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MIITGVDVHVVNLPLTSPFRSSFETKTGETRTVVRVTTDDGHVGWGETMWGSPVARLTEQLSSSLIGKSP FALEEFHATHTMVPFFYGYIGYAALAGLDVACWDLMGKITGRPLTDLIGGRVRDTVPITALITRADAPDA PPADLPVALAEHAAKVVAIGGFTAVKLKGTKDVDGDVKIMRALRAVLPDVELRVDPNAAWSVPESIRAGL RMEELDLEYLEDPCWGIDGMARVREKIRIPLCTNMCVVAFEDFAPAMRLGAVDVIHGDVYKWGGIKATKD LAAHCSTFGLGMNLHSGGELGIATAAHLAVVASTPVLNRAIDSMYYLHDDDIIDPIPLHNGRLSVPDGPG LGVVVDEDKLAHYAALNAREGDLVK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6871 | - | - | 100% (375) | isomerase |
| M. smegmatis MC2 155 | MSMEG_6132 | - | 1e-55 | 37.18% (355) | glucarate dehydratase |
| M. smegmatis MC2 155 | MSMEG_6177 | - | 3e-32 | 29.86% (355) | galactonate dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0568 | menC | 6e-14 | 28.07% (228) | O-succinylbenzoate synthase |
| M. gilvum PYR-GCK | Mflv_1357 | - | 9e-26 | 28.87% (381) | mandelate racemase/muconate lactonizing protein |
| M. tuberculosis H37Rv | Rv0553 | menC | 6e-14 | 28.07% (228) | O-succinylbenzoate synthase |
| M. leprae Br4923 | MLBr_02268 | - | 2e-09 | 26.63% (199) | O-succinylbenzoate synthase |
| M. abscessus ATCC 19977 | MAB_3935c | - | 6e-10 | 25.88% (228) | O-succinylbenzoate synthase |
| M. marinum M | MMAR_0899 | menC | 9e-17 | 29.85% (268) | muconate cycloisomerase, MenC |
| M. avium 104 | MAV_4590 | - | 5e-12 | 29.27% (205) | O-succinylbenzoate synthase |
| M. thermoresistible (build 8) | TH_0152 | menC | 7e-13 | 26.94% (245) | PROBABLE MUCONATE CYCLOISOMERASE MENC (CIS,CIS-MUCONATE |
| M. ulcerans Agy99 | MUL_0652 | menC | 2e-16 | 30.69% (202) | O-succinylbenzoate synthase |
| M. vanbaalenii PYR-1 | Mvan_1029 | - | 7e-53 | 36.36% (352) | mandelate racemase/muconate lactonizing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0899|M.marinum_M -----MIPGPATLPDLLDRLHVVALPMRVRFRGITTREVALIEGPSGWGE
MUL_0652|M.ulcerans_Agy99 -----MIPGPATLPDLLDRLQVVALPMRVRFRGITTREVALIEGPSGWGE
MAV_4590|M.avium_104 -----MIP---PLQDLLDRLHVVALPMRVRFRGITTREVALIDGPAGWGE
Mb0568|M.bovis_AF2122/97 -----MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGWGE
Rv0553|M.tuberculosis_H37Rv -----MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGWGE
MLBr_02268|M.leprae_Br4923 -----MIP---TLTELLDRLHVVALPMRVRFRGITTREVALIDGPAGWGE
MAB_3935c|M.abscessus_ATCC_199 ----MELP---VLDDVLDRLHVVALPMRVRFRGITTREVALIDGPAGWGE
TH_0152|M.thermoresistible__bu --VGDTGPVMPTLDELLERLRVVALPMRVPFRGVTVREVALIEGPVAWGE
MSMEG_6871|M.smegmatis_MC2_155 ---MIITGVDVHVVNLPLTSPFRSSFETKTGETRTVVRVTTDDGHVGWGE
Mvan_1029|M.vanbaalenii_PYR-1 MAPIRVTGARITPVAFADPPLLNTVGVHQPYALRAIIQLDTDAGLVGLGE
Mflv_1357|M.gilvum_PYR-GCK ---MKITAVDAIPFAIPYTKPLKFASGEVHTAEHVLVRVHTDEGVVGVAE
. . . .: * . .*
MMAR_0899|M.marinum_M FG------------------------------------------------
MUL_0652|M.ulcerans_Agy99 FG------------------------------------------------
MAV_4590|M.avium_104 FG------------------------------------------------
Mb0568|M.bovis_AF2122/97 FG------------------------------------------------
Rv0553|M.tuberculosis_H37Rv FG------------------------------------------------
MLBr_02268|M.leprae_Br4923 FG------------------------------------------------
MAB_3935c|M.abscessus_ATCC_199 FG------------------------------------------------
TH_0152|M.thermoresistible__bu FG------------------------------------------------
MSMEG_6871|M.smegmatis_MC2_155 TMWGSPVARLTEQLSSSLIGKSPFALEEFHATH------------TMVPF
Mvan_1029|M.vanbaalenii_PYR-1 TYADTRHLARLRAAAEAITGLDVFALNRIRASIGSRLEGDTTAVGTAGMI
Mflv_1357|M.gilvum_PYR-GCK APPRPFTYGETQDGILAVIRQIFAPQIVGLTLTEREVVN--------ARL
MMAR_0899|M.marinum_M -----AFLEYQPPEAAAWLASAIDAAYGQPPPVR---RGRIPINATVPA-
MUL_0652|M.ulcerans_Agy99 -----AFLEYQPPEAAAWLASAIDAAYGQPPPVR---RGRIPINATVPA-
MAV_4590|M.avium_104 -----AFVEYGPPEAAHWLASAVESAYRPAPPVR---RDRIPINATVPA-
Mb0568|M.bovis_AF2122/97 -----AFVEYQSAQACAWLASAIETAYCAPPPVR---RDRVPINATVPA-
Rv0553|M.tuberculosis_H37Rv -----AFVEYQSAQACAWLASAIETAYCAPPPVR---RDRVPINATVPA-
MLBr_02268|M.leprae_Br4923 -----AFLEYQPLEASAWLVAGIEAAYGEPPEGR---RDRIPINATVPA-
MAB_3935c|M.abscessus_ATCC_199 -----AFPEYQPAEASAWLSAAIEAAYRALPTPR---RDRIPVNATVPA-
TH_0152|M.thermoresistible__bu -----AFPEYGPAEAAAWLAAGIEAAFKSPPLIR---RHRIPINATVPA-
MSMEG_6871|M.smegmatis_MC2_155 FYGYIGYAALAGLDVACWDLMGKITGRPLTDLIGGRVRDTVPITALITR-
Mvan_1029|M.vanbaalenii_PYR-1 TSASVVDQVLSPFEVACLDVQGQSLGRPVSDLLGGAVRDAVPFSAYLFYK
Mflv_1357|M.gilvum_PYR-GCK ARTVGNPTAKAAVDMAIWDALGRSLDLSVSALLGG-YGDHMRVSHMLGFD
: . . : .. :
MMAR_0899|M.marinum_M ----------------VPPAQVPELLARFPGARTAKVKVAEPGQTLASDV
MUL_0652|M.ulcerans_Agy99 ----------------VPPAQVPELLARFPGARTAKVKVAEPGQTLASDV
MAV_4590|M.avium_104 ----------------VPAAAVPDVLARFPGARTAKVKVAEPGQTLADDV
Mb0568|M.bovis_AF2122/97 ----------------VAAAQVGEVLARFPGARTAKVKVAEPGQSLADDI
Rv0553|M.tuberculosis_H37Rv ----------------VAAAQVGEVLARFPGARTAKVKVAEPGQSLADDI
MLBr_02268|M.leprae_Br4923 ----------------VSATQVPEVLARFPGVRTAKVKVAEPGQNLADDV
MAB_3935c|M.abscessus_ATCC_199 ----------------VTAADVPEVLSRFPGAQTAKVKVAEPGQTLDEDV
TH_0152|M.thermoresistible__bu ----------------VPAQRVPEVLSRFPGARTAKVKVAEPGQTLTDDV
MSMEG_6871|M.smegmatis_MC2_155 -ADAPDAPP-----ADLPVALAEHAAKVVAIGGFTAVKLKG-TKDVDGDV
Mvan_1029|M.vanbaalenii_PYR-1 WAGHPNAEPDRFGEAMDPNGLVAQARRIIDEYGFTAIKLKGGVFPPEEEM
Mflv_1357|M.gilvum_PYR-GCK ----------------TPDTMVAEAERIRDEYGISTFKVKVGRRPVTLDT
. . . : .*: :
MMAR_0899|M.marinum_M ERVNAVRALVP---TVRVDANGGWSVDQAAQAAVALTADGPLEYLEQPCA
MUL_0652|M.ulcerans_Agy99 ERVNAVRALVP---TVRVDANGGWSVDQAAQAAVALTADGPLEYLEQPCA
MAV_4590|M.avium_104 ARVNAVRDLVP---TVRVDANGGWSVDEAARAARALSADGPLEYLEQPCA
Mb0568|M.bovis_AF2122/97 ERVNAVRELVP---MVRVDANGGWGVAEAVAAAAALTADGPLEYLEQPCA
Rv0553|M.tuberculosis_H37Rv ERVNAVRELVP---MVRVDANGGWGVAEAVAAAAALTADGPLEYLEQPCA
MLBr_02268|M.leprae_Br4923 DRVNAVRELVE---TVRVDANGGWSVEAAAQAAVALTADGPLEYLEQPCA
MAB_3935c|M.abscessus_ATCC_199 ARVEAVRARIR---TVRVDANGGWTVAQAVHALTALTRDGALEYAEQPCA
TH_0152|M.thermoresistible__bu ARVNAVRELVP---TVRVDVNGAWTVDEAVKAAAALTADGPLEYLEQPCA
MSMEG_6871|M.smegmatis_MC2_155 KIMRALRAVLPD-VELRVDPNAAWSVPESIRAGLRMEELD-LEYLEDPCW
Mvan_1029|M.vanbaalenii_PYR-1 AAIEALSRNFPG-LPLRLDPNAAWTPHTAVKVASGLAGI--LEYLEDPTP
Mflv_1357|M.gilvum_PYR-GCK AVVRALRERFGDTVELYVDGNRGWTASESLRALKDMADLD-LLFAEELCP
:.*: . : :* * .* : . : * : *:
MMAR_0899|M.marinum_M TVGELAELRRR---IEVPIAADEAIRKAEDPLAVVRAGAADVAVLKVAPL
MUL_0652|M.ulcerans_Agy99 TVGELAELRRR---IEVPIAADEAIRKAEDPLAVVRAGAADVAVLKVAPL
MAV_4590|M.avium_104 TVGELAELRRRPDMPDVPIAADESIRKADDPLAVVRARAADIAVLKVAPL
Mb0568|M.bovis_AF2122/97 TVAELAELRRR---VDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPL
Rv0553|M.tuberculosis_H37Rv TVAELAELRRR---VDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPL
MLBr_02268|M.leprae_Br4923 TVAELAALRRR---VDIPIAADESIRKADDPLAVVRSHAADVAVLKVAPL
MAB_3935c|M.abscessus_ATCC_199 TVEELAELRRR--LPGVPIAADESIRRASDPLRVAQARAADIAVLKVAPL
TH_0152|M.thermoresistible__bu TIAELAELRRR---IDVPIAADESIRKADDPLRVVRAGAADIAVLKVAPL
MSMEG_6871|M.smegmatis_MC2_155 GIDGMARVREK---IRIPLCTNMCVVAFEDFAPAMRLGAVDVIHGDVYKW
Mvan_1029|M.vanbaalenii_PYR-1 GLAGMAEVAQQ---APMPLATNMCVVAFDQLAPAVTKNAVRVVLSDHHYW
Mflv_1357|M.gilvum_PYR-GCK ADDVLGRRWLVEH-TEIPFIADESVPTPADVTREVLGGSATAISIKTART
:. :*: :: .: : :. .
MMAR_0899|M.marinum_M GGVWA---LLDIAAQIDIPVVISSALDSAVGIAAGLSAAAALPQLQHACG
MUL_0652|M.ulcerans_Agy99 GGVWA---LLDIAAQIDIPVVISSALDSAVGIAAGLSAAAALPQLQHACG
MAV_4590|M.avium_104 GGISA---LLEIAARIDIPVVISSALDSAVGIAAGLTAAAALPVLGHACG
Mb0568|M.bovis_AF2122/97 GGISA---LLDIAARIAVPVVVSSALDSAVGIAAGLTAAAALPELDHACG
Rv0553|M.tuberculosis_H37Rv GGISA---LLDIAARIAVPVVVSSALDSAVGIAAGLTAAAALPELDHACG
MLBr_02268|M.leprae_Br4923 GGIAS---FLAIAAQIDIPVVVSSALDSVVGITAGLIAAAALPELDYACG
MAB_3935c|M.abscessus_ATCC_199 GGVHA---LLEIAARIGMPAVISSALDSAVGIGIGLRAAAALPELDHACG
TH_0152|M.thermoresistible__bu GGAYR---LLEIATAIDIPIVVSSALDTAVGIGRGLLAAAALPQLNHACG
MSMEG_6871|M.smegmatis_MC2_155 GGIKATKDLAAHCSTFGLGMNLHSGGELGIATAAHLAVVASTPVLNRAID
Mvan_1029|M.vanbaalenii_PYR-1 GGLQRSRLLAGICDTFGLGLSMHSNSHLGISLAAMVHLAGATPNLTYACD
Mflv_1357|M.gilvum_PYR-GCK G-FTGSRRVHHLAEGLGLEVVMGNQIDGQLGTACAVAFGAAFELTSRRAG
* . . : : : . . :. : .: .
MMAR_0899|M.marinum_M LGTGGLFVEDVAEP--AIPVDGALAPQR-----VVPDPARLRALGAAPDR
MUL_0652|M.ulcerans_Agy99 LGTGGLFVEDVAEP--AIPVDGALAPQR-----VAPDPARLRALGAAPDR
MAV_4590|M.avium_104 LGTGGLFVEDVADV--AAPVDGALPVGP-----VTPDPARLRALAAPPQR
Mb0568|M.bovis_AF2122/97 LGTGGLFEEDVAEP--AAPVDGFLAVAR-----TTPDPARLQALGAPPQR
Rv0553|M.tuberculosis_H37Rv LGTGGLFEEDVAEP--AAPVDGFLAVAR-----TTPDPARLQALGAPPQR
MLBr_02268|M.leprae_Br4923 LGTGRLFVADVAEP--MLPVDGFLPVGP-----VTPDPARLQALGTPPAR
MAB_3935c|M.abscessus_ATCC_199 LGTGGFFLADVADV--PPVVDGHLPVTS-----CTPDPARLAALAVPADR
TH_0152|M.thermoresistible__bu LGTGRLFVEDVAEP--LELVDGHLPAAP-----VRPDPQRVLELAAPPDR
MSMEG_6871|M.smegmatis_MC2_155 S-MYYLHDDDIIDP--IPLHNGRLSVPDGPGLGVVVDEDKLAHYAALNAR
Mvan_1029|M.vanbaalenii_PYR-1 T-HWPWKTEDVVKDGALAFVDGAVPVPTSPGLGVEIDDDALDALHEQYVR
Mflv_1357|M.gilvum_PYR-GCK ELSNFLDMSDDLLTHPLRIRDGRLHVPPGPGLGIEIDPDKLDHYRTDH--
* :* : * :
MMAR_0899|M.marinum_M RQWWIDRIKACYPLLYRRSGD----------
MUL_0652|M.ulcerans_Agy99 RQWWIDRIKACYPLLYRRSGD----------
MAV_4590|M.avium_104 RQWWIDRVTACHGLLVPSSG-----------
Mb0568|M.bovis_AF2122/97 RQWWIDRVKACYSLLVPSFG-----------
Rv0553|M.tuberculosis_H37Rv RQWWIDRVKACYSLLVPSFG-----------
MLBr_02268|M.leprae_Br4923 RQWWIDRVKTCYSLLVPCAGDQSGLRRPRDR
MAB_3935c|M.abscessus_ATCC_199 LDRWRRRVADCHALLNR--------------
TH_0152|M.thermoresistible__bu RRWWMDRTRECFALLET--------------
MSMEG_6871|M.smegmatis_MC2_155 EGDLVK-------------------------
Mvan_1029|M.vanbaalenii_PYR-1 CGIRDRDDTGYMRTVDPSFEPAGPRW-----
Mflv_1357|M.gilvum_PYR-GCK -------------------------------