For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTRLYHVAIVGSGPSGFFAAAALLKAANASDQIDVAVDMLEMLPTPWGLVRSGVAPDHPKIKSVSQQFEK TAQDPRFRFFGNIKVGEHVEAADLALRYDAVIYAVGAQSERALDIAGEQLPGSVAAVDFVGWYNAHPHFE QMAPDLSGARAVVIGNGNVAVDVARILVTDPDVLAATDIADHALESLRARTVEEVVTIGRRGPLQRAFTT LELRELGELDGVDVVVDPAQLDGISDDDAAAIGKVAKQNLKVLRDYASRPARPGHRRIVLRFLTSPIEIK GDGKVESIVVGRNDLVSDASGRMMAKDTGAHEELPAHLVVRAVGYRGIPTPGLPFDTNSATIPHSGGRVA GSSNEYVVGWIKRGPTGVIGTNKKDSQDTVDTLLEDLAHQPATPAADQNRGDALAQWLISRQPQLIAAAH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2699 | fprA | - | 100% (420) | NADPH:adrenodoxin oxidoreductase FprA |
| M. ulcerans Agy99 | MUL_2413 | fprA_1 | e-179 | 73.92% (418) | NADPH:adrenodoxin oxidoreductase FprA_1 |
| M. ulcerans Agy99 | MUL_0264 | fprB | 4e-76 | 41.84% (423) | NADPH:adrenodoxin oxidoreductase FprB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3133 | fprA | 0.0 | 74.82% (421) | NADPH:adrenodoxin oxidoreductase FprA |
| M. gilvum PYR-GCK | Mflv_4452 | - | 1e-164 | 68.56% (423) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv3106 | fprA | 0.0 | 74.58% (421) | NADPH:adrenodoxin oxidoreductase FPRA (NADPH-ferredoxin |
| M. leprae Br4923 | MLBr_00666 | fprA | 0.0 | 74.82% (417) | putative NADPH-ferredoxin reductase |
| M. abscessus ATCC 19977 | MAB_3482 | - | 1e-142 | 62.05% (419) | NADPH-ferredoxin reductase FprA |
| M. marinum M | MMAR_3420 | fprA | 0.0 | 97.38% (420) | NADPH:adrenodoxin oxidoreductase FprA |
| M. avium 104 | MAV_4007 | - | 0.0 | 77.38% (420) | NADPH-ferredoxin reductase fpra |
| M. smegmatis MC2 155 | MSMEG_5681 | - | 1e-76 | 40.10% (419) | ferredoxin/ferredoxin--NADP reductase |
| M. thermoresistible (build 8) | TH_2151 | fprA | 1e-173 | 72.66% (417) | NADPH:ADRENODOXIN OXIDOREDUCTASE FPRA (NADPH-FERREDOXIN |
| M. vanbaalenii PYR-1 | Mvan_1910 | - | 1e-167 | 69.60% (421) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4452|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1910|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2151|M.thermoresistible__bu --------------------------------------------------
MUL_2699|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3420|M.marinum_M --------------------------------------------------
Mb3133|M.bovis_AF2122/97 --------------------------------------------------
Rv3106|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00666|M.leprae_Br4923 --------------------------------------------------
MAV_4007|M.avium_104 --------------------------------------------------
MAB_3482|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_5681|M.smegmatis_MC2_155 MPHVITQSCCSDGSCVYACPVNCIHPSPDEPGFATAEMLYIDPDACVDCG
Mflv_4452|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1910|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2151|M.thermoresistible__bu --------------------------------------------------
MUL_2699|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3420|M.marinum_M --------------------------------------------------
Mb3133|M.bovis_AF2122/97 --------------------------------------------------
Rv3106|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00666|M.leprae_Br4923 --------------------------------------------------
MAV_4007|M.avium_104 --------------------------------------------------
MAB_3482|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_5681|M.smegmatis_MC2_155 ACVSACPVGAIAPDTRLEPRQLPFVEINAAFYPKREGKLPPTSKLAPVIE
Mflv_4452|M.gilvum_PYR-GCK ---MPPLRPYYVAIVGSGPSGYFAAASLLKSGGADGNRDVCVDMLEMLPT
Mvan_1910|M.vanbaalenii_PYR-1 ---MPVMRPYYVAIVGSGPSGFFAAASLLKFGDSPENRDVRVDMLEMLPT
TH_2151|M.thermoresistible__bu ---------LQVAIVGSGPSGFFAAASLLKSADSAEGRDVRVDMLEMLPT
MUL_2699|M.ulcerans_Agy99 ---MTR--LYHVAIVGSGPSGFFAAAALLKAANASDQIDVAVDMLEMLPT
MMAR_3420|M.marinum_M ---MTR--LYHVAIVGSGPSGFFAAAALLKAANASDQIDVAVDMLEMLPT
Mb3133|M.bovis_AF2122/97 ---MRP---YYIAIVGSGPSAFFAAASLLKAADTTEDLDMAVDMLEMLPT
Rv3106|M.tuberculosis_H37Rv ---MRP---YYIAIVGSGPSAFFAAASLLKAADTTEDLDMAVDMLEMLPT
MLBr_00666|M.leprae_Br4923 ---MRPHHIHHIAIVGSGPSGFFAAASVLKAADASDEINVAVDMLEMLPT
MAV_4007|M.avium_104 ---MRP---YHVAIVGSGPSGFFAAASLLKAADGSEHPDIAVDMLEMLPT
MAB_3482|M.abscessus_ATCC_1997 ---MRA---VHVAIVGAGPSGFFAAGSLLKHTD----FDVHVDMLEMLPT
MSMEG_5681|M.smegmatis_MC2_155 APKITRDGPLTVAIVGSGPAAMYAADELLTQRG------VRVNVFEKLPT
:****:**:. :** :*. . : *:::* ***
Mflv_4452|M.gilvum_PYR-GCK PWGLVRSGVAPDHPKIKSISAQFDKTSADPRFRFFGNVVIGEHVHPDELA
Mvan_1910|M.vanbaalenii_PYR-1 PWGLVRSGVAPDHPKIKSISAQFEKTSLDPRFRFFGNVDVGEHVHPSELA
TH_2151|M.thermoresistible__bu PWGLVRSGVAPDHPKIKSISAQFEKVAADPRFRFFGNITVGDHVRPDELA
MUL_2699|M.ulcerans_Agy99 PWGLVRSGVAPDHPKIKSVSQQFEKTAQDPRFRFFGNIKVGEHVEAADLA
MMAR_3420|M.marinum_M PWGLVRSGVAPDHPKIKSVSQQFEKTAQDPRFRFFGNIKVGEHVEAADLA
Mb3133|M.bovis_AF2122/97 PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVVVGEHVQPGELS
Rv3106|M.tuberculosis_H37Rv PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVVVGEHVQPGELS
MLBr_00666|M.leprae_Br4923 PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVIVGKHIEPAELA
MAV_4007|M.avium_104 PWGLVRSGVAPDHPKIKSISKQFEKTAADPRFRFFGNVSVGEHVQASELA
MAB_3482|M.abscessus_ATCC_1997 PWGLVRSGVAPDHPKIKSVSAVFEKTAAHPRFRFFGNIEVGAKITAEELA
MSMEG_5681|M.smegmatis_MC2_155 PYGLVRAGVAPDHQSTKRVTELFDRMAAQRGFTFYLNVEVGKHLTHADLL
*:****:****** . * :: *:: : . * *: *: :* :: :*
Mflv_4452|M.gilvum_PYR-GCK ERYDAVIYAIGAQSDRALGIPGEDLPGSVPAVDFVGWYNAHPHFVDMAPD
Mvan_1910|M.vanbaalenii_PYR-1 ERYDAVIYAIGAQADRELGIPGEDLPGSLAAVDFVGWYNAHPYFEGMAPD
TH_2151|M.thermoresistible__bu ERYDAVIYAIGTQADRALNIPGEELPGSVAAVDFVGWYNAHPHFENIDPD
MUL_2699|M.ulcerans_Agy99 LRYDAVIYAVGAQSERALDIAGEQLPGSVAAVDFVGWYNAHPHFEQMAPD
MMAR_3420|M.marinum_M LRYDAVIYAVGAQSDRALDIAGEQLPGSVAAVDFVGWYNAHPHFEQMAPD
Mb3133|M.bovis_AF2122/97 ERYDAVIYAVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQISPD
Rv3106|M.tuberculosis_H37Rv ERYDAVIYAVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQVSPD
MLBr_00666|M.leprae_Br4923 ERYDAVIYAVGAQSDRALNIPGEDLPGSIAAVDFVGWYNAHPNFHERSPD
MAV_4007|M.avium_104 ERYDAVIYAVGAQSDRALNIPGEDLPGSIAAVDFVGWYNAHPNFEEATPD
MAB_3482|M.abscessus_ATCC_1997 SRYDAVIYAVGAQSDKPLGIPGDQLSGCIAAVDVVGWYNANPTYQKVSVD
MSMEG_5681|M.smegmatis_MC2_155 GHHHAVVYAVGAPNDRRLDIEGMDLPGTATATEVVAWINGHPDHTDLPVR
::.**:**:*: :: *.* * :*.* .*.:.*.* *.:* .
Mflv_4452|M.gilvum_PYR-GCK VSGGRAVVVGNGNVAIDVARILVSDPDVLAETDIADHALESLHARGVEEV
Mvan_1910|M.vanbaalenii_PYR-1 LSGGRAVVVGNGNVAIDVARILVSDPDVLAETDIADHALRSLHARGVEEV
TH_2151|M.thermoresistible__bu LSGGRAVVIGNGNVALDVARILVTDPEALAKTDIADHALEALRSRGIEEV
MUL_2699|M.ulcerans_Agy99 LSGARAVVIGNGNVAVDVARILVTDPDVLAATDIADHALESLRARTVEEV
MMAR_3420|M.marinum_M LSGARAVVIGNGNVAVDVARILVTDPDVLAATDIADHALESLRARTVEEV
Mb3133|M.bovis_AF2122/97 LSGARAVVIGNGNVALDVARILLTDPDVLARTDIADHALESLRPRGIQEV
Rv3106|M.tuberculosis_H37Rv LSGARAVVIGNGNVALDVARILLTDPDVLARTDIADHALESLRPRGIQEV
MLBr_00666|M.leprae_Br4923 LSGSRAVVIGNGNVALDVTRILITDPDVLAFTDIADHALESLRPRGIEEV
MAV_4007|M.avium_104 LSGSRAVVVGNGNVALDVARILVTDPDVLGLTDIADHALESLRPCGVDEV
MAB_3482|M.abscessus_ATCC_1997 LSGERAVVVGNGNVALDVARILGMDPESLHTTDIADRALDSLDHNAIREV
MSMEG_5681|M.smegmatis_MC2_155 LDHERVVIVGNGNVALDVARVLTSDPDALARTDISDHALAALRSSAVQEV
:. *.*::******:**:*:* **: * ***:*:** :* : **
Mflv_4452|M.gilvum_PYR-GCK LIIGRRGPLQAPFTTLELRELGDLEALGDVDVIVDPGDFADITDEDLEAA
Mvan_1910|M.vanbaalenii_PYR-1 MIIGRRGPLQAPFTTLELRELGDLEALGDVDIVIDPADFADITDDDLEAA
TH_2151|M.thermoresistible__bu VIVGRRGPLQATFTTLELRELGALEGLADVDVVVDPADFADITDEDLEAA
MUL_2699|M.ulcerans_Agy99 VTIGRRGPLQRAFTTLELRELGELDG---VDVVVDPAQLDGISDDDAAAI
MMAR_3420|M.marinum_M VIIGRRGPLQSAFTTLELRELGELDG---VDVVVDPAQLDGISDDDAAAI
Mb3133|M.bovis_AF2122/97 VIVGRRGPLQAAFTTLELRELADLDG---VDVVIDPAELDGITDEDAAAV
Rv3106|M.tuberculosis_H37Rv VIVGRRGPLQAAFTTLELRELADLDG---VDVVIDPAELDGITDEDAAAV
MLBr_00666|M.leprae_Br4923 VIVGRRGPLQTAFTTLELRELADIEG---VDVLVDPAQLEGISDENAAAA
MAV_4007|M.avium_104 VVIGRRGPLQTAFTTLELRELGELDN---VDVIVDPAQLEGVTDEDVAAA
MAB_3482|M.abscessus_ATCC_1997 VIIGRRGPLQATFTPLELREMGELPG---VDVVVDPEDLADITDEQLAAA
MSMEG_5681|M.smegmatis_MC2_155 VIAARRGPAASAFT---LPELIGLTS--TCDVVLDSADHDLVLRDLAQET
: .**** .** * *: : *:::*. : : :
Mflv_4452|M.gilvum_PYR-GCK GKTVRNNIKVLRGYAETTPKGAKRRIVFRFRTSPIEIRGD----GKVESI
Mvan_1910|M.vanbaalenii_PYR-1 GKTVRNNIKVLRGYADKAPKGARRRIVFRFRTSPIEIKGG----DRVQSI
TH_2151|M.thermoresistible__bu GKTVKQNVKVLRGYAEQGVRGAPRRIVFRFRTSPIEIRGD----GRVQSI
MUL_2699|M.ulcerans_Agy99 GKVAKQNLKVLRDYASRPARPGHRRIVLRFLTSPIEIKGD----GKVESI
MMAR_3420|M.marinum_M GKVAKQNLKVLRDYASRPARPGHRRIVLRFLTSPIEIKGD----GKVESI
Mb3133|M.bovis_AF2122/97 GKVCKQNIKVLRGYADREPRPGHRRMVFRFLTSPIEIKGK----RKVERI
Rv3106|M.tuberculosis_H37Rv GKVCKQNIKVLRGYADREPRPGHRRMVFRFLTSPIEIKGK----RKVERI
MLBr_00666|M.leprae_Br4923 GKTTRQNIKVLRDYTVRTPKPGHRRIVFRFLTSPIEIKGK----GKVERI
MAV_4007|M.avium_104 GKTAKQNISVLRDYAKRSPRPGHRRIVLRFMTSPIEIKGD----GRVESI
MAB_3482|M.abscessus_ATCC_1997 PKPTRTNIETLRKFSERPHTEGHRRVVFRFRTSPIELHSDSAGVGVVESI
MSMEG_5681|M.smegmatis_MC2_155 DPLTRNKLEILAKLGDASAPITRPRIRFAYQLTPRRVLGE----NQVTAV
: ::. * *: : : :* .: . * :
Mflv_4452|M.gilvum_PYR-GCK VLGRNELIRGDDGRISAKDTGERDEVAAQLVVRAVGYRGLPTPGLPFDDR
Mvan_1910|M.vanbaalenii_PYR-1 VLGRNELTKGADGRVSAADTGEREEVPAQLVVRAVGYRGLPTPGLPFDER
TH_2151|M.thermoresistible__bu VLGRNELVSDATGRIVAKDTGAREELPAQLVVRAIGYRGLPTPGLPFDER
MUL_2699|M.ulcerans_Agy99 VVGRNDLVSDASGRMMAKDTGAHEELPAHLVVRAVGYRGIPTPGLPFDTN
MMAR_3420|M.marinum_M VVGRNDLVSDANGRMMAKDTGAREELPAQLVVRAVGYRGLPTPGLPFDTN
Mb3133|M.bovis_AF2122/97 VLGRNELVSDGSGRVAAKDTGEREELPAQLVVRSVGYRGVPTPGLPFDDQ
Rv3106|M.tuberculosis_H37Rv VLGRNELVSDGSGRVAAKDTGEREELPAQLVVRSVGYRGVPTPGLPFDDQ
MLBr_00666|M.leprae_Br4923 VLGQNELVTDDNGRVAAKDTGVREELPAQLIVRSIGYRGVPTPGLPFDDS
MAV_4007|M.avium_104 VLGRNELVTDETGRVLARDTGEREELPVQLVVRSVGYRGVPTPGLPFDEK
MAB_3482|M.abscessus_ATCC_1997 TVGRNKLVEE-DGYVVAHDTGERQTLPTHLVVRAIGYRGVPVPGLPFDSR
MSMEG_5681|M.smegmatis_MC2_155 EFG-------------VTGTDEVRTLDAGLLLTSIGYRGKAIADLPFDED
.* . .*. : . *:: ::**** . ..****
Mflv_4452|M.gilvum_PYR-GCK AGTIPHVDGKVEGRRN------DYVVGWIKRGPTGVIGSNKKDSADTVAT
Mvan_1910|M.vanbaalenii_PYR-1 AGTIPHTDGRVAGSRN------EYVVGWIKRGPTGVIGSNKKDSADTVDT
TH_2151|M.thermoresistible__bu SGTIPHTDGRIEGSRN------EYVVGWIKRGPSGVIGSNKKDSQDTVDT
MUL_2699|M.ulcerans_Agy99 SATIPHSGGRVAGSSN------EYVVGWIKRGPTGVIGTNKKDSQDTVDT
MMAR_3420|M.marinum_M SATIPHSGGRVAGSSN------EYVVGWIKRGPTGVIGTNKKDSQDTVDT
Mb3133|M.bovis_AF2122/97 SGTIPNVGGRINGSPN------EYVVGWIKRGPTGVIGTNKKDAQDTVDT
Rv3106|M.tuberculosis_H37Rv SGTIPNVGGRINGSPN------EYVVGWIKRGPTGVIGTNKKDAQDTVDT
MLBr_00666|M.leprae_Br4923 SVTIPNTNGRVNGSRN------EYVVGWIKRGPTGVIGTNKKDSQDTVDT
MAV_4007|M.avium_104 TATIPNTGGRVEGSRN------EYVVGWIKRGPTGVIGTNKKDSQDTVDT
MAB_3482|M.abscessus_ATCC_1997 RGVILNEAGRIQGRDN------EYVVGWIKRGPVGVIGTNKSDSQETVDT
MSMEG_5681|M.smegmatis_MC2_155 ASVVPNDGGRVIDPATGAPVPGAYVAGWIKRGPTGFIGTNKSCAAQTVHH
.: : *:: . . **.******* *.**:**. : :**
Mflv_4452|M.gilvum_PYR-GCK LLNDLSSAELAD----FGSDHPDKVQQWLQERQPKLITSEHWKLIDTHER
Mvan_1910|M.vanbaalenii_PYR-1 LLADLAAAELTE----FDAGHLEDIERWLLERQPKLVTNEHWKLIDAHER
TH_2151|M.thermoresistible__bu LLADLRDAELAD----FGPDHHDELAAWLSSRQPKLVTADHWNVIDEHER
MUL_2699|M.ulcerans_Agy99 LLEDLAHQPATP---AADQNRGDALAQWLISRQPQLIAAAH---------
MMAR_3420|M.marinum_M LLEDLAHQPAKP---AADQNRGDALAEWLNSCQPQLIAAAHWEAIDNFER
Mb3133|M.bovis_AF2122/97 LIKDLGNAKEGAECKSFPEDHADQVADWLAARQPKLVTSAHWQVIDAFER
Rv3106|M.tuberculosis_H37Rv LIKNLGNAKEGAECKSFPEDHADQVADWLAARQPKLVTSAHWQVIDAFER
MLBr_00666|M.leprae_Br4923 LMENLAGAND---TEKFGADHADRLAEWLAERQPKLVTSAHWQAIDRFER
MAV_4007|M.avium_104 LLADLANAGPDG-LADFPDDHADRLADWLASRQPKLVTTAHWELIDAHER
MAB_3482|M.abscessus_ATCC_1997 LLADLATAELRD------APDVAALEEWLLGHEPHIVSQSDWLTIDSHER
MSMEG_5681|M.smegmatis_MC2_155 LVDDYNAGALTD-----PPRKPSALDKLVRARQPDVVDAAGWRAIDAAEI
*: : : : :*.::
Mflv_4452|M.gilvum_PYR-GCK TAGEGSGRPRVKVTSVEDLLRIG--HA--------------
Mvan_1910|M.vanbaalenii_PYR-1 SAGAGSGRPRVKLSNVAEMLRVG--GRG-------------
TH_2151|M.thermoresistible__bu GAGQQCGRPRVKLASVAELLRVG--HG--------------
MUL_2699|M.ulcerans_Agy99 -----------------------------------------
MMAR_3420|M.marinum_M EAGQSQQRPRVKVASLPELLRIG--HG--------------
Mb3133|M.bovis_AF2122/97 AAGEPHGRPRVKLASLAELLRIG--LG--------------
Rv3106|M.tuberculosis_H37Rv AAGEPHGRPRVKLASLAELLRIG--LG--------------
MLBr_00666|M.leprae_Br4923 AAGEPHGRPRVKLPNLAELLRIG--HG--------------
MAV_4007|M.avium_104 AAGEARGRPRVKLPSLAKLLRVS--HG--------------
MAB_3482|M.abscessus_ATCC_1997 ATGEPQGRPRVKLETVPDLLAATGRHGEP------------
MSMEG_5681|M.smegmatis_MC2_155 ARG-GDDRPRDKFTTVPEMLAVAVTAPKPSVRQRLTAGLLG