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M. ulcerans Agy99 MUL_0227 (aslA)

annotation: arylsulfatase, AslA
coordinates: 231548 - 233098
length: 516

SNGKPNILVIWGDDIGITNLSCYSDGLMGYRTPHIDRIANEGMRFTDAYGEQSCTAGRAAFISGQSVYRT
GMSKVGMPDSDIGWSGQDPTIADLLKPLGYATGQFGKNHLGDRNKHLPTVHGFDEFFGNLCHLNAEEEPE
LPDYPKSDRFPVLAELNRPRGVLRCWATEEVSDEPDDPKYGPVGKQRIVDTGPLTKQRMETIDDETTEAC
VDFIKRQAAADTPFFVWMNMTHMHLRTHTKPESVGQAGVWQSPYHDTMIDHDRNVGQLLDALDELGIAQD
TIVIYSTDNGPHANTWPDGATTPFRSEKNTNWEGALRIPEMIRWPGKISAGVVSNEIIQHHDRLPTFLAA
AGEPDIIEKLKKGHKISVRGDDKEFKVHLDAFNLLPYLTGEVEESPRQGFIYFSDDCDVLGIRFHNWKIV
FQEQRCQGTLQVWAEPFIPLRVPKIFNLRTDPYERADITSNTYYDWFLDHDFIAFYGTAICTQFLETFKE
FPPRHPPARFTIDQAVEKLQAIVKD*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_0227aslA-100% (516)arylsulfatase, AslA
M. ulcerans Agy99MUL_2658atsB1e-1131.39% (137) arylsulfatase AtsB (aryl-sulfate sulphohydrolase)
M. ulcerans Agy99MUL_0454atsD2e-0923.29% (438) arylsulfatase AtsD

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3327catsB8e-1029.93% (137) arylsulfatase AtsB
M. gilvum PYR-GCKMflv_5039-2e-0927.63% (152) sulfatase
M. tuberculosis H37RvRv0711atsA2e-1028.29% (152) arylsulfatase AtsA
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4469c-9e-1025.44% (338) sulfatase family protein
M. marinum MMMAR_4410aslA0.098.45% (516) arylsulfatase, AslA
M. avium 104MAV_2989-2e-1724.36% (427) arylsulfatase
M. smegmatis MC2 155MSMEG_1228-2e-4229.09% (471) sulfatase
M. thermoresistible (build 8)TH_0315-1e-1022.93% (314) arylsulfatase
M. vanbaalenii PYR-1Mvan_4629-0.063.09% (512) sulfatase

CLUSTAL 2.0.9 multiple sequence alignment


MUL_0227|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4410|M.marinum_M               --------------------------------------------------
Mvan_4629|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_5039|M.gilvum_PYR-GCK          --------------------------------------------------
Rv0711|M.tuberculosis_H37Rv         --------------------------------------------------
TH_0315|M.thermoresistible__bu      --------------------------------------------------
Mb3327c|M.bovis_AF2122/97           MMSEDNALVLVAGYQDLDSARHDFQTLVDAAKDKSIPLQGAVLIGKDAEG
MAV_2989|M.avium_104                --------------------------------------------------
MSMEG_1228|M.smegmatis_MC2_155      --------------------------------------------------
MAB_4469c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MUL_0227|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4410|M.marinum_M               --------------------------------------------------
Mvan_4629|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_5039|M.gilvum_PYR-GCK          --------------------------------------------------
Rv0711|M.tuberculosis_H37Rv         --------------------------------------------------
TH_0315|M.thermoresistible__bu      --------------------------------------------------
Mb3327c|M.bovis_AF2122/97           SPVLVDTGNRLGRRGAAWGAGVGLAIGLFSPALLASAALGAATGALAGTF
MAV_2989|M.avium_104                --------------------------------------------------
MSMEG_1228|M.smegmatis_MC2_155      --------------------------------------------------
MAB_4469c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MUL_0227|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4410|M.marinum_M               --------------------------------------------------
Mvan_4629|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_5039|M.gilvum_PYR-GCK          --------------------------------------------------
Rv0711|M.tuberculosis_H37Rv         --------------------------------------------------
TH_0315|M.thermoresistible__bu      --------------------------------------------------
Mb3327c|M.bovis_AF2122/97           AHHRIKTGLADKIGQALAAGRAVVIAVTEAQGRLEAGQALASSPMKSVAE
MAV_2989|M.avium_104                --------------------------------------------------
MSMEG_1228|M.smegmatis_MC2_155      --------------------------------------------------
MAB_4469c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MUL_0227|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4410|M.marinum_M               --------------------------------------------------
Mvan_4629|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_5039|M.gilvum_PYR-GCK          -----------------------------MTTEFNGKIALDIRDSEPDWG
Rv0711|M.tuberculosis_H37Rv         -------------------------MAPEATEAFNGTIELDIRDSEPDWG
TH_0315|M.thermoresistible__bu      ------------------------------MADFGGKIELDIRDSEPDWG
Mb3327c|M.bovis_AF2122/97           LSRSTLRSLGAALREAMGKFNPDRTRLPLPQRRFGGVVGRTMAESVGDWS
MAV_2989|M.avium_104                --------------------------------------------------
MSMEG_1228|M.smegmatis_MC2_155      --------------------------------------------------
MAB_4469c|M.abscessus_ATCC_199      ----------------MAELNRRTVLTTGAIAAGAAAVGFGGYELLGTPR
                                                                                      

MUL_0227|M.ulcerans_Agy99           ------MSNGKPNILVIWGDDIGITNLSCYSDGLM-GYRTPHIDRIANEG
MMAR_4410|M.marinum_M               ------MPNGKPNILVIWGDDIGITNLSCYSDGLM-GYRTPHIDRIANEG
Mvan_4629|M.vanbaalenii_PYR-1       ------MGD-KPNILIIWGDDIGQSNLSCYSDGLM-GYRTANIDRIAAEG
Mflv_5039|M.gilvum_PYR-GCK          PFAAPTAQPEAPNVLYLVWDDIGIATWDCFGG----LVDMPAMSRIAERG
Rv0711|M.tuberculosis_H37Rv         PYAAPVAPEHSPNILYLVWDDVGIATWDCFGG----LVEMPAMTRVAERG
TH_0315|M.thermoresistible__bu      PFAAPTAPEGAPNILYVVWDDVGIGTWDCFGG----LVEMPTMSRIAEQG
Mb3327c|M.bovis_AF2122/97           IVPSPFPPDDAPNVLIVLIDDAGFGGPDTFGG----AIRTPTLSRLAQNG
MAV_2989|M.avium_104                --------MKRPNFLVIVADDLGFSDLGAFGG----EIETPNLDRLAYAG
MSMEG_1228|M.smegmatis_MC2_155      -------MPEKPNIVYFHVDNLGMGELGCYGGGILRGADTVRMDAFAAES
MAB_4469c|M.abscessus_ATCC_199      RNSSSGSDGNKPNILVIVVDQMR--APQWFPDVQKLTNILPNLSRLHRDS
                                               **.: .  *:        : .          :  .   .

MUL_0227|M.ulcerans_Agy99           MRFTDAYGEQ-SCTAGRAAFISGQSVYRTGMSKVG---------MPDSDI
MMAR_4410|M.marinum_M               MRFTDAYGEQ-SCTAGRAAFISGQSVYRTGMSKVG---------MPGSDI
Mvan_4629|M.vanbaalenii_PYR-1       ARFTDYYGEQ-SCTAGRAAFITGQNPYRTGLTKVG---------MPGAPI
Mflv_5039|M.gilvum_PYR-GCK          VRLSQFHTTA-LCSPTRASLLTGRNATTVGMATIEEFTD----GFPNCNG
Rv0711|M.tuberculosis_H37Rv         VRLSQFHTTA-LCSPTRASLLTGRNATTVGMATIEEFTD----GFPNCNG
TH_0315|M.thermoresistible__bu      VRLSQFHTTA-LCSPTRAALLTGRNPTTVGMATIEEFTD----GFPNCSG
Mb3327c|M.bovis_AF2122/97           LIYNRFHVTA-VCSPTRAALLTGRNHHRVGFGSVCEFPG----PYPGYSA
MAV_2989|M.avium_104                IRLTDFHSAP-ACSPTRAMLLTGTDHHIAGIGTMLEVAAPQFHGAPGYEG
MSMEG_1228|M.smegmatis_MC2_155      LKLTHFVVEP-QCTPTRSALMTGRYPIRSGNHTIA---------LGGNGG
MAB_4469c|M.abscessus_ATCC_199      VSFASHYTASNMCTPSRGAMTTGLYSHQTGCLYTGE---------GPSES
                                                *:. *. : :*      *                    

MUL_0227|M.ulcerans_Agy99           GWSGQDPTIADLLKPLGYATGQFGKNHLG--------DRNKHLPTVHGFD
MMAR_4410|M.marinum_M               GWSGQDPTIADLLKPLGYATGQFGKNHLG--------DRNKHLPTVHGFD
Mvan_4629|M.vanbaalenii_PYR-1       GLQAEDPTIATALKAQGYATGQFGKNHLG--------DRDEFLPTMHGFD
Mflv_5039|M.gilvum_PYR-GCK          RIPFDTALLSEVLSENGYNTYCIGKWHLTPLEESNLAATKRHWPLSRGFE
Rv0711|M.tuberculosis_H37Rv         RIPADTALLPEVLAEHGYNTYCVGKWHLTPLEESNMASTKRHWPTSRGFE
TH_0315|M.thermoresistible__bu      RIPVDTGLISEVLAEHGWNTYCVGKWHLTPLEESNMAATKRHWPVSRGFE
Mb3327c|M.bovis_AF2122/97           VRPRSCAALPRILRDNGYVTGAFGKWHLTPDNVQGAAGPFDNWPLGWGFD
MAV_2989|M.avium_104                YLNDRVVALPELLRDAGYLTLMSGKWHLG--------ATIETSPWARGFE
MSMEG_1228|M.smegmatis_MC2_155      GIVSWERTMGDILSEAGYATACFGKWHIG--------AEDGRWPTDHGFD
MAB_4469c|M.abscessus_ATCC_199      SLAPQFPTWGTMLRQQGYRTWWWGKWHLG--------DWSDTNPEGLDAH
                                                *   *: *   ** *:               *   . .

MUL_0227|M.ulcerans_Agy99           EFFG-NLCHLNAEEEPELPDYPKSDRFPVLAELNR-----------PRGV
MMAR_4410|M.marinum_M               EFFG-NLYHLNAEEEPELPDYPKSDRFPVLAELNR-----------PRGV
Mvan_4629|M.vanbaalenii_PYR-1       EFFG-NLYHLNAEEEPENVDYPKD---PEFRKKFG-----------PRGV
Mflv_5039|M.gilvum_PYR-GCK          RFYG-FMGGETDQWYPDLMYDNHPVAPP-ATPEEG-----YHLSKDLADK
Rv0711|M.tuberculosis_H37Rv         RFYG-FLGGETDQWYPDLVYDNHPVSPP-GTPEGG-----YHLSKDIADK
TH_0315|M.thermoresistible__bu      RFYG-FLGGETDQWYPDLVHDNHPVAPP-ATPEDG-----YHLSKDLADK
Mb3327c|M.bovis_AF2122/97           HFWG-FPSGAAGQYDPIISQDNSVIGIPEGSGEDGR---PYYFPDDLTDK
MAV_2989|M.avium_104                RSFA-LLPAGASHYGGSGARGFSPVPTLYTEDDRFVSVGDDFYSSDSYTD
MSMEG_1228|M.smegmatis_MC2_155      EWYG-PARTYDECLWPDDPWYDGERDGYSYMYEGT---------------
MAB_4469c|M.abscessus_ATCC_199      GFSGGTFPSPNGMPNQGLQKDPGIVDQFAGWFDAEAG-------KGPWCT
                                       .                                              

MUL_0227|M.ulcerans_Agy99           LRCWATEEVSDEPDDPKYGPVGKQRIVDTGPLTKQRMETIDDETTEACVD
MMAR_4410|M.marinum_M               LRCWATEEVSDEPDDPKYGPVGKQRIVDTGPLTKQRMETIDDETTEACVD
Mvan_4629|M.vanbaalenii_PYR-1       IRAWANGD-------------GTQRIEDTGPLTRKRMETCDEEFRDAAID
Mflv_5039|M.gilvum_PYR-GCK          TIEFIRDSKVIAPDKPWFSYVCPGAGHAPHHVFKEWADRYAGRFDMGYEA
Rv0711|M.tuberculosis_H37Rv         TIEFIRDAKVIAPDKPWFSYVCPGAGHAPHHVFKEWADRYAGRFDMGYER
TH_0315|M.thermoresistible__bu      TIEFIRDAKVIAPDKPWFTYLCPGAGHAPHHAPRDWADRYAGRFDMGYER
Mb3327c|M.bovis_AF2122/97           AIEWLHTVRAQNATKPWMLYYATGATHAPHHVFKEWADKYRGEFDDGWDV
MAV_2989|M.avium_104                TLLRYLDERAPDDDRPFFAYLPFQAPHWPLQAPDESIAKYRGRYDEGPDV
MSMEG_1228|M.smegmatis_MC2_155      --------------------KADGVHATDQQLTVKLKGEMDGEYDRRAKA
MAB_4469c|M.abscessus_ATCC_199      TVSLVN---------------PHDICWWPKNPLPEDVPHWFDGLPVNFQT
                                                                      .               

MUL_0227|M.ulcerans_Agy99           FIKRQAAADTPFFVWMNMTHMHLR-----------------------THT
MMAR_4410|M.marinum_M               FIKRQAAADTPFFVWMNMTHMHLR-----------------------THT
Mvan_4629|M.vanbaalenii_PYR-1       FIKRQHEADTPFFVWFNSTHMHFR-----------------------THP
Mflv_5039|M.gilvum_PYR-GCK          YREIVLENQKRLGLVPPDTELSAVNPYLDVKGPDGQDWPAQDTVRPWDSL
Rv0711|M.tuberculosis_H37Rv         YREIVLERQKALGIVPPDTELSPINPYLDVPGPNGETWPLQDTVRPWDSL
TH_0315|M.thermoresistible__bu      YREVVLENQKKLGIVPPDTELPPINPYQDVKGPHGEPWPLQDTVRPWDSL
Mb3327c|M.bovis_AF2122/97           YRQKTFERQKRLGIIPPDAELTER----------------PDLFPAWDSM
MAV_2989|M.avium_104                LRAERLAALKRLGLCPPDVTPHPV---------------VADGAPEWADM
MSMEG_1228|M.smegmatis_MC2_155      FMKRSVEADKPFFLYHNHSLMHFP-------------------------M
MAB_4469c|M.abscessus_ATCC_199      PDELRQHGKPRLQIDYANFMSPIMTG-------------------AVTYS
                                               : :                                    

MUL_0227|M.ulcerans_Agy99           KPESVGQAGVWQSPYHDTMIDHDRNVGQLLDALDELGIAQDTIVIYST-D
MMAR_4410|M.marinum_M               KPESVGQAGVWQSPYHDTMIDHDRNVGQLLDALDELGIAQDTIVIYST-D
Mvan_4629|M.vanbaalenii_PYR-1       KPESIGRSGRWQSEYHDTMLDHDDIVGDLLNTLDELGIADGTIVMYST-D
Mflv_5039|M.gilvum_PYR-GCK          SEDEKRLFARMAEVFAGFLSYTDAQIGRVLDYLEESGQLDNTVIVVIS-D
Rv0711|M.tuberculosis_H37Rv         SDEEKKLFCRMAEVFAGFLSYTDAQIGRILDYLEESGQLDNTIIVVIS-D
TH_0315|M.thermoresistible__bu      SDAEKRLFCRMAEVFAGFLSYTDHQIGRVLDYLEESDQLDNTLIVVLS-D
Mb3327c|M.bovis_AF2122/97           SEAQKRLFARQMEVFAGFSENADWNVGRLLDAIEDLGESDNTLVFYIWGD
MAV_2989|M.avium_104                TDEERARSARTMEVYAGMVDRMDYNVGRVIDYLSRSGELDNTVVIFLS-D
MSMEG_1228|M.smegmatis_MC2_155      EVREEFKGKSTNGQWGDSLLMLDYDFGSILDYLAELGIEDNTIVIMAG-D
MAB_4469c|M.abscessus_ATCC_199      GPDMARQWARCLDMYLWLQQQVDAQIGRVLDKLASRPEIDGNTIVVFTSD
                                                  :       *  .* ::: :      :.. :.    *

MUL_0227|M.ulcerans_Agy99           NGPHAN--------------------------------------------
MMAR_4410|M.marinum_M               NGPHAN--------------------------------------------
Mvan_4629|M.vanbaalenii_PYR-1       NGPHMN--------------------------------------------
Mflv_5039|M.gilvum_PYR-GCK          NGASGEGGPNGSVNEVKFFNGYIDSAEESLKVFDELGGPQTYN------H
Rv0711|M.tuberculosis_H37Rv         NGASGEGGPNGSVNEGKFFNGYIDTVAESMKLFDHLGGPQTYN------H
TH_0315|M.thermoresistible__bu      NGASGEGGPDGSVNEVKFFNGYVDTVEESMRFYDQLGGPQTYN------H
Mb3327c|M.bovis_AF2122/97           NGASMEGTNTGSFNEMTFLNGLDLDAERQLELIEQYGGIAALGDEFTAPH
MAV_2989|M.avium_104                NGAEGAIVEAMPLRGPQIAAQIEKHCDNSLDNLGRPTSFIWYG-------
MSMEG_1228|M.smegmatis_MC2_155      NGAEDH--------------------------------------------
MAB_4469c|M.abscessus_ATCC_199      HGEYAG--------------------------------------------
                                    :*                                                

MUL_0227|M.ulcerans_Agy99           ---TWPDGATTPFRSEK-NTNWEGALRIPEMIRWPGKISAG---VVSNEI
MMAR_4410|M.marinum_M               ---TWPDGATTPFRSEK-NTNWEGAFRIPEMIRWPGKISAG---VVSNEI
Mvan_4629|M.vanbaalenii_PYR-1       ---SWPDAGMTPFRNEK-NSNWEGAYRVPAVVRWPGRIPAG---TVLNGI
Mflv_5039|M.gilvum_PYR-GCK          YPIGWAMAFNTPYKLFKRYASHEGGIADTAIISWPKGIAAHG--EIRDNY
Rv0711|M.tuberculosis_H37Rv         YPIGWAMAFNTPYKLFKRYASHEGGIADPAIISWPNGIAAHG--EIRDNY
TH_0315|M.thermoresistible__bu      YPTGWAMAFNTPYKLFKRYASHEGGIADPAIISWPNGITARD--AVCDRY
Mb3327c|M.bovis_AF2122/97           FASAWAHASNTPLQWGKQMASHLGGTRDPLVVAWPARIRPDG--RVRSQF
MAV_2989|M.avium_104                --PRWAQAATAPSRLHKAFTTQGG-IRVPGFITWPG-FARQG--QIGTAF
MSMEG_1228|M.smegmatis_MC2_155      ----LAGRGTAGFFDGSYFSSAEGGIRTPCLIRWPGKVVPR----ESNEM
MAB_4469c|M.abscessus_ATCC_199      ----------SHGLRGKGATAYEEAIRVPLYIRDPQGVLTPKPGETRTQL
                                              :     .  :        .  :  *  .            

MUL_0227|M.ulcerans_Agy99           IQHHDRLPTFLAAAGEPDIIEKLKKGHKISVRGDDKEFKVHLDAFNLLPY
MMAR_4410|M.marinum_M               IQHHDWLPTFLAAAGEPDIIEKLKKGHKISVRGDDKEFKVHLDAFNLLPY
Mvan_4629|M.vanbaalenii_PYR-1       VSHNDWFVTLLAAAGDPDIAERLRAGTDLNG----TTYKVHLDGHNQLDY
Mflv_5039|M.gilvum_PYR-GCK          VNVADITPTVYDLLDITPP-ATVRG-----------VAQKPLDGVSFKVA
Rv0711|M.tuberculosis_H37Rv         VNVSDITPTVYDLLGMTPP-GTVKG-----------IPQKPMDGVSFIAA
TH_0315|M.thermoresistible__bu      INVVDVTPTVYELIGLTPP-DTVRG-----------VRQRPLEGVSFRAA
Mb3327c|M.bovis_AF2122/97           THCIDIAPTVLAAIGLPEP-THVDG-----------FEQEPMDGTSFVRT
MAV_2989|M.avium_104                STVMDIAPTLLELAGTSHPGTAYRG-----------REVAPMRGRSLVGY
MSMEG_1228|M.smegmatis_MC2_155      VHVTDMFPTLLRWVGCDIP------------------DDRIIDGIDQREF
MAB_4469c|M.abscessus_ATCC_199      TSSVDLAPLLLTIGSGGNAWRSDPRFSYLAAR--ADIAAIAKNNAAGRKW
                                        *    .    .                                   

MUL_0227|M.ulcerans_Agy99           LTGEVEESPRQGFIYFSDDCDVLGIRFHNWKIVFQEQRCQG---------
MMAR_4410|M.marinum_M               LTGEVEESPRQGFIYFSDDCDVLGIRFHNWKIVFQEQRCQG---------
Mvan_4629|M.vanbaalenii_PYR-1       LTGATDESPRQYFFYVSDDGDLTALRYDNWKIVFLEQRAAG---------
Mflv_5039|M.gilvum_PYR-GCK          LE--NPNAPTGKETQFYTMLGTRGIWHRGWFANTVHAASPAGWS------
Rv0711|M.tuberculosis_H37Rv         LA--DPAADTGKTTQFYTMLGTRGIWHEGWFANTIHAATPAGWS------
TH_0315|M.thermoresistible__bu      LA--DPDADTGKRTQFYSMLGTRGIWSDGWFANTVHAASPAGWS------
Mb3327c|M.bovis_AF2122/97           FD--DAEAEDRHTVQYFENFGSRAIYKDGWWACARLDKAPWDLSPETMRR
MAV_2989|M.avium_104                LSGAADTVHDADTETGWELFGRRAIRQGNWKALHLPAP------------
MSMEG_1228|M.smegmatis_MC2_155      FSG--AEESNRDGCMVWLNEELHAVKWSQFKINFKRQQ------------
MAB_4469c|M.abscessus_ATCC_199      IAHVTDDMSVEEMATLLKDPRIRAVMGENAPTEIPTSAASHIVAVR----
                                    :                      .:                         

MUL_0227|M.ulcerans_Agy99           --------TLQVWAEPFIPLRVPKIFNLRTDPYERADITSNTYYDWFLDH
MMAR_4410|M.marinum_M               --------TLQVWAEPFVPLRVPKIFNLRTDPFERADITSNTYYDWFLDH
Mvan_4629|M.vanbaalenii_PYR-1       --------TLQVWLEPYTELRAPKLFNLRTDPYERADITSNTYFDWVLDR
Mflv_5039|M.gilvum_PYR-GCK          ------HFDDDRWELYHVDADRSQVHDLAAEYPEKLDELKALWFSEAQKY
Rv0711|M.tuberculosis_H37Rv         ------NFNADRWELFHIAADRSQCHDLAAEHPDKLEELKALWFSEAAKY
TH_0315|M.thermoresistible__bu      ------NFDADRWELYHLESDRSQSRDLAAEHPEKLEELKQLWFDEAAKY
Mb3327c|M.bovis_AF2122/97           FAPGTYDPDQDVWELYYLPDDFSQAKNLAAEHPDKVAELTQLWWQEAERN
MAV_2989|M.avium_104                -------YGPGSWQLYDLASDPGEVDDLAAARPDKLAELLALWDRYVEET
MSMEG_1228|M.smegmatis_MC2_155      -----------HFHDPEVPLGFARITNLLEDPKEREPVNQTWVRWWVMQH
MAB_4469c|M.abscessus_ATCC_199      -TAEAKLANYSYWKPGGMRIDTSRPSEHEFYDYSTPSGKQESQNQAGDST
                                                :          .  :      .                

MUL_0227|M.ulcerans_Agy99           DFIAFYGTAICTQFLETFKEFPPRHPPARFTIDQAVEKLQAIVKD-----
MMAR_4410|M.marinum_M               DFIAFYGTAICTQFLETFKEFPPRHPPASFTIDQAVEKLQAIVKD-----
Mvan_4629|M.vanbaalenii_PYR-1       VFVFTPAQAFVAQMLQTLVEFPQRQASASFNLEQVMAKLQAGIPDS----
Mflv_5039|M.gilvum_PYR-GCK          NGLPLGDLDIFETMSRWRPTLSGERSAYVYYPGTADVGIGAVVELRGRSF
Rv0711|M.tuberculosis_H37Rv         NGLPLADLNLLETMTRSRPYLVSERASYVYYPDCADVGIGAAVEIRGRSF
TH_0315|M.thermoresistible__bu      NGLPLGDLNLFETLGRWRPHLSRGRTSYTYYPGTAEVGLGAAVDIRGQSF
Mb3327c|M.bovis_AF2122/97           RVLPL--LGGLAVMFGDLPPLP-TTARFSFKGDVQNIQRGMVPRICGRSY
MAV_2989|M.avium_104                G-VILDPISVFDAEL-----------------------------------
MSMEG_1228|M.smegmatis_MC2_155      AYRFIQEFEASVEKEQLIPAGAPLDFVPARNP------------------
MAB_4469c|M.abscessus_ATCC_199      KQAQLQALIDNEVLPEVQAPLPAFLGQAQEQGLADMQKLMVLRGG-----
                                                                                      

MUL_0227|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4410|M.marinum_M               --------------------------------------------------
Mvan_4629|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_5039|M.gilvum_PYR-GCK          AVLAEVEVDPGGANGVVVKHGGAHGGYVMYLQGGR-LHFCYNFLGEYEQT
Rv0711|M.tuberculosis_H37Rv         AVLADVTIDTTGAEGVLFKHGGAHGGHVLFVRDGR-LHYVYNFLGERQQL
TH_0315|M.thermoresistible__bu      TVLADVTVDAAGAQGVIVKHGAGHGGYVLFLQDGR-LHFVYNFMGEEEQR
Mb3327c|M.bovis_AF2122/97           AIEARLHIPDGGAQGVIVANADFMGGFALWVDEQRHLHHTYSFLGVETYR
MAV_2989|M.avium_104                --------------------------------------------------
MSMEG_1228|M.smegmatis_MC2_155      --------------------------------------------------
MAB_4469c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MUL_0227|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4410|M.marinum_M               --------------------------------------------------
Mvan_4629|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_5039|M.gilvum_PYR-GCK          LAAPDPVPPGLHTLGFTYTVTGTAEGSHTPIGDAELFLDTERVASLAEMR
Rv0711|M.tuberculosis_H37Rv         VSSSGPVPSGRHLLGVRYLRTGTVPNSHTPVGDLELFFDENLVGALTNVL
TH_0315|M.thermoresistible__bu      VSSADPIPAGRHILGVSYHRTGTVDGSHTPLGEVALYVDGTVVATRPDVR
Mb3327c|M.bovis_AF2122/97           QVSSEPLPTGDVTVRMLFDSHQPVAASG---GRVTLWADDRLIGEGELPQ
MAV_2989|M.avium_104                --------------------------------------------------
MSMEG_1228|M.smegmatis_MC2_155      --------------------------------------------------
MAB_4469c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MUL_0227|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4410|M.marinum_M               --------------------------------------------------
Mvan_4629|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_5039|M.gilvum_PYR-GCK          SQPGTFGLAGASLSVGRNNGSPVSEAYH--PPFAFAGGRIARVNIDTS--
Rv0711|M.tuberculosis_H37Rv         THPGTFGLAGAAISVGRNGGSAVSSHYE--APFAFTGGTITQVTVDVS--
TH_0315|M.thermoresistible__bu      AHPANFGLAGGGIAVGRNTGQPVSSAYR--APFAFTGGSIAKVIVDIS--
Mb3327c|M.bovis_AF2122/97           TVPLAF-TSYAGMDIGRDNGLVVDRGYEDKAPYAFTG-TVTEVIFDLKPV
MAV_2989|M.avium_104                --------------------------------------------------
MSMEG_1228|M.smegmatis_MC2_155      --------------------------------------------------
MAB_4469c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MUL_0227|M.ulcerans_Agy99           -----------------------
MMAR_4410|M.marinum_M               -----------------------
Mvan_4629|M.vanbaalenii_PYR-1       -----------------------
Mflv_5039|M.gilvum_PYR-GCK          --GAPYVDLERDFARAFARD---
Rv0711|M.tuberculosis_H37Rv         --GRPFEDVESDLALAFSRD---
TH_0315|M.thermoresistible__bu      --GTPYRDVEREAAMAFARD---
Mb3327c|M.bovis_AF2122/97           HPEAARALHEHASVQAVGQGAAG
MAV_2989|M.avium_104                -----------------------
MSMEG_1228|M.smegmatis_MC2_155      -----------------------
MAB_4469c|M.abscessus_ATCC_199      -----------------------