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M. thermoresistible (build 8) TH_0152 (menC)

annotation: PROBABLE MUCONATE CYCLOISOMERASE MENC (CIS,CIS-MUCONATE LACTONIZING ENZYME) (MLE)
coordinates: 325691 - 326671
length: 327

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0152menC-100% (327)PROBABLE MUCONATE CYCLOISOMERASE MENC (CIS,CIS-MUCONATE LACTONIZING ENZYME) (MLE)
M. thermoresistible (build 8)TH_2569-1e-3247.75% (178) PUTATIVE O-succinylbenzoate synthase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0568menC1e-13173.35% (319) O-succinylbenzoate synthase
M. gilvum PYR-GCKMflv_5268-1e-12971.97% (314) O-succinylbenzoate synthase
M. tuberculosis H37RvRv0553menC1e-13173.35% (319) O-succinylbenzoate synthase
M. leprae Br4923MLBr_02268-1e-13373.58% (318) O-succinylbenzoate synthase
M. abscessus ATCC 19977MAB_3935c-1e-12069.18% (318) O-succinylbenzoate synthase
M. marinum MMMAR_0899menC1e-13273.98% (319) muconate cycloisomerase, MenC
M. avium 104MAV_4590-1e-13374.45% (321) O-succinylbenzoate synthase
M. smegmatis MC2 155MSMEG_1103-1e-13374.45% (317) O-succinylbenzoate synthase
M. ulcerans Agy99MUL_0652menC1e-13373.98% (319) O-succinylbenzoate synthase
M. vanbaalenii PYR-1Mvan_0971-1e-13574.45% (317) O-succinylbenzoate synthase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_5268|M.gilvum_PYR-GCK          ----------------------------MADLADILDRLHVVALPMRVRF
Mvan_0971|M.vanbaalenii_PYR-1       MGRRPRRRVRSRGRAGACAFRLLRHDEAVPELADVLDRLHVVALPMRVRF
MSMEG_1103|M.smegmatis_MC2_155      ------------------------MTNGVPALDDILERLHVVALPMRVRF
Mb0568|M.bovis_AF2122/97            ------------------------MIPVLPPLEALLDRLYVVALPMRVRF
Rv0553|M.tuberculosis_H37Rv         ------------------------MIPVLPPLEALLDRLYVVALPMRVRF
MMAR_0899|M.marinum_M               ------------------------MIPGPATLPDLLDRLHVVALPMRVRF
MUL_0652|M.ulcerans_Agy99           ------------------------MIPGPATLPDLLDRLQVVALPMRVRF
MAV_4590|M.avium_104                ------------------------MIP---PLQDLLDRLHVVALPMRVRF
MLBr_02268|M.leprae_Br4923          ------------------------MIP---TLTELLDRLHVVALPMRVRF
TH_0152|M.thermoresistible__bu      ---------------------VGDTGPVMPTLDELLERLRVVALPMRVPF
MAB_3935c|M.abscessus_ATCC_199      --------------------------MELPVLDDVLDRLHVVALPMRVRF
                                                                   *  :*:** ******** *

Mflv_5268|M.gilvum_PYR-GCK          RGITTREVALIDGPAGWGEFGPFLEYEPPEAAHWLASGVAAAYRPMPEVR
Mvan_0971|M.vanbaalenii_PYR-1       RGITTRELALIDGPAGWGEFGAFVEYRPAEAAHWLAAGIEAAYRPLPEVR
MSMEG_1103|M.smegmatis_MC2_155      RGITVRELALIDGPAGWGEFGAFVEYEPPEAAAWLSSALEAAYRPAPAAL
Mb0568|M.bovis_AF2122/97            RGITTREVALIEGPAGWGEFGAFVEYQSAQACAWLASAIETAYCAPPPVR
Rv0553|M.tuberculosis_H37Rv         RGITTREVALIEGPAGWGEFGAFVEYQSAQACAWLASAIETAYCAPPPVR
MMAR_0899|M.marinum_M               RGITTREVALIEGPSGWGEFGAFLEYQPPEAAAWLASAIDAAYGQPPPVR
MUL_0652|M.ulcerans_Agy99           RGITTREVALIEGPSGWGEFGAFLEYQPPEAAAWLASAIDAAYGQPPPVR
MAV_4590|M.avium_104                RGITTREVALIDGPAGWGEFGAFVEYGPPEAAHWLASAVESAYRPAPPVR
MLBr_02268|M.leprae_Br4923          RGITTREVALIDGPAGWGEFGAFLEYQPLEASAWLVAGIEAAYGEPPEGR
TH_0152|M.thermoresistible__bu      RGVTVREVALIEGPVAWGEFGAFPEYGPAEAAAWLAAGIEAAFKSPPLIR
MAB_3935c|M.abscessus_ATCC_199      RGITTREVALIDGPAGWGEFGAFPEYQPAEASAWLSAAIEAAYRALPTPR
                                    **:*.**:***:** .*****.* ** . :*. ** :.: :*:   *   

Mflv_5268|M.gilvum_PYR-GCK          RARIPINATVPAVPADAVPDVLVRFPGARTAKVKVAEPGHTLADDVARVN
Mvan_0971|M.vanbaalenii_PYR-1       RPRIPINATVPAVAAHDVPGVLARFPGVRTAKVKVAEPGQTLADDVARVN
MSMEG_1103|M.smegmatis_MC2_155      RDRVPINATVPAVSAERVPEVLARFPGARTAKVKVAEPGQSLADDVARVN
Mb0568|M.bovis_AF2122/97            RDRVPINATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLADDIERVN
Rv0553|M.tuberculosis_H37Rv         RDRVPINATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLADDIERVN
MMAR_0899|M.marinum_M               RGRIPINATVPAVPPAQVPELLARFPGARTAKVKVAEPGQTLASDVERVN
MUL_0652|M.ulcerans_Agy99           RGRIPINATVPAVPPAQVPELLARFPGARTAKVKVAEPGQTLASDVERVN
MAV_4590|M.avium_104                RDRIPINATVPAVPAAAVPDVLARFPGARTAKVKVAEPGQTLADDVARVN
MLBr_02268|M.leprae_Br4923          RDRIPINATVPAVSATQVPEVLARFPGVRTAKVKVAEPGQNLADDVDRVN
TH_0152|M.thermoresistible__bu      RHRIPINATVPAVPAQRVPEVLSRFPGARTAKVKVAEPGQTLTDDVARVN
MAB_3935c|M.abscessus_ATCC_199      RDRIPVNATVPAVTAADVPEVLSRFPGAQTAKVKVAEPGQTLDEDVARVE
                                    * *:*:*******..  *  :* ****.:**********:.* .*: **:

Mflv_5268|M.gilvum_PYR-GCK          AVRAAGLTARVDANGGWTVEQAVAAAQALTADGALEYLEQPCRTVPELAE
Mvan_0971|M.vanbaalenii_PYR-1       AVRDAVPTVRVDANGGWTVDEAVAAARALTADGPLEYLEQPCRTVPELAE
MSMEG_1103|M.smegmatis_MC2_155      AVRESVPVVRVDANGGWSVDDAVEAAAALTADGELEYLEQPCATVEELAA
Mb0568|M.bovis_AF2122/97            AVRELVPMVRVDANGGWGVAEAVAAAAALTADGPLEYLEQPCATVAELAE
Rv0553|M.tuberculosis_H37Rv         AVRELVPMVRVDANGGWGVAEAVAAAAALTADGPLEYLEQPCATVAELAE
MMAR_0899|M.marinum_M               AVRALVPTVRVDANGGWSVDQAAQAAVALTADGPLEYLEQPCATVGELAE
MUL_0652|M.ulcerans_Agy99           AVRALVPTVRVDANGGWSVDQAAQAAVALTADGPLEYLEQPCATVGELAE
MAV_4590|M.avium_104                AVRDLVPTVRVDANGGWSVDEAARAARALSADGPLEYLEQPCATVGELAE
MLBr_02268|M.leprae_Br4923          AVRELVETVRVDANGGWSVEAAAQAAVALTADGPLEYLEQPCATVAELAA
TH_0152|M.thermoresistible__bu      AVRELVPTVRVDVNGAWTVDEAVKAAAALTADGPLEYLEQPCATIAELAE
MAB_3935c|M.abscessus_ATCC_199      AVRARIRTVRVDANGGWTVAQAVHALTALTRDGALEYAEQPCATVEELAE
                                    ***     .***.**.* *  *. *  **: ** *** **** *: *** 

Mflv_5268|M.gilvum_PYR-GCK          VRRR---VDVPVAADESIRKADDPLHVVRSGAADVAVLKVAPLGGVQTML
Mvan_0971|M.vanbaalenii_PYR-1       VRRR---VDVPVAADESIRKAEDPLHVVRSGAADVAVLKVAPLGGVHAML
MSMEG_1103|M.smegmatis_MC2_155      LRAR---VDVPIAADESIRKAEDPLRVVRAHAADIAVLKVAPLGGVARML
Mb0568|M.bovis_AF2122/97            LRRR---VDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGGISALL
Rv0553|M.tuberculosis_H37Rv         LRRR---VDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGGISALL
MMAR_0899|M.marinum_M               LRRR---IEVPIAADEAIRKAEDPLAVVRAGAADVAVLKVAPLGGVWALL
MUL_0652|M.ulcerans_Agy99           LRRR---IEVPIAADEAIRKAEDPLAVVRAGAADVAVLKVAPLGGVWALL
MAV_4590|M.avium_104                LRRRPDMPDVPIAADESIRKADDPLAVVRARAADIAVLKVAPLGGISALL
MLBr_02268|M.leprae_Br4923          LRRR---VDIPIAADESIRKADDPLAVVRSHAADVAVLKVAPLGGIASFL
TH_0152|M.thermoresistible__bu      LRRR---IDVPIAADESIRKADDPLRVVRAGAADIAVLKVAPLGGAYRLL
MAB_3935c|M.abscessus_ATCC_199      LRRR--LPGVPIAADESIRRASDPLRVAQARAADIAVLKVAPLGGVHALL
                                    :* *     :*:****:**:*.*** *.:: ***:**********   :*

Mflv_5268|M.gilvum_PYR-GCK          DIAAQIDIPVVVSSALDTAVGIGAGLVAAGCLPRLEHACGLGTGSLFVDD
Mvan_0971|M.vanbaalenii_PYR-1       DIAAQIDIPVVVSSALDSAVGIGVGLVAAGSLPTLDHACGLGTGGLFVDD
MSMEG_1103|M.smegmatis_MC2_155      DIAAQIDIPIVVSSALDSSVGIGRGLLAAAALPELRHACGLGTGGLFVDD
Mb0568|M.bovis_AF2122/97            DIAARIAVPVVVSSALDSAVGIAAGLTAAAALPELDHACGLGTGGLFEED
Rv0553|M.tuberculosis_H37Rv         DIAARIAVPVVVSSALDSAVGIAAGLTAAAALPELDHACGLGTGGLFEED
MMAR_0899|M.marinum_M               DIAAQIDIPVVISSALDSAVGIAAGLSAAAALPQLQHACGLGTGGLFVED
MUL_0652|M.ulcerans_Agy99           DIAAQIDIPVVISSALDSAVGIAAGLSAAAALPQLQHACGLGTGGLFVED
MAV_4590|M.avium_104                EIAARIDIPVVISSALDSAVGIAAGLTAAAALPVLGHACGLGTGGLFVED
MLBr_02268|M.leprae_Br4923          AIAAQIDIPVVVSSALDSVVGITAGLIAAAALPELDYACGLGTGRLFVAD
TH_0152|M.thermoresistible__bu      EIATAIDIPIVVSSALDTAVGIGRGLLAAAALPQLNHACGLGTGRLFVED
MAB_3935c|M.abscessus_ATCC_199      EIAARIGMPAVISSALDSAVGIGIGLRAAAALPELDHACGLGTGGFFLAD
                                     **: * :* *:*****: ***  ** **..** * :******* :*  *

Mflv_5268|M.gilvum_PYR-GCK          VAEPRTPVDGYLPAAAVTPDPARITALAASDDRRQWWIDRVRACYPLMS-
Mvan_0971|M.vanbaalenii_PYR-1       VAAPVVPVDGYLPAAPVTPDLDRIAALAAPPDRRQWWIARVRECFPLVS-
MSMEG_1103|M.smegmatis_MC2_155      VAEPRVPVDGCLAVEPAVPDPARLAALAAPEPRRQWWIDRVCACHALI--
Mb0568|M.bovis_AF2122/97            VAEPAAPVDGFLAVARTTPDPARLQALGAPPQRRQWWIDRVKACYSLLVP
Rv0553|M.tuberculosis_H37Rv         VAEPAAPVDGFLAVARTTPDPARLQALGAPPQRRQWWIDRVKACYSLLVP
MMAR_0899|M.marinum_M               VAEPAIPVDGALAPQRVVPDPARLRALGAAPDRRQWWIDRIKACYPLLYR
MUL_0652|M.ulcerans_Agy99           VAEPAIPVDGALAPQRVAPDPARLRALGAAPDRRQWWIDRIKACYPLLYR
MAV_4590|M.avium_104                VADVAAPVDGALPVGPVTPDPARLRALAAPPQRRQWWIDRVTACHGLLVP
MLBr_02268|M.leprae_Br4923          VAEPMLPVDGFLPVGPVTPDPARLQALGTPPARRQWWIDRVKTCYSLLVP
TH_0152|M.thermoresistible__bu      VAEPLELVDGHLPAAPVRPDPQRVLELAAPPDRRRWWMDRTRECFALLET
MAB_3935c|M.abscessus_ATCC_199      VADVPPVVDGHLPVTSCTPDPARLAALAVPADRLDRWRRRVADCHALLNR
                                    **     *** *.     **  *:  *...  *   *  *   *. *:  

Mflv_5268|M.gilvum_PYR-GCK          --------------
Mvan_0971|M.vanbaalenii_PYR-1       --------------
MSMEG_1103|M.smegmatis_MC2_155      --------------
Mb0568|M.bovis_AF2122/97            SFG-----------
Rv0553|M.tuberculosis_H37Rv         SFG-----------
MMAR_0899|M.marinum_M               RSGD----------
MUL_0652|M.ulcerans_Agy99           RSGD----------
MAV_4590|M.avium_104                SSG-----------
MLBr_02268|M.leprae_Br4923          CAGDQSGLRRPRDR
TH_0152|M.thermoresistible__bu      --------------
MAB_3935c|M.abscessus_ATCC_199      --------------