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M. smegmatis MC2 155 MSMEG_6351 (hisC)

annotation: putative aminotransferase
coordinates: 6410654 - 6411739
length: 361

VSIRLRAEMADLPAYAPGKTVPGAIKIASNETVHGPLPSVREAILKATDLINRYPDNGYLDLRERLAKHV
NFAPENISVGCGSVSLCQQLIQITSSVGDEVLFAWRSFEIYPLQVRTAGATPVAVALRDHTHDLDAMLAA
ITDRTRLIFVCNPNNPTSTVVDPGELARFVAAVPPHILVVLDEAYVEYIRDGLLPDSLGLVREHRNVVVL
RTFSKAYGLAGLRVGYAVADPEIVTALGKVYVPFSATSVSQAAAIACLDAADELLARTDAVVAERTRVSD
ALRAAGYTLPPSQANFVWLPLAERTLDFVARAADNRIIVRPYGEDGVRVTIGAPHENDAFLDFAQRWIAP
GGAGPRTGDSA
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_6351hisC-100% (361)putative aminotransferase
M. smegmatis MC2 155MSMEG_1491-8e-4435.81% (310) histidinol-phosphate aminotransferase 2
M. smegmatis MC2 155MSMEG_3206hisC1e-3734.59% (344) histidinol-phosphate aminotransferase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3800hisC21e-15174.79% (349) putative aminotransferase
M. gilvum PYR-GCKMflv_1195-1e-16683.95% (349) putative aminotransferase
M. tuberculosis H37RvRv3772hisC21e-15174.50% (349) putative aminotransferase
M. leprae Br4923MLBr_01258hisC7e-3831.98% (344) histidinol-phosphate aminotransferase
M. abscessus ATCC 19977MAB_0220c-1e-14472.05% (347) putative aminotransferase
M. marinum MMMAR_5326hisC21e-14271.19% (354) histidinol-phosphate aminotransferase HisC2
M. avium 104MAV_0250hisC1e-13468.38% (351) putative aminotransferase
M. thermoresistible (build 8)TH_1662hisC21e-16179.66% (349) PROBABLE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE HISC2
M. ulcerans Agy99MUL_4407hisC21e-14070.34% (354) putative aminotransferase
M. vanbaalenii PYR-1Mvan_5611-1e-16985.88% (347) putative aminotransferase

CLUSTAL 2.0.9 multiple sequence alignment


Mb3800|M.bovis_AF2122/97            ---------MTARLRPELAGLPVYVPGKTVPGAIKLASNETVFGP----L
Rv3772|M.tuberculosis_H37Rv         ---------MTARLRPELAGLPVYVPGKTVPGAIKLASNETVFGP----L
MMAR_5326|M.marinum_M               ---------MTARLRPVLAGLPVYVPGKTVPGAIKLASNETVFGP----L
MUL_4407|M.ulcerans_Agy99           ---------MTAHLRPVLAGLPVYVPGKTVPGAIKLASNETVFGP----L
MAV_0250|M.avium_104                ---------MTARLRPELAGLPVYVPGKNVPGSIKLASNETVYGP----L
Mflv_1195|M.gilvum_PYR-GCK          MRAGHKLSQVSARLRPELADLPAYTPGRTVPGAIKIASNETVHGP----L
Mvan_5611|M.vanbaalenii_PYR-1       ---------MSARLRPELADLPAYAPGKTVPGAIKIASNETVHGP----L
MSMEG_6351|M.smegmatis_MC2_155      ---------MSIRLRAEMADLPAYAPGKTVPGAIKIASNETVHGP----L
TH_1662|M.thermoresistible__bu      ---------VTARLRPELADIPAYVPGKMVPGAIKIASNETVHPP----L
MAB_0220c|M.abscessus_ATCC_199      ---------MPARLRPELTELPAYTPGRNVPGAIKLASNETVQEP----L
MLBr_01258|M.leprae_Br4923          -MNVPEPTLDDLPLRDNLRGKSPYG-AMQLLVPVLLNTNENPHPPTKALV
                                                 **  :   . *  .  :  .: : :**.   *    :

Mb3800|M.bovis_AF2122/97            PSVRAAIDRATDTVNRYPDNGCVQLKAALARHLG----PDFAPEHVAVGC
Rv3772|M.tuberculosis_H37Rv         PSVRAAIDRATDTVNRYPDNGCVQLKAALARHLG----PDFAPEHVAVGC
MMAR_5326|M.marinum_M               PSVRAAIEHATQSINRYPDNGCLAVKAALARHVSSLSAADFGPEHIAVGC
MUL_4407|M.ulcerans_Agy99           PSVRAAIEHATQSINRYPDNGCLAVKAALARHVSSLSAADFGPEHIAVGC
MAV_0250|M.avium_104                PSVHAAIERAVAIVNRYPDNACVDLKAALAMHLG----SDVAPEQIAVGS
Mflv_1195|M.gilvum_PYR-GCK          PSVRAAIADAVGGINRYPDNGYVDLNERLAKYVG------FAPENISVGC
Mvan_5611|M.vanbaalenii_PYR-1       PSVRAAIEKAIDGINRYPDNGYVELRERLAKHVN------FAPEYISVGC
MSMEG_6351|M.smegmatis_MC2_155      PSVREAILKATDLINRYPDNGYLDLRERLAKHVN------FAPENISVGC
TH_1662|M.thermoresistible__bu      PSVREAIARAGETLNRYPDNGYLDLRDRLARHVG------FAPEHISVGC
MAB_0220c|M.abscessus_ATCC_199      PSVRAALAEAGSLINRYPDNGYAELRSHLAKHVD------MPPEHIAVGC
MLBr_01258|M.leprae_Br4923          DDVVRSVQKVAVDLHRYPDRDAVALRQDLASYLTAQTGIRLGVENIWAAN
                                     .*  ::  .   ::****.    :.  ** ::       .  * : .. 

Mb3800|M.bovis_AF2122/97            GSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVR-VAGAIPIQVPLTDH
Rv3772|M.tuberculosis_H37Rv         GSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVR-VAGAIPIQVPLTDH
MMAR_5326|M.marinum_M               GSVSLCQQLVQITASVGDEVIFGWRSFELYPPQVQ-VAGATAIQVPLTNH
MUL_4407|M.ulcerans_Agy99           GSVSLCQQLVQITASVGDEVIFGWRSFELYPPQVQ-VAGATAIQVPLTNH
MAV_0250|M.avium_104                GSVTLCQQLVQITSAAGDEVMMGWRSFECYLPIVQ-VAGAIAVKVPLREH
Mflv_1195|M.gilvum_PYR-GCK          GSVSLCQQLIQITATVGDEVLFGWRSFEIYPLQVR-TAGATPVQVPLTDH
Mvan_5611|M.vanbaalenii_PYR-1       GSVSLCQQLIQITSTVGDEVLFGWRSFEIYPLQVR-TAGATPVQVPLTDH
MSMEG_6351|M.smegmatis_MC2_155      GSVSLCQQLIQITSSVGDEVLFAWRSFEIYPLQVR-TAGATPVAVALRDH
TH_1662|M.thermoresistible__bu      GSVSLCQQLVQITAGAGDEVLFGWRSFEIYPLQVR-TAGAVPVQVPLTDH
MAB_0220c|M.abscessus_ATCC_199      GSVSLCQQLVQITATVGDEVLFGWRSFETYPLVVR-VAGATPVQVPLVDH
MLBr_01258|M.leprae_Br4923          GSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIIADGTHTEWLETVRADDF
                                    **  : ***:*  .  * ..:    *:. :   .  .       *   :.

Mb3800|M.bovis_AF2122/97            TFDLYAMLAAVTDRTR-LIFVCNPNNPTSTVVGPDALARFVEAVPAHILI
Rv3772|M.tuberculosis_H37Rv         TFDLYAMLATVTDRTR-LIFVCNPNNPTSTVVGPDALARFVEAVPAHILI
MMAR_5326|M.marinum_M               TFDLEAMLAAVTERTR-LIIVCNPNNPTSTVVQPEALAEFVRSVPPHILV
MUL_4407|M.ulcerans_Agy99           TFDLEAMLAAVTERTR-LIIVCDPNNPTSTVVQPEALAEFVRSVPPHILV
MAV_0250|M.avium_104                TYDLDAMLAAITDRTR-LIFVCNPNNPTSTVVDPDALVRFVDAVPADILI
Mflv_1195|M.gilvum_PYR-GCK          TFDLDAMLAAITDRTR-LIFVCNPNNPSSTVVDPGALARFVAAVPPHILV
Mvan_5611|M.vanbaalenii_PYR-1       TFDLDAMLAAITDRTR-LIFVCNPNNPTSTVVDPDALARFVEAVPPHIMV
MSMEG_6351|M.smegmatis_MC2_155      THDLDAMLAAITDRTR-LIFVCNPNNPTSTVVDPGELARFVAAVPPHILV
TH_1662|M.thermoresistible__bu      TFDLDAILAAITDRTR-LIFICNPNNPTSTVVDPDALARFVAAVPEHILI
MAB_0220c|M.abscessus_ATCC_199      TYDLAAMAAAVTDVTR-LIFVCNPNNPTGTVVRPAELRRFVESVPPHILI
MLBr_01258|M.leprae_Br4923          SLDVEAAVTAVADRKPDVVFIASPNNPSGQSISLADLRRLLDVVPG--IL
                                    : *: *  ::::: .  ::::..****:.  :    * .::  **   ::

Mb3800|M.bovis_AF2122/97            AIDEAYVEYIRDGMRPDSLGLVRAH-NNVVVLRTFSKAYGLAGLRIGYAI
Rv3772|M.tuberculosis_H37Rv         AIDEAYVEYIRDGMRPDSLGLVRAH-NNVVVLRTFSKAYGLAGLRIGYAI
MMAR_5326|M.marinum_M               AIDEAYVEYLRDGTVPDSPHLVRTH-SNVVVLRTFSKAYGLAGLRVGYAV
MUL_4407|M.ulcerans_Agy99           AIDEAYVEYLRDGTVPDSPHLVRTH-SNVVVLRTFSKAYGLAGLRVGYAV
MAV_0250|M.avium_104                AIDEAYVEYIRDGLLPNSLELALSR-SNVVVLRTFSKAYGLAGLRVGYAI
Mflv_1195|M.gilvum_PYR-GCK          VLDEAYIEYVRGDLVPDSFGLVRAH-SNVVVLRTFSKAYGLAGLRIGYAV
Mvan_5611|M.vanbaalenii_PYR-1       VVDEAYVEYIRDGLAPDSFGLVRAH-SNVVVLRTFSKAYGLAGLRIGYAV
MSMEG_6351|M.smegmatis_MC2_155      VLDEAYVEYIRDGLLPDSLGLVREH-RNVVVLRTFSKAYGLAGLRVGYAV
TH_1662|M.thermoresistible__bu      ALDEAYIEYVRPPFVPDSLGLVRAH-DNVVVLRTFSKAYGLAGLRVGYAV
MAB_0220c|M.abscessus_ATCC_199      AIDEAYVEYVREDFT-DSLALVREH-PNVVVLRTFSKAYGLAGLRVGYAV
MLBr_01258|M.leprae_Br4923          IVDEAYGEFS---SRPSAVALVGEYPTKIVVTRTTSKAFAFAGGRLGYLI
                                     :**** *:       .:  *.     ::** ** ***:.:** *:** :

Mb3800|M.bovis_AF2122/97            GHPDVITALDKVYVPFTVSSIGQAAAIASLDAADELLARTDTVVAERARV
Rv3772|M.tuberculosis_H37Rv         GHPDVITALDKVYVPFTVSSIGQAAAIASLDAADELLARTDTVVAERARV
MMAR_5326|M.marinum_M               GQPDVIAALDKVYVPFTVSSLAQAAAIASVQAADELLARTDAVVAERGRV
MUL_4407|M.ulcerans_Agy99           GQPDVIAPLDKVYVPFTVSSLAQAAAIASVQAADELLARTDAVVAERGRV
MAV_0250|M.avium_104                GHPELITALDKVVMPFAVTNVAQAAAIASLEASGELMARTDALVAERTRV
Mflv_1195|M.gilvum_PYR-GCK          ADPDIVTALSKVYVPFTATTVSQAAAIACLDAADELLERTDAVVAERTRV
Mvan_5611|M.vanbaalenii_PYR-1       ADPDIIAALSKVYVPFTATSVSQAAAIACLDAADELLERTDAVVAERTRV
MSMEG_6351|M.smegmatis_MC2_155      ADPEIVTALGKVYVPFSATSVSQAAAIACLDAADELLARTDAVVAERTRV
TH_1662|M.thermoresistible__bu      AAPEIVTALGKVYVPFSVSTLAQAAAIASLDAADELLARTDEVVAERARV
MAB_0220c|M.abscessus_ATCC_199      GDPDVITTLGKVYVPFSASSLAQAAAVASLGAAEELLARTNDVVTERARV
MLBr_01258|M.leprae_Br4923          ATPALVEAMLLVRLPYHLSSVTQAAARAALRHADDTLGSVAALIAERERV
                                    . * :: .:  * :*:  :.: **** *.:  : : :  .  :::** **

Mb3800|M.bovis_AF2122/97            SAELRAAGFTLPPSQANFVWLPLGSRTQDFVEQAADARIVVRPYGTDG-V
Rv3772|M.tuberculosis_H37Rv         SAELRAAGFTLPPSQANFVWLPLGSRTQDFVEQAADARIVVRPYGTDG-V
MMAR_5326|M.marinum_M               SAELRAAGFTVPPSQANFVWLPLEDRTTDFVTQAAKAHIVVRPYGADG-V
MUL_4407|M.ulcerans_Agy99           SAELRAAGFTVPPSQANFVWLPLEDRTTDFVTQAAKAHIVVRPYGADG-V
MAV_0250|M.avium_104                STTLRDAGFELPPSQANFLWLPLGSRTEDFVQEAANARLVVRPFASEG-V
Mflv_1195|M.gilvum_PYR-GCK          SAALREAGYDLPPSQANFVWLPLVGRAQQFAADAADARIIVRPYGEDG-V
Mvan_5611|M.vanbaalenii_PYR-1       SAALREAGYDLPPSQANFVWLPLVGRAQQFAADAANSRVIVRPYGEDG-V
MSMEG_6351|M.smegmatis_MC2_155      SDALRAAGYTLPPSQANFVWLPLAERTLDFVARAADNRIIVRPYGEDG-V
TH_1662|M.thermoresistible__bu      TAALRDAGYTVPESGANFVWLPLAERTVDFVNSAAEDRLLVRPYGTDG-V
MAB_0220c|M.abscessus_ATCC_199      TSALREAGYQVPPSQANFVWLPLGERSTEFAQASAEARIIVRPFGTDG-V
MLBr_01258|M.leprae_Br4923          TKSLVHMGFRVIPSDANFVLFGHFSDAAGAWQHYLDTGVLIRDVGIPGYL
                                    :  *   *: :  * ***: :     :        .  :::*  .  * :

Mb3800|M.bovis_AF2122/97            RVTVAAPEENDAFLRFARRWRSDQ----------
Rv3772|M.tuberculosis_H37Rv         RVTVAAPEENDAFLRFARRWRSDQ----------
MMAR_5326|M.marinum_M               RVTIAAPEENDALLRFARCWITHRDGAR------
MUL_4407|M.ulcerans_Agy99           RVTIAAPEENDALLRFARCWITHRDGAR------
MAV_0250|M.avium_104                RVTIGAPAENDALLQFACDWIARTER--------
Mflv_1195|M.gilvum_PYR-GCK          RVTVASPDENDMFLDFARDWIARP----------
Mvan_5611|M.vanbaalenii_PYR-1       RVTIAAPHENDAFLGFARGWDGLR----------
MSMEG_6351|M.smegmatis_MC2_155      RVTIGAPHENDAFLDFAQRWIAPGGAGPRTGDSA
TH_1662|M.thermoresistible__bu      RVTVAAPHENDAFLSFATRWISER----------
MAB_0220c|M.abscessus_ATCC_199      RVTIGAPMENDAFLKFSRAWR-------------
MLBr_01258|M.leprae_Br4923          RATTGLAEENDAFLKASSEIAATELAPATTLGAS
                                    *.* . . *** :*  :