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MNRPAYHHGDLRAVILDEAARLVAQRGADRVSMRELARDAGVSHAAPAHHFTDRRGLFTALATQGFQLLA AALVAARGHFADAALAYVRFAIEHPGHYQVMFNRSLHDADDADLAAAQAAAAAELAAGVATLRDPGARFD PEGAQLAAWSLVHGFSTLWLNDAFDAQVRALDPMDTVLRIAMMLFKASRSGCRRFGEGCRRDEGRHHQHH DNPENHRVGVGEIMHHVVGEVGGEGLGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0500 | - | - | 100% (238) | transcriptional regulator |
| M. ulcerans Agy99 | MUL_2639 | - | 3e-58 | 63.24% (185) | transcriptional regulatory protein |
| M. ulcerans Agy99 | MUL_0990 | - | 2e-09 | 31.01% (158) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0672c | - | 9e-09 | 29.00% (200) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1618 | - | 4e-66 | 68.11% (185) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0653c | - | 9e-09 | 29.00% (200) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_01733 | - | 2e-06 | 32.18% (87) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0499 | - | 7e-48 | 56.35% (181) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4906 | - | 1e-102 | 98.40% (187) | transcriptional regulator |
| M. avium 104 | MAV_0728 | - | 5e-80 | 80.00% (185) | TetR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5838 | - | 2e-65 | 68.51% (181) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_4347 | - | 1e-09 | 28.35% (194) | PUTATIVE transcriptional regulator, TetR family |
| M. vanbaalenii PYR-1 | Mvan_5135 | - | 1e-63 | 65.45% (191) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0672c|M.bovis_AF2122/97 --------------------------------------------------
Rv0653c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4347|M.thermoresistible__bu --------------------------------------------------
MUL_0500|M.ulcerans_Agy99 -------------------------------------------------M
MMAR_4906|M.marinum_M -------------------------------------------------M
MAV_0728|M.avium_104 -------------------------------------------------M
Mflv_1618|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_5135|M.vanbaalenii_PYR-1 ------------------------------------------------MS
MSMEG_5838|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0499|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01733|M.leprae_Br4923 MTRRSIHTRKPLKWSGCAGQHVRSGKVFDVGRISLSYPSMKPGVKIDARS
Mb0672c|M.bovis_AF2122/97 ---MTSQTGVRDELLHAGVRLLDDHGPDALQTRKVAAAAGTSTMAVYTHF
Rv0653c|M.tuberculosis_H37Rv ---MTSQTGVRDELLHAGVRLLDDHGPDALQTRKVAAAAGTSTMAVYTHF
TH_4347|M.thermoresistible__bu ----VTADDIREKLVDAGVRLLERDGVQALSARNLAAEAGTSTMAVYTRF
MUL_0500|M.ulcerans_Agy99 NRPAYHHGDLRAVILDEAARLVAQRGADRVSMRELARDAGVSHAAPAHHF
MMAR_4906|M.marinum_M NRPAYHHGDLRAVILDEAARLVAQRGADRVSMRELARDAGVSHAAPAHHF
MAV_0728|M.avium_104 TRHSYHHGDLPAVILAEAARLVAERGAERVSLRELARCAGVSHAAPAHHF
Mflv_1618|M.gilvum_PYR-GCK TRGSYHHGDLKAVILAQAATLVAERGADGVSLRELARAAGVSHAAPAHHF
Mvan_5135|M.vanbaalenii_PYR-1 SRGTYHHGDLRATILARAADLVAERGADGVSLRELARAAGVSHAAPAHHF
MSMEG_5838|M.smegmatis_MC2_155 --MAYHHGDLKAVILQHAATLVAERGADGISLRELARTAGVSHAAPAHHF
MAB_0499|M.abscessus_ATCC_1997 --MSYHHGDLRAAILTSAADMVARRGATELSLRELAREAGVSHAAPAHHF
MLBr_01733|M.leprae_Br4923 ERWREHRKKVRGEIVDAAFRALDRLGP-EVSVREIAEEAGTAKPKIYRHF
: :: . : * :. *::* **.: :*
Mb0672c|M.bovis_AF2122/97 GGMRGLIAAIAEEGLRQFDVALT-VPQTA--DPVADLLAIGTAYRRYAIE
Rv0653c|M.tuberculosis_H37Rv GGMRGLIAAIAEEGLRQFDVALT-VPQTA--DPVADLLAIGTAYRRYAIE
TH_4347|M.thermoresistible__bu GGMPGVLEAVAGEIFARFADALTQIPQTG--DPVADFLLMGAAYREYALT
MUL_0500|M.ulcerans_Agy99 TDRRGLFTALATQGFQLLAAALV--------AARGHFADAALAYVRFAIE
MMAR_4906|M.marinum_M TDRRGLFTALATQGFQLLAAALV--------AARGHFADAALAYVRFAIE
MAV_0728|M.avium_104 TDRRGLFTALATQGFELLTRALA--------DARGDFADAALAYVQFALD
Mflv_1618|M.gilvum_PYR-GCK TDRRGVFTALATQGWRMLAAALG--------ESRPEFLDAALAYVRFAVD
Mvan_5135|M.vanbaalenii_PYR-1 TDRRGLFTALATEGFRSLAEELS--------RARPEFLDAALAYVRFALA
MSMEG_5838|M.smegmatis_MC2_155 TDRRGLFTALATEGYQLLADALK--------DVRGQFIDAAKAYVRFALD
MAB_0499|M.abscessus_ATCC_1997 GDRRGLFTALAADGFTRLADALD--------GAHPDFHAAALAYVEFALA
MLBr_01733|M.leprae_Br4923 TDKSDLFEAIGIRLRDMLWAAIFPAIDLATDSAREIIRRSVDEYVSLVDK
. .:: *:. : : : * .
Mb0672c|M.bovis_AF2122/97 RPHMYRLMFGSTSAHGIN-VPARDVLTLKVAEIEHQHPSFAHVVRAVHRC
Rv0653c|M.tuberculosis_H37Rv RPHMYRLMFGSTSAHGIN-VPARDVLTLKVAEIEHQHPSFAHVVRAVHRC
TH_4347|M.thermoresistible__bu HPQRYLLMFGTATPASIAGSRADLTATGEVSDRTEWAASFEALRTMVRRM
MUL_0500|M.ulcerans_Agy99 HPGHYQVMFNRSLHDADD----ADLAAAQAAAAAELAAGVATLRDPGARF
MMAR_4906|M.marinum_M HPGHYQVMFNRSLHDADD----ADLAAAQAAAAAELAAGVATLRDPGARS
MAV_0728|M.avium_104 HPGHYQVMFNRSLLDASD----GGLAAAEGAAGAELSRGVATLRDPHARA
Mflv_1618|M.gilvum_PYR-GCK HPGHYEVMFDRSLVDPDN----PELVAAQTEAGAELAAGVGTLDDARARE
Mvan_5135|M.vanbaalenii_PYR-1 NPGHYEVMFDKSLYHADD----PALVDAETAAGSELAAGVGTLDDPRAKD
MSMEG_5838|M.smegmatis_MC2_155 HPGHYAVMFDKSLYDDTD----PGLVAAASAAGAELNRGVGTLDDPKAKD
MAB_0499|M.abscessus_ATCC_1997 NPGHYSVMFEPALLDLAD----GRLAEARDRAAAALDSGIATLTPQQTSA
MLBr_01733|M.leprae_Br4923 HPNVLRVFIQGRFSAQSEAT-VRTLDEGREITLTMAEMFNNELREMELNR
.* ::: :
Mb0672c|M.bovis_AF2122/97 LLAGRFATALGADDDTAIVATAAQFWSQIHGFVMLELAGFYG-DRGAAVE
Rv0653c|M.tuberculosis_H37Rv LLAGRFATALGADDDTAIVATAAQFWSQIHGFVMLELAGFYG-DRGAAVE
TH_4347|M.thermoresistible__bu IAAGRIR-------DDGEAAIAGRLWSLIHGEVMLELAGFFG-AEGHGLT
MUL_0500|M.ulcerans_Agy99 DPE----------------GAQLAAWSLVHGFSTLWLNDAFD-AQVRALD
MMAR_4906|M.marinum_M DPE----------------GAQLAAWSLVHGFSTLWLNDALD-AQVRALD
MAV_0728|M.avium_104 DPG----------------GAELAAWSLVHGFATLWLNDAVD-AAVRAAD
Mflv_1618|M.gilvum_PYR-GCK DPQ----------------AAGLAAWSLVHGFAMLWLNEAID-TDA---D
Mvan_5135|M.vanbaalenii_PYR-1 DPQ----------------AAALAAWSLVHGFALLWLNGAVN-TTG---D
MSMEG_5838|M.smegmatis_MC2_155 DPA----------------GAALAAWSMVHGFSLLWLNDAID-TDR---D
MAB_0499|M.abscessus_ATCC_1997 DRI----------------TAARAAWSLVHGFVSLWTTGALA-DSRDDAD
MLBr_01733|M.leprae_Br4923 AAS---------------ELAAFAAFGSVASATEWWLGPEPDSPRRMPRE
:. : .
Mb0672c|M.bovis_AF2122/97 PVLAAMTVNLLVALGDSPERAQCSLRAEQTQKNTLGRAT-----------
Rv0653c|M.tuberculosis_H37Rv PVLAAMTVNLLVALGDSPERAQCSLRAEQTQKNTLGRAT-----------
TH_4347|M.thermoresistible__bu KILTPMTVDMLVGLGDDRARVEASL---TTAAEAHGR-------------
MUL_0500|M.ulcerans_Agy99 PMDTVLRIAMMLFKASRSGCRRFGEGCRRDEGRHHQHHDNPENHRVGVGE
MMAR_4906|M.marinum_M PMDTVLRIAMMLFKS-----------------------------------
MAV_0728|M.avium_104 PMDTVRRIATMLFAG-----------------------------------
Mflv_1618|M.gilvum_PYR-GCK AVVTARRVARMLFTPGPVGDAGRG--------------------------
Mvan_5135|M.vanbaalenii_PYR-1 PMATVRRVAGMLFGGEPVTCPT----------------------------
MSMEG_5838|M.smegmatis_MC2_155 PIATVERLGAILFDG-----------------------------------
MAB_0499|M.abscessus_ATCC_1997 PLRIASQIAYVLFPEAG---------------------------------
MLBr_01733|M.leprae_Br4923 QFVAHLTIIMMAVIVGTAETLGISMNPDRPIHDAVPLDRSAS--------
. : :
Mb0672c|M.bovis_AF2122/97 ----------------
Rv0653c|M.tuberculosis_H37Rv ----------------
TH_4347|M.thermoresistible__bu ----------------
MUL_0500|M.ulcerans_Agy99 IMHHVVGEVGGEGLGR
MMAR_4906|M.marinum_M ----------------
MAV_0728|M.avium_104 ----------------
Mflv_1618|M.gilvum_PYR-GCK ----------------
Mvan_5135|M.vanbaalenii_PYR-1 ----------------
MSMEG_5838|M.smegmatis_MC2_155 ----------------
MAB_0499|M.abscessus_ATCC_1997 ----------------
MLBr_01733|M.leprae_Br4923 ----------------