For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
PHVITQSCCNDGSCVFACPVNCIHPTPDEPGFATSEMLYIDPVTCVDCGACVSACPVGAIAPDSRLDSKQ LPFVEINASYYPQRQGGEKLPPTSKLAPVIPAAQVRPRSQPLTVAIVGSGPAAMYAADELLVQHGVRVNV FEKLPTPYGLVRAGVAPDHQNTKRVTRLFDRVARHRRFRFYLNVEIGRQLSHADLLAHHHAVVYAVGAPD DRRLHIDGMGLPGTGTATELVAWINGHPDFTDLPVDLSHERAVITGNGNVALDVARMLTANPDDLARTDI ADPALRALRNSAVREVVIAARRGPAHSAFTLPELIGLTGCAEVVLDAADRQRVLDDLATVSDQLTKRKLE ILATLGEGSAASGPRIRLAYQLTPRSVRGEQRASGVEFSVTGTDEMRTLDAGLVLTSIGYRGTKIGDLPF DDNAAVVRNDGGRVVDPVRGAPVPGVYVAGWIKRGPSGFIGTNKSCSLQTVAALVADFNAGKLGDPVCKP AALAKLVHTREPDVIDSAGWFAIDAAEIARGNAEGRPRNKFTDVADMLGAAASGAPVRPSRGLLAAILGR *
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_0264 | fprB | - | 100% (561) | NADPH:adrenodoxin oxidoreductase FprB |
M. ulcerans Agy99 | MUL_2413 | fprA_1 | 1e-83 | 39.33% (478) | NADPH:adrenodoxin oxidoreductase FprA_1 |
M. ulcerans Agy99 | MUL_2699 | fprA | 5e-76 | 41.84% (423) | NADPH:adrenodoxin oxidoreductase FprA |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0910 | fprB | 0.0 | 79.22% (563) | NADPH:adrenodoxin oxidoreductase FprB |
M. gilvum PYR-GCK | Mflv_1720 | - | 0.0 | 69.68% (564) | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein |
M. tuberculosis H37Rv | Rv0886 | fprB | 0.0 | 79.22% (563) | NADPH:adrenodoxin oxidoreductase FprB |
M. leprae Br4923 | MLBr_02134 | fprB | 0.0 | 78.36% (550) | ferredoxin, ferredoxin-NADP reductase |
M. abscessus ATCC 19977 | MAB_0930 | - | 1e-170 | 58.54% (533) | putative ferredoxin/ferredoxin--NADP reductase |
M. marinum M | MMAR_4646 | fprB | 0.0 | 98.22% (561) | NADPH:adrenodoxin oxidoreductase FprB |
M. avium 104 | MAV_1015 | - | 0.0 | 79.26% (540) | ferredoxin/ferredoxin--NADP reductase |
M. smegmatis MC2 155 | MSMEG_5681 | - | 0.0 | 73.98% (561) | ferredoxin/ferredoxin--NADP reductase |
M. thermoresistible (build 8) | TH_1806 | - | 0.0 | 71.71% (562) | probable ferredoxin/ferredoxin--NADP reductase |
M. vanbaalenii PYR-1 | Mvan_5031 | - | 0.0 | 71.25% (560) | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment MUL_0264|M.ulcerans_Agy99 MPHVITQSCCNDGSCVFACPVNCIHPTPDEPGFATSEMLYIDPVTCVDCG MMAR_4646|M.marinum_M MPHVITQSCCNDGSCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCG MLBr_02134|M.leprae_Br4923 MPYIITQSCCNDGSCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCG Mb0910|M.bovis_AF2122/97 MPHVITQSCCNDASCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCG Rv0886|M.tuberculosis_H37Rv MPHVITQSCCNDASCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCG MAV_1015|M.avium_104 --------------------MNCIHPTPDEPGFATSEMLYIDPAACVDCG MSMEG_5681|M.smegmatis_MC2_155 MPHVITQSCCSDGSCVYACPVNCIHPSPDEPGFATAEMLYIDPDACVDCG TH_1806|M.thermoresistible__bu ---VITQSCCSDASCVYACPVNCIHPTPDEPGFATTEMLYIDPVACVDCG Mflv_1720|M.gilvum_PYR-GCK MPHVITQSCCSDGSCVYACPVNCIHPSPDEPGFATAEMLYIDPVACVDCG Mvan_5031|M.vanbaalenii_PYR-1 MPHVITQSCCSDGSCVYACPVNCIHPTPDEPGFATAEMLYIDPVACVDCG MAB_0930|M.abscessus_ATCC_1997 --------------------MNCIHPTPDEPDFLKAEMLHIDASACVDCG :*****:****.* .:***:**. :***** MUL_0264|M.ulcerans_Agy99 ACVSACPVGAIAPDSRLDSKQLPFVEINASYYPQRQGGEKLPPTSKLAPV MMAR_4646|M.marinum_M ACVSACPVGAIAPDSRLDSKQLPFVEINASYYPQRQGGEKLPPTSKLAPV MLBr_02134|M.leprae_Br4923 ACVSACPVGAIASDTRLAPKQLPFIEINASYYPARPIDLKLPPTSKLAPV Mb0910|M.bovis_AF2122/97 ACVTACPVSAIAPNTRLDFEQLPFVEINASYYPKRPAGVKLAPTSKLAPV Rv0886|M.tuberculosis_H37Rv ACVTACPVSAIAPNTRLDFEQLPFVEINASYYPKRPAGVKLAPTSKLAPV MAV_1015|M.avium_104 ACVSACPVGAIAPDNRLDDKQLPFVEINASFYPKRPAGQKLPPTSKLAPV MSMEG_5681|M.smegmatis_MC2_155 ACVSACPVGAIAPDTRLEPRQLPFVEINAAFYPKRE--GKLPPTSKLAPV TH_1806|M.thermoresistible__bu ACVTACPVGAIAPDHRLDATQRPFIELNAAFYPPRDPDEKLPPTSKLAPV Mflv_1720|M.gilvum_PYR-GCK ACVSACPVGAIAPDSKLTPEQLPFVELNAAFYPKRE--GKLPPTSKLAPV Mvan_5031|M.vanbaalenii_PYR-1 ACVSACPVGAIAPETGLAPDQLPFVELNAAFYPKRD--GKLPPTSKLAPV MAB_0930|M.abscessus_ATCC_1997 ACVAACPVDAIKPDSTLKEEQLPFLRINSEFYPREI------PRASLAPV ***:****.** .: * * **:.:*: :** . * :.**** MUL_0264|M.ulcerans_Agy99 IPAAQVRPR-SQPLTVAIVGSGPAAMYAADELLVQHGVRVNVFEKLPTPY MMAR_4646|M.marinum_M IPAAQVRPR-SQPLTVAIVGSGPAAMYAADELLVQHGVCVNVFEKLPTPY MLBr_02134|M.leprae_Br4923 IPAAQVHVR-RRPLTVAIVGSGPAAMYAADELLTQPGVWVNVFEKLPTPY Mb0910|M.bovis_AF2122/97 TPAAEVRVR-RQPLTVAVVGSGPAAMYAADELLVQQGVQVNVFEKLPTPY Rv0886|M.tuberculosis_H37Rv TPAAEVRVR-RQPLTVAVVGSGPAAMYAADELLVQQGVQVNVFEKLPTPY MAV_1015|M.avium_104 IPAVPVRPR-GRPLTVAIVGSGPAAMYAADELLTQDGVRVNVFEKLPTPY MSMEG_5681|M.smegmatis_MC2_155 IEAPKITR--DGPLTVAIVGSGPAAMYAADELLTQRGVRVNVFEKLPTPY TH_1806|M.thermoresistible__bu IPAPRIERR-GGPLRVAIVGSGPAAMYAADELLTQDDVLVNVFERLPTPY Mflv_1720|M.gilvum_PYR-GCK LEAPVVHRKSGGPLTVAIVGSGPAAMYAADELLTQPDVRVNVFEKLPTRY Mvan_5031|M.vanbaalenii_PYR-1 LEAPEVRRRPGGPLTVAIVGSGPAAMYAADELLTQQGVRVNVFEKLPTPY MAB_0930|M.abscessus_ATCC_1997 IQAPPVRGT--SALKVAIVGSGPAAMYAADELLTQPNVKVNMFERLPAPY * : .* **:***************.* .* **:**:**: * MUL_0264|M.ulcerans_Agy99 GLVRAGVAPDHQNTKRVTRLFDRVARHRRFRFYLNVEIGRQLSHADLLAH MMAR_4646|M.marinum_M GLVRAGVAPDHQNTKRVTRLFDRVARHRRFRFYLNVEIGRKLSHADLLAH MLBr_02134|M.leprae_Br4923 GLVRAGLAPDHQNTKKVTELFDRVAEHRRFRFFLNVEIGRHLSHDELLAH Mb0910|M.bovis_AF2122/97 GLVRSGVAPDHQNTKRVTRLFDRIAGHRRFRFYLNVEIGKHLGHAELLAH Rv0886|M.tuberculosis_H37Rv GLVRSGVAPDHQNTKRVTRLFDRIAGHRRFRFYLNVEIGKHLGHAELLAH MAV_1015|M.avium_104 GLVRAGVAPDHQNTKKVTRLFDRVAGHDRFRFYLNVEVGKHLSHADLLAH MSMEG_5681|M.smegmatis_MC2_155 GLVRAGVAPDHQSTKRVTELFDRMAAQRGFTFYLNVEVGKHLTHADLLGH TH_1806|M.thermoresistible__bu GLVRAGVAPDHQKTKGVTDLFDKIAQQPGFEFYLNVEVGTHLSHAELLAH Mflv_1720|M.gilvum_PYR-GCK GLVRAGVAPDHQHTKRVTELFDTIADKPGFTFFLNTEVGSDLTHDELLRY Mvan_5031|M.vanbaalenii_PYR-1 GLVRAGVAPDHQHTKRVTKLFESISGLPGFTLYLNVEVGADLTHDELLAH MAB_0930|M.abscessus_ATCC_1997 GLVRAGVAPDHQQTKRVTKLFDTMAAQPNFEFFLNVEVGKDITHEELLAH ****:*:***** ** ** **: :: * ::**.*:* .: * :** : MUL_0264|M.ulcerans_Agy99 HHAVVYAVGAPDDRRLHIDGMGLPGTGTATELVAWINGHPDFTDLPVDLS MMAR_4646|M.marinum_M HHAVVYAVGAPDDRRLHIDGMGLPGTGTATELVAWINGHPDFTDLPVDLS MLBr_02134|M.leprae_Br4923 HHAVLYAVGAPDDRRLNIDGMGIPGTGTATELVAWINAHPDFAYLPVDLS Mb0910|M.bovis_AF2122/97 HHAVLYAVGAPDDRRLTIDGMGLPGTGTATELVAWLNGHPDFNDLPVDLS Rv0886|M.tuberculosis_H37Rv HHAVLYAVGAPDDRRLTIDGMGLPGTGTATELVAWLNGHPDFNDLPVDLS MAV_1015|M.avium_104 HHAVLYAVGAPDDRRLDIEGMGLAGSGTATELVAWINGHPEFTALPVDLR MSMEG_5681|M.smegmatis_MC2_155 HHAVVYAVGAPNDRRLDIEGMDLPGTATATEVVAWINGHPDHTDLPVRLD TH_1806|M.thermoresistible__bu HHAVLYAVGAPNDRRLDIDGMGLPGTGTATEVVAWYNGHPDFADLPVDLS Mflv_1720|M.gilvum_PYR-GCK HHAVLYAVGAPSDRRLDIDGMELPGTATATDLVAWYNGHPEAADLRVDLH Mvan_5031|M.vanbaalenii_PYR-1 HHAVLYAVGAPDDRRLDIDGIGRPGTATATEVVAWYNGHPEFAHLPVDLS MAB_0930|M.abscessus_ATCC_1997 HHAVIYSVGASSDRRLDIPGIELPGNATATQVVAWINAHPDYADFRVDLD ****:*:***..**** * *: .*..***::*** *.**: : * * MUL_0264|M.ulcerans_Agy99 HERAVITGNGNVALDVARMLTANPDDLARTDIADPALRALRNSAVREVVI MMAR_4646|M.marinum_M HERAVIIGNGNVALDVARMLTANPDDLARTDIADPALRALRNSAVREVVI MLBr_02134|M.leprae_Br4923 HERVVVIGNGNVALDVARLLTADPDNLARTDISEFALHVLGGSAVREVVV Mb0910|M.bovis_AF2122/97 HERVVIIGNGNVALDVARVLAADPHELAATDIADHALSALRNSAVREVVV Rv0886|M.tuberculosis_H37Rv HERVVIIGNGNVALDVARVLAADPHELAATDIADHALSALRNSAVREVVV MAV_1015|M.avium_104 HERVVIIGNGNVALDVARVLTADPDDLARTDIADHALAALRGSAVREVVI MSMEG_5681|M.smegmatis_MC2_155 HERVVIVGNGNVALDVARVLTSDPDALARTDISDHALAALRSSAVQEVVI TH_1806|M.thermoresistible__bu GDRVVIVGNGNVALDVARILTADPDELARTDIADHALAALRSSRVREVVI Mflv_1720|M.gilvum_PYR-GCK TERVVVIGNGNVALDVARILTTDPDALARTDIADHALARLRDSQVREVVV Mvan_5031|M.vanbaalenii_PYR-1 GDRVVIIGNGNVALDVARILTAEPDVLARTDIADHALAVLRDSRVREVVI MAB_0930|M.abscessus_ATCC_1997 HERAVVIGNGNVALDVARVLTGDVERLARTDISDTALTALRSSKLREVVI :*.*: ***********:*: : . ** ***:: ** * .* ::***: MUL_0264|M.ulcerans_Agy99 AARRGPAHSAFTLPELIGLTGC--AEVVLDAADRQRVLDDLATVSDQLTK MMAR_4646|M.marinum_M AARRGPAHSAFTLPELIGLTGC--AEVVLDAADRQRVLDDLATVSDQLTK MLBr_02134|M.leprae_Br4923 AARRGPAHSAFTLPELIGLKAT--SEVVLDAGDRKLVEGDFATVSDSLTR Mb0910|M.bovis_AF2122/97 AARRGPAHSAFTLPELIGLTAG--ADVVLDPGDHQRVLDDLAIVADPLTR Rv0886|M.tuberculosis_H37Rv AARRGPAHSAFTLPELIGLTAG--ADVVLDPGDHQRVLDDLAIVADPLTR MAV_1015|M.avium_104 AARRGPAQSAFTLPELIGLTGS--REVVLSAADRELVAADLANASDALTK MSMEG_5681|M.smegmatis_MC2_155 AARRGPAASAFTLPELIGLTST--CDVVLDSADHDLVLRDLAQETDPLTR TH_1806|M.thermoresistible__bu AARRGPADSAFTLPELIGLTAT--ADVVLDARDHELVDRDLARTTDSLTR Mflv_1720|M.gilvum_PYR-GCK AARRGPAAAAFTLPELIGLTSS--CDVVLDPADHDSVLAELAEATDPLTR Mvan_5031|M.vanbaalenii_PYR-1 AARRGPAASSFTLPELIGLTST--CEVVLDPADHERVLTDLAAATDPLTR MAB_0930|M.abscessus_ATCC_1997 VGRRGPEHSAFTLPELLGLVGLPDMTVVVDQETADLVDQALQTHLEPLTR ..**** ::******:** . **:. . * : : **: MUL_0264|M.ulcerans_Agy99 RKLEILATLGEGS-AASGP---RIRLAYQLTPRSVRGE-----QRASGVE MMAR_4646|M.marinum_M RKLEILATLGEGS-AASGP---RIRLAYQLTPRSVRGE-----QRVSGVE MLBr_02134|M.leprae_Br4923 KKLEVLSSLVDSSKPTSRR---RIRLAYQLTPKRVLGN-----QRATGVE Mb0910|M.bovis_AF2122/97 NKLEILSTLGDGSAPARRVGRPRIRLAYRLTPRRVLGQ-----RRAGGVQ Rv0886|M.tuberculosis_H37Rv NKLEILSTLGDGSAPARRVGRPRIRLAYRLTPRRVLGQ-----RRAGGVQ MAV_1015|M.avium_104 AKLEVLSTLGDAAAPSERP---RIRLAYRLTPDRILGE-----QRVTGVQ MSMEG_5681|M.smegmatis_MC2_155 NKLEILAKLGDASAPITRP---RIRFAYQLTPRRVLGE-----NQVTAVE TH_1806|M.thermoresistible__bu NKLEILAKLPDAAAPITRP---RIRFAYQLTPRAILRAGAPAADRAAGIE Mflv_1720|M.gilvum_PYR-GCK NKLEILSTLGDTTAPVTRP---RIRLAYQLTPRRITGD-----ARAAGVE Mvan_5031|M.vanbaalenii_PYR-1 SKLEIMSKLGDATAPVTRP---RIRLAYRLTPRRVLGE-----ERATGVQ MAB_0930|M.abscessus_ATCC_1997 QKLEVLSTCPREAREPGGK---TIRFAYNRTPARVLGE-----DRVEAIE ***:::. : **:**. ** : :. .:: MUL_0264|M.ulcerans_Agy99 FSVTGTDEMRTLDAGLVLTSIGYRGTKIGDLPFDDNAAVVRNDGGRVVDP MMAR_4646|M.marinum_M FSVTGTDEMRTLDAGLVLTSIGYRGKKIGDLPFDDNAAVVPNDGGRVVDP MLBr_02134|M.leprae_Br4923 FSVTGTEESRRFDAGLVLTSVGYRGKRIRDLPFDEEAAVIPNDGGRVVDP Mb0910|M.bovis_AF2122/97 FSVTGTDELRQLDAGLVLTSIGYRGKPIPDLPFDEQAALVPNDGGRVIDP Rv0886|M.tuberculosis_H37Rv FSVTGTDELRQLDAGLVLTSIGYRGKPIPDLPFDEQAALVPNDGGRVIDP MAV_1015|M.avium_104 FTLTGTDETHCLPTGLVLTSIGYRGKPIRDLPYDEAAAVVPNDGGRVVDP MSMEG_5681|M.smegmatis_MC2_155 FGVTGTDEVRTLDAGLLLTSIGYRGKAIADLPFDEDASVVPNDGGRVIDP TH_1806|M.thermoresistible__bu FVRTGTDEVCRLDAGLVLTSIGYRGRPIRDLPFDDTAAVVPNDGGRVVDP Mflv_1720|M.gilvum_PYR-GCK FTVTGGDEVVEISAGLVLTSIGYRGTPIRGLPFDADAAVVPNDGGRVIA- Mvan_5031|M.vanbaalenii_PYR-1 FDVTGTGETCELTAGLVLTSIGYRGKPIRGLPFDEAAAVVPNAGGRVVDP MAB_0930|M.abscessus_ATCC_1997 FQHGDTTDT--IKAGLFLTSIGYRGVPMPDVPFDSQRGTIPNEQGRVKDS * . : : :**.***:**** : .:*:* . : * *** MUL_0264|M.ulcerans_Agy99 VRGAPVPGVYVAGWIKRGPSGFIGTNKSCSLQTVAALVADFNAGKLGDPV MMAR_4646|M.marinum_M VRGAPVPGVYVAGWIKRGPSGFIGTNKSCSLQTVAALVADFNAGKLGDPV MLBr_02134|M.leprae_Br4923 SRGRPMPGAYVAGWIKRGPTGFIGTNKLCSVQTVQAVVADFNAGWLTDPV Mb0910|M.bovis_AF2122/97 GTGEPVPGAYVAGWIKRGPTGFIGTNKSCSMQTVQALVADFNDGRLTDPV Rv0886|M.tuberculosis_H37Rv GTGEPVPGAYVAGWIKRGPTGFIGTNKSCSMQTVQALVADFNDGRLTDPV MAV_1015|M.avium_104 ASRRPVPGAYVAGWIKRGPSGFIGTNKSCSLQTVQALVADFNAGELADPA MSMEG_5681|M.smegmatis_MC2_155 ATGAPVPGAYVAGWIKRGPTGFIGTNKSCAAQTVHHLVDDYNAGALTDPP TH_1806|M.thermoresistible__bu ATGRPVPGSYVAGWIKRGPTGFIGTNKSCAAETVHKLVDDYNAGLLTEPI Mflv_1720|M.gilvum_PYR-GCK -GADPVRGSYVAGWIKRGPTGFIGTNKSCAAETVHNLVADYNDGLLADPV Mvan_5031|M.vanbaalenii_PYR-1 ETGEPVRGSYVAGWIKRGPTGFIGTNKSCAAETVHHLAADYNAGLLADPS MAB_0930|M.abscessus_ATCC_1997 STGQAHPGTYVAGWIKRGPTGFIGTNKSCSQQTVTSLVEDYNNGLLADPP . * **********:******* *: :** :. *:* * * :* MUL_0264|M.ulcerans_Agy99 CKPAALAKLVHTREPDVIDSAGWFAIDAAEIARGNAEGRPRNKFTDVADM MMAR_4646|M.marinum_M CKPAALAKLVHTREPDVIDSAGWFAIDAAEIARGNGEGRPRNKFTDVADM MLBr_02134|M.leprae_Br4923 AEPAELAKLVHARQPDTVDSVGWRAIDAAEIAQGSTEGRPRRKFTDVADM Mb0910|M.bovis_AF2122/97 ATPTALDQLVQARQPQAIGCAGWRAIDAAEIARGSADGRVRNKFTDVAEM Rv0886|M.tuberculosis_H37Rv ATPTALDQLVQARQPQAIGCAGWRAIDAAEIARGSADGRVRNKFTDVAEM MAV_1015|M.avium_104 AKPEALTALVRARRPDAIDAAGWRAIDAAEIARGSADGRPRNKFTDIGDM MSMEG_5681|M.smegmatis_MC2_155 RKPSALDKLVRARQPDVVDAAGWRAIDAAEIARGGDD-RPRDKFTTVPEM TH_1806|M.thermoresistible__bu HRPSALDKLVRSRRPDLVTAAGWRAIDAAEIDRGGQE-RPRVKFTGTDQM Mflv_1720|M.gilvum_PYR-GCK HRGAALEHFVRGRRPAVIGTAGWKAIDEAEIARGAGV-RPREKFTSVAEM Mvan_5031|M.vanbaalenii_PYR-1 HKASALDRFVRGRQPAVIDACGWRAIDAAEVARGAGL-RPRDKFTTVAEM MAB_0930|M.abscessus_ATCC_1997 QRLSGLSKVIQRRQPTIIGHDGWLAIDRAEIARGKGAGRPRDKFVSVPEM * .:: *.* : ** *** **: :* * * **. :* MUL_0264|M.ulcerans_Agy99 LGAAASGA--PVRP-----SRGLLAAILGR----- MMAR_4646|M.marinum_M LGAAASGA--PVRS-----SRGLLAGILGR----- MLBr_02134|M.leprae_Br4923 LAVAAGAP--PLR------LRALS----------- Mb0910|M.bovis_AF2122/97 LAAATSAPKEPLRRRVLARLRDLGQPIVLTVPL-- Rv0886|M.tuberculosis_H37Rv LAAATSAPKEPLRRRVLARLRDLGQPIVLTVPL-- MAV_1015|M.avium_104 LAAAAAAEPAPPPR------RRLLARLVPSGRG-- MSMEG_5681|M.smegmatis_MC2_155 LAVAVTAPKPSVR-------QRLTAGLLG------ TH_1806|M.thermoresistible__bu LAVARTAPAPPLR-------QRLLAALRQPLTGVV Mflv_1720|M.gilvum_PYR-GCK VEVAANAPAPPIH-------RRVLAALRR------ Mvan_5031|M.vanbaalenii_PYR-1 ENVAAAAAAPPMS-------KRLLEALRR------ MAB_0930|M.abscessus_ATCC_1997 LRVAADAPQPPLWR------KAIRGSALEDLLR-- .* . . : :