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MPRSGCPPQFDAVVIGSGISGLTAAINLQRNGIRTLVVERREVPGGLCGTFTLDGYEFVTGCNDFGGGLV RHLEELGVGTEFRTPAARFHLGEHRIEMPPTLPTLATVARRLPALFSAFRTVRKGPGQTLGQLIDGAVQD RLLMAAAAIPAYALLRSPDDLTVEQVGQAYSKQLGYRYQKSYTPVGGPAAMIAAMVQRFEALGGELWLGC HSTQVERVGAEKRVHTSDALVPARVVLSSAGRWSEFPKTTKAGMEFAVLLFAVRKGFTYPRGYHTIAWLQ QDIGEELRKLDAGQPISRPSFHIFRSDLPQPRDHYTINAFIPLPRGEGDPSARRRQDLSAHAVATIDKDL PGFKDALIYQRFLSPVEYASRLGLHSAPSPFVPPTGFAGLPSYDAARDTYFIGTSVGPAGEHAGAACLSG KMAADLAIKQLRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1172 | - | - | 100% (433) | dehydrogenase |
| M. marinum M | MMAR_1853 | - | 1e-30 | 41.71% (175) | hypothetical protein MMAR_1853 |
| M. marinum M | MMAR_5383 | - | 4e-08 | 43.24% (74) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3859c | - | 1e-07 | 50.00% (50) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1677 | - | 4e-06 | 46.00% (50) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv3829c | - | 1e-07 | 50.00% (50) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. avium 104 | MAV_0198 | - | 1e-07 | 42.47% (73) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_2347 | - | 6e-07 | 44.26% (61) | phytoene dehydrogenase |
| M. thermoresistible (build 8) | TH_2567 | - | 1e-08 | 39.24% (79) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_1423 | - | 0.0 | 99.52% (421) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5076 | - | 4e-07 | 50.00% (50) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1172|M.marinum_M MPRSGCPPQFDAVVIGSGISGLTAAINLQRNGIRTLVVERREVPGGLCGT
MUL_1423|M.ulcerans_Agy99 ------------MVIGSGISGLTAAINLQRNGIRTLVVERREVPGGLCGT
Mb3859c|M.bovis_AF2122/97 ------MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGGMAST
Rv3829c|M.tuberculosis_H37Rv ------MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGGMAST
MAV_0198|M.avium_104 ------MNDYDAIVIGAGHNGLTAAVLLQKAGLRTLCLDAKLYAGGMAST
Mflv_1677|M.gilvum_PYR-GCK ------MTDFDAIVVGAGHNGLTAAALLQQAGLRTVCLDFKLYAGGMAST
Mvan_5076|M.vanbaalenii_PYR-1 ------MADFDAIVVGAGHNGLTAAALLQRAGLRTLCLDAKLYAGGMAST
MSMEG_2347|M.smegmatis_MC2_155 MSRAIPGPTDHVVVVGAGLSGLSAALHLAGRGRRVTVVEREPWPGGRAGR
TH_2567|M.thermoresistible__bu ---MTTEQEFDAIVIGAGAGGLFTAARLAHQGFRTVVVERLDKVGGRAST
:*:*:* .** :* * * *. :: ** ..
MMAR_1172|M.marinum_M FT-LDGYEFVTGCNDFGGGLVRHLEELGVG----TEFRTP----AARFH-
MUL_1423|M.ulcerans_Agy99 FT-LDGYEFVTGCNDFGGGLVRHLEELGVG----TEFRTP----AARFH-
Mb3859c|M.bovis_AF2122/97 VELFDGYRFDIAGSVQFPTSSAVSSELGLDSLPTVDLEVM----SVALRG
Rv3829c|M.tuberculosis_H37Rv VELFDGYRFEIAGSVQFPTSSAVSSELGLDSLPTVDLEVM----SVALRG
MAV_0198|M.avium_104 VELFDGYRFEIAGSVQFPTSQAVVDELGLDTIPTIDLDVM----SVAVRG
Mflv_1677|M.gilvum_PYR-GCK VELFDGFRFEIAGSVQVPTSAVVSDALELGDLPTVDLDVM----SVQLRG
Mvan_5076|M.vanbaalenii_PYR-1 VELFDGFRFEIAGSVQVPTSAVVSDALGLAELPTVDLDVM----SVQLRG
MSMEG_2347|M.smegmatis_MC2_155 ID-TGGYRIDTGPTVLTMPDILDDVFAAVGESVGDRLQLLPVDPAYRAQF
TH_2567|M.thermoresistible__bu DD-IDGFKVNNGAIVIETGGITQQTCEEVG--------------------
.*:.. . :
MMAR_1172|M.marinum_M LGEHRIEMPPTLPTLATVARRLP-----ALFSAFRTVRKGPG-QTLGQLI
MUL_1423|M.ulcerans_Agy99 LGEHRIEMPPTLPTLATVARRLP-----ALFSAFRTVRKGPG-QTLGQLI
Mb3859c|M.bovis_AF2122/97 VGDDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPT-RALGRFE
Rv3829c|M.tuberculosis_H37Rv VGDDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPT-RALGRFE
MAV_0198|M.avium_104 VGDDPLVQYSDPVKLFTHLNEVHGADAVNGMAGLMAWAQAPT-RALDRFE
Mflv_1677|M.gilvum_PYR-GCK VGDDPLVYYTDPMKLLTHLNDVHGAEAVNGMAGLMAWCQAPT-RALGRFE
Mvan_5076|M.vanbaalenii_PYR-1 IGDDPLVYYTDPMKLLTHLNEVHGAEAVNGMAGLMAWCQAPT-RAVGRFD
MSMEG_2347|M.smegmatis_MC2_155 ADGSALEVHSDADRMAAAIADLAGPSEAAGYRRLRDWLTRLYRIEIDGFI
TH_2567|M.thermoresistible__bu ---APFDIREPKPPILYRIGGKNVDVTGGGWGFLLGKLTRQGAKLVKGIG
. : : : :
MMAR_1172|M.marinum_M DGAVQDRLLMAAAAIPAYALLRSPDDLTVEQVGQAYSKQLGYR-------
MUL_1423|M.ulcerans_Agy99 DGAVQDRLLMAAAAIPAYALLRSPDDLTVEQVGQAYSKQLGYR-------
Mb3859c|M.bovis_AF2122/97 AGTLPKSFDEMYACATNEFERSAIDDMLFGSVTDVLDRHFPDREKHGALR
Rv3829c|M.tuberculosis_H37Rv AGTLPKSFDEMYACATNEFERSAIDDMLFGSVTDVLDRHFPDREKHGALR
MAV_0198|M.avium_104 AGTPPKSLDEMYACATNEFERSAIDDMLFGSVTDILDRYLPDREKHGALR
Mflv_1677|M.gilvum_PYR-GCK AAQPPKTLDEMFACATNEFERQAISDILFGSVTDVLDRYLPDREKHGALR
Mvan_5076|M.vanbaalenii_PYR-1 AAQRPKSLDEMFACATNEFERQAISDMLFGSVTDVLDRYLPDREKHGALR
MSMEG_2347|M.smegmatis_MC2_155 GANFDSPLSLLTPQLAQLAAIGG-----FGKWDHMVRRHLRDPR------
TH_2567|M.thermoresistible__bu AARNDSGLPEDEISTAEWVAKYTKNEGVHGIFRNMCASVFAVGSEDLPAR
. . : . . :
MMAR_1172|M.marinum_M -----------YQKSYTP-----------------------VGGPAAMIA
MUL_1423|M.ulcerans_Agy99 -----------YQKSYTP-----------------------VGGPAAMIA
Mb3859c|M.bovis_AF2122/97 GSMTVLAVNTLYRGPATPGSAAALAFGLGVPEGDFVRWKKLRGGIGALTT
Rv3829c|M.tuberculosis_H37Rv GSMTVLAVNTLYRGPATPGSAAALAFGLGVPEGDFVRWKKLRGGIGALTT
MAV_0198|M.avium_104 GSMTVLAVNTLYRGPATPGSAAALAFGLGVPDGDTMQMKKLRGGIGALTS
Mflv_1677|M.gilvum_PYR-GCK GMLAFLAVNTTYRGPATPGSAAALAFGLAVPDENATLIKKFRGGMGAVTE
Mvan_5076|M.vanbaalenii_PYR-1 GMLAFLAVNTTYRGPATPGSAAALAFGLAVPDENATLIKKFRGGMGAVTE
MSMEG_2347|M.smegmatis_MC2_155 -LQRVFTFQSLYAGVSPQRALAAYAVIAYMDTISGVFFP--KGGVRAVPD
TH_2567|M.thermoresistible__bu VFLTYFTRKSAFKRFGFHP-----------------------EGTIGLWR
: * .:
MMAR_1172|M.marinum_M AMVQRFEALGGELWLGCHSTQVERVG-------AEKRVHTSDALVPARVV
MUL_1423|M.ulcerans_Agy99 AMVQRFEALGGELWLGCHSTQVERVG-------AEKRVHTSDALVPARVV
Mb3859c|M.bovis_AF2122/97 HLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGDTLTSPIVV
Rv3829c|M.tuberculosis_H37Rv HLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGDTLTSPIVV
MAV_0198|M.avium_104 HLCDVLERHGGELRLRTKVTEILVEHAGSGGRVTGVRTESGETLSAPIVV
Mflv_1677|M.gilvum_PYR-GCK HLLQMFTAAGGELRLRTKVDEILVD----GGRVTGVRLEDGATLSAPVVV
Mvan_5076|M.vanbaalenii_PYR-1 HLLQMFSAAGGELRLRSKVDEIIVE----DGRVAGVRLEDGSTLAAPMVV
MSMEG_2347|M.smegmatis_MC2_155 ALAAAGADAGVRFHYGATVNCLERS----ADRVTAVHTDTGERIPCDAVV
TH_2567|M.thermoresistible__bu GLAGAVERHGGQVWLSTPATKILTDG-TAVQGVVVERDGRQLTLTAPVVV
: * .. : : : **
MMAR_1172|M.marinum_M LSSAGRWSEFPKTTKAGM---------------EFAVLLFAVRKGFTYPR
MUL_1423|M.ulcerans_Agy99 LSSAGRWSEFPKTTKAGM---------------EFAVLLFAVRKGFTYPR
Mb3859c|M.bovis_AF2122/97 SAIAPDVTINELIDPAVLPSEIRDRYLRIDHRGSYLQMHFALAQPPAFAA
Rv3829c|M.tuberculosis_H37Rv SAIAPDVTINELIDPAVLPSEIRDRYLRIDHRGSYLQMHFALAQPPAFAA
MAV_0198|M.avium_104 SGIAPDVTLNELLDPAALPADLRARYARIDHRGSYLQMHFALQEAPVFAA
Mflv_1677|M.gilvum_PYR-GCK SNLAPDLTVNQLVDGSAIPADIRERFARIDHRGSYVQMHFALDGPPTFAE
Mvan_5076|M.vanbaalenii_PYR-1 SAVAPDLTVNTLVDGGAVPPDVRERFSRIDHRGSYLQMHFALDGAPTFAE
MSMEG_2347|M.smegmatis_MC2_155 LTTELPRTYELLGRTPRRPRPWRAS-------PSAVVVHVGCRRIDRPVA
TH_2567|M.thermoresistible__bu SDVGPAATVTLLGEENVP--------------ADYRKMVKKGDRPTSMIS
: . :
MMAR_1172|M.marinum_M GYHTIA---------------WLQQDIGEELRKLDAGQPISRPSFHIFRS
MUL_1423|M.ulcerans_Agy99 GYHTIA---------------WLQQDIGEELRKLDAGQPISRPSFHIFRS
Mb3859c|M.bovis_AF2122/97 PYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADPTVVLQIPSLHD
Rv3829c|M.tuberculosis_H37Rv PYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADPTVVLQIPSLHD
MAV_0198|M.avium_104 PYQVLNEPAMQASIGLFCTPEEVQQQWEQARRGVVPADPTVVLQIPSQND
Mflv_1677|M.gilvum_PYR-GCK PYEVLNDPEYQSAIGIFTTPEELQQQWEDSRRGVVPADPAIALQIPSAND
Mvan_5076|M.vanbaalenii_PYR-1 PYEMLNDPGYQSAIGIFTTPEELQQQWEDSRRGVVPADPAIALQIPSAND
MSMEG_2347|M.smegmatis_MC2_155 HHNILFG------------DAWHDTFTDIIDDGRLMRDPSLLVTRPTRGD
TH_2567|M.thermoresistible__bu VN-------------------FASRERLVDVPGMLSFAKSRRLAYIANFT
.
MMAR_1172|M.marinum_M DLPQPRDHYTINAFIPLPRGEGDPSARR-----RQDLSAHAVATIDK-DL
MUL_1423|M.ulcerans_Agy99 DLPQPRDHYTINAFIPLPRGEGDPSARR-----RQDLSAHAVATIDK-DL
Mb3859c|M.bovis_AF2122/97 PSLAPAGKQAASAFAMWFPIEGG-SKYGGYGRAKVEMGQNVIDKITR-LA
Rv3829c|M.tuberculosis_H37Rv PSLAPAGKQAASAFAMWFPIEGG-SKYGGYGRAKVEMGQNVIDKITR-LA
MAV_0198|M.avium_104 PGLAPEGKHAASAFALWFPIEGE-VDYG---QAKIEMGQRVIDKITR-LA
Mflv_1677|M.gilvum_PYR-GCK PTLAPPGKHAVSAFSLWFPLSEEISGYG---ALKTEMGRRVIDKITR-LA
Mvan_5076|M.vanbaalenii_PYR-1 PGLAPPGKHAVSAFALWFPLSEERASYG---EMKAEMGQRVIDKITR-LA
MSMEG_2347|M.smegmatis_MC2_155 PALAPAGRDLLYLLAPTPNLSSTAIDWET---EGPAYAQRVVDTVAERLL
TH_2567|M.thermoresistible__bu DTCPEMAPEGWNLYVGTAVPKPSIGDFD-----QAAETELLLQDLRDNID
. : :
MMAR_1172|M.marinum_M PGFKDALIYQRFLSPVEYASRLGLHSAPSPFVPPTGFAGLPSYDAAR---
MUL_1423|M.ulcerans_Agy99 PGFKDALMYQRFLSPVEYASRLGLHSAPSSFVPPTGFAGLPSYDAAR---
Mb3859c|M.bovis_AF2122/97 PNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHSDQIGPNRPGPKGFI
Rv3829c|M.tuberculosis_H37Rv PNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHSDQIGPNRPGPKGFI
MAV_0198|M.avium_104 PNFEDSIIRHTTFTPRHMGVMFGAPGGDYCHGLLNANQVGPNRPGPRGFL
Mflv_1677|M.gilvum_PYR-GCK TDFEKLILRHTTFTPKHMGTMFNAPGGDYCHGLIHPEQMGPNRPGPKGYV
Mvan_5076|M.vanbaalenii_PYR-1 PDFESLMLRHTTFTPKHMGTMFGAPGGDYCHGLIHPEQMGPNRPGPKGYA
MSMEG_2347|M.smegmatis_MC2_155 PELRDDAQVLQVVTPADWARQGMVAGTPFALAHTFSQTG-PFRPGNTVRG
TH_2567|M.thermoresistible__bu DFDNRARILNIAITRDDWPPQRAVAGFDLPHDTPFANLWNVGDGVKEYAN
. .: . .
MMAR_1172|M.marinum_M --DTYFIGTSVGPAGEHAG--AACLSGKMAADLAIKQLRR----------
MUL_1423|M.ulcerans_Agy99 --DTYFIGTSVGPAGEHAG--AACLSGKMAADLAIKQLRR----------
Mb3859c|M.bovis_AF2122/97 GQPIPIAGLYLGSAGCHGGPGITFIPGYNAARQALADRRAANCCVLSGR-
Rv3829c|M.tuberculosis_H37Rv GQPIPIAGLYLGSAGCHGGPGITFIPGYNAARQALADRRAANCCVLSGR-
MAV_0198|M.avium_104 GQPIPIEGLYLGSAGCHGGPGITFIPGYNAARQALTDR--------SG--
Mflv_1677|M.gilvum_PYR-GCK DQPIPIAGLYLAGAGCHGGPGITFIPGYNAAQQVLAEH------------
Mvan_5076|M.vanbaalenii_PYR-1 DQPIPVDGLYLASAGCHGGPGITFIPGYNAAQQVLADRT-----------
MSMEG_2347|M.smegmatis_MC2_155 VANAVLAGSSTVPG---VGVPTALLSGRLAADRVTGTVRRTRTHHDINSV
TH_2567|M.thermoresistible__bu -----------------GGTTACAETAKLVVDKILASHRPAASR------
* .. ..
MMAR_1172|M.marinum_M ------------
MUL_1423|M.ulcerans_Agy99 ------------
Mb3859c|M.bovis_AF2122/97 ------------
Rv3829c|M.tuberculosis_H37Rv ------------
MAV_0198|M.avium_104 ------------
Mflv_1677|M.gilvum_PYR-GCK ------------
Mvan_5076|M.vanbaalenii_PYR-1 ------------
MSMEG_2347|M.smegmatis_MC2_155 TAATADRKARMP
TH_2567|M.thermoresistible__bu ------------