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WYLSVAPDELAAAATELRGVGSIVSTVNAAAAVPTTALWPAAADEVSAAIAALFSSHAQQYQSLSVQVAA YHDQFVRALAAGGASYSLAEAASASPLEQLLDLINLPSQTLLGRPLIGDGADGTASAPNGGAGGLLYGNG GNGYDNSASAGVAGGAGGSAGLVGNGGIGGAGGALAAGGAGGTGGLLFGNGGSSGAGGLGAVGGQGGGAG TLSLVGSGGDGGHGGEGTPGGSGGTGGGGSAGLFGRGGFGGSGGTGGDGVVGSPAALDGGAGGTGGSGGR GGLFAVGGDGGHGGIGGNGARGADGVGDGESGTAGGNGGAGGAGGVGGTGISSGSDGVGGGGGNGGRGGD GIRGADGVLDCESGYLGGSGGAGGAGGAGGGGSQVGSDGVGGAGGAGGTGGAGGHGARGADGLLDGEAGS KGGAGGGGGAGGAGGAGSQAGSDGVGGAGGDGGDGGHGAYGDGKAGGGGGAGGRGGDGGDGDTGGAAGNG GDGGEGGNAVANSGRGGGTGGAGGVGGDGGNGTNGVGGAGGHGGMGGNAGSSDAANGAVGSRGGDGGDGG KGGQGTTGGDGGNGGSAGKGGTGGAAAQTNDAGDGGDGGASSTSTGGAPGGVGGDGDDGDPPTGQTGGGG TGGGGGAPGVV*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_2354 | - | - | 100% (642) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_3318 | - | e-165 | 49.20% (685) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_4367 | - | e-162 | 46.51% (759) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3537 | PE_PGRS53 | 1e-173 | 50.43% (692) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-126 | 46.48% (596) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv1091 | PE_PGRS22 | 1e-178 | 48.67% (750) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 2e-12 | 37.50% (96) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 6e-48 | 34.25% (435) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_3105 | - | 0.0 | 93.10% (652) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 2e-21 | 42.13% (178) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-110 | 40.42% (663) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 4e-46 | 41.72% (302) | PUTATIVE - |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-124 | 46.01% (602) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MUL_2354|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3105|M.marinum_M -------------------------------------------------- Mb3537|M.bovis_AF2122/97 -------------------------------------------------- Rv1091|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_2354|M.ulcerans_Agy99 ----------MWYLSVAPDELAAAATELRGVGSIVSTVNAAAAVPTTALW MMAR_3105|M.marinum_M ----------MWYLSVAPDELAAAATELRDVGSIVSTVNAAAAVPTTALW Mb3537|M.bovis_AF2122/97 ----------MSFVLVSPETVAAVATDLKRIGASLAHENASAAASTTAVV Rv1091|M.tuberculosis_H37Rv ----------MSFVIAAPEALVAVASDLAGIGSALAEANAAALAPTTALL Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAA MUL_2354|M.ulcerans_Agy99 PAAADEVSAAIAALFSSHAQQYQSLSVQVAAYHDQFVRALAAGGASYSLA MMAR_3105|M.marinum_M PAAADEVSAAIAALFSSHAQQYQSLSVQVAAYHDQFVRALAAGGASYSLA Mb3537|M.bovis_AF2122/97 SAAADEVSTAVAALFSQHAQGYQAAAAQVAAFHSRFVQALTAGAGAYAFA Rv1091|M.tuberculosis_H37Rv AAGADEVSAAIAALFGAHGQAYQTVSAQASAFHAQFVQALTGGGGAYAAA Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 TASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARR MUL_2354|M.ulcerans_Agy99 EAASAS--------------------------------PLEQ----LLDL MMAR_3105|M.marinum_M EAASAS--------------------------------PLEQ----LLDL Mb3537|M.bovis_AF2122/97 EAANAS--------------------------------PLQS----AMGA Rv1091|M.tuberculosis_H37Rv EAANVS--------------------------------AAQSTDQRLLDL Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LLSPRDN-------------------------------DFLSHNDTDFAS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 IDN----------------------------------------------- MUL_2354|M.ulcerans_Agy99 IN--------------------LPSQTLLG--------RPLIGDGADGTA MMAR_3105|M.marinum_M IN--------------------LPSQTLLG--------RPLIGDGADGTA Mb3537|M.bovis_AF2122/97 VS--------------------ASAQTLLS--------RPLIGNGANATT Rv1091|M.tuberculosis_H37Rv IN--------------------GPTQALLG--------RPLIGDGANG-G Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 HN------------------PIASGNQVMS---------PSGNVDSFNRG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------VMLVS--------AFLAAAALAQNV MUL_2354|M.ulcerans_Agy99 SAPNGGAGGLLYGNGGNGYDNSASAGVAGGAGG----SAGLVGNGGIGGA MMAR_3105|M.marinum_M SAPNGGAGGLLYGNGGNGYDNSASAGVAGGAGG----SAGLIGNGGIGGA Mb3537|M.bovis_AF2122/97 PGGNGGDGGWLFGSGGNGAP--GAAGQSGGNGG----SAGLWGNGGAGGA Rv1091|M.tuberculosis_H37Rv PGQDGGPGGLLYGNGGNGGT-STTAGVAGGNGG----AAGLIGNGGAGGG Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWN-SDVVGMDGGNGG----NGGLFGGNGGNGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWN-SEIAGVSGGNGG----NAGLFGGNGGNGG MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYD-GSAAGLAGGNGG----NAGLFG-NGGNGG TH_3810|M.thermoresistible__bu ----------VDGDGG-----------SGGRTG----LFSKLSRGGDGGD MAB_4284c|M.abscessus_ATCC_199 PLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNGDVRD MLBr_01183|M.leprae_Br4923 -------MPLFLNAEPQALT-----AAANTLEG---LSAATVASNAAAAQ MAV_4827|M.avium_104 GGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQ . . . . MUL_2354|M.ulcerans_Agy99 GG-ALAAGGAGGTGG--LLFGNGGSSGAGGLGAVGGQG------------ MMAR_3105|M.marinum_M GG-ALAAGGAGGTGG--LLFGNGGSGGAGGLGAVGGQG------------ Mb3537|M.bovis_AF2122/97 GGSGGAAGGNGGNGG--WLFGAGGTGGIGGTGAPGAMGGTGGNGGNGALL Rv1091|M.tuberculosis_H37Rv GG-AGAAGGNGGAGG--WLYGNGGAGGAGGTSVIPGVAG----------- Mflv_5091|M.gilvum_PYR-GCK NGLGGGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--------- Mvan_1264|M.vanbaalenii_PYR-1 NGLGSGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--------- MSMEG_0868|M.smegmatis_MC2_155 VGWAGLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDG-------- TH_3810|M.thermoresistible__bu GG-LGGNGGHGGGTGIISLLSLAGNGGNGGNGYRTTDNN----------- MAB_4284c|M.abscessus_ATCC_199 SNIINADHGSNVGVDQSQTRVGGDYTNVSGHGSADIDKSVT--------- MLBr_01183|M.leprae_Br4923 LT-TEIAPPAADDVS---ILLAHFFSGHGR-------------------- MAV_4827|M.avium_104 LSAMVAGLEKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVS------- MUL_2354|M.ulcerans_Agy99 ------GGAGTLS------------------LVGSGGDGGHG-------- MMAR_3105|M.marinum_M ------GGAGTLS------------------LVGSGGDGGHG-------- Mb3537|M.bovis_AF2122/97 IGGGGLGGAGGMGGTGGGTGGTGGNGGNGALLIGAGGVGGAGGIGGQGT- Rv1091|M.tuberculosis_H37Rv ----GNGGAGGSAG-----------------LWGTGGAGGDGGNGRSG-- Mflv_5091|M.gilvum_PYR-GCK --APGVAGATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG- Mvan_1264|M.vanbaalenii_PYR-1 --APGVAGATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG- MSMEG_0868|M.smegmatis_MC2_155 -GTGGTGGTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGN TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------VVDDHSQRNTTNINDSFN- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------VAEEPETALARG------- MUL_2354|M.ulcerans_Agy99 ---------GEGTPGGSGGTGGGG-SAGLFGRGGFGGSGGTGGDGVVG-- MMAR_3105|M.marinum_M ---------GEGTPGGSGGTGGGGGSAGLFGRGGFGGSGGTGGDGVVG-- Mb3537|M.bovis_AF2122/97 ---------GAGGAAGAGGTGGNGGAGGLFMNGGDGGAGGQGGDGAAG-- Rv1091|M.tuberculosis_H37Rv ---------PVNVAGSAGGNGGAGGAAGLFGDAGAGGNGGKGGAGGAA-- Mflv_5091|M.gilvum_PYR-GCK -------------AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG-- Mvan_1264|M.vanbaalenii_PYR-1 -------------AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG-- MSMEG_0868|M.smegmatis_MC2_155 GGFGYVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGG TH_3810|M.thermoresistible__bu --------------ALDGGHGGNGGNVGFFSLFNLGGAGGWGGSGVDG-- MAB_4284c|M.abscessus_ATCC_199 ----------TDRSTNIGSGNTTNTEIGSHNQANIGTSTSAGGSAAVG-- MLBr_01183|M.leprae_Br4923 -------------QYQAHASQGATNHQDLIQSLLTSSS-AYAGTETAN-- MAV_4827|M.avium_104 ------------AALAAANAPLFASSTAALAYAQDPGTGAVDQYSLPD-- MUL_2354|M.ulcerans_Agy99 -------------SPAALDGGAG------GTGGSGGRGG----------- MMAR_3105|M.marinum_M -------------SPAALDGGAG------GTGGSGGRGG----------- Mb3537|M.bovis_AF2122/97 -------------DAAASAGGTG------GKGGQGGDGGTGGA----GGA Rv1091|M.tuberculosis_H37Rv -------------FSINFTAGDG------GAGGAGGSGG----------- Mflv_5091|M.gilvum_PYR-GCK --------------AVGAAGAAG------TVGTAGATGGTG--------- Mvan_1264|M.vanbaalenii_PYR-1 --------------AIGTAGVAG------AAGTAGATGGTG--------- MSMEG_0868|M.smegmatis_MC2_155 AILIGANGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGS TH_3810|M.thermoresistible__bu ---------------VDVVGGNP--------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------GNAGLAGNAG--------------------------- MLBr_01183|M.leprae_Br4923 ------------------HDSL---------------------------- MAV_4827|M.avium_104 ----------YLYVPVDPEPGDD--------------------------- MUL_2354|M.ulcerans_Agy99 ---LFAVGGDGGHGGIGGNGARGADG------------------------ MMAR_3105|M.marinum_M ---LFAVGGDGGHGGIGGNGARGADG------------------------ Mb3537|M.bovis_AF2122/97 GPVLFGHGGAGGMGGQGGTGGMGGAGGDGTTVIAAGTGGEGGTGGTGGTG Rv1091|M.tuberculosis_H37Rv HALLWGAGGAGGNGGSGGTGGAGGST------------------------ Mflv_5091|M.gilvum_PYR-GCK ------TGANGGAGGVGGVGGTGAAG------------------------ Mvan_1264|M.vanbaalenii_PYR-1 ------VGGNGGAGQAGGIGGTGAAG------------------------ MSMEG_0868|M.smegmatis_MC2_155 TAEGTATGGDGGHSTGTGIGGNGGIGSVYAY------------------- TH_3810|M.thermoresistible__bu ------DGGTPGAHGESHTPGVYTDR------------------------ MAB_4284c|M.abscessus_ATCC_199 ------LAGNAGLAGNAGLAGNAGLA------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---ELAYSAVGEEDAESPTVVIEKLFLP---------------------- MUL_2354|M.ulcerans_Agy99 ---------------------------------------VGDGESGTAGG MMAR_3105|M.marinum_M ---------------------------------------VGDGESGTAGG Mb3537|M.bovis_AF2122/97 GNGADAAAVVGFGANGDPGFAGGKGGNGGIGGAAVTGGVAGDGGTGGKGG Rv1091|M.tuberculosis_H37Rv ---------------------------------------AGAGGNGGAGG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------AAGGAGGLGETGT Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------AAGQAGTAGETGV MSMEG_0868|M.smegmatis_MC2_155 ----------------------------GNNGAVSGTATGGRGGDGIDGG TH_3810|M.thermoresistible__bu -----------------------------------------QGEDGEDGT MAB_4284c|M.abscessus_ATCC_199 ------------------------------------------GNAGLAGN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------------------------------------EDSEPRRR MUL_2354|M.ulcerans_Agy99 NGGAGGAG----------------GVGGTGISSGSDGVGGG--------- MMAR_3105|M.marinum_M NGGAGGAG----------------GVGGTGILSGSDGVGGG--------- Mb3537|M.bovis_AF2122/97 TGGAGGAGNDAGSTGNPGGKGGDGGIGGAGGAGGAAGTGNGGHAGNTGDG Rv1091|M.tuberculosis_H37Rv GGGTGGLLFG------------NGGAGGHGAAAG-NGLAAGNGVSSSGGG Mflv_5091|M.gilvum_PYR-GCK TGGAGGVGGQ----GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGG Mvan_1264|M.vanbaalenii_PYR-1 TGGVGGIGGQ----GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGG MSMEG_0868|M.smegmatis_MC2_155 TGGAGGMGEIY--SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAG TH_3810|M.thermoresistible__bu GTGIGGRG------------------GNGGSSSGTHPMAED--------- MAB_4284c|M.abscessus_ATCC_199 AGLAGNAG----------------LAGNAGLAGNAGLAGNAG-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PVLLVGSG--------------LAVVGISAVLALEIALAIG--------- MUL_2354|M.ulcerans_Agy99 -----------------GGNGGRGGDGIRGADGVLD-------------- MMAR_3105|M.marinum_M -----------------GGNGGRGGDGIRGADGVLD-------------- Mb3537|M.bovis_AF2122/97 GD------------GGTGGNGGNGTGGVNGADNTLNPD------------ Rv1091|M.tuberculosis_H37Rv GA------------GGTGGAGGDGGAGGAGGNARLWG------------- Mflv_5091|M.gilvum_PYR-GCK QG-------------LQGGKGGDGGAGGKGGDADSMGS------------ Mvan_1264|M.vanbaalenii_PYR-1 QG-------------LQGGQGGDGGTGGTGGDATSMGE------------ MSMEG_0868|M.smegmatis_MC2_155 YGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAI TH_3810|M.thermoresistible__bu ------------------GEHVKALDGRPGLD------------------ MAB_4284c|M.abscessus_ATCC_199 ----------------LAGNAGLAGNAGLAGNAGLAGN------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------IRTTGTVALQPTPNQHLIVPTEQAP--------- MUL_2354|M.ulcerans_Agy99 -------CESGYLGGSGG------------------------AGGAGGAG MMAR_3105|M.marinum_M -------GESGYLGGSGG------------------------AGGAGGAG Mb3537|M.bovis_AF2122/97 -----TPGGAGEPGGAGG------------------------AGGAGGAA Rv1091|M.tuberculosis_H37Rv ------VGGAGGAGGDGG------------------------AGGAGGKG Mflv_5091|M.gilvum_PYR-GCK ------AGATGGKGGNGGNGGRGGLFG---------------KGGNAGNG Mvan_1264|M.vanbaalenii_PYR-1 ------AGATGGKGGNGGNGGRGSLFG---------------RGGNAGNG MSMEG_0868|M.smegmatis_MC2_155 GGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNG TH_3810|M.thermoresistible__bu -------------GGNGS------------------------HGGNGGHG MAB_4284c|M.abscessus_ATCC_199 ----------AGLAGNAG------------------------LAGNAGLA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------APPPVQASAPQPKISVPEP----------------------- MUL_2354|M.ulcerans_Agy99 GG-------------------------------------------GSQVG MMAR_3105|M.marinum_M GG-------------------------------------------GSQVG Mb3537|M.bovis_AF2122/97 GGPGGTGGTGGNGGNAGNNSTNAPVGGEGGAGGDGGAGGAGGAANGGTAG Rv1091|M.tuberculosis_H37Rv GS------------------------------------GLSGNANGGAGG Mflv_5091|M.gilvum_PYR-GCK AD----------------------------------------GGTGGAGG Mvan_1264|M.vanbaalenii_PYR-1 GN----------------------------------------GGTGGNGG MSMEG_0868|M.smegmatis_MC2_155 GNGW------------------VQAYDPNGPAGTTIDKGKAAGGNGGDGG TH_3810|M.thermoresistible__bu GR-------------------------------------------GGFLG MAB_4284c|M.abscessus_ATCC_199 GN-------------------------------------------AGLAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------VAAPKPL MUL_2354|M.ulcerans_Agy99 SDGVGG-AGGAGGTGG---------------------------------- MMAR_3105|M.marinum_M SDGVG----GAGGTGG---------------------------------- Mb3537|M.bovis_AF2122/97 SQGTGG-VGGDGGAGGNGGGGKAGTGNSGNFGVDGEAGFSGGAGGNGGVG Rv1091|M.tuberculosis_H37Rv DSGRGG-TGGAGGEGGAAG------------------------------- Mflv_5091|M.gilvum_PYR-GCK AGGTGG-TGGAGGTGG---------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 NGGTGG-TGGNGGTGG---------------------------------- MSMEG_0868|M.smegmatis_MC2_155 FNGTGGATGGRGGDGAGASVWKA--------------------------- TH_3810|M.thermoresistible__bu IGGSGG-WGGHGGNGG---------------------------------- MAB_4284c|M.abscessus_ATCC_199 NAGLAG-NAGLAGNAG---------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 SPPVAAPLPAAPPPAAP--------------------------------- MUL_2354|M.ulcerans_Agy99 ---------------------------------------AGGHGARGADG MMAR_3105|M.marinum_M ---------------------------------------AGGHGARGADG Mb3537|M.bovis_AF2122/97 GAAGANGGTGGSGGNGGDGGAGGIGGAGGNGIPGTGTEPAGGTGAKGGDG Rv1091|M.tuberculosis_H37Rv --------------------------------------LLVGTGGHGGDG Mflv_5091|M.gilvum_PYR-GCK ---------------------------------------TGGTGGIGGAG Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------------TGGTGGIGGAG MSMEG_0868|M.smegmatis_MC2_155 -----------------------------NGQHSTGQTDTGGNGGRGGDG TH_3810|M.thermoresistible__bu --------------------------------------DTDADGGNGGDG MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------LAGNAAVAGNA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------------------------------------PLPEAPPIPAAP MUL_2354|M.ulcerans_Agy99 LLDGEAGSKGGAGGGGGA--GGAGGAGSQAGSDGVGGAG----------- MMAR_3105|M.marinum_M LLDGEAGSKGGAGGGGGA--GGAGGAGSQAGSDGVGGAG----------- Mb3537|M.bovis_AF2122/97 GDGGAGGAGGNAGGAGGN--GGAGGQGGNAGQGGAGGAGGNAVIPGDGVG Rv1091|M.tuberculosis_H37Rv GAGGAAVKGGDGGAAAGT--GIAG-AGGRGGAGGSGGSG----------- Mflv_5091|M.gilvum_PYR-GCK STGGTGGTGGTGGTGGTG--GTG-GTGGTGGTGGTGGKG----------- Mvan_1264|M.vanbaalenii_PYR-1 STGGTGGTGGTGGTGGTG--GTG-GTGGTGGTGGTGGKG----------- MSMEG_0868|M.smegmatis_MC2_155 GTFVNAGANGNGGAGGAG--GVSEGEGGTGGHGGDGGRG----------- TH_3810|M.thermoresistible__bu GNGGSAGRGGTGGLRGVF--GIN-GGNGRAGLGGRGXXX----------- MAB_4284c|M.abscessus_ATCC_199 AVAGNAAVAGNAAVGGVLNTGVSGAIGGSSHVGGAINESLG--------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PVVPVPVVVPPVPVPVPVRIPVPDPVSPPQLLAPPRLSVPQP-------- MUL_2354|M.ulcerans_Agy99 -----------GDGGDGGHGAYG--------------------------- MMAR_3105|M.marinum_M -----------GDGGDGGHGAYG--------------------------- Mb3537|M.bovis_AF2122/97 KAPHGGAGGSGGDGGKGGQGGSGGTGGSGAPIGGGAGGTGGSGGHAGKGG Rv1091|M.tuberculosis_H37Rv -----------GDGGGGAAGPAG--------------------------- Mflv_5091|M.gilvum_PYR-GCK -----------GTGGTGGAGGTG--------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------GTGGTGGDGGTG--------------------------- MSMEG_0868|M.smegmatis_MC2_155 -----------GDGALGGNGGTGG-------------------------- TH_3810|M.thermoresistible__bu -----------XGGGVGAAVRSG--------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------GSGSVGGSTAVG--------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------VQPPVRVPQPPS--------------------------- MUL_2354|M.ulcerans_Agy99 ---------------------DGKAGGGGGAGGRGGDG------GDGDTG MMAR_3105|M.marinum_M ---------------------DGKAGGGGGAGGRGGDG------GDGDTG Mb3537|M.bovis_AF2122/97 AGGIGAQGTTITVPGNGGNAGDGGNGGGGGAGGTGGDG------ATGTPA Rv1091|M.tuberculosis_H37Rv -----------------WLFGDGGAGGNGGAAAAGGAGG-----QAGGGG Mflv_5091|M.gilvum_PYR-GCK --------------------GDGGTGGTGGTGGTG---------GTGGTG Mvan_1264|M.vanbaalenii_PYR-1 --------------------GTGGTGGTGGTGGTG---------GTGGTG MSMEG_0868|M.smegmatis_MC2_155 -----------------VGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNG TH_3810|M.thermoresistible__bu ---------------------NGVFSGGGGTPSAG----------FGVPT MAB_4284c|M.abscessus_ATCC_199 ---------------------GGAHTGVGGGVSTG----------VGVGS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------------PPQVGGTVPQSPPQHQTP----PGEGTPP MUL_2354|M.ulcerans_Agy99 GAAGNG------------GDGGEGGN------------------------ MMAR_3105|M.marinum_M GAAGNG------------GDGGEGGN------------------------ Mb3537|M.bovis_AF2122/97 GNGGNG------------GNAGDGGNGGSGDFGGNTTSGASGSGGNGGNA Rv1091|M.tuberculosis_H37Rv GNGGNG------------GNGGNGGNGGNGATGG---------------- Mflv_5091|M.gilvum_PYR-GCK GTGGAG-----------DGTGGTGGTGG---------------------- Mvan_1264|M.vanbaalenii_PYR-1 GTGGAG-----------DGLGGTGGTGG---------------------- MSMEG_0868|M.smegmatis_MC2_155 GNGGAGRIRVNNGTATGTATGGNGGNGGNGD------------------- TH_3810|M.thermoresistible__bu TIQFPA-------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 H-VGGG-------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 KPDGPG-------------------------------------------- MUL_2354|M.ulcerans_Agy99 AVANSGRGGGTG--------------------GAGGVGG--DGGNGTNG- MMAR_3105|M.marinum_M AVANSGRGGGTG--------------------GAGGVGG--DGGNGTNG- Mb3537|M.bovis_AF2122/97 GTAGSGGAGGTGGTG--------------LSGGNGGNGG--DGGNGAHGT Rv1091|M.tuberculosis_H37Rv WLYGNGGAGGQG-----------------ATAGAGGAGA--NGVSSTNG- Mflv_5091|M.gilvum_PYR-GCK -TGGQGGQGGQGG-----------------TGGTGGQGG-LGGGGGTG-- Mvan_1264|M.vanbaalenii_PYR-1 -TGGFGGQGGQGG-----------------TGGTGGQGG-LGGVGGTG-- MSMEG_0868|M.smegmatis_MC2_155 ADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ISESLGGSGSVG--------------------GSTAVGG--GAHTGVGG- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --NYGGGHVPTP--------------------GAGGSGGSGGGHVPTPG- MUL_2354|M.ulcerans_Agy99 ----------------------VGGAGGHGGMG----------------- MMAR_3105|M.marinum_M ----------------------VGGAGGHGGMG----------------- Mb3537|M.bovis_AF2122/97 --------VGAQFVPATSLPTPNGGAGGNGGTGSNGGAPGPAGAPGPTTG Rv1091|M.tuberculosis_H37Rv -----------------------GGTGGNGGIG----------------- Mflv_5091|M.gilvum_PYR-GCK ---------------------GQGGTGGTGGQG----------------- Mvan_1264|M.vanbaalenii_PYR-1 ---------------------GTGGTGGTGGQG----------------- MSMEG_0868|M.smegmatis_MC2_155 ATIVAYNVVQANPQASGTATDGHGGSGINGGHG----------------- TH_3810|M.thermoresistible__bu ------------------------GSCTSRAVS----------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------GVSTGVGVG----------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------AGGSGGSG----------------- MUL_2354|M.ulcerans_Agy99 GNAGSS----DAANG-----AVGSRGGD---------------------- MMAR_3105|M.marinum_M GNAGSS----DAANG-----AVGSRGGD---------------------- Mb3537|M.bovis_AF2122/97 GNAGSQGIGGDGGNG-----GDGGKGGDGADAVNVVFMPTEPQAATGTAG Rv1091|M.tuberculosis_H37Rv GTGGSGGAGGNAGLL-----GVGGAGGHG--------------------- Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTGGTG--------GTGGAGGDG--------------------- Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGTG--------GTGGAGGDG--------------------- MSMEG_0868|M.smegmatis_MC2_155 GNGGQGTIEANGPSAVASGIGAGGNGGDG--------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------SHVGGGISES--------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_2354|M.ulcerans_Agy99 ---------------------------------GGDGGKGGQGTT----- MMAR_3105|M.marinum_M ---------------------------------GGAGGKGGQGTT----- Mb3537|M.bovis_AF2122/97 SAGDPTGGNGGPGTPGSPMVAPPPPTPITQVQQGGDGGAGGTGSTNANDG Rv1091|M.tuberculosis_H37Rv -------------------------------ASGGAGDRGGAGGTG---- Mflv_5091|M.gilvum_PYR-GCK -------------------------------GLGGLGGFGGSGGTG---- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------GLGGLGGFGGVGGTG---- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------IDGGLGGNGGDGVVN---- TH_3810|M.thermoresistible__bu ----------------------------------------REGIMP---- MAB_4284c|M.abscessus_ATCC_199 --------------------------------LGGSGSVGGSTAVG---- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------------------------GGHVPTPGTGGPG---- MUL_2354|M.ulcerans_Agy99 ----------------GGDGGNGGS------------------------- MMAR_3105|M.marinum_M ----------------GGDGGNGGS------------------------- Mb3537|M.bovis_AF2122/97 TATGGKGGEGGVGSILGGPGGNGGTGGNASATGTNGVANAGNGGKGGDGG Rv1091|M.tuberculosis_H37Rv -----------FISSDGGAGGDGGD------------------------- Mflv_5091|M.gilvum_PYR-GCK ----GQGGLGGPGGSTGGAGGAGG-------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----GQGGQGGPGGSTGGAGGAGG-------------------------- MSMEG_0868|M.smegmatis_MC2_155 ----TTANAANPGSATGTATGGDGG------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------GGAHTGVGGG------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_2354|M.ulcerans_Agy99 ----------------------AGKGGTGG-------------------- MMAR_3105|M.marinum_M ----------------------AGKGGTGG-------------------- Mb3537|M.bovis_AF2122/97 QFGAGGNGGAGGSVTDGSAGSTAGNGGNGGNATNGTIAGQPAGGNGSAGG Rv1091|M.tuberculosis_H37Rv ----------------------GGNGGAGG-------------------- Mflv_5091|M.gilvum_PYR-GCK ------------------QAGTAGKGGLFG------------------GS Mvan_1264|M.vanbaalenii_PYR-1 ------------------QAGVAGKGGLFG------------------GS MSMEG_0868|M.smegmatis_MC2_155 -----------------KATGTASQGGNGGPS--------------WVQS TH_3810|M.thermoresistible__bu ----------------------SSRAASAR-------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------VNTGVGVGSHVG-------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------------GTGGSGG-------------------- MUL_2354|M.ulcerans_Agy99 --------AAAQTNDAGDGGDG---------------------------- MMAR_3105|M.marinum_M --------SAVQTNDAGNGGDGGAGGDGGI----GTLGPGGDGGAGGNGG Mb3537|M.bovis_AF2122/97 KGGDGGNIAAGATGTAGNGGNGGNGNDGAVNA--GTGGSGGNGGNAGGGG Rv1091|M.tuberculosis_H37Rv -------TGGLLFGAGGNGGPGGSGGAADIG---GNGGAGNGGGTDGNGG Mflv_5091|M.gilvum_PYR-GCK GSAGKAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAG Mvan_1264|M.vanbaalenii_PYR-1 GSAGTAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASG MSMEG_0868|M.smegmatis_MC2_155 GYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTA TH_3810|M.thermoresistible__bu --------AGAACASSTSRSRRSFCCSRA--------------------- MAB_4284c|M.abscessus_ATCC_199 --------GGISESLGGSGSVGGSTAVG-----------GGAHTSAINDA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------GHVPTPGAGTPGGSGGGHLPFPG---------------AGST MUL_2354|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3105|M.marinum_M SGGDGNTQPVGHSLGGGGGVGGNGGQGGAGGQGITGGSGGAGGSGGNGGT Mb3537|M.bovis_AF2122/97 ANGGDGGAGGAGGAGGRGGKGIDGGFGGDGGNGGSNNGTGAGGNGGNGGT Rv1091|M.tuberculosis_H37Rv NGGSGGGAGSGGDGGGAGGNG-----AWLFGNGGAGGGGGKGGNGAGGGL Mflv_5091|M.gilvum_PYR-GCK KAGATGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQ Mvan_1264|M.vanbaalenii_PYR-1 AQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQ MSMEG_0868|M.smegmatis_MC2_155 TGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGK TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LGGSGSVGGSTAVGGG---------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PGGSGGGHLPTPGAGTPG-------------------------------- MUL_2354|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3105|M.marinum_M GGDDTENAEPSAGGAGGEGGMGGGGGDGVVGTGGMGG-----GGGQGGAG Mb3537|M.bovis_AF2122/97 GGVGSVGAAGGDGGNGGTGGFAGFGGTAGNGGSGGTGGAGGDGGTGGGGG Rv1091|M.tuberculosis_H37Rv GG-----------GSFGLPGLNGSGGDGGDGGNGAPG-----GVLYGNGG Mflv_5091|M.gilvum_PYR-GCK GAAG----KAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGG Mvan_1264|M.vanbaalenii_PYR-1 GAAG----KAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGG MSMEG_0868|M.smegmatis_MC2_155 GADG----WVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_2354|M.ulcerans_Agy99 ----------------------------GASSTS--------TGGAPGGV MMAR_3105|M.marinum_M GDAIDSV-----GGIGGKGGGGADGGGGGASSTS--------TGGAPGGV Mb3537|M.bovis_AF2122/97 NGGTGVI-----AGGGGTGGNGGASGAGGAGGTGGFAGN--GNAGGNGGT Rv1091|M.tuberculosis_H37Rv AGGQGSS-----GGIGGPGATGGAGGKGGDGGDAQLIGD--GGNGGNGGA Mflv_5091|M.gilvum_PYR-GCK AGG-----------AGGEGGEGGDGGKGGAGAE--------GGAGGGGGA Mvan_1264|M.vanbaalenii_PYR-1 AGG-----------AGGEGGEGGAGGAGGDGSE--------GGAGGSGGA MSMEG_0868|M.smegmatis_MC2_155 NGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------AHTSAINESMNSSINASHSSSMNESFGSSMGSHGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------------GGLGGFGGGHAPAP--------GGGLGGG MUL_2354|M.ulcerans_Agy99 GGDGDDGDP------PTGQTGGGG-TGGGGGAPGVV----- MMAR_3105|M.marinum_M GGDGDDGDP------PTGQTGGGGGTGGGGGAPGVV----- Mb3537|M.bovis_AF2122/97 GGASEDGDNGNAGSGATGGTGGNGGTGGDGGAAGLGGVA-- Rv1091|M.tuberculosis_H37Rv GGTGGTPGPG----GPGGSGGLGGLLFGQTGTAGVSP---- Mflv_5091|M.gilvum_PYR-GCK GGSGAGGAG------GAGGSGGSGGSGGSGGSGGAAGDSDD Mvan_1264|M.vanbaalenii_PYR-1 GGSGTGGAG------GAGGSGGSGGSGGAGGSGGAAGDSD- MSMEG_0868|M.smegmatis_MC2_155 GGTTAGGSGN----GGNGGNGGNGGADGTPGTAGTTGANNP TH_3810|M.thermoresistible__bu ----------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AGTGFEAQG---------HAQGHASETAHTTLPGAEHH--- MLBr_01183|M.leprae_Br4923 ----------------------------------------- MAV_4827|M.avium_104 GGHAPAPGGG------LGGFGGGHSGGGLGGLGGGHK----