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IPPLQDLLDRLHVVALPMRVRFRGITTREVALIDGPAGWGEFGAFVEYGPPEAAHWLASAVESAYRPAPP VRRDRIPINATVPAVPAAAVPDVLARFPGARTAKVKVAEPGQTLADDVARVNAVRDLVPTVRVDANGGWS VDEAARAARALSADGPLEYLEQPCATVGELAELRRRPDMPDVPIAADESIRKADDPLAVVRARAADIAVL KVAPLGGISALLEIAARIDIPVVISSALDSAVGIAAGLTAAAALPVLGHACGLGTGGLFVEDVADVAAPV DGALPVGPVTPDPARLRALAAPPQRRQWWIDRVTACHGLLVPSSG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4590 | - | - | 100% (326) | O-succinylbenzoate synthase |
| M. avium 104 | MAV_4624 | - | 2e-07 | 30.60% (232) | mandelate racemase/muconate lactonizing enzyme |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0568 | menC | 1e-147 | 81.90% (326) | O-succinylbenzoate synthase |
| M. gilvum PYR-GCK | Mflv_5268 | - | 1e-137 | 76.56% (320) | O-succinylbenzoate synthase |
| M. tuberculosis H37Rv | Rv0553 | menC | 1e-147 | 81.90% (326) | O-succinylbenzoate synthase |
| M. leprae Br4923 | MLBr_02268 | - | 1e-142 | 78.22% (326) | O-succinylbenzoate synthase |
| M. abscessus ATCC 19977 | MAB_3935c | - | 1e-128 | 74.06% (320) | O-succinylbenzoate synthase |
| M. marinum M | MMAR_0899 | menC | 1e-145 | 81.99% (322) | muconate cycloisomerase, MenC |
| M. smegmatis MC2 155 | MSMEG_1103 | - | 1e-141 | 78.12% (320) | O-succinylbenzoate synthase |
| M. thermoresistible (build 8) | TH_0152 | menC | 1e-133 | 74.45% (321) | PROBABLE MUCONATE CYCLOISOMERASE MENC (CIS,CIS-MUCONATE |
| M. ulcerans Agy99 | MUL_0652 | menC | 1e-144 | 81.68% (322) | O-succinylbenzoate synthase |
| M. vanbaalenii PYR-1 | Mvan_0971 | - | 1e-141 | 78.44% (320) | O-succinylbenzoate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0568|M.bovis_AF2122/97 ------------------------MIPVLPPLEALLDRLYVVALPMRVRF
Rv0553|M.tuberculosis_H37Rv ------------------------MIPVLPPLEALLDRLYVVALPMRVRF
MMAR_0899|M.marinum_M ------------------------MIPGPATLPDLLDRLHVVALPMRVRF
MUL_0652|M.ulcerans_Agy99 ------------------------MIPGPATLPDLLDRLQVVALPMRVRF
MAV_4590|M.avium_104 ------------------------MIP---PLQDLLDRLHVVALPMRVRF
MLBr_02268|M.leprae_Br4923 ------------------------MIP---TLTELLDRLHVVALPMRVRF
Mflv_5268|M.gilvum_PYR-GCK ----------------------------MADLADILDRLHVVALPMRVRF
Mvan_0971|M.vanbaalenii_PYR-1 MGRRPRRRVRSRGRAGACAFRLLRHDEAVPELADVLDRLHVVALPMRVRF
MSMEG_1103|M.smegmatis_MC2_155 ------------------------MTNGVPALDDILERLHVVALPMRVRF
TH_0152|M.thermoresistible__bu ---------------------VGDTGPVMPTLDELLERLRVVALPMRVPF
MAB_3935c|M.abscessus_ATCC_199 --------------------------MELPVLDDVLDRLHVVALPMRVRF
* :*:** ******** *
Mb0568|M.bovis_AF2122/97 RGITTREVALIEGPAGWGEFGAFVEYQSAQACAWLASAIETAYCAPPPVR
Rv0553|M.tuberculosis_H37Rv RGITTREVALIEGPAGWGEFGAFVEYQSAQACAWLASAIETAYCAPPPVR
MMAR_0899|M.marinum_M RGITTREVALIEGPSGWGEFGAFLEYQPPEAAAWLASAIDAAYGQPPPVR
MUL_0652|M.ulcerans_Agy99 RGITTREVALIEGPSGWGEFGAFLEYQPPEAAAWLASAIDAAYGQPPPVR
MAV_4590|M.avium_104 RGITTREVALIDGPAGWGEFGAFVEYGPPEAAHWLASAVESAYRPAPPVR
MLBr_02268|M.leprae_Br4923 RGITTREVALIDGPAGWGEFGAFLEYQPLEASAWLVAGIEAAYGEPPEGR
Mflv_5268|M.gilvum_PYR-GCK RGITTREVALIDGPAGWGEFGPFLEYEPPEAAHWLASGVAAAYRPMPEVR
Mvan_0971|M.vanbaalenii_PYR-1 RGITTRELALIDGPAGWGEFGAFVEYRPAEAAHWLAAGIEAAYRPLPEVR
MSMEG_1103|M.smegmatis_MC2_155 RGITVRELALIDGPAGWGEFGAFVEYEPPEAAAWLSSALEAAYRPAPAAL
TH_0152|M.thermoresistible__bu RGVTVREVALIEGPVAWGEFGAFPEYGPAEAAAWLAAGIEAAFKSPPLIR
MAB_3935c|M.abscessus_ATCC_199 RGITTREVALIDGPAGWGEFGAFPEYQPAEASAWLSAAIEAAYRALPTPR
**:*.**:***:** .*****.* ** . :*. ** :.: :*: *
Mb0568|M.bovis_AF2122/97 RDRVPINATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLADDIERVN
Rv0553|M.tuberculosis_H37Rv RDRVPINATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLADDIERVN
MMAR_0899|M.marinum_M RGRIPINATVPAVPPAQVPELLARFPGARTAKVKVAEPGQTLASDVERVN
MUL_0652|M.ulcerans_Agy99 RGRIPINATVPAVPPAQVPELLARFPGARTAKVKVAEPGQTLASDVERVN
MAV_4590|M.avium_104 RDRIPINATVPAVPAAAVPDVLARFPGARTAKVKVAEPGQTLADDVARVN
MLBr_02268|M.leprae_Br4923 RDRIPINATVPAVSATQVPEVLARFPGVRTAKVKVAEPGQNLADDVDRVN
Mflv_5268|M.gilvum_PYR-GCK RARIPINATVPAVPADAVPDVLVRFPGARTAKVKVAEPGHTLADDVARVN
Mvan_0971|M.vanbaalenii_PYR-1 RPRIPINATVPAVAAHDVPGVLARFPGVRTAKVKVAEPGQTLADDVARVN
MSMEG_1103|M.smegmatis_MC2_155 RDRVPINATVPAVSAERVPEVLARFPGARTAKVKVAEPGQSLADDVARVN
TH_0152|M.thermoresistible__bu RHRIPINATVPAVPAQRVPEVLSRFPGARTAKVKVAEPGQTLTDDVARVN
MAB_3935c|M.abscessus_ATCC_199 RDRIPVNATVPAVTAADVPEVLSRFPGAQTAKVKVAEPGQTLDEDVARVE
* *:*:*******.. * :* ****.:**********:.* .*: **:
Mb0568|M.bovis_AF2122/97 AVRELVPMVRVDANGGWGVAEAVAAAAALTADGPLEYLEQPCATVAELAE
Rv0553|M.tuberculosis_H37Rv AVRELVPMVRVDANGGWGVAEAVAAAAALTADGPLEYLEQPCATVAELAE
MMAR_0899|M.marinum_M AVRALVPTVRVDANGGWSVDQAAQAAVALTADGPLEYLEQPCATVGELAE
MUL_0652|M.ulcerans_Agy99 AVRALVPTVRVDANGGWSVDQAAQAAVALTADGPLEYLEQPCATVGELAE
MAV_4590|M.avium_104 AVRDLVPTVRVDANGGWSVDEAARAARALSADGPLEYLEQPCATVGELAE
MLBr_02268|M.leprae_Br4923 AVRELVETVRVDANGGWSVEAAAQAAVALTADGPLEYLEQPCATVAELAA
Mflv_5268|M.gilvum_PYR-GCK AVRAAGLTARVDANGGWTVEQAVAAAQALTADGALEYLEQPCRTVPELAE
Mvan_0971|M.vanbaalenii_PYR-1 AVRDAVPTVRVDANGGWTVDEAVAAARALTADGPLEYLEQPCRTVPELAE
MSMEG_1103|M.smegmatis_MC2_155 AVRESVPVVRVDANGGWSVDDAVEAAAALTADGELEYLEQPCATVEELAA
TH_0152|M.thermoresistible__bu AVRELVPTVRVDVNGAWTVDEAVKAAAALTADGPLEYLEQPCATIAELAE
MAB_3935c|M.abscessus_ATCC_199 AVRARIRTVRVDANGGWTVAQAVHALTALTRDGALEYAEQPCATVEELAE
*** .***.**.* * *. * **: ** *** **** *: ***
Mb0568|M.bovis_AF2122/97 LRRR---VDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGGISALL
Rv0553|M.tuberculosis_H37Rv LRRR---VDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGGISALL
MMAR_0899|M.marinum_M LRRR---IEVPIAADEAIRKAEDPLAVVRAGAADVAVLKVAPLGGVWALL
MUL_0652|M.ulcerans_Agy99 LRRR---IEVPIAADEAIRKAEDPLAVVRAGAADVAVLKVAPLGGVWALL
MAV_4590|M.avium_104 LRRRPDMPDVPIAADESIRKADDPLAVVRARAADIAVLKVAPLGGISALL
MLBr_02268|M.leprae_Br4923 LRRR---VDIPIAADESIRKADDPLAVVRSHAADVAVLKVAPLGGIASFL
Mflv_5268|M.gilvum_PYR-GCK VRRR---VDVPVAADESIRKADDPLHVVRSGAADVAVLKVAPLGGVQTML
Mvan_0971|M.vanbaalenii_PYR-1 VRRR---VDVPVAADESIRKAEDPLHVVRSGAADVAVLKVAPLGGVHAML
MSMEG_1103|M.smegmatis_MC2_155 LRAR---VDVPIAADESIRKAEDPLRVVRAHAADIAVLKVAPLGGVARML
TH_0152|M.thermoresistible__bu LRRR---IDVPIAADESIRKADDPLRVVRAGAADIAVLKVAPLGGAYRLL
MAB_3935c|M.abscessus_ATCC_199 LRRR--LPGVPIAADESIRRASDPLRVAQARAADIAVLKVAPLGGVHALL
:* * :*:****:**:*.*** *.:: ***:********** :*
Mb0568|M.bovis_AF2122/97 DIAARIAVPVVVSSALDSAVGIAAGLTAAAALPELDHACGLGTGGLFEED
Rv0553|M.tuberculosis_H37Rv DIAARIAVPVVVSSALDSAVGIAAGLTAAAALPELDHACGLGTGGLFEED
MMAR_0899|M.marinum_M DIAAQIDIPVVISSALDSAVGIAAGLSAAAALPQLQHACGLGTGGLFVED
MUL_0652|M.ulcerans_Agy99 DIAAQIDIPVVISSALDSAVGIAAGLSAAAALPQLQHACGLGTGGLFVED
MAV_4590|M.avium_104 EIAARIDIPVVISSALDSAVGIAAGLTAAAALPVLGHACGLGTGGLFVED
MLBr_02268|M.leprae_Br4923 AIAAQIDIPVVVSSALDSVVGITAGLIAAAALPELDYACGLGTGRLFVAD
Mflv_5268|M.gilvum_PYR-GCK DIAAQIDIPVVVSSALDTAVGIGAGLVAAGCLPRLEHACGLGTGSLFVDD
Mvan_0971|M.vanbaalenii_PYR-1 DIAAQIDIPVVVSSALDSAVGIGVGLVAAGSLPTLDHACGLGTGGLFVDD
MSMEG_1103|M.smegmatis_MC2_155 DIAAQIDIPIVVSSALDSSVGIGRGLLAAAALPELRHACGLGTGGLFVDD
TH_0152|M.thermoresistible__bu EIATAIDIPIVVSSALDTAVGIGRGLLAAAALPQLNHACGLGTGRLFVED
MAB_3935c|M.abscessus_ATCC_199 EIAARIGMPAVISSALDSAVGIGIGLRAAAALPELDHACGLGTGGFFLAD
**: * :* *:*****: *** ** **..** * :******* :* *
Mb0568|M.bovis_AF2122/97 VAEPAAPVDGFLAVARTTPDPARLQALGAPPQRRQWWIDRVKACYSLLVP
Rv0553|M.tuberculosis_H37Rv VAEPAAPVDGFLAVARTTPDPARLQALGAPPQRRQWWIDRVKACYSLLVP
MMAR_0899|M.marinum_M VAEPAIPVDGALAPQRVVPDPARLRALGAAPDRRQWWIDRIKACYPLLYR
MUL_0652|M.ulcerans_Agy99 VAEPAIPVDGALAPQRVAPDPARLRALGAAPDRRQWWIDRIKACYPLLYR
MAV_4590|M.avium_104 VADVAAPVDGALPVGPVTPDPARLRALAAPPQRRQWWIDRVTACHGLLVP
MLBr_02268|M.leprae_Br4923 VAEPMLPVDGFLPVGPVTPDPARLQALGTPPARRQWWIDRVKTCYSLLVP
Mflv_5268|M.gilvum_PYR-GCK VAEPRTPVDGYLPAAAVTPDPARITALAASDDRRQWWIDRVRACYPLMS-
Mvan_0971|M.vanbaalenii_PYR-1 VAAPVVPVDGYLPAAPVTPDLDRIAALAAPPDRRQWWIARVRECFPLVS-
MSMEG_1103|M.smegmatis_MC2_155 VAEPRVPVDGCLAVEPAVPDPARLAALAAPEPRRQWWIDRVCACHALI--
TH_0152|M.thermoresistible__bu VAEPLELVDGHLPAAPVRPDPQRVLELAAPPDRRRWWMDRTRECFALLET
MAB_3935c|M.abscessus_ATCC_199 VADVPPVVDGHLPVTSCTPDPARLAALAVPADRLDRWRRRVADCHALLNR
** *** *. ** *: *... * * * *. *:
Mb0568|M.bovis_AF2122/97 SFG-----------
Rv0553|M.tuberculosis_H37Rv SFG-----------
MMAR_0899|M.marinum_M RSGD----------
MUL_0652|M.ulcerans_Agy99 RSGD----------
MAV_4590|M.avium_104 SSG-----------
MLBr_02268|M.leprae_Br4923 CAGDQSGLRRPRDR
Mflv_5268|M.gilvum_PYR-GCK --------------
Mvan_0971|M.vanbaalenii_PYR-1 --------------
MSMEG_1103|M.smegmatis_MC2_155 --------------
TH_0152|M.thermoresistible__bu --------------
MAB_3935c|M.abscessus_ATCC_199 --------------