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PHVITQSCCSDGSCVYACPVNCIHPSPDEPGFATAEMLYIDPDACVDCGACVSACPVGAIAPDTRLEPRQ LPFVEINAAFYPKREGKLPPTSKLAPVIEAPKITRDGPLTVAIVGSGPAAMYAADELLTQRGVRVNVFEK LPTPYGLVRAGVAPDHQSTKRVTELFDRMAAQRGFTFYLNVEVGKHLTHADLLGHHHAVVYAVGAPNDRR LDIEGMDLPGTATATEVVAWINGHPDHTDLPVRLDHERVVIVGNGNVALDVARVLTSDPDALARTDISDH ALAALRSSAVQEVVIAARRGPAASAFTLPELIGLTSTCDVVLDSADHDLVLRDLAQETDPLTRNKLEILA KLGDASAPITRPRIRFAYQLTPRRVLGENQVTAVEFGVTGTDEVRTLDAGLLLTSIGYRGKAIADLPFDE DASVVPNDGGRVIDPATGAPVPGAYVAGWIKRGPTGFIGTNKSCAAQTVHHLVDDYNAGALTDPPRKPSA LDKLVRARQPDVVDAAGWRAIDAAEIARGGDDRPRDKFTTVPEMLAVAVTAPKPSVRQRLTAGLLG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_5681 | - | - | 100% (557) | ferredoxin/ferredoxin--NADP reductase |
M. smegmatis MC2 155 | MSMEG_6458 | gltD | 4e-16 | 30.38% (260) | glutamate synthase subunit beta |
M. smegmatis MC2 155 | MSMEG_3226 | - | 7e-13 | 35.71% (154) | glutamate synthase, NADH/NADPH, small subunit |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0910 | fprB | 0.0 | 74.56% (562) | NADPH:adrenodoxin oxidoreductase FprB |
M. gilvum PYR-GCK | Mflv_1720 | - | 0.0 | 75.58% (557) | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein |
M. tuberculosis H37Rv | Rv0886 | fprB | 0.0 | 74.56% (562) | NADPH:adrenodoxin oxidoreductase FprB |
M. leprae Br4923 | MLBr_02134 | fprB | 0.0 | 72.10% (552) | ferredoxin, ferredoxin-NADP reductase |
M. abscessus ATCC 19977 | MAB_0930 | - | 0.0 | 62.20% (537) | putative ferredoxin/ferredoxin--NADP reductase |
M. marinum M | MMAR_4646 | fprB | 0.0 | 74.87% (561) | NADPH:adrenodoxin oxidoreductase FprB |
M. avium 104 | MAV_1015 | - | 0.0 | 75.42% (541) | ferredoxin/ferredoxin--NADP reductase |
M. thermoresistible (build 8) | TH_1806 | - | 0.0 | 78.21% (560) | probable ferredoxin/ferredoxin--NADP reductase |
M. ulcerans Agy99 | MUL_0264 | fprB | 0.0 | 73.98% (561) | NADPH:adrenodoxin oxidoreductase FprB |
M. vanbaalenii PYR-1 | Mvan_5031 | - | 0.0 | 77.38% (557) | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment Mb0910|M.bovis_AF2122/97 MPHVITQSCCNDASCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCG Rv0886|M.tuberculosis_H37Rv MPHVITQSCCNDASCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCG MMAR_4646|M.marinum_M MPHVITQSCCNDGSCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCG MUL_0264|M.ulcerans_Agy99 MPHVITQSCCNDGSCVFACPVNCIHPTPDEPGFATSEMLYIDPVTCVDCG MLBr_02134|M.leprae_Br4923 MPYIITQSCCNDGSCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCG MAV_1015|M.avium_104 --------------------MNCIHPTPDEPGFATSEMLYIDPAACVDCG MSMEG_5681|M.smegmatis_MC2_155 MPHVITQSCCSDGSCVYACPVNCIHPSPDEPGFATAEMLYIDPDACVDCG TH_1806|M.thermoresistible__bu ---VITQSCCSDASCVYACPVNCIHPTPDEPGFATTEMLYIDPVACVDCG Mflv_1720|M.gilvum_PYR-GCK MPHVITQSCCSDGSCVYACPVNCIHPSPDEPGFATAEMLYIDPVACVDCG Mvan_5031|M.vanbaalenii_PYR-1 MPHVITQSCCSDGSCVYACPVNCIHPTPDEPGFATAEMLYIDPVACVDCG MAB_0930|M.abscessus_ATCC_1997 --------------------MNCIHPTPDEPDFLKAEMLHIDASACVDCG :*****:****.* .:***:**. :***** Mb0910|M.bovis_AF2122/97 ACVTACPVSAIAPNTRLDFEQLPFVEINASYYPKRPAGVKLAPTSKLAPV Rv0886|M.tuberculosis_H37Rv ACVTACPVSAIAPNTRLDFEQLPFVEINASYYPKRPAGVKLAPTSKLAPV MMAR_4646|M.marinum_M ACVSACPVGAIAPDSRLDSKQLPFVEINASYYPQRQGGEKLPPTSKLAPV MUL_0264|M.ulcerans_Agy99 ACVSACPVGAIAPDSRLDSKQLPFVEINASYYPQRQGGEKLPPTSKLAPV MLBr_02134|M.leprae_Br4923 ACVSACPVGAIASDTRLAPKQLPFIEINASYYPARPIDLKLPPTSKLAPV MAV_1015|M.avium_104 ACVSACPVGAIAPDNRLDDKQLPFVEINASFYPKRPAGQKLPPTSKLAPV MSMEG_5681|M.smegmatis_MC2_155 ACVSACPVGAIAPDTRLEPRQLPFVEINAAFYPKRE--GKLPPTSKLAPV TH_1806|M.thermoresistible__bu ACVTACPVGAIAPDHRLDATQRPFIELNAAFYPPRDPDEKLPPTSKLAPV Mflv_1720|M.gilvum_PYR-GCK ACVSACPVGAIAPDSKLTPEQLPFVELNAAFYPKRE--GKLPPTSKLAPV Mvan_5031|M.vanbaalenii_PYR-1 ACVSACPVGAIAPETGLAPDQLPFVELNAAFYPKRD--GKLPPTSKLAPV MAB_0930|M.abscessus_ATCC_1997 ACVAACPVDAIKPDSTLKEEQLPFLRINSEFYPREI------PRASLAPV ***:****.** .: * * **:.:*: :** . * :.**** Mb0910|M.bovis_AF2122/97 TPAAEVRVR-RQPLTVAVVGSGPAAMYAADELLVQQGVQVNVFEKLPTPY Rv0886|M.tuberculosis_H37Rv TPAAEVRVR-RQPLTVAVVGSGPAAMYAADELLVQQGVQVNVFEKLPTPY MMAR_4646|M.marinum_M IPAAQVRPR-SQPLTVAIVGSGPAAMYAADELLVQHGVCVNVFEKLPTPY MUL_0264|M.ulcerans_Agy99 IPAAQVRPR-SQPLTVAIVGSGPAAMYAADELLVQHGVRVNVFEKLPTPY MLBr_02134|M.leprae_Br4923 IPAAQVHVR-RRPLTVAIVGSGPAAMYAADELLTQPGVWVNVFEKLPTPY MAV_1015|M.avium_104 IPAVPVRPR-GRPLTVAIVGSGPAAMYAADELLTQDGVRVNVFEKLPTPY MSMEG_5681|M.smegmatis_MC2_155 IEAPKITR--DGPLTVAIVGSGPAAMYAADELLTQRGVRVNVFEKLPTPY TH_1806|M.thermoresistible__bu IPAPRIERR-GGPLRVAIVGSGPAAMYAADELLTQDDVLVNVFERLPTPY Mflv_1720|M.gilvum_PYR-GCK LEAPVVHRKSGGPLTVAIVGSGPAAMYAADELLTQPDVRVNVFEKLPTRY Mvan_5031|M.vanbaalenii_PYR-1 LEAPEVRRRPGGPLTVAIVGSGPAAMYAADELLTQQGVRVNVFEKLPTPY MAB_0930|M.abscessus_ATCC_1997 IQAPPVRGT--SALKVAIVGSGPAAMYAADELLTQPNVKVNMFERLPAPY * : .* **:***************.* .* **:**:**: * Mb0910|M.bovis_AF2122/97 GLVRSGVAPDHQNTKRVTRLFDRIAGHRRFRFYLNVEIGKHLGHAELLAH Rv0886|M.tuberculosis_H37Rv GLVRSGVAPDHQNTKRVTRLFDRIAGHRRFRFYLNVEIGKHLGHAELLAH MMAR_4646|M.marinum_M GLVRAGVAPDHQNTKRVTRLFDRVARHRRFRFYLNVEIGRKLSHADLLAH MUL_0264|M.ulcerans_Agy99 GLVRAGVAPDHQNTKRVTRLFDRVARHRRFRFYLNVEIGRQLSHADLLAH MLBr_02134|M.leprae_Br4923 GLVRAGLAPDHQNTKKVTELFDRVAEHRRFRFFLNVEIGRHLSHDELLAH MAV_1015|M.avium_104 GLVRAGVAPDHQNTKKVTRLFDRVAGHDRFRFYLNVEVGKHLSHADLLAH MSMEG_5681|M.smegmatis_MC2_155 GLVRAGVAPDHQSTKRVTELFDRMAAQRGFTFYLNVEVGKHLTHADLLGH TH_1806|M.thermoresistible__bu GLVRAGVAPDHQKTKGVTDLFDKIAQQPGFEFYLNVEVGTHLSHAELLAH Mflv_1720|M.gilvum_PYR-GCK GLVRAGVAPDHQHTKRVTELFDTIADKPGFTFFLNTEVGSDLTHDELLRY Mvan_5031|M.vanbaalenii_PYR-1 GLVRAGVAPDHQHTKRVTKLFESISGLPGFTLYLNVEVGADLTHDELLAH MAB_0930|M.abscessus_ATCC_1997 GLVRAGVAPDHQQTKRVTKLFDTMAAQPNFEFFLNVEVGKDITHEELLAH ****:*:***** ** ** **: :: * ::**.*:* .: * :** : Mb0910|M.bovis_AF2122/97 HHAVLYAVGAPDDRRLTIDGMGLPGTGTATELVAWLNGHPDFNDLPVDLS Rv0886|M.tuberculosis_H37Rv HHAVLYAVGAPDDRRLTIDGMGLPGTGTATELVAWLNGHPDFNDLPVDLS MMAR_4646|M.marinum_M HHAVVYAVGAPDDRRLHIDGMGLPGTGTATELVAWINGHPDFTDLPVDLS MUL_0264|M.ulcerans_Agy99 HHAVVYAVGAPDDRRLHIDGMGLPGTGTATELVAWINGHPDFTDLPVDLS MLBr_02134|M.leprae_Br4923 HHAVLYAVGAPDDRRLNIDGMGIPGTGTATELVAWINAHPDFAYLPVDLS MAV_1015|M.avium_104 HHAVLYAVGAPDDRRLDIEGMGLAGSGTATELVAWINGHPEFTALPVDLR MSMEG_5681|M.smegmatis_MC2_155 HHAVVYAVGAPNDRRLDIEGMDLPGTATATEVVAWINGHPDHTDLPVRLD TH_1806|M.thermoresistible__bu HHAVLYAVGAPNDRRLDIDGMGLPGTGTATEVVAWYNGHPDFADLPVDLS Mflv_1720|M.gilvum_PYR-GCK HHAVLYAVGAPSDRRLDIDGMELPGTATATDLVAWYNGHPEAADLRVDLH Mvan_5031|M.vanbaalenii_PYR-1 HHAVLYAVGAPDDRRLDIDGIGRPGTATATEVVAWYNGHPEFAHLPVDLS MAB_0930|M.abscessus_ATCC_1997 HHAVIYSVGASSDRRLDIPGIELPGNATATQVVAWINAHPDYADFRVDLD ****:*:***..**** * *: .*..***::*** *.**: : * * Mb0910|M.bovis_AF2122/97 HERVVIIGNGNVALDVARVLAADPHELAATDIADHALSALRNSAVREVVV Rv0886|M.tuberculosis_H37Rv HERVVIIGNGNVALDVARVLAADPHELAATDIADHALSALRNSAVREVVV MMAR_4646|M.marinum_M HERAVIIGNGNVALDVARMLTANPDDLARTDIADPALRALRNSAVREVVI MUL_0264|M.ulcerans_Agy99 HERAVITGNGNVALDVARMLTANPDDLARTDIADPALRALRNSAVREVVI MLBr_02134|M.leprae_Br4923 HERVVVIGNGNVALDVARLLTADPDNLARTDISEFALHVLGGSAVREVVV MAV_1015|M.avium_104 HERVVIIGNGNVALDVARVLTADPDDLARTDIADHALAALRGSAVREVVI MSMEG_5681|M.smegmatis_MC2_155 HERVVIVGNGNVALDVARVLTSDPDALARTDISDHALAALRSSAVQEVVI TH_1806|M.thermoresistible__bu GDRVVIVGNGNVALDVARILTADPDELARTDIADHALAALRSSRVREVVI Mflv_1720|M.gilvum_PYR-GCK TERVVVIGNGNVALDVARILTTDPDALARTDIADHALARLRDSQVREVVV Mvan_5031|M.vanbaalenii_PYR-1 GDRVVIIGNGNVALDVARILTAEPDVLARTDIADHALAVLRDSRVREVVI MAB_0930|M.abscessus_ATCC_1997 HERAVVIGNGNVALDVARVLTGDVERLARTDISDTALTALRSSKLREVVI :*.*: ***********:*: : . ** ***:: ** * .* ::***: Mb0910|M.bovis_AF2122/97 AARRGPAHSAFTLPELIGLTAG--ADVVLDPGDHQRVLDDLAIVADPLTR Rv0886|M.tuberculosis_H37Rv AARRGPAHSAFTLPELIGLTAG--ADVVLDPGDHQRVLDDLAIVADPLTR MMAR_4646|M.marinum_M AARRGPAHSAFTLPELIGLTGC--AEVVLDAADRQRVLDDLATVSDQLTK MUL_0264|M.ulcerans_Agy99 AARRGPAHSAFTLPELIGLTGC--AEVVLDAADRQRVLDDLATVSDQLTK MLBr_02134|M.leprae_Br4923 AARRGPAHSAFTLPELIGLKAT--SEVVLDAGDRKLVEGDFATVSDSLTR MAV_1015|M.avium_104 AARRGPAQSAFTLPELIGLTGS--REVVLSAADRELVAADLANASDALTK MSMEG_5681|M.smegmatis_MC2_155 AARRGPAASAFTLPELIGLTST--CDVVLDSADHDLVLRDLAQETDPLTR TH_1806|M.thermoresistible__bu AARRGPADSAFTLPELIGLTAT--ADVVLDARDHELVDRDLARTTDSLTR Mflv_1720|M.gilvum_PYR-GCK AARRGPAAAAFTLPELIGLTSS--CDVVLDPADHDSVLAELAEATDPLTR Mvan_5031|M.vanbaalenii_PYR-1 AARRGPAASSFTLPELIGLTST--CEVVLDPADHERVLTDLAAATDPLTR MAB_0930|M.abscessus_ATCC_1997 VGRRGPEHSAFTLPELLGLVGLPDMTVVVDQETADLVDQALQTHLEPLTR ..**** ::******:** . **:. . * : : **: Mb0910|M.bovis_AF2122/97 NKLEILSTLGDGSAPARRVGRPRIRLAYRLTPRRVLGQ-----RRAGGVQ Rv0886|M.tuberculosis_H37Rv NKLEILSTLGDGSAPARRVGRPRIRLAYRLTPRRVLGQ-----RRAGGVQ MMAR_4646|M.marinum_M RKLEILATLGEGS-AASGP---RIRLAYQLTPRSVRGE-----QRVSGVE MUL_0264|M.ulcerans_Agy99 RKLEILATLGEGS-AASGP---RIRLAYQLTPRSVRGE-----QRASGVE MLBr_02134|M.leprae_Br4923 KKLEVLSSLVDSSKPTSRR---RIRLAYQLTPKRVLGN-----QRATGVE MAV_1015|M.avium_104 AKLEVLSTLGDAAAPSERP---RIRLAYRLTPDRILGE-----QRVTGVQ MSMEG_5681|M.smegmatis_MC2_155 NKLEILAKLGDASAPITRP---RIRFAYQLTPRRVLGE-----NQVTAVE TH_1806|M.thermoresistible__bu NKLEILAKLPDAAAPITRP---RIRFAYQLTPRAILRAGAPAADRAAGIE Mflv_1720|M.gilvum_PYR-GCK NKLEILSTLGDTTAPVTRP---RIRLAYQLTPRRITGD-----ARAAGVE Mvan_5031|M.vanbaalenii_PYR-1 SKLEIMSKLGDATAPVTRP---RIRLAYRLTPRRVLGE-----ERATGVQ MAB_0930|M.abscessus_ATCC_1997 QKLEVLSTCPREAREPGGK---TIRFAYNRTPARVLGE-----DRVEAIE ***:::. : **:**. ** : :. .:: Mb0910|M.bovis_AF2122/97 FSVTGTDELRQLDAGLVLTSIGYRGKPIPDLPFDEQAALVPNDGGRVIDP Rv0886|M.tuberculosis_H37Rv FSVTGTDELRQLDAGLVLTSIGYRGKPIPDLPFDEQAALVPNDGGRVIDP MMAR_4646|M.marinum_M FSVTGTDEMRTLDAGLVLTSIGYRGKKIGDLPFDDNAAVVPNDGGRVVDP MUL_0264|M.ulcerans_Agy99 FSVTGTDEMRTLDAGLVLTSIGYRGTKIGDLPFDDNAAVVRNDGGRVVDP MLBr_02134|M.leprae_Br4923 FSVTGTEESRRFDAGLVLTSVGYRGKRIRDLPFDEEAAVIPNDGGRVVDP MAV_1015|M.avium_104 FTLTGTDETHCLPTGLVLTSIGYRGKPIRDLPYDEAAAVVPNDGGRVVDP MSMEG_5681|M.smegmatis_MC2_155 FGVTGTDEVRTLDAGLLLTSIGYRGKAIADLPFDEDASVVPNDGGRVIDP TH_1806|M.thermoresistible__bu FVRTGTDEVCRLDAGLVLTSIGYRGRPIRDLPFDDTAAVVPNDGGRVVDP Mflv_1720|M.gilvum_PYR-GCK FTVTGGDEVVEISAGLVLTSIGYRGTPIRGLPFDADAAVVPNDGGRVIA- Mvan_5031|M.vanbaalenii_PYR-1 FDVTGTGETCELTAGLVLTSIGYRGKPIRGLPFDEAAAVVPNAGGRVVDP MAB_0930|M.abscessus_ATCC_1997 FQHGDTTDT--IKAGLFLTSIGYRGVPMPDVPFDSQRGTIPNEQGRVKDS * . : : :**.***:**** : .:*:* . : * *** Mb0910|M.bovis_AF2122/97 GTGEPVPGAYVAGWIKRGPTGFIGTNKSCSMQTVQALVADFNDGRLTDPV Rv0886|M.tuberculosis_H37Rv GTGEPVPGAYVAGWIKRGPTGFIGTNKSCSMQTVQALVADFNDGRLTDPV MMAR_4646|M.marinum_M VRGAPVPGVYVAGWIKRGPSGFIGTNKSCSLQTVAALVADFNAGKLGDPV MUL_0264|M.ulcerans_Agy99 VRGAPVPGVYVAGWIKRGPSGFIGTNKSCSLQTVAALVADFNAGKLGDPV MLBr_02134|M.leprae_Br4923 SRGRPMPGAYVAGWIKRGPTGFIGTNKLCSVQTVQAVVADFNAGWLTDPV MAV_1015|M.avium_104 ASRRPVPGAYVAGWIKRGPSGFIGTNKSCSLQTVQALVADFNAGELADPA MSMEG_5681|M.smegmatis_MC2_155 ATGAPVPGAYVAGWIKRGPTGFIGTNKSCAAQTVHHLVDDYNAGALTDPP TH_1806|M.thermoresistible__bu ATGRPVPGSYVAGWIKRGPTGFIGTNKSCAAETVHKLVDDYNAGLLTEPI Mflv_1720|M.gilvum_PYR-GCK -GADPVRGSYVAGWIKRGPTGFIGTNKSCAAETVHNLVADYNDGLLADPV Mvan_5031|M.vanbaalenii_PYR-1 ETGEPVRGSYVAGWIKRGPTGFIGTNKSCAAETVHHLAADYNAGLLADPS MAB_0930|M.abscessus_ATCC_1997 STGQAHPGTYVAGWIKRGPTGFIGTNKSCSQQTVTSLVEDYNNGLLADPP . * **********:******* *: :** :. *:* * * :* Mb0910|M.bovis_AF2122/97 ATPTALDQLVQARQPQAIGCAGWRAIDAAEIARGSADGRVRNKFTDVAEM Rv0886|M.tuberculosis_H37Rv ATPTALDQLVQARQPQAIGCAGWRAIDAAEIARGSADGRVRNKFTDVAEM MMAR_4646|M.marinum_M CKPAALAKLVHTREPDVIDSAGWFAIDAAEIARGNGEGRPRNKFTDVADM MUL_0264|M.ulcerans_Agy99 CKPAALAKLVHTREPDVIDSAGWFAIDAAEIARGNAEGRPRNKFTDVADM MLBr_02134|M.leprae_Br4923 AEPAELAKLVHARQPDTVDSVGWRAIDAAEIAQGSTEGRPRRKFTDVADM MAV_1015|M.avium_104 AKPEALTALVRARRPDAIDAAGWRAIDAAEIARGSADGRPRNKFTDIGDM MSMEG_5681|M.smegmatis_MC2_155 RKPSALDKLVRARQPDVVDAAGWRAIDAAEIARGGDD-RPRDKFTTVPEM TH_1806|M.thermoresistible__bu HRPSALDKLVRSRRPDLVTAAGWRAIDAAEIDRGGQE-RPRVKFTGTDQM Mflv_1720|M.gilvum_PYR-GCK HRGAALEHFVRGRRPAVIGTAGWKAIDEAEIARGAGV-RPREKFTSVAEM Mvan_5031|M.vanbaalenii_PYR-1 HKASALDRFVRGRQPAVIDACGWRAIDAAEVARGAGL-RPRDKFTTVAEM MAB_0930|M.abscessus_ATCC_1997 QRLSGLSKVIQRRQPTIIGHDGWLAIDRAEIARGKGAGRPRDKFVSVPEM * .:: *.* : ** *** **: :* * * **. :* Mb0910|M.bovis_AF2122/97 LAAATSAPKEPLRRRVLARLRDLGQPIVLTVPL-- Rv0886|M.tuberculosis_H37Rv LAAATSAPKEPLRRRVLARLRDLGQPIVLTVPL-- MMAR_4646|M.marinum_M LGAAASGA--PVRS-----SRGLLAGILGR----- MUL_0264|M.ulcerans_Agy99 LGAAASGA--PVRP-----SRGLLAAILGR----- MLBr_02134|M.leprae_Br4923 LAVAAGAP--PLR------LRALS----------- MAV_1015|M.avium_104 LAAAAAAEPAPPPR------RRLLARLVPSGRG-- MSMEG_5681|M.smegmatis_MC2_155 LAVAVTAPKPSVR-------QRLTAGLLG------ TH_1806|M.thermoresistible__bu LAVARTAPAPPLR-------QRLLAALRQPLTGVV Mflv_1720|M.gilvum_PYR-GCK VEVAANAPAPPIH-------RRVLAALRR------ Mvan_5031|M.vanbaalenii_PYR-1 ENVAAAAAAPPMS-------KRLLEALRR------ MAB_0930|M.abscessus_ATCC_1997 LRVAADAPQPPLWR------KAIRGSALEDLLR-- .* . . : :