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M. ulcerans Agy99 MUL_2354 (-)

annotation: PE-PGRS family protein
coordinates: 2640512 - 2642440
length: 642

WYLSVAPDELAAAATELRGVGSIVSTVNAAAAVPTTALWPAAADEVSAAIAALFSSHAQQYQSLSVQVAA
YHDQFVRALAAGGASYSLAEAASASPLEQLLDLINLPSQTLLGRPLIGDGADGTASAPNGGAGGLLYGNG
GNGYDNSASAGVAGGAGGSAGLVGNGGIGGAGGALAAGGAGGTGGLLFGNGGSSGAGGLGAVGGQGGGAG
TLSLVGSGGDGGHGGEGTPGGSGGTGGGGSAGLFGRGGFGGSGGTGGDGVVGSPAALDGGAGGTGGSGGR
GGLFAVGGDGGHGGIGGNGARGADGVGDGESGTAGGNGGAGGAGGVGGTGISSGSDGVGGGGGNGGRGGD
GIRGADGVLDCESGYLGGSGGAGGAGGAGGGGSQVGSDGVGGAGGAGGTGGAGGHGARGADGLLDGEAGS
KGGAGGGGGAGGAGGAGSQAGSDGVGGAGGDGGDGGHGAYGDGKAGGGGGAGGRGGDGGDGDTGGAAGNG
GDGGEGGNAVANSGRGGGTGGAGGVGGDGGNGTNGVGGAGGHGGMGGNAGSSDAANGAVGSRGGDGGDGG
KGGQGTTGGDGGNGGSAGKGGTGGAAAQTNDAGDGGDGGASSTSTGGAPGGVGGDGDDGDPPTGQTGGGG
TGGGGGAPGVV*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_2354--100% (642)PE-PGRS family protein
M. ulcerans Agy99MUL_3318-e-16549.20% (685) PE-PGRS family protein
M. ulcerans Agy99MUL_4367-e-16246.51% (759) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3537PE_PGRS531e-17350.43% (692) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-1e-12646.48% (596) triple helix repeat-containing collagen
M. tuberculosis H37RvRv1091PE_PGRS221e-17848.67% (750) PE-PGRS family protein
M. leprae Br4923MLBr_01183-2e-1237.50% (96) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-6e-4834.25% (435) hypothetical protein MAB_4284c
M. marinum MMMAR_3105-0.093.10% (652) PE-PGRS family protein
M. avium 104MAV_4827-2e-2142.13% (178) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-1e-11040.42% (663) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3810-4e-4641.72% (302) PUTATIVE -
M. vanbaalenii PYR-1Mvan_1264-1e-12446.01% (602) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


MUL_2354|M.ulcerans_Agy99           --------------------------------------------------
MMAR_3105|M.marinum_M               --------------------------------------------------
Mb3537|M.bovis_AF2122/97            --------------------------------------------------
Rv1091|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           ----------MWYLSVAPDELAAAATELRGVGSIVSTVNAAAAVPTTALW
MMAR_3105|M.marinum_M               ----------MWYLSVAPDELAAAATELRDVGSIVSTVNAAAAVPTTALW
Mb3537|M.bovis_AF2122/97            ----------MSFVLVSPETVAAVATDLKRIGASLAHENASAAASTTAVV
Rv1091|M.tuberculosis_H37Rv         ----------MSFVIAAPEALVAVASDLAGIGSALAEANAAALAPTTALL
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAA
                                                                                      

MUL_2354|M.ulcerans_Agy99           PAAADEVSAAIAALFSSHAQQYQSLSVQVAAYHDQFVRALAAGGASYSLA
MMAR_3105|M.marinum_M               PAAADEVSAAIAALFSSHAQQYQSLSVQVAAYHDQFVRALAAGGASYSLA
Mb3537|M.bovis_AF2122/97            SAAADEVSTAVAALFSQHAQGYQAAAAQVAAFHSRFVQALTAGAGAYAFA
Rv1091|M.tuberculosis_H37Rv         AAGADEVSAAIAALFGAHGQAYQTVSAQASAFHAQFVQALTGGGGAYAAA
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      VMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPS
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                TASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARR
                                                                                      

MUL_2354|M.ulcerans_Agy99           EAASAS--------------------------------PLEQ----LLDL
MMAR_3105|M.marinum_M               EAASAS--------------------------------PLEQ----LLDL
Mb3537|M.bovis_AF2122/97            EAANAS--------------------------------PLQS----AMGA
Rv1091|M.tuberculosis_H37Rv         EAANVS--------------------------------AAQSTDQRLLDL
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LLSPRDN-------------------------------DFLSHNDTDFAS
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                IDN-----------------------------------------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           IN--------------------LPSQTLLG--------RPLIGDGADGTA
MMAR_3105|M.marinum_M               IN--------------------LPSQTLLG--------RPLIGDGADGTA
Mb3537|M.bovis_AF2122/97            VS--------------------ASAQTLLS--------RPLIGNGANATT
Rv1091|M.tuberculosis_H37Rv         IN--------------------GPTQALLG--------RPLIGDGANG-G
Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1       S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      HN------------------PIASGNQVMS---------PSGNVDSFNRG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -------------------------VMLVS--------AFLAAAALAQNV
                                                                                      

MUL_2354|M.ulcerans_Agy99           SAPNGGAGGLLYGNGGNGYDNSASAGVAGGAGG----SAGLVGNGGIGGA
MMAR_3105|M.marinum_M               SAPNGGAGGLLYGNGGNGYDNSASAGVAGGAGG----SAGLIGNGGIGGA
Mb3537|M.bovis_AF2122/97            PGGNGGDGGWLFGSGGNGAP--GAAGQSGGNGG----SAGLWGNGGAGGA
Rv1091|M.tuberculosis_H37Rv         PGQDGGPGGLLYGNGGNGGT-STTAGVAGGNGG----AAGLIGNGGAGGG
Mflv_5091|M.gilvum_PYR-GCK          QN-----GGILFGNGGSGWN-SDVVGMDGGNGG----NGGLFGGNGGNGG
Mvan_1264|M.vanbaalenii_PYR-1       QN-----GGILFGNGGSGWN-SEIAGVSGGNGG----NAGLFGGNGGNGG
MSMEG_0868|M.smegmatis_MC2_155      DNPNGGTGGLLFGDGGHGYD-GSAAGLAGGNGG----NAGLFG-NGGNGG
TH_3810|M.thermoresistible__bu      ----------VDGDGG-----------SGGRTG----LFSKLSRGGDGGD
MAB_4284c|M.abscessus_ATCC_199      PLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNGDVRD
MLBr_01183|M.leprae_Br4923          -------MPLFLNAEPQALT-----AAANTLEG---LSAATVASNAAAAQ
MAV_4827|M.avium_104                GGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQ
                                                                .   .         . .     

MUL_2354|M.ulcerans_Agy99           GG-ALAAGGAGGTGG--LLFGNGGSSGAGGLGAVGGQG------------
MMAR_3105|M.marinum_M               GG-ALAAGGAGGTGG--LLFGNGGSGGAGGLGAVGGQG------------
Mb3537|M.bovis_AF2122/97            GGSGGAAGGNGGNGG--WLFGAGGTGGIGGTGAPGAMGGTGGNGGNGALL
Rv1091|M.tuberculosis_H37Rv         GG-AGAAGGNGGAGG--WLYGNGGAGGAGGTSVIPGVAG-----------
Mflv_5091|M.gilvum_PYR-GCK          NGLGGGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG---------
Mvan_1264|M.vanbaalenii_PYR-1       NGLGSGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG---------
MSMEG_0868|M.smegmatis_MC2_155      VGWAGLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDG--------
TH_3810|M.thermoresistible__bu      GG-LGGNGGHGGGTGIISLLSLAGNGGNGGNGYRTTDNN-----------
MAB_4284c|M.abscessus_ATCC_199      SNIINADHGSNVGVDQSQTRVGGDYTNVSGHGSADIDKSVT---------
MLBr_01183|M.leprae_Br4923          LT-TEIAPPAADDVS---ILLAHFFSGHGR--------------------
MAV_4827|M.avium_104                LSAMVAGLEKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVS-------
                                                                                      

MUL_2354|M.ulcerans_Agy99           ------GGAGTLS------------------LVGSGGDGGHG--------
MMAR_3105|M.marinum_M               ------GGAGTLS------------------LVGSGGDGGHG--------
Mb3537|M.bovis_AF2122/97            IGGGGLGGAGGMGGTGGGTGGTGGNGGNGALLIGAGGVGGAGGIGGQGT-
Rv1091|M.tuberculosis_H37Rv         ----GNGGAGGSAG-----------------LWGTGGAGGDGGNGRSG--
Mflv_5091|M.gilvum_PYR-GCK          --APGVAGATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG-
Mvan_1264|M.vanbaalenii_PYR-1       --APGVAGATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG-
MSMEG_0868|M.smegmatis_MC2_155      -GTGGTGGTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGN
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------------------------VVDDHSQRNTTNINDSFN-
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -------------------------------VAEEPETALARG-------
                                                                                      

MUL_2354|M.ulcerans_Agy99           ---------GEGTPGGSGGTGGGG-SAGLFGRGGFGGSGGTGGDGVVG--
MMAR_3105|M.marinum_M               ---------GEGTPGGSGGTGGGGGSAGLFGRGGFGGSGGTGGDGVVG--
Mb3537|M.bovis_AF2122/97            ---------GAGGAAGAGGTGGNGGAGGLFMNGGDGGAGGQGGDGAAG--
Rv1091|M.tuberculosis_H37Rv         ---------PVNVAGSAGGNGGAGGAAGLFGDAGAGGNGGKGGAGGAA--
Mflv_5091|M.gilvum_PYR-GCK          -------------AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG--
Mvan_1264|M.vanbaalenii_PYR-1       -------------AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG--
MSMEG_0868|M.smegmatis_MC2_155      GGFGYVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGG
TH_3810|M.thermoresistible__bu      --------------ALDGGHGGNGGNVGFFSLFNLGGAGGWGGSGVDG--
MAB_4284c|M.abscessus_ATCC_199      ----------TDRSTNIGSGNTTNTEIGSHNQANIGTSTSAGGSAAVG--
MLBr_01183|M.leprae_Br4923          -------------QYQAHASQGATNHQDLIQSLLTSSS-AYAGTETAN--
MAV_4827|M.avium_104                ------------AALAAANAPLFASSTAALAYAQDPGTGAVDQYSLPD--
                                                                                      

MUL_2354|M.ulcerans_Agy99           -------------SPAALDGGAG------GTGGSGGRGG-----------
MMAR_3105|M.marinum_M               -------------SPAALDGGAG------GTGGSGGRGG-----------
Mb3537|M.bovis_AF2122/97            -------------DAAASAGGTG------GKGGQGGDGGTGGA----GGA
Rv1091|M.tuberculosis_H37Rv         -------------FSINFTAGDG------GAGGAGGSGG-----------
Mflv_5091|M.gilvum_PYR-GCK          --------------AVGAAGAAG------TVGTAGATGGTG---------
Mvan_1264|M.vanbaalenii_PYR-1       --------------AIGTAGVAG------AAGTAGATGGTG---------
MSMEG_0868|M.smegmatis_MC2_155      AILIGANGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGS
TH_3810|M.thermoresistible__bu      ---------------VDVVGGNP---------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------GNAGLAGNAG---------------------------
MLBr_01183|M.leprae_Br4923          ------------------HDSL----------------------------
MAV_4827|M.avium_104                ----------YLYVPVDPEPGDD---------------------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           ---LFAVGGDGGHGGIGGNGARGADG------------------------
MMAR_3105|M.marinum_M               ---LFAVGGDGGHGGIGGNGARGADG------------------------
Mb3537|M.bovis_AF2122/97            GPVLFGHGGAGGMGGQGGTGGMGGAGGDGTTVIAAGTGGEGGTGGTGGTG
Rv1091|M.tuberculosis_H37Rv         HALLWGAGGAGGNGGSGGTGGAGGST------------------------
Mflv_5091|M.gilvum_PYR-GCK          ------TGANGGAGGVGGVGGTGAAG------------------------
Mvan_1264|M.vanbaalenii_PYR-1       ------VGGNGGAGQAGGIGGTGAAG------------------------
MSMEG_0868|M.smegmatis_MC2_155      TAEGTATGGDGGHSTGTGIGGNGGIGSVYAY-------------------
TH_3810|M.thermoresistible__bu      ------DGGTPGAHGESHTPGVYTDR------------------------
MAB_4284c|M.abscessus_ATCC_199      ------LAGNAGLAGNAGLAGNAGLA------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ---ELAYSAVGEEDAESPTVVIEKLFLP----------------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           ---------------------------------------VGDGESGTAGG
MMAR_3105|M.marinum_M               ---------------------------------------VGDGESGTAGG
Mb3537|M.bovis_AF2122/97            GNGADAAAVVGFGANGDPGFAGGKGGNGGIGGAAVTGGVAGDGGTGGKGG
Rv1091|M.tuberculosis_H37Rv         ---------------------------------------AGAGGNGGAGG
Mflv_5091|M.gilvum_PYR-GCK          -------------------------------------AAGGAGGLGETGT
Mvan_1264|M.vanbaalenii_PYR-1       -------------------------------------AAGQAGTAGETGV
MSMEG_0868|M.smegmatis_MC2_155      ----------------------------GNNGAVSGTATGGRGGDGIDGG
TH_3810|M.thermoresistible__bu      -----------------------------------------QGEDGEDGT
MAB_4284c|M.abscessus_ATCC_199      ------------------------------------------GNAGLAGN
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ------------------------------------------EDSEPRRR
                                                                                      

MUL_2354|M.ulcerans_Agy99           NGGAGGAG----------------GVGGTGISSGSDGVGGG---------
MMAR_3105|M.marinum_M               NGGAGGAG----------------GVGGTGILSGSDGVGGG---------
Mb3537|M.bovis_AF2122/97            TGGAGGAGNDAGSTGNPGGKGGDGGIGGAGGAGGAAGTGNGGHAGNTGDG
Rv1091|M.tuberculosis_H37Rv         GGGTGGLLFG------------NGGAGGHGAAAG-NGLAAGNGVSSSGGG
Mflv_5091|M.gilvum_PYR-GCK          TGGAGGVGGQ----GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGG
Mvan_1264|M.vanbaalenii_PYR-1       TGGVGGIGGQ----GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGG
MSMEG_0868|M.smegmatis_MC2_155      TGGAGGMGEIY--SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAG
TH_3810|M.thermoresistible__bu      GTGIGGRG------------------GNGGSSSGTHPMAED---------
MAB_4284c|M.abscessus_ATCC_199      AGLAGNAG----------------LAGNAGLAGNAGLAGNAG--------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                PVLLVGSG--------------LAVVGISAVLALEIALAIG---------
                                                                                      

MUL_2354|M.ulcerans_Agy99           -----------------GGNGGRGGDGIRGADGVLD--------------
MMAR_3105|M.marinum_M               -----------------GGNGGRGGDGIRGADGVLD--------------
Mb3537|M.bovis_AF2122/97            GD------------GGTGGNGGNGTGGVNGADNTLNPD------------
Rv1091|M.tuberculosis_H37Rv         GA------------GGTGGAGGDGGAGGAGGNARLWG-------------
Mflv_5091|M.gilvum_PYR-GCK          QG-------------LQGGKGGDGGAGGKGGDADSMGS------------
Mvan_1264|M.vanbaalenii_PYR-1       QG-------------LQGGQGGDGGTGGTGGDATSMGE------------
MSMEG_0868|M.smegmatis_MC2_155      YGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAI
TH_3810|M.thermoresistible__bu      ------------------GEHVKALDGRPGLD------------------
MAB_4284c|M.abscessus_ATCC_199      ----------------LAGNAGLAGNAGLAGNAGLAGN------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ----------------IRTTGTVALQPTPNQHLIVPTEQAP---------
                                                                                      

MUL_2354|M.ulcerans_Agy99           -------CESGYLGGSGG------------------------AGGAGGAG
MMAR_3105|M.marinum_M               -------GESGYLGGSGG------------------------AGGAGGAG
Mb3537|M.bovis_AF2122/97            -----TPGGAGEPGGAGG------------------------AGGAGGAA
Rv1091|M.tuberculosis_H37Rv         ------VGGAGGAGGDGG------------------------AGGAGGKG
Mflv_5091|M.gilvum_PYR-GCK          ------AGATGGKGGNGGNGGRGGLFG---------------KGGNAGNG
Mvan_1264|M.vanbaalenii_PYR-1       ------AGATGGKGGNGGNGGRGSLFG---------------RGGNAGNG
MSMEG_0868|M.smegmatis_MC2_155      GGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNG
TH_3810|M.thermoresistible__bu      -------------GGNGS------------------------HGGNGGHG
MAB_4284c|M.abscessus_ATCC_199      ----------AGLAGNAG------------------------LAGNAGLA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------APPPVQASAPQPKISVPEP-----------------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           GG-------------------------------------------GSQVG
MMAR_3105|M.marinum_M               GG-------------------------------------------GSQVG
Mb3537|M.bovis_AF2122/97            GGPGGTGGTGGNGGNAGNNSTNAPVGGEGGAGGDGGAGGAGGAANGGTAG
Rv1091|M.tuberculosis_H37Rv         GS------------------------------------GLSGNANGGAGG
Mflv_5091|M.gilvum_PYR-GCK          AD----------------------------------------GGTGGAGG
Mvan_1264|M.vanbaalenii_PYR-1       GN----------------------------------------GGTGGNGG
MSMEG_0868|M.smegmatis_MC2_155      GNGW------------------VQAYDPNGPAGTTIDKGKAAGGNGGDGG
TH_3810|M.thermoresistible__bu      GR-------------------------------------------GGFLG
MAB_4284c|M.abscessus_ATCC_199      GN-------------------------------------------AGLAG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -------------------------------------------VAAPKPL
                                                                                      

MUL_2354|M.ulcerans_Agy99           SDGVGG-AGGAGGTGG----------------------------------
MMAR_3105|M.marinum_M               SDGVG----GAGGTGG----------------------------------
Mb3537|M.bovis_AF2122/97            SQGTGG-VGGDGGAGGNGGGGKAGTGNSGNFGVDGEAGFSGGAGGNGGVG
Rv1091|M.tuberculosis_H37Rv         DSGRGG-TGGAGGEGGAAG-------------------------------
Mflv_5091|M.gilvum_PYR-GCK          AGGTGG-TGGAGGTGG----------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       NGGTGG-TGGNGGTGG----------------------------------
MSMEG_0868|M.smegmatis_MC2_155      FNGTGGATGGRGGDGAGASVWKA---------------------------
TH_3810|M.thermoresistible__bu      IGGSGG-WGGHGGNGG----------------------------------
MAB_4284c|M.abscessus_ATCC_199      NAGLAG-NAGLAGNAG----------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                SPPVAAPLPAAPPPAAP---------------------------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           ---------------------------------------AGGHGARGADG
MMAR_3105|M.marinum_M               ---------------------------------------AGGHGARGADG
Mb3537|M.bovis_AF2122/97            GAAGANGGTGGSGGNGGDGGAGGIGGAGGNGIPGTGTEPAGGTGAKGGDG
Rv1091|M.tuberculosis_H37Rv         --------------------------------------LLVGTGGHGGDG
Mflv_5091|M.gilvum_PYR-GCK          ---------------------------------------TGGTGGIGGAG
Mvan_1264|M.vanbaalenii_PYR-1       ---------------------------------------TGGTGGIGGAG
MSMEG_0868|M.smegmatis_MC2_155      -----------------------------NGQHSTGQTDTGGNGGRGGDG
TH_3810|M.thermoresistible__bu      --------------------------------------DTDADGGNGGDG
MAB_4284c|M.abscessus_ATCC_199      ---------------------------------------LAGNAAVAGNA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------PLPEAPPIPAAP
                                                                                      

MUL_2354|M.ulcerans_Agy99           LLDGEAGSKGGAGGGGGA--GGAGGAGSQAGSDGVGGAG-----------
MMAR_3105|M.marinum_M               LLDGEAGSKGGAGGGGGA--GGAGGAGSQAGSDGVGGAG-----------
Mb3537|M.bovis_AF2122/97            GDGGAGGAGGNAGGAGGN--GGAGGQGGNAGQGGAGGAGGNAVIPGDGVG
Rv1091|M.tuberculosis_H37Rv         GAGGAAVKGGDGGAAAGT--GIAG-AGGRGGAGGSGGSG-----------
Mflv_5091|M.gilvum_PYR-GCK          STGGTGGTGGTGGTGGTG--GTG-GTGGTGGTGGTGGKG-----------
Mvan_1264|M.vanbaalenii_PYR-1       STGGTGGTGGTGGTGGTG--GTG-GTGGTGGTGGTGGKG-----------
MSMEG_0868|M.smegmatis_MC2_155      GTFVNAGANGNGGAGGAG--GVSEGEGGTGGHGGDGGRG-----------
TH_3810|M.thermoresistible__bu      GNGGSAGRGGTGGLRGVF--GIN-GGNGRAGLGGRGXXX-----------
MAB_4284c|M.abscessus_ATCC_199      AVAGNAAVAGNAAVGGVLNTGVSGAIGGSSHVGGAINESLG---------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                PVVPVPVVVPPVPVPVPVRIPVPDPVSPPQLLAPPRLSVPQP--------
                                                                                      

MUL_2354|M.ulcerans_Agy99           -----------GDGGDGGHGAYG---------------------------
MMAR_3105|M.marinum_M               -----------GDGGDGGHGAYG---------------------------
Mb3537|M.bovis_AF2122/97            KAPHGGAGGSGGDGGKGGQGGSGGTGGSGAPIGGGAGGTGGSGGHAGKGG
Rv1091|M.tuberculosis_H37Rv         -----------GDGGGGAAGPAG---------------------------
Mflv_5091|M.gilvum_PYR-GCK          -----------GTGGTGGAGGTG---------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -----------GTGGTGGDGGTG---------------------------
MSMEG_0868|M.smegmatis_MC2_155      -----------GDGALGGNGGTGG--------------------------
TH_3810|M.thermoresistible__bu      -----------XGGGVGAAVRSG---------------------------
MAB_4284c|M.abscessus_ATCC_199      -----------GSGSVGGSTAVG---------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -----------VQPPVRVPQPPS---------------------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           ---------------------DGKAGGGGGAGGRGGDG------GDGDTG
MMAR_3105|M.marinum_M               ---------------------DGKAGGGGGAGGRGGDG------GDGDTG
Mb3537|M.bovis_AF2122/97            AGGIGAQGTTITVPGNGGNAGDGGNGGGGGAGGTGGDG------ATGTPA
Rv1091|M.tuberculosis_H37Rv         -----------------WLFGDGGAGGNGGAAAAGGAGG-----QAGGGG
Mflv_5091|M.gilvum_PYR-GCK          --------------------GDGGTGGTGGTGGTG---------GTGGTG
Mvan_1264|M.vanbaalenii_PYR-1       --------------------GTGGTGGTGGTGGTG---------GTGGTG
MSMEG_0868|M.smegmatis_MC2_155      -----------------VGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNG
TH_3810|M.thermoresistible__bu      ---------------------NGVFSGGGGTPSAG----------FGVPT
MAB_4284c|M.abscessus_ATCC_199      ---------------------GGAHTGVGGGVSTG----------VGVGS
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ---------------------PPQVGGTVPQSPPQHQTP----PGEGTPP
                                                                                      

MUL_2354|M.ulcerans_Agy99           GAAGNG------------GDGGEGGN------------------------
MMAR_3105|M.marinum_M               GAAGNG------------GDGGEGGN------------------------
Mb3537|M.bovis_AF2122/97            GNGGNG------------GNAGDGGNGGSGDFGGNTTSGASGSGGNGGNA
Rv1091|M.tuberculosis_H37Rv         GNGGNG------------GNGGNGGNGGNGATGG----------------
Mflv_5091|M.gilvum_PYR-GCK          GTGGAG-----------DGTGGTGGTGG----------------------
Mvan_1264|M.vanbaalenii_PYR-1       GTGGAG-----------DGLGGTGGTGG----------------------
MSMEG_0868|M.smegmatis_MC2_155      GNGGAGRIRVNNGTATGTATGGNGGNGGNGD-------------------
TH_3810|M.thermoresistible__bu      TIQFPA--------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      H-VGGG--------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                KPDGPG--------------------------------------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           AVANSGRGGGTG--------------------GAGGVGG--DGGNGTNG-
MMAR_3105|M.marinum_M               AVANSGRGGGTG--------------------GAGGVGG--DGGNGTNG-
Mb3537|M.bovis_AF2122/97            GTAGSGGAGGTGGTG--------------LSGGNGGNGG--DGGNGAHGT
Rv1091|M.tuberculosis_H37Rv         WLYGNGGAGGQG-----------------ATAGAGGAGA--NGVSSTNG-
Mflv_5091|M.gilvum_PYR-GCK          -TGGQGGQGGQGG-----------------TGGTGGQGG-LGGGGGTG--
Mvan_1264|M.vanbaalenii_PYR-1       -TGGFGGQGGQGG-----------------TGGTGGQGG-LGGVGGTG--
MSMEG_0868|M.smegmatis_MC2_155      ADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ISESLGGSGSVG--------------------GSTAVGG--GAHTGVGG-
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --NYGGGHVPTP--------------------GAGGSGGSGGGHVPTPG-
                                                                                      

MUL_2354|M.ulcerans_Agy99           ----------------------VGGAGGHGGMG-----------------
MMAR_3105|M.marinum_M               ----------------------VGGAGGHGGMG-----------------
Mb3537|M.bovis_AF2122/97            --------VGAQFVPATSLPTPNGGAGGNGGTGSNGGAPGPAGAPGPTTG
Rv1091|M.tuberculosis_H37Rv         -----------------------GGTGGNGGIG-----------------
Mflv_5091|M.gilvum_PYR-GCK          ---------------------GQGGTGGTGGQG-----------------
Mvan_1264|M.vanbaalenii_PYR-1       ---------------------GTGGTGGTGGQG-----------------
MSMEG_0868|M.smegmatis_MC2_155      ATIVAYNVVQANPQASGTATDGHGGSGINGGHG-----------------
TH_3810|M.thermoresistible__bu      ------------------------GSCTSRAVS-----------------
MAB_4284c|M.abscessus_ATCC_199      ------------------------GVSTGVGVG-----------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -------------------------AGGSGGSG-----------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           GNAGSS----DAANG-----AVGSRGGD----------------------
MMAR_3105|M.marinum_M               GNAGSS----DAANG-----AVGSRGGD----------------------
Mb3537|M.bovis_AF2122/97            GNAGSQGIGGDGGNG-----GDGGKGGDGADAVNVVFMPTEPQAATGTAG
Rv1091|M.tuberculosis_H37Rv         GTGGSGGAGGNAGLL-----GVGGAGGHG---------------------
Mflv_5091|M.gilvum_PYR-GCK          GTGGTGGTGGTG--------GTGGAGGDG---------------------
Mvan_1264|M.vanbaalenii_PYR-1       GTGGTGGTGGTG--------GTGGAGGDG---------------------
MSMEG_0868|M.smegmatis_MC2_155      GNGGQGTIEANGPSAVASGIGAGGNGGDG---------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------------SHVGGGISES---------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           ---------------------------------GGDGGKGGQGTT-----
MMAR_3105|M.marinum_M               ---------------------------------GGAGGKGGQGTT-----
Mb3537|M.bovis_AF2122/97            SAGDPTGGNGGPGTPGSPMVAPPPPTPITQVQQGGDGGAGGTGSTNANDG
Rv1091|M.tuberculosis_H37Rv         -------------------------------ASGGAGDRGGAGGTG----
Mflv_5091|M.gilvum_PYR-GCK          -------------------------------GLGGLGGFGGSGGTG----
Mvan_1264|M.vanbaalenii_PYR-1       -------------------------------GLGGLGGFGGVGGTG----
MSMEG_0868|M.smegmatis_MC2_155      -------------------------------IDGGLGGNGGDGVVN----
TH_3810|M.thermoresistible__bu      ----------------------------------------REGIMP----
MAB_4284c|M.abscessus_ATCC_199      --------------------------------LGGSGSVGGSTAVG----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ---------------------------------GGHVPTPGTGGPG----
                                                                                      

MUL_2354|M.ulcerans_Agy99           ----------------GGDGGNGGS-------------------------
MMAR_3105|M.marinum_M               ----------------GGDGGNGGS-------------------------
Mb3537|M.bovis_AF2122/97            TATGGKGGEGGVGSILGGPGGNGGTGGNASATGTNGVANAGNGGKGGDGG
Rv1091|M.tuberculosis_H37Rv         -----------FISSDGGAGGDGGD-------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----GQGGLGGPGGSTGGAGGAGG--------------------------
Mvan_1264|M.vanbaalenii_PYR-1       ----GQGGQGGPGGSTGGAGGAGG--------------------------
MSMEG_0868|M.smegmatis_MC2_155      ----TTANAANPGSATGTATGGDGG-------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------GGAHTGVGGG-------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           ----------------------AGKGGTGG--------------------
MMAR_3105|M.marinum_M               ----------------------AGKGGTGG--------------------
Mb3537|M.bovis_AF2122/97            QFGAGGNGGAGGSVTDGSAGSTAGNGGNGGNATNGTIAGQPAGGNGSAGG
Rv1091|M.tuberculosis_H37Rv         ----------------------GGNGGAGG--------------------
Mflv_5091|M.gilvum_PYR-GCK          ------------------QAGTAGKGGLFG------------------GS
Mvan_1264|M.vanbaalenii_PYR-1       ------------------QAGVAGKGGLFG------------------GS
MSMEG_0868|M.smegmatis_MC2_155      -----------------KATGTASQGGNGGPS--------------WVQS
TH_3810|M.thermoresistible__bu      ----------------------SSRAASAR--------------------
MAB_4284c|M.abscessus_ATCC_199      ------------------VNTGVGVGSHVG--------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                -----------------------GTGGSGG--------------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           --------AAAQTNDAGDGGDG----------------------------
MMAR_3105|M.marinum_M               --------SAVQTNDAGNGGDGGAGGDGGI----GTLGPGGDGGAGGNGG
Mb3537|M.bovis_AF2122/97            KGGDGGNIAAGATGTAGNGGNGGNGNDGAVNA--GTGGSGGNGGNAGGGG
Rv1091|M.tuberculosis_H37Rv         -------TGGLLFGAGGNGGPGGSGGAADIG---GNGGAGNGGGTDGNGG
Mflv_5091|M.gilvum_PYR-GCK          GSAGKAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAG
Mvan_1264|M.vanbaalenii_PYR-1       GSAGTAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASG
MSMEG_0868|M.smegmatis_MC2_155      GYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTA
TH_3810|M.thermoresistible__bu      --------AGAACASSTSRSRRSFCCSRA---------------------
MAB_4284c|M.abscessus_ATCC_199      --------GGISESLGGSGSVGGSTAVG-----------GGAHTSAINDA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------GHVPTPGAGTPGGSGGGHLPFPG---------------AGST
                                                                                      

MUL_2354|M.ulcerans_Agy99           --------------------------------------------------
MMAR_3105|M.marinum_M               SGGDGNTQPVGHSLGGGGGVGGNGGQGGAGGQGITGGSGGAGGSGGNGGT
Mb3537|M.bovis_AF2122/97            ANGGDGGAGGAGGAGGRGGKGIDGGFGGDGGNGGSNNGTGAGGNGGNGGT
Rv1091|M.tuberculosis_H37Rv         NGGSGGGAGSGGDGGGAGGNG-----AWLFGNGGAGGGGGKGGNGAGGGL
Mflv_5091|M.gilvum_PYR-GCK          KAGATGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQ
Mvan_1264|M.vanbaalenii_PYR-1       AQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQ
MSMEG_0868|M.smegmatis_MC2_155      TGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGK
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LGGSGSVGGSTAVGGG----------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                PGGSGGGHLPTPGAGTPG--------------------------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           --------------------------------------------------
MMAR_3105|M.marinum_M               GGDDTENAEPSAGGAGGEGGMGGGGGDGVVGTGGMGG-----GGGQGGAG
Mb3537|M.bovis_AF2122/97            GGVGSVGAAGGDGGNGGTGGFAGFGGTAGNGGSGGTGGAGGDGGTGGGGG
Rv1091|M.tuberculosis_H37Rv         GG-----------GSFGLPGLNGSGGDGGDGGNGAPG-----GVLYGNGG
Mflv_5091|M.gilvum_PYR-GCK          GAAG----KAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGG
Mvan_1264|M.vanbaalenii_PYR-1       GAAG----KAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGG
MSMEG_0868|M.smegmatis_MC2_155      GADG----WVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGG
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_2354|M.ulcerans_Agy99           ----------------------------GASSTS--------TGGAPGGV
MMAR_3105|M.marinum_M               GDAIDSV-----GGIGGKGGGGADGGGGGASSTS--------TGGAPGGV
Mb3537|M.bovis_AF2122/97            NGGTGVI-----AGGGGTGGNGGASGAGGAGGTGGFAGN--GNAGGNGGT
Rv1091|M.tuberculosis_H37Rv         AGGQGSS-----GGIGGPGATGGAGGKGGDGGDAQLIGD--GGNGGNGGA
Mflv_5091|M.gilvum_PYR-GCK          AGG-----------AGGEGGEGGDGGKGGAGAE--------GGAGGGGGA
Mvan_1264|M.vanbaalenii_PYR-1       AGG-----------AGGEGGEGGAGGAGGDGSE--------GGAGGSGGA
MSMEG_0868|M.smegmatis_MC2_155      NGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------AHTSAINESMNSSINASHSSSMNESFGSSMGSHGA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_4827|M.avium_104                ---------------------GGLGGFGGGHAPAP--------GGGLGGG
                                                                                      

MUL_2354|M.ulcerans_Agy99           GGDGDDGDP------PTGQTGGGG-TGGGGGAPGVV-----
MMAR_3105|M.marinum_M               GGDGDDGDP------PTGQTGGGGGTGGGGGAPGVV-----
Mb3537|M.bovis_AF2122/97            GGASEDGDNGNAGSGATGGTGGNGGTGGDGGAAGLGGVA--
Rv1091|M.tuberculosis_H37Rv         GGTGGTPGPG----GPGGSGGLGGLLFGQTGTAGVSP----
Mflv_5091|M.gilvum_PYR-GCK          GGSGAGGAG------GAGGSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1       GGSGTGGAG------GAGGSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155      GGTTAGGSGN----GGNGGNGGNGGADGTPGTAGTTGANNP
TH_3810|M.thermoresistible__bu      -----------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AGTGFEAQG---------HAQGHASETAHTTLPGAEHH---
MLBr_01183|M.leprae_Br4923          -----------------------------------------
MAV_4827|M.avium_104                GGHAPAPGGG------LGGFGGGHSGGGLGGLGGGHK----