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M. ulcerans Agy99 MUL_0454 (atsD)

annotation: arylsulfatase AtsD
coordinates: 465476 - 467974
length: 832

MGAWQGSEAAAARVSEAVKPIDKEVMMAKAAKKTPAKKSSTGAASDAHREPHLAREHLPIPDPKHVGLTT
YDAKDPNTKYPPIKQLCPSQGAPNVLIVLIDDVGFGASSAFGGPCRTPVAERLAAGGLQLNRFHTTALCS
PTRQALLTGRGRNHHSVGMGAITEMATSAPGNNSIRPKEKAPLAETLKLNGYSTAQFGKCHEVSGWEVTP
MGPFHQWPTGSGFEYFYGFVGGEANQYYPGLYEGTTAVEPPKTPEQGYTLTEDLADRAITWVRQQKALMP
DKPFFMYFAPGATHAPHHVPKVWSDKYRGKFDDGWDALREKTLNRQKELGVVSDGAELTKRHDEIPAWDD
MPDEPKPVLARQMEIYAGFLEQTDHEVGRLVGAIDDLGVLDDTLIYYIIGDNGASAEGTINGCFNEMTTL
NGLPGIETTEFLLSKTDDFGTPDAYNHYAVGWAHALCAPYQWTKQVASHWGGTRNGTVVHWPNGLTEQGG
MRDQFHPVIDVAPTILEAAGLPAPHSVNGIAQAPLEGVSMMSTLRDAAAPETHEVQYFEMMGNRGIYFQG
WTAVTKHRTPWKADAPPPFDDDVWELYAPGDWTQAHNLATQNPAKLAELQRLWLIEATKYNVVPLDDRGF
ERINPDIAGRPQLVRGNSQLLFDGMRVSEWCVLTIKNKSHSVTAEVEVPTGGASGLLITQGGSAGGWTLY
AHEGRLKYCYNFLGIDHYMVAATKPIPTGKHQVRMEFGYDGGGLGRGGDVTLFYDGKAVGQGRVERTQPM
AFSADEACDVGCDTGSPASPDYGPTGNAFSGTIAWVQIDLGADSHDHLITAEDRFNITMAKQ
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_0454atsD-100% (832)arylsulfatase AtsD
M. ulcerans Agy99MUL_2500atsD_10.053.20% (718) arylsulfatase AtsD_1
M. ulcerans Agy99MUL_2658atsBe-17142.27% (809) arylsulfatase AtsB (aryl-sulfate sulphohydrolase)

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0682atsD0.065.99% (785) arylsulfatase AtsD
M. gilvum PYR-GCKMflv_5039-1e-15340.05% (774) sulfatase
M. tuberculosis H37RvRv0663atsD0.065.86% (785) arylsulfatase AtsD
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4307-1e-14739.11% (767) arylsulfatase AtsA
M. marinum MMMAR_4950atsD0.097.89% (806) arylsulfatase AtsD
M. avium 104MAV_4461-1e-15140.13% (770) arylsulfatase
M. smegmatis MC2 155MSMEG_1451-1e-14838.82% (778) arylsulfatase
M. thermoresistible (build 8)TH_0315-1e-14938.65% (771) arylsulfatase
M. vanbaalenii PYR-1Mvan_4467-0.078.53% (778) sulfatase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_5039|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1451|M.smegmatis_MC2_155      --------------------------------------------------
MAV_4461|M.avium_104                --------------------------------------------------
TH_0315|M.thermoresistible__bu      --------------------------------------------------
MAB_4307|M.abscessus_ATCC_1997      MHIPGDDAPEPEQNAERGRLTRRSMLGGIAAAGMGVAAASALVAGCDDDS
MUL_0454|M.ulcerans_Agy99           --MGAWQGSEAAAARVSEAVKPIDKEVMMAKAAKKTPAKKSSTGAASDAH
MMAR_4950|M.marinum_M               ----------------------------MAKAAK-TPAKKSSTGAASDAH
Mvan_4467|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb0682|M.bovis_AF2122/97            --------------------------------------------------
Rv0663|M.tuberculosis_H37Rv         --------------------------------------------------
                                                                                      

Mflv_5039|M.gilvum_PYR-GCK          ------------MTTEFNGKIALDIRDSEPDWGPFAAPTAQPEAPNVLYL
MSMEG_1451|M.smegmatis_MC2_155      ------------MAAEFNGKIELDIRDSEPDWGPFAAPTAAEGAPNVLYV
MAV_4461|M.avium_104                ------MVAGSGQSAEFSGRVELDIRDSEPDWGPYAAPTAPPNAPNILYL
TH_0315|M.thermoresistible__bu      -------------MADFGGKIELDIRDSEPDWGPFAAPTAPEGAPNILYV
MAB_4307|M.abscessus_ATCC_1997      SSRTDRSSAAEEANAGFNGKIELDVRDSKPDWTPYELKHAPDGAPNVLVV
MUL_0454|M.ulcerans_Agy99           REPHLAREHLPIPDPKHVGLTTYDAKDPNTKYPPIKQLCPSQGAPNVLIV
MMAR_4950|M.marinum_M               REPHLAREYLPIPDPKHVGLTTYDAKDPNTKYPPIKQLRPPQGAPNVLIV
Mvan_4467|M.vanbaalenii_PYR-1       ----MRRDILPIPDPQHVGLTTYDAKDPDTTYPPITPLRPPQGAPNVLIV
Mb0682|M.bovis_AF2122/97            --MPQPRTHLPIPSAARTGLITYDAKDPDSTYPPIEQLRPPAGAPNVLLI
Rv0663|M.tuberculosis_H37Rv         --MPQPRTHLPIPSAARTGLITYDAKDPDSTYPPIEQLRPPAGAPNVLLI
                                                  .   *    * :*... : *     .   ***:* :

Mflv_5039|M.gilvum_PYR-GCK          VWDDIGIATWDCFGGLVDMPAMSRIAERGVRLSQFHTTALCSPTRASLLT
MSMEG_1451|M.smegmatis_MC2_155      VWDDIGIATWDCFGGLVEMPAMSRIAEHGVRLSQFHTTALCSPTRAALLT
MAV_4461|M.avium_104                VWDDTGIATWDCFGGLVEMPAMSRIAERGVRLSQFHTTALCSPTRAALLT
TH_0315|M.thermoresistible__bu      VWDDVGIGTWDCFGGLVEMPTMSRIAEQGVRLSQFHTTALCSPTRAALLT
MAB_4307|M.abscessus_ATCC_1997      LFDDTGMATWSPYGGRVNMPTLQRLADNGLTYSQWHTTALCSPTRSCLLT
MUL_0454|M.ulcerans_Agy99           LIDDVGFGASSAFGGPCRTPVAERLAAGGLQLNRFHTTALCSPTRQALLT
MMAR_4950|M.marinum_M               LIDDVGFGASSAFGGPCRTPVAERLAAGGLKLNRFHTTALCSPTRQALLT
Mvan_4467|M.vanbaalenii_PYR-1       LLDDVGFGASSAFGGPCATPTAERLAANGLKLNRFHTTALCSPTRQALLT
Mb0682|M.bovis_AF2122/97            LLDDVGFGASSAFGGPCRTSTAELLAGNGLRYNRFHTTALCSPTRQALLT
Rv0663|M.tuberculosis_H37Rv         LLDDVGFGASSAFGGPCRTSTAELLAGNGLRYNRFHTTALCSPTRQALLT
                                    : ** *:.: . :**    .. . :*  *:  .::********** .***

Mflv_5039|M.gilvum_PYR-GCK          G--RNATTVGMATIEEFTDGFPNCNGRIPFDTALLSEVLSENGYNTYCIG
MSMEG_1451|M.smegmatis_MC2_155      G--RNPTTVGMATIEEFTDGFPNCSGRIPFETALLPEVLAENGYNTYCIG
MAV_4461|M.avium_104                G--RNATTVGMATIEEFTEGFPNANGRIPFDTALLSEALAEHGYNTYCVG
TH_0315|M.thermoresistible__bu      G--RNPTTVGMATIEEFTDGFPNCSGRIPVDTGLISEVLAEHGWNTYCVG
MAB_4307|M.abscessus_ATCC_1997      G--RNHHVNRFASITEGSDGYPGAAGRLPAQCATIGQVLQDNGYSTFWVG
MUL_0454|M.ulcerans_Agy99           GRGRNHHSVGMGAITEMATSAPGNNSIRPKEKAPLAETLKLNGYSTAQFG
MMAR_4950|M.marinum_M               G--RNHHSVGMGAITEMATSAPGNNSIRPKEKAPLAETLKLNGYSTAQFG
Mvan_4467|M.vanbaalenii_PYR-1       G--RNHHSVGMGGVTEIATSAPGYSSIRPKDKAPVAETLRLNGYSTSQFG
Mb0682|M.bovis_AF2122/97            G--RNHHSAGMGGITEIATGAPGYSSVLPNTMSPIARTLKLNGYNTAQFG
Rv0663|M.tuberculosis_H37Rv         G--RNHHSAGMGGITEIATGAPGYSSVLPNTMSPIARTLKLNGYNTAQFG
                                    *  **     :. : * : . *.  .  *   . : ..*  :*:.*  .*

Mflv_5039|M.gilvum_PYR-GCK          KWHLTPLEESNLAATKRHWPLSRG-FERFYGFMGGETDQWYPDLMYDNHP
MSMEG_1451|M.smegmatis_MC2_155      KWHLTPLEESNLASTKRHWPCSRG-FERFYGFMGGETDQWYPDLTYDNHP
MAV_4461|M.avium_104                KWHLTPLEESNMASTKRHWPTSRG-FERFYGFLGGETDQWYPDLVYDNHP
TH_0315|M.thermoresistible__bu      KWHLTPLEESNMAATKRHWPVSRG-FERFYGFLGGETDQWYPDLVHDNHP
MAB_4307|M.abscessus_ATCC_1997      KNHNVPQEDVSCGGSKSEWPLQKG-FDRYYGFLGGETNNWYPDLVEDNRF
MUL_0454|M.ulcerans_Agy99           KCHEVSGWEVTPMGPFHQWPTGSG-FEYFYGFVGGEANQYYPGLYEGTTA
MMAR_4950|M.marinum_M               KCHEVPGWEVTPMGPFHQWPTGSG-FEYFYGFVGGEANQYYPGLYEGTTA
Mvan_4467|M.vanbaalenii_PYR-1       KCHEVPVWEVSPVGPFGQWPTGSG-FEHFYGFIGGEANQYYPGLYEGTKP
Mb0682|M.bovis_AF2122/97            KCHEVPVWQTSPVGPFDAWPSGGGGFEYFYGFIGGEANQWYPSLYEGTTP
Rv0663|M.tuberculosis_H37Rv         KCHEVPVWQTSPVGPFDAWPSGGGGFEYFYGFIGGEANQWYPSLYEGTTP
                                    * * ..  : .  ..   **   * *: :***:***::::**.*  ..  

Mflv_5039|M.gilvum_PYR-GCK          VAPPATPEEGYHLSKDLADKTIEFIRDSKVIAPDKPWFSYVCPGAGHAPH
MSMEG_1451|M.smegmatis_MC2_155      VDPPATPEEGYHLSKDLADKTIEFIRDAKVVASDKPWFTYLCPGAGHAPH
MAV_4461|M.avium_104                VSPPATPEDGYHLSKDLADKTIEFIRDAKVIAPEKPWFSYVCPGAGHAPH
TH_0315|M.thermoresistible__bu      VAPPATPEDGYHLSKDLADKTIEFIRDAKVIAPDKPWFTYLCPGAGHAPH
MAB_4307|M.abscessus_ATCC_1997      IEQPTSPEQGYHLSKDLADQALRMLRDQRNTNPSKPWYMWFCPGANHAPH
MUL_0454|M.ulcerans_Agy99           VEPPKTPEQGYTLTEDLADRAITWVRQQKALMPDKPFFMYFAPGATHAPH
MMAR_4950|M.marinum_M               VEPPKTPEQGYTLTEDLADRAITWVRQQKALMPDKPFFMYFAPGATHAPH
Mvan_4467|M.vanbaalenii_PYR-1       VEPEKTPEQGYTLTEDLADRAITWVRQQQALTPDKPFFMYFAPGATHAPH
Mb0682|M.bovis_AF2122/97            VEVNRTPEEGYHFMADMTDKALGWIGQQKALAPDRPFFVYFAPGATHAPH
Rv0663|M.tuberculosis_H37Rv         VEVNRTPEEGYHFMADMTDKALGWIGQQKALAPDRPFFVYFAPGATHAPH
                                    :    :**:** :  *::*:::  : : :   ..:*:: :..*** ****

Mflv_5039|M.gilvum_PYR-GCK          HVFKEWADRYAGRFDMGYEAYREIVLENQKRLGLVPPDTELSAVNPYLDV
MSMEG_1451|M.smegmatis_MC2_155      HVFKEWADRYKGRFDMGYERYREIVLENQKRMGLVPPDTELSPVNPYSEV
MAV_4461|M.avium_104                HVFKEWADRYAGRFDMGYERYREVVLERQKAMGIVPSDTELSPVNPYLDV
TH_0315|M.thermoresistible__bu      HAPRDWADRYAGRFDMGYERYREVVLENQKKLGIVPPDTELPPINPYQDV
MAB_4307|M.abscessus_ATCC_1997      HSPAEYADKYRGKFDDGYEAYREWVLARMIDKGIMPRETKLTPINPLPND
MUL_0454|M.ulcerans_Agy99           HVPKVWSDKYRGKFDDGWDALREKTLNRQKELGVVSDGAELTKR------
MMAR_4950|M.marinum_M               HVPKVWSDKYRGKFDDGWDALREKTLNRQKELGVVSDDAELTKR------
Mvan_4467|M.vanbaalenii_PYR-1       HVPKQWSDKYRGKFDDGWDVLRESMLDNQKALGVVPEDAQLTAR------
Mb0682|M.bovis_AF2122/97            HVPREWADKYRGRFDVGWDALREETFARQKELGVIPADCQLTAR------
Rv0663|M.tuberculosis_H37Rv         HVPREWADKYRGRFDVGWDALREETFARQKELGVIPADCQLTAR------
                                    *    ::*:* *:** *::  **  : .    *::.   :*.        

Mflv_5039|M.gilvum_PYR-GCK          KGPDGQDWPAQDTVRPWDSLSEDEKRLFARMAEVFAGFLSYTDAQIGRVL
MSMEG_1451|M.smegmatis_MC2_155      TGPDGQPWPAQDTVRPWDSLSDDEKALFCRMAEVFAGFLSYTDAQIGRVL
MAV_4461|M.avium_104                TGPSGEPWPLQDTVRPWDSLNDEEKKLFARMAEVFAGFLSYTDAQIGRIL
TH_0315|M.thermoresistible__bu      KGPHGEPWPLQDTVRPWDSLSDAEKRLFCRMAEVFAGFLSYTDHQIGRVL
MAB_4307|M.abscessus_ATCC_1997      VAVEA------DSVRPWNTLNPDEKRLFSRMAEVFAGFSEYTDAQVGRVI
MUL_0454|M.ulcerans_Agy99           ----------HDEIPAWDDMPDEPKPVLARQMEIYAGFLEQTDHEVGRLV
MMAR_4950|M.marinum_M               ----------HDEIPAWDDMPDELKPVLARQMEIYAGFLEQTDHEVGRLV
Mvan_4467|M.vanbaalenii_PYR-1       ----------HDEIPAWDDMPDVLKPVLARQMEIYAGFLEQTDHEIGRLV
Mb0682|M.bovis_AF2122/97            ----------HAEIPAWDDMPEDLKPVLCRQMEVYAGFLEYTDHHVGRLV
Rv0663|M.tuberculosis_H37Rv         ----------HAEIPAWDDMPEDLKPVLCRQMEVYAGFLEYTDHHVGRLV
                                                 : .*: :    * ::.*  *::*** . ** .:**::

Mflv_5039|M.gilvum_PYR-GCK          DYLEESGQLDNTVIVVIS-DNGASGEGGPNGSVNEVKFFNGY--IDSAEE
MSMEG_1451|M.smegmatis_MC2_155      DYLEESGQIDNTIIVVIS-DNGASGEGGPNGSVNETKFFNGY--IDTAEE
MAV_4461|M.avium_104                DYLEESGQLDDTIIVVIS-DNGASGEGGPNGSVNEGKFFNGY--IDTVEE
TH_0315|M.thermoresistible__bu      DYLEESDQLDNTLIVVLS-DNGASGEGGPDGSVNEVKFFNGY--VDTVEE
MAB_4307|M.abscessus_ATCC_1997      DYLEQTGQLDNTVVFYCA-DNGASGEGSPNGSVNENKFFNGY--PDDLAE
MUL_0454|M.ulcerans_Agy99           GAIDDLGVLDDTLIYYIIGDNGASAEGTINGCFNEMTTLNGLPGIETTEF
MMAR_4950|M.marinum_M               DAIDDLGVLDDTLIYYIIGDNGASAEGTINGCFNEMTTLNGLPGIETTEF
Mvan_4467|M.vanbaalenii_PYR-1       DAIDDLGALDNTLIYYIIGDNGASAEGTPNGCFNEMCTLNGLAGIETPEF
Mb0682|M.bovis_AF2122/97            DGLQRLGVLDDTLVFYIIGDNGASAEGTINGTYNEMLNFNGLADIETPRF
Rv0663|M.tuberculosis_H37Rv         DGLQRLGVLDDTLVFYIIDDNGASAEGTINGTYNEMLNFNGLADIETPRF
                                    . ::  . :*:*::     *****.**  :*  **   :**    :    

Mflv_5039|M.gilvum_PYR-GCK          SLKVFDELGGPQTYNHYPIGWAMAFNTPYKLFKRYASHEGGIADTAIISW
MSMEG_1451|M.smegmatis_MC2_155      GLKFIDKLGGPQTYNHYPIGWAMAFNTPYKLFKRYASHEGGIADPAIISW
MAV_4461|M.avium_104                SMKLFDQLGGPQTYNHYPIGWAMAFNTPYKLYKRYASHEGGIADTAIISW
TH_0315|M.thermoresistible__bu      SMRFYDQLGGPQTYNHYPTGWAMAFNTPYKLFKRYASHEGGIADPAIISW
MAB_4307|M.abscessus_ATCC_1997      NMKYIDRLGTPDTYNHYPTGWAVAFSTPFQMFKRYSQFSGGTCDPLVIHW
MUL_0454|M.ulcerans_Agy99           LLSKTDDFGTPDAYNHYAVGWAHALCAPYQWTKQVASHWGGTRNGTVVHW
MMAR_4950|M.marinum_M               LLSKTDDFGTPDAYNHYAVGWAHALCAPYQWTKQVASHWGGTRNGTVVHW
Mvan_4467|M.vanbaalenii_PYR-1       LLSKIDDFGTPDAYNHYAVGWAHALCGPYQWTKQVASHWGGTRNGTIVHW
Mb0682|M.bovis_AF2122/97            MTDRLDKFGGPESYNHYSVGWAHAMDTPYQWTKQVASHWGGTRNGTIVHW
Rv0663|M.tuberculosis_H37Rv         MTDRLDKFGGPESYNHYSVGWAHAMDTPYQWTKQVASHWGGTRNGTIVHW
                                         * :* *::****. *** *:  *::  *: :.. **  :  :: *

Mflv_5039|M.gilvum_PYR-GCK          PKGIAAHGEIRDNYVNVADITPTVYDLLDITPPATVRGVAQKPLDGVSFK
MSMEG_1451|M.smegmatis_MC2_155      PKGIAARGEVRDNYVNVCDVTPTVYDMLGITPPATVRGVPQKPLDGVSFK
MAV_4461|M.avium_104                PNGIAAHGEIRDNYVNVCDITPTVYDLLGMSPPETVKGIAQKPLDGVSFK
TH_0315|M.thermoresistible__bu      PNGITARDAVCDRYINVVDVTPTVYELIGLTPPDTVRGVRQRPLEGVSFR
MAB_4307|M.abscessus_ATCC_1997      PKGIKAKGEVRHQYHHVTDIVPTILDVAGLTMPETYRGVDQFPVNGVSMR
MUL_0454|M.ulcerans_Agy99           PNGLTEQGGMRDQFHPVIDVAPTILEAAGLPAPHSVNGIAQAPLEGVSMM
MMAR_4950|M.marinum_M               PNGLTEQGGMRDQFHHVIDVAPTILEAAGLPAPHSVNGISQAPLEGVSMM
Mvan_4467|M.vanbaalenii_PYR-1       PNGIAAKGETRNQFHHVIDVVPTILEAAKLPAPTVVNSIQQAPLEGVSMM
Mb0682|M.bovis_AF2122/97            PNGIAAKGEMRWQFHHVIDVAPTILEAAGLPEPLFVNGVQQHPIEGVSMA
Rv0663|M.tuberculosis_H37Rv         PNGIAAKGEMRWQFHHVIDVAPTILEAAGLPEPLFVNGVQQHPIEGVSMA
                                    *:*:  :.    .:  * *:.**: :   :. *   ..: * *::***: 

Mflv_5039|M.gilvum_PYR-GCK          VALENPNAPTGKETQFYTMLGTRGIWHRGWFANTVHAASPAGWS----HF
MSMEG_1451|M.smegmatis_MC2_155      AALADPDAPTGKETQFYAMLGTRGIWHKGWFANTVHAATPSGWG----HF
MAV_4461|M.avium_104                AALDDPNADTGKTTQFYTMLGTRGIWHEGWFANTVHAATPAGWS----HF
TH_0315|M.thermoresistible__bu      AALADPDADTGKRTQFYSMLGTRGIWSDGWFANTVHAASPAGWS----NF
MAB_4307|M.abscessus_ATCC_1997      YTFDDKDAATTKKRQYYAMLGTRGIWEDGWKASALHAP-ISGKG----HF
MUL_0454|M.ulcerans_Agy99           STLRDAAAPETHEVQYFEMMGNRGIYFQGWTAVTKHRTPWKAD--APPPF
MMAR_4950|M.marinum_M               STLRDAAAPETHEVQYFEMMGNRGIYFQGWTAVTKHRTPWKAD--APPPF
Mvan_4467|M.vanbaalenii_PYR-1       STLRDRDADETHTVQYFEMFGNRGIYHKGWTAVTKHRTPWIAD--QPP-L
Mb0682|M.bovis_AF2122/97            YSFDDAQAPDRHETQYFEMFGNRGIYHKGWTAVTKHKTPWILVGEQTVAF
Rv0663|M.tuberculosis_H37Rv         YSFDDAQAPDRHETQYFEMFGNRGIYHKGWTAVTKHKTPWILVGEQTVAF
                                     :: :  *   :  *:: *:*.***:  ** * : * .           :

Mflv_5039|M.gilvum_PYR-GCK          DDDRWELYHVDADRSQVHDLAAEYPEKLDELKALWFSEAQKYNGLPLGD-
MSMEG_1451|M.smegmatis_MC2_155      ADDRWELFHIDADRSQCHDLAAEHPDRLEELKALWFSEADKYNGLPLGD-
MAV_4461|M.avium_104                DADRWELFHIEADRSQCHDLAAENPDKLEELKALWFAEAARYNGLPLSD-
TH_0315|M.thermoresistible__bu      DADRWELYHLESDRSQSRDLAAEHPEKLEELKQLWFDEAAKYNGLPLGD-
MAB_4307|M.abscessus_ATCC_1997      DQDKWELFHVDEDRSESTDLADQHPDKLKALIDAWFEEADNNFVLPLDD-
MUL_0454|M.ulcerans_Agy99           DDDVWELYAP-GDWTQAHNLATQNPAKLAELQRLWLIEATKYNVVPLDDR
MMAR_4950|M.marinum_M               DDDVWELYAP-GDWTQAHNLATQNPAKLAELQRLWLIEATKYNVVPLDDR
Mvan_4467|M.vanbaalenii_PYR-1       DEDVWELYAP-DDWTQAHDLAAEQPERLAALQRLWLIEAVKYNVVPLDDR
Mb0682|M.bovis_AF2122/97            DDDVWELYDTTKDWSQAKDLAKEMPEKLHELQRLWLIEATRYNVLPLDDD
Rv0663|M.tuberculosis_H37Rv         DDDVWELYDTTKDWSQAKDLAKEMPEKLHELQRLWLIEATRYNVLPLDDD
                                      * ***:    * ::  :** : * :*  *   *: ** .   :**.* 

Mflv_5039|M.gilvum_PYR-GCK          -LDIFETMSRWRPTLSGERSAYVYYPGTADVGIGAVVELRGRSFAVLAEV
MSMEG_1451|M.smegmatis_MC2_155      -LSILETTTRWRPYLTGERTSYTYYPHTAEVGMGAVVELRGQSFKVLAEV
MAV_4461|M.avium_104                -LNILETMTRSRPYLVGERDSYVYYPDCADVGIGAAAEIRGRSFSVLAEA
TH_0315|M.thermoresistible__bu      -LNLFETLGRWRPHLSRGRTSYTYYPGTAEVGLGAAVDIRGQSFTVLADV
MAB_4307|M.abscessus_ATCC_1997      -RLPTELLTIERPQFEPRRNRYLYYPDASPVPEGVAVNIRGKSYKIVANT
MUL_0454|M.ulcerans_Agy99           GFERINPDIAGRPQLVRG-NSQLLFDGM-RVSEWCVLTIKNKSHSVTAEV
MMAR_4950|M.marinum_M               GFERINPDIAGRPQLVRG-NSQLLFDGM-RVSEWCVLTIKNKSHSVTAEV
Mvan_4467|M.vanbaalenii_PYR-1       SFERFNPDIAGRPQLIKG-TTQTLFSGM-RLLENCVLNIKNRSHAVSALI
Mb0682|M.bovis_AF2122/97            TASRINPDLAGRPVLIRG-NTQVLFSNMGRLSENCVLNLKNKSHTVTAEV
Rv0663|M.tuberculosis_H37Rv         TASRINPDLAGRPVLIRG-NTQVLFSNMGRLSENCVLNLKNKSHTVTAEV
                                         :     ** :         :     :    .  ::.:*. : *  

Mflv_5039|M.gilvum_PYR-GCK          EVDPGGANGVVVKHGGAHGGYVMYLQGGRLHFCYNFLGEYEQTLAAPDPV
MSMEG_1451|M.smegmatis_MC2_155      TVDSAEAQGVIFKHGGAHGGHVLFIADGHLHYVYNFLGEREQVLSAPDPV
MAV_4461|M.avium_104                TVDTTGAEGVLFKQGGAHGGHVLFIQDGRLHYVYNFLGERQQEVSSSVPV
TH_0315|M.thermoresistible__bu      TVDAAGAQGVIVKHGAGHGGYVLFLQDGRLHFVYNFMGEEEQRVSSADPI
MAB_4307|M.abscessus_ATCC_1997      DIS-AQAQGVIFAHGSRFGGHVLFIKDGRLHYVYNFLGIKPEQEFISAPL
MUL_0454|M.ulcerans_Agy99           EVPTGGASGLLITQGGSAGGWTLYAHEGRLKYCYNFLGIDHYMVAATKPI
MMAR_4950|M.marinum_M               EVPTGGASGVLITQGGSAGGWTLYAHQGRLKYCYNFLGIDHYMVAATKPI
Mvan_4467|M.vanbaalenii_PYR-1       SVPDSGAQGVIVSQGGGVGGWCVYAHENTLKYCYNFFGIEYYFVTAELPL
Mb0682|M.bovis_AF2122/97            EVPETGAEGVIVAQGASIGGWSLYANDGKLKYCYNLGGIKHFYAESADPL
Rv0663|M.tuberculosis_H37Rv         EVPETGAEGVIVAQGASIGGWSLYANDGKLKYCYNLGGIKHFYAESADPL
                                     :    *.*::. :*.  **  ::   . *:: **: *          *:

Mflv_5039|M.gilvum_PYR-GCK          PPGLHTLGFTYTVTGTAEGSHTPIGDAELFLDTERVASLAEMRSQPGTFG
MSMEG_1451|M.smegmatis_MC2_155      PLGHHIFGVRYERTGTVPNSHTPVGVATLFVDGGAVADLADVQTHPAIFA
MAV_4461|M.avium_104                PLGRHLFGASYARTGTVPDSHTPLGDLTLFIDDEVVGTLAGVSTHPGTFG
TH_0315|M.thermoresistible__bu      PAGRHILGVSYHRTGTVDGSHTPLGEVALYVDGTVVATRPDVRAHPANFG
MAB_4307|M.abscessus_ATCC_1997      TPGNRTLGVEFVRRDKGQYGES-LGTTNLYVDGKLAATGP-MRTQVGTFT
MUL_0454|M.ulcerans_Agy99           PTGKHQVRMEFGYDG---GGLGRGGDVTLFYDGKAVGQGRVERTQPMAFS
MMAR_4950|M.marinum_M               PTGKHQVRMEFGYDG---GGLGRGGDVTLFYDGKAVGQGRVERTQPMAFS
Mvan_4467|M.vanbaalenii_PYR-1       PGGQHLVGFEFAYDG---GGLGKGGTVTLYCDGEPVGTGRVERTEPMAFS
Mb0682|M.bovis_AF2122/97            PAGAHQVRMEFAYAG---GGLGKGGEVTLYVDGQQVGEGHVEATLAIVFS
Rv0663|M.tuberculosis_H37Rv         PAGAHQVRMEFAYAG---GGLGKGGEVTLYVDGQQVGEGHVEATLAIVFS
                                    . * : .   :   .    .    *   *: *   ..      :    * 

Mflv_5039|M.gilvum_PYR-GCK          LAGASLSVGRNNGSPVSEAYHPPFAFAGGRIARVNIDTS-----GAPYVD
MSMEG_1451|M.smegmatis_MC2_155      LAGGGIAVGRNTGSGVSRSYRVPFPFTGGEIAQVTVDLS-----GEPYED
MAV_4461|M.avium_104                LAGAGITVGRNGGSGVSSRFKAPFVFTGGTIARVTLDLS-----GRPYRD
TH_0315|M.thermoresistible__bu      LAGGGIAVGRNTGQPVSSAYRAPFAFTGGSIAKVIVDIS-----GTPYRD
MAB_4307|M.abscessus_ATCC_1997      LAGDGLCVGYDSGDNVSPQYTNPGRFTGGTIKVVAVDVS-----DESFID
MUL_0454|M.ulcerans_Agy99           -ADEACDVGCDTGSPASPDYGPTGNAFSGTIAWVQIDLG--ADSHDHLIT
MMAR_4950|M.marinum_M               -ADEACDVGCDTGSPASPDYGPTANAFSGTIAWVQIDLG--ADSHDHLIT
Mvan_4467|M.vanbaalenii_PYR-1       -ADEACDVGSDTGSPTSPDYGPHGNGFNGRIDWVKIDIS--TDDHEHLIT
Mb0682|M.bovis_AF2122/97            -ADDGCDVGMDSGSPVSPDYAPGSNAFNGRIKGVQLAIAEAAAAAGHLVD
Rv0663|M.tuberculosis_H37Rv         -ADDGCDVGMDSGSPVSPDYAPGSNAFNGRIKGVQLAIAEAAAAAGHLVD
                                     *. .  ** : *. .*  :       .* *  * :  .           

Mflv_5039|M.gilvum_PYR-GCK          LERDFARAFARD
MSMEG_1451|M.smegmatis_MC2_155      LVTRRATAFARD
MAV_4461|M.avium_104                VETEIALAFSRD
TH_0315|M.thermoresistible__bu      VEREAAMAFARD
MAB_4307|M.abscessus_ATCC_1997      LEKEAQAAFARD
MUL_0454|M.ulcerans_Agy99           AEDRFNITMAKQ
MMAR_4950|M.marinum_M               AEDRFNIAMAKQ
Mvan_4467|M.vanbaalenii_PYR-1       PQDRFNISMARQ
Mb0682|M.bovis_AF2122/97            PEHAIRIALARQ
Rv0663|M.tuberculosis_H37Rv         PEHAIRIALARQ
                                           :::::