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APIRVTGARITPVAFADPPLLNTVGVHQPYALRAIIQLDTDAGLVGLGETYADTRHLARLRAAAEAITGL DVFALNRIRASIGSRLEGDTTAVGTAGMITSASVVDQVLSPFEVACLDVQGQSLGRPVSDLLGGAVRDAV PFSAYLFYKWAGHPNAEPDRFGEAMDPNGLVAQARRIIDEYGFTAIKLKGGVFPPEEEMAAIEALSRNFP GLPLRLDPNAAWTPHTAVKVASGLAGILEYLEDPTPGLAGMAEVAQQAPMPLATNMCVVAFDQLAPAVTK NAVRVVLSDHHYWGGLQRSRLLAGICDTFGLGLSMHSNSHLGISLAAMVHLAGATPNLTYACDTHWPWKT EDVVKDGALAFVDGAVPVPTSPGLGVEIDDDALDALHEQYVRCGIRDRDDTGYMRTVDPSFEPAGPRW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1029 | - | - | 100% (419) | mandelate racemase/muconate lactonizing protein |
| M. vanbaalenii PYR-1 | Mvan_1017 | - | 1e-56 | 32.73% (440) | glucarate dehydratase |
| M. vanbaalenii PYR-1 | Mvan_0971 | - | 1e-06 | 27.47% (182) | O-succinylbenzoate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0568 | menC | 1e-06 | 27.39% (157) | O-succinylbenzoate synthase |
| M. gilvum PYR-GCK | Mflv_1357 | - | 6e-15 | 25.37% (402) | mandelate racemase/muconate lactonizing protein |
| M. tuberculosis H37Rv | Rv0553 | menC | 1e-06 | 27.39% (157) | O-succinylbenzoate synthase |
| M. leprae Br4923 | MLBr_02268 | - | 1e-06 | 28.24% (131) | O-succinylbenzoate synthase |
| M. abscessus ATCC 19977 | MAB_3935c | - | 4e-05 | 29.14% (151) | O-succinylbenzoate synthase |
| M. marinum M | MMAR_0899 | menC | 2e-05 | 25.95% (131) | muconate cycloisomerase, MenC |
| M. avium 104 | MAV_3096 | - | 5e-11 | 26.80% (347) | mandelate racemase/muconate lactonizing enzyme |
| M. smegmatis MC2 155 | MSMEG_6132 | - | 0.0 | 81.34% (418) | glucarate dehydratase |
| M. thermoresistible (build 8) | TH_0152 | menC | 7e-09 | 28.33% (180) | PROBABLE MUCONATE CYCLOISOMERASE MENC (CIS,CIS-MUCONATE |
| M. ulcerans Agy99 | MUL_0652 | menC | 2e-05 | 25.95% (131) | O-succinylbenzoate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3935c|M.abscessus_ATCC_199 ---------MELPVLDDVLDRLHVVALPMRVRFRGITTREVALIDGPAGW
TH_0152|M.thermoresistible__bu ----VGDTGPVMPTLDELLERLRVVALPMRVPFRGVTVREVALIEGPVAW
Mb0568|M.bovis_AF2122/97 -------MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGW
Rv0553|M.tuberculosis_H37Rv -------MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGW
MMAR_0899|M.marinum_M -------MIPGPATLPDLLDRLHVVALPMRVRFRGITTREVALIEGPSGW
MUL_0652|M.ulcerans_Agy99 -------MIPGPATLPDLLDRLQVVALPMRVRFRGITTREVALIEGPSGW
MLBr_02268|M.leprae_Br4923 -------MIP---TLTELLDRLHVVALPMRVRFRGITTREVALIDGPAGW
Mvan_1029|M.vanbaalenii_PYR-1 MAP--IRVTGARITPVAFADPPLLNTVGVHQPYALRAIIQLDTDAGLVGL
MSMEG_6132|M.smegmatis_MC2_155 MAHNRIRITGARVTPVAFADPPLLNTVGVHQPYALRAVIQLDTDAGLTGL
Mflv_1357|M.gilvum_PYR-GCK -----MKITAVDAIPFAIPYTKPLKFASGEVHTAEHVLVRVHTDEGVVGV
MAV_3096|M.avium_104 -MTPDPAIDEVTARVYQIPTDAPEADGTLSWSSTTLVLAEVAAG-GRRGI
. . .: * .
MAB_3935c|M.abscessus_ATCC_199 GEFGAFPEYQPAEASAWLSAAIEAAYRA----------------------
TH_0152|M.thermoresistible__bu GEFGAFPEYGPAEAAAWLAAGIEAAFKS----------------------
Mb0568|M.bovis_AF2122/97 GEFGAFVEYQSAQACAWLASAIETAYCA----------------------
Rv0553|M.tuberculosis_H37Rv GEFGAFVEYQSAQACAWLASAIETAYCA----------------------
MMAR_0899|M.marinum_M GEFGAFLEYQPPEAAAWLASAIDAAYGQ----------------------
MUL_0652|M.ulcerans_Agy99 GEFGAFLEYQPPEAAAWLASAIDAAYGQ----------------------
MLBr_02268|M.leprae_Br4923 GEFGAFLEYQPLEASAWLVAGIEAAYGE----------------------
Mvan_1029|M.vanbaalenii_PYR-1 GETYADTRHLARLRAAAEAITGLDVFALNRIRASIGSRLEGDTTAVGT--
MSMEG_6132|M.smegmatis_MC2_155 GETYADTVHLERLQAAAHAIVGRSVFSTNVIRALISDALGGDRTGDGSGL
Mflv_1357|M.gilvum_PYR-GCK AEAPPRPFTYGETQDGILAVIRQIFAPQIVGLTLTEREVVN---------
MAV_3096|M.avium_104 GYTYADGACAALITGALAGSVTGHSALDVPARWQAMVRAMR---------
. . .
MAB_3935c|M.abscessus_ATCC_199 ------LPTPRRDRIPVNATVPAVTAADVPEVLSRFPG------------
TH_0152|M.thermoresistible__bu ------PPLIRRHRIPINATVPAVPAQRVPEVLSRFPG------------
Mb0568|M.bovis_AF2122/97 ------PPPVRRDRVPINATVPAVAAAQVGEVLARFPG------------
Rv0553|M.tuberculosis_H37Rv ------PPPVRRDRVPINATVPAVAAAQVGEVLARFPG------------
MMAR_0899|M.marinum_M ------PPPVRRGRIPINATVPAVPPAQVPELLARFPG------------
MUL_0652|M.ulcerans_Agy99 ------PPPVRRGRIPINATVPAVPPAQVPELLARFPG------------
MLBr_02268|M.leprae_Br4923 ------PPEGRRDRIPINATVPAVSATQVPEVLARFPG------------
Mvan_1029|M.vanbaalenii_PYR-1 AGMITSASVVDQVLSPFEVACLDVQGQSLGRPVSDLLGGAVRDAVPFSAY
MSMEG_6132|M.smegmatis_MC2_155 AGMITSASVVDRVFSPFEVACLDVQGQVTGRPVSDLLGGAVRDAVPFSAY
Mflv_1357|M.gilvum_PYR-GCK -ARLARTVGNPTAKAAVDMAIWDALGRSLDLSVSALLGG-----------
MAV_3096|M.avium_104 --NNGRPGLVSCAISAVDTALWDLKGKLLGLPVCRLLG------------
..: : :. : *
MAB_3935c|M.abscessus_ATCC_199 -------------------------AQTAKVKVAEPGQ------------
TH_0152|M.thermoresistible__bu -------------------------ARTAKVKVAEPGQ------------
Mb0568|M.bovis_AF2122/97 -------------------------ARTAKVKVAEPGQ------------
Rv0553|M.tuberculosis_H37Rv -------------------------ARTAKVKVAEPGQ------------
MMAR_0899|M.marinum_M -------------------------ARTAKVKVAEPGQ------------
MUL_0652|M.ulcerans_Agy99 -------------------------ARTAKVKVAEPGQ------------
MLBr_02268|M.leprae_Br4923 -------------------------VRTAKVKVAEPGQ------------
Mvan_1029|M.vanbaalenii_PYR-1 LFYKWAGHPNAEPDRFGEAMDPNGLVAQARRIIDEYGFTAIKLKGGV---
MSMEG_6132|M.smegmatis_MC2_155 LFYKWAAHPGAEPDGWGAALDPDGIVAQARRMIDEYGFSAIKLKGGV---
Mflv_1357|M.gilvum_PYR-GCK ------YGDHMRVSHMLGFDTPDTMVAEAERIRDEYGISTFKVKVGR---
MAV_3096|M.avium_104 ---MAHDSVPIYGSGGFTSYDDNATRAQLERWVHEWRIPRVKIKIGESWG
. *
MAB_3935c|M.abscessus_ATCC_199 -TLDEDVARVEAVRARIR---TVRVDANGGWTVAQAVHALTALTRDGALE
TH_0152|M.thermoresistible__bu -TLTDDVARVNAVRELVP---TVRVDVNGAWTVDEAVKAAAALTADGPLE
Mb0568|M.bovis_AF2122/97 -SLADDIERVNAVRELVP---MVRVDANGGWGVAEAVAAAAALTADGPLE
Rv0553|M.tuberculosis_H37Rv -SLADDIERVNAVRELVP---MVRVDANGGWGVAEAVAAAAALTADGPLE
MMAR_0899|M.marinum_M -TLASDVERVNAVRALVP---TVRVDANGGWSVDQAAQAAVALTADGPLE
MUL_0652|M.ulcerans_Agy99 -TLASDVERVNAVRALVP---TVRVDANGGWSVDQAAQAAVALTADGPLE
MLBr_02268|M.leprae_Br4923 -NLADDVDRVNAVRELVE---TVRVDANGGWSVEAAAQAAVALTADGPLE
Mvan_1029|M.vanbaalenii_PYR-1 FPPEEEMAAIEALSRNFPG-LPLRLDPNAAWTPHTAVKVASGL--AGILE
MSMEG_6132|M.smegmatis_MC2_155 FAPEEEMAAVEALRAAFPD-HPLRLDPNAAWTPQTSVKVAAGL--EGVLE
Mflv_1357|M.gilvum_PYR-GCK RPVTLDTAVVRALRERFGDTVELYVDGNRGWTASESLRALKDMADLDLLF
MAV_3096|M.avium_104 SHERRDLDRIALARTVIGPDTELYVDANGGYRRKQAIRMAHAMAGHDVTW
: : . : :* * .: : : .
MAB_3935c|M.abscessus_ATCC_199 YAEQPCATVEELAELRRRLPGVPIAADESIRRASDPLRVAQARAADIAVL
TH_0152|M.thermoresistible__bu YLEQPCATIAELAELRRRID-VPIAADESIRKADDPLRVVRAGAADIAVL
Mb0568|M.bovis_AF2122/97 YLEQPCATVAELAELRRRVD-VPIAADESIRKAEDPLAVVRAQAADIAVL
Rv0553|M.tuberculosis_H37Rv YLEQPCATVAELAELRRRVD-VPIAADESIRKAEDPLAVVRAQAADIAVL
MMAR_0899|M.marinum_M YLEQPCATVGELAELRRRIE-VPIAADEAIRKAEDPLAVVRAGAADVAVL
MUL_0652|M.ulcerans_Agy99 YLEQPCATVGELAELRRRIE-VPIAADEAIRKAEDPLAVVRAGAADVAVL
MLBr_02268|M.leprae_Br4923 YLEQPCATVAELAALRRRVD-IPIAADESIRKADDPLAVVRSHAADVAVL
Mvan_1029|M.vanbaalenii_PYR-1 YLEDPTPGLAGMAEVAQQAP-MPLATNMCVVAFDQLAPAVTKNAVRVVLS
MSMEG_6132|M.smegmatis_MC2_155 YLEDPTPGLDGMAEVAAQAP-MPLATNMCVVAFDQLPAAVAKNSVQVVLS
Mflv_1357|M.gilvum_PYR-GCK AEELCPADDVLGRRWLVEHTEIPFIADESVPTPADVTREVLGGSATAISI
MAV_3096|M.avium_104 FEEPVSSDDLAGLREVRDQVSADVTAGEYGYDLAYFHRMLAADAVDCLQI
* . . :. :.
MAB_3935c|M.abscessus_ATCC_199 KVAPLGGVHA---LLEIAARIGMPAVISSALDSAVGIGIGLRAAAALPEL
TH_0152|M.thermoresistible__bu KVAPLGGAYR---LLEIATAIDIPIVVSSALDTAVGIGRGLLAAAALPQL
Mb0568|M.bovis_AF2122/97 KVAPLGGISA---LLDIAARIAVPVVVSSALDSAVGIAAGLTAAAALPEL
Rv0553|M.tuberculosis_H37Rv KVAPLGGISA---LLDIAARIAVPVVVSSALDSAVGIAAGLTAAAALPEL
MMAR_0899|M.marinum_M KVAPLGGVWA---LLDIAAQIDIPVVISSALDSAVGIAAGLSAAAALPQL
MUL_0652|M.ulcerans_Agy99 KVAPLGGVWA---LLDIAAQIDIPVVISSALDSAVGIAAGLSAAAALPQL
MLBr_02268|M.leprae_Br4923 KVAPLGGIAS---FLAIAAQIDIPVVVSSALDSVVGITAGLIAAAALPEL
Mvan_1029|M.vanbaalenii_PYR-1 DHHYWGGLQRSRLLAGICDTFGLGLSMHSNSHLGISLAAMVHLAGATPNL
MSMEG_6132|M.smegmatis_MC2_155 DHHYWGGLQRSRLLAGICDTFGLGLSMHSNSHLGISLAAMVHLAAATPNL
Mflv_1357|M.gilvum_PYR-GCK KTARTG-FTGSRRVHHLAEGLGLEVVMGNQIDGQLGTACAVAFGAAFELT
MAV_3096|M.avium_104 DVTRCGGITDWLRAAAVAAAHNVDVSGHCAPNLHAHVATAVANLRHLEYF
. * :. : . :
MAB_3935c|M.abscessus_ATCC_199 D-HACGLGTGGFFLADVADVPPVVDGHLPVTSCTP------DPARLAALA
TH_0152|M.thermoresistible__bu N-HACGLGTGRLFVEDVAEPLELVDGHLPAAPVRP------DPQRVLELA
Mb0568|M.bovis_AF2122/97 D-HACGLGTGGLFEEDVAEPAAPVDGFLAVARTTP------DPARLQALG
Rv0553|M.tuberculosis_H37Rv D-HACGLGTGGLFEEDVAEPAAPVDGFLAVARTTP------DPARLQALG
MMAR_0899|M.marinum_M Q-HACGLGTGGLFVEDVAEPAIPVDGALAPQRVVP------DPARLRALG
MUL_0652|M.ulcerans_Agy99 Q-HACGLGTGGLFVEDVAEPAIPVDGALAPQRVAP------DPARLRALG
MLBr_02268|M.leprae_Br4923 D-YACGLGTGRLFVADVAEPMLPVDGFLPVGPVTP------DPARLQALG
Mvan_1029|M.vanbaalenii_PYR-1 T-YACDTHWPWKTEDVVKDGALAFVDGAVPVPTSPGLGVEIDDDALDALH
MSMEG_6132|M.smegmatis_MC2_155 T-YACDTHWPWRHEDVVAPGALNFCDGEVQVPATPGLGVEIDEDALAALH
Mflv_1357|M.gilvum_PYR-GCK SRRAGELSNFLDMSDDLLTHPLRIRDGRLHVPPGPGLGIEIDPDKLDHYR
MAV_3096|M.avium_104 H-------DHHRIERMFFDGALSPQGGVLRPDQQR------PGFGLEFKQ
. . :
MAB_3935c|M.abscessus_ATCC_199 VPADRLDRWRRRVADCHALLNR--------------
TH_0152|M.thermoresistible__bu APPDRRRWWMDRTRECFALLET--------------
Mb0568|M.bovis_AF2122/97 APPQRRQWWIDRVKACYSLLVPSFG-----------
Rv0553|M.tuberculosis_H37Rv APPQRRQWWIDRVKACYSLLVPSFG-----------
MMAR_0899|M.marinum_M AAPDRRQWWIDRIKACYPLLYRRSGD----------
MUL_0652|M.ulcerans_Agy99 AAPDRRQWWIDRIKACYPLLYRRSGD----------
MLBr_02268|M.leprae_Br4923 TPPARRQWWIDRVKTCYSLLVPCAGDQSGLRRPRDR
Mvan_1029|M.vanbaalenii_PYR-1 EQYVRCGIRDRDDTGYMRTVDPSFEPAGPRW-----
MSMEG_6132|M.smegmatis_MC2_155 EQYLRCGIRDRDDTGYMRSIDPGFNASGPRW-----
Mflv_1357|M.gilvum_PYR-GCK TDH---------------------------------
MAV_3096|M.avium_104 RDADRYRMR---------------------------