus_ATCC_199 QWYLHLFAPEQPDVNWDNPEVFDDFADTLRFWLDRGIDGFRLDVAHGMAK
MAV_2842|M.avium_104 T-----------------------------FWAATLPRVRDRYPQAWFVG
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MMAR_2753|M.marinum_M Q-----------------------------FWAKVLPRVRDRYPRAWFVG
MUL_3001|M.ulcerans_Agy99 Q-----------------------------FWAKVLPRVRDRYPQAWFVG
Mflv_3333|M.gilvum_PYR-GCK R-----------------------------FWAQVLPRVRQAHPAAWFVG
Mvan_3059|M.vanbaalenii_PYR-1 S-----------------------------FWAGVLPRVRERHPQAWFVG
MSMEG_3576|M.smegmatis_MC2_155 R-----------------------------FWAQVLPIVRSDFGDAWFVG
TH_2297|M.thermoresistible__bu R-----------------------------FWARVLPDVRRSHPEAWFVG
Mb2498|M.bovis_AF2122/97 PPGLPDSPDLGIEVLHHRDDDPRFNHPNVHAIHRDIRTVIDEYPGAVTVG
Rv2471|M.tuberculosis_H37Rv PPGLPDSPDLGIEVLHHRDDDPRFNHPNVHAIHRDIRTVIDEYPGAVTVG
MAB_1565c|M.abscessus_ATCC_199 PPGLPDIEDTETSMLHIADEDPRFNNEGVHEYHRKIRKVLDQYRDVVAVG
MAV_2842|M.avium_104 ELIHGD---YAAVVRAAGFDSATQYELWKAIWSSLNDGNFYELDWALQRH
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MMAR_2753|M.marinum_M EIIHGD---YAAAVQGAGFDSVTQYELWKAIWSGLNDGNFFELDWALQRH
MUL_3001|M.ulcerans_Agy99 EIIHGD---YAAAVQGAGFDSVTQYELWKAIWSGLNDGNFFELDWALQRH
Mflv_3333|M.gilvum_PYR-GCK EVIHGD---YVARVRDSGFDSVTQYELWKAVWSSINDANFHELDWALTRH
Mvan_3059|M.vanbaalenii_PYR-1 EVIHGD---YPARVRDSGFDSVTQYELWKAIWSSLNDGNFHELDWALTRH
MSMEG_3576|M.smegmatis_MC2_155 EVIHGD---YAATVAASTFDSVTQYELWKAVWSALNDGNFHELDWALQRH
TH_2297|M.thermoresistible__bu EVIHGD---YAATVSAASFDSVTQYELWKAVWSSLNDGNFFELDWALQRH
Mb2498|M.bovis_AF2122/97 EVWVHDNARWAEYLRPDELHLGFNFRLARTEFDAAEIRDAVANSLAAAAL
Rv2471|M.tuberculosis_H37Rv EVWVHDNARWAEYLRPDELHLGFNFRLARTEFDAAEIRDAVANSLAAAAL
MAB_1565c|M.abscessus_ATCC_199 EIWVNDNTRFAEYVRPDELHLGFNFKLVEADFDADQIRAAIQNSLAAVDS
MAV_2842|M.avium_104 NAFLGRFSPLTFIGNHDVTRIASQLNNPAHLAHALVLLLTVGGVPSVYAG
MLBr_02045|M.leprae_Br4923 -----------------MSRIASQLGQPEHLTHALIILLTVAGVPSVYAG
MMAR_2753|M.marinum_M NEFVASFAPLTFIGNHDVTRIASRLERPEHLAHALVILMTVGGIPSIYAG
MUL_3001|M.ulcerans_Agy99 NEFVASFAPLTFIGNHDVTRIASRLERPEHLAHALVILMTVGGIPSIYAG
Mflv_3333|M.gilvum_PYR-GCK NEFLDTFVPLTFIGNHDVTRIASRLTDPAHVEHALVVLLTTGGTPSVYAG
Mvan_3059|M.vanbaalenii_PYR-1 DEFLDTFVPMTFVGNHDVTRIASQLTDPTHVEHALVLLMTVGGTPSVYAG
MSMEG_3576|M.smegmatis_MC2_155 NDFLASFVPMTFVGNHDVTRIASQLSDARHLEHALVILFTTGGIPSVYAG
TH_2297|M.thermoresistible__bu NDFLAVFTPLTFIGNHDVTRIASRLADRRHVEHAVVLLLTVGGVPSIYAG
Mb2498|M.bovis_AF2122/97 QNATPTWTLANHDVGREVSRYGGGEIGLRRAKAMAVVMLALPGVVFLYNG
Rv2471|M.tuberculosis_H37Rv QNATPTWTLANHDVGREVSRYGGGEIGLRRAKAMAVVMLALPGVVFLYNG
MAB_1565c|M.abscessus_ATCC_199 VGATPTWTLSNHDVEREVTRYGDGQIGQWRARAMALVMLALPGTVFIYNG
::* .. : ::::: * :* *
MAV_2842|M.avium_104 DELGFRGVKE----------ERFGGDDAVRPEFGSPP--------IPLDD
MLBr_02045|M.leprae_Br4923 DEFGFRGLKE----------ERYGVDDAVLPEFFSPP--------MQLDV
MMAR_2753|M.marinum_M DEFGWRAVKE----------ERYGGDDAIRPEFGSPP--------LQLTH
MUL_3001|M.ulcerans_Agy99 DEFGWRAVKE----------ERCGGDDAIRPEFGSPP--------FELTH
Mflv_3333|M.gilvum_PYR-GCK DEVAYRGVKE----------ERFGGDDAVRPEFRSPF--------DGVGE
Mvan_3059|M.vanbaalenii_PYR-1 DEVAYRGVKE----------ERFGGDDAVRPEFGSPF--------EGVGE
MSMEG_3576|M.smegmatis_MC2_155 DEWGHQGVKE----------ERRGGDDAVRPEFGERP---------GPDA
TH_2297|M.thermoresistible__bu DEAGYLGVKE----------ERFSGDDAIRPEFGSPPIVS----GAGENT
Mb2498|M.bovis_AF2122/97 QELGLPDVDLPDEVLQDPTWERSGRTERGRDGCRVPIPWSGNIPPFGFST
Rv2471|M.tuberculosis_H37Rv QELGLPDVDLPDEVLQDPTWERSGRTERGRDGCRVPIPWSGNIPPFGFST
MAB_1565c|M.abscessus_ATCC_199 SELGLPNVELPDEALQDPVWERSGHTERGRDGCRVPIPWEGTDPPYGFSS
.* . :. ** . :
MAV_2842|M.avium_104 FGTEVWRLHQYLIGLRRRHPWLHAATTTALLLQNRHYVYETRSGDEALLI
MLBr_02045|M.leprae_Br4923 FGVHAWALHQYLIGLRRRHP------------------------------
MMAR_2753|M.marinum_M DQASVWALHQYLVGLRRRYPWLHTASTSALRLRNRQYVYQTRSADNALVV
MUL_3001|M.ulcerans_Agy99 DQASVWALHQYLVGLRRRYPWLHTASTSALRLRNRQYVYQTRSADNALVV
Mflv_3333|M.gilvum_PYR-GCK QGHQMFRSHQHLIGLRRRHPWLHEARTTALSVTNTGYVYITRSGDDALVV
Mvan_3059|M.vanbaalenii_PYR-1 HGHQVFRSHQHLIGLRRRNPWLHTARTTPLRVTNRGYVYTTRHGDDALVV
MSMEG_3576|M.smegmatis_MC2_155 PGADVLRLHQYLIGLRRRHPWLHSATTTPLLLTNTQYVYRSAGAAGALVV
TH_2297|M.thermoresistible__bu VAADLVRLHQHLIGLRRRNPWLHTATTAPLHLTNTQYVYESRSGEHALVV
Mb2498|M.bovis_AF2122/97 CPDTWLPMPPEWAALTAEKQRADAGSTLSFFRLALRLRRERNEFDG-DVD
Rv2471|M.tuberculosis_H37Rv CPDTWLPMPPEWAALTAEKQRADAGSTLSFFRLALRLRRERNEFDG-DVD
MAB_1565c|M.abscessus_ATCC_199 NAQTWLPMPHGWAEYTVERQLEHTDSMLSLYRRAIELRKSRKEFTGTSLE
.
MAV_2842|M.avium_104 VLNIGDEPLRVSLDELGGRRGRVIGGSAAPPPEVLDTVVVEPQGWRILSP
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MMAR_2753|M.marinum_M ILNADDEPLRMSLPDLGIPRAEVLAGSAAPPQEVTDEVLVEGHGWRILQP
MUL_3001|M.ulcerans_Agy99 ILNADDEPLRMSLPDLGIPHAEVLAGSAAPPQEVTDEVLVEGHGWRILQP
Mflv_3333|M.gilvum_PYR-GCK ALNVADEPLPVALSGLGLGHAEIVAGSGAPPAEVVPDIVVPPHGWVILNP
Mvan_3059|M.vanbaalenii_PYR-1 ALNIDDDAMPVSLAEFGLARAEVVAGSGAPPAQVVADTVVPAHGWLILAP
MSMEG_3576|M.smegmatis_MC2_155 ALNLDDAPLRVALPELGLASGVVVAGSKAPPQEQIEVTEVPPHGWLVIEP
TH_2297|M.thermoresistible__bu ALNIDTAPLPLRLSEIGLGAGRVVAGSGAPPAADLTNVDVAPHGWLIIEP
Mb2498|M.bovis_AF2122/97 WLAAPDDALIFRRHGGGLVCALNAAERPLALPAGEPILASAPLTDATLPP
Rv2471|M.tuberculosis_H37Rv WLAAPDDALIFRRHGGGLVCALNAAERPLALPAGEPILASAPLTDATLPP
MAB_1565c|M.abscessus_ATCC_199 WYGSPPGALAFRVKGGGLTCALNVSSDLVDLPEGEVILTSGPLVNGKLPR
MAV_2842|M.avium_104 I---------------
MLBr_02045|M.leprae_Br4923 ----------------
MMAR_2753|M.marinum_M A---------------
MUL_3001|M.ulcerans_Agy99 ASRFSCASVSGSSRRA
Mflv_3333|M.gilvum_PYR-GCK R---------------
Mvan_3059|M.vanbaalenii_PYR-1 R---------------
MSMEG_3576|M.smegmatis_MC2_155 R---------------
TH_2297|M.thermoresistible__bu AR--------------
Mb2498|M.bovis_AF2122/97 NAAAWLV---------
Rv2471|M.tuberculosis_H37Rv NAAAWLV---------
MAB_1565c|M.abscessus_ATCC_199 NTAAWIV---------