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MTDPRIDPTETTAMRRARGEAIVTQLSGGTRPASLDALDHEHPFLSHAVNAFAVGEIFDRDVLDVRTRQL ALVAAFATLGLTDFIKIHGAYALGAGATEDELKEIAVLTLIPGGFPRAIQASQAISALLAERKDHAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6797 | - | - | 100% (137) | carboxymuconolactone decarboxylase |
| M. smegmatis MC2 155 | MSMEG_2604 | pcaC | 3e-06 | 33.73% (83) | 4-carboxymuconolactone decarboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0794 | - | 7e-06 | 32.53% (83) | 4-carboxymuconolactone decarboxylase |
| M. gilvum PYR-GCK | Mflv_0527 | - | 3e-07 | 28.10% (121) | 4-carboxymuconolactone decarboxylase |
| M. tuberculosis H37Rv | Rv0771 | - | 7e-06 | 32.53% (83) | 4-carboxymuconolactone decarboxylase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1221 | - | 1e-05 | 30.95% (84) | 4-carboxymuconolactone decarboxylase |
| M. marinum M | MMAR_4925 | - | 5e-05 | 34.94% (83) | 4-carboxymuconolactone decarboxylase |
| M. avium 104 | MAV_0716 | pcaC | 4e-05 | 32.53% (83) | hypothetical protein MAV_0716 |
| M. thermoresistible (build 8) | TH_0621 | - | 2e-06 | 32.93% (82) | 4-carboxymuconolactone decarboxylase |
| M. ulcerans Agy99 | MUL_0480 | - | 3e-05 | 34.94% (83) | 4-carboxymuconolactone decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_0563 | - | 8e-08 | 28.93% (121) | 4-carboxymuconolactone decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4925|M.marinum_M --------------------------------------------------
MUL_0480|M.ulcerans_Agy99 --------------------------------------------------
MAV_0716|M.avium_104 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1221|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK MSNPPLTAIHLGGPDDGPLLLLGPSLGTTTATLWTGVAQRLVDHVRVVGW
Mvan_0563|M.vanbaalenii_PYR-1 MSNPPLTAIHLGGPDDGPLLLLGPSLGTTTATLWTGVAQRLVDHVRVVGW
MSMEG_6797|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4925|M.marinum_M --------------------------------------------------
MUL_0480|M.ulcerans_Agy99 --------------------------------------------------
MAV_0716|M.avium_104 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1221|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK DLPGHGRGRRAHPFTIADLAAAVLVIADDLNVETFHYAGDSVGGCVGLQL
Mvan_0563|M.vanbaalenii_PYR-1 DLPGHGRGRRAHPFTIADLAAAVLVIADDLNVETFHYAGDSVGGCVGLQL
MSMEG_6797|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4925|M.marinum_M --------------------------------------------------
MUL_0480|M.ulcerans_Agy99 --------------------------------------------------
MAV_0716|M.avium_104 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1221|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK LLDAPQRVSSATLLCTGAAIGTPDGWLARAATVRAGGVDTMLTGAAERWF
Mvan_0563|M.vanbaalenii_PYR-1 LLDAPQRVSSATLLCTGAAIGTPDGWLARAATVRAGGVDTMLAGAAERWF
MSMEG_6797|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4925|M.marinum_M --------------------------------------------------
MUL_0480|M.ulcerans_Agy99 --------------------------------------------------
MAV_0716|M.avium_104 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1221|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK APGFVDREPGTASALLDALSHTDAESYAQVCEALAVFDVTDRLSEIVTPV
Mvan_0563|M.vanbaalenii_PYR-1 APGFVDREPGTASALLDALSHTDAESYAQVCEALAVFDVTNQLSEIVTPV
MSMEG_6797|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4925|M.marinum_M --------------------------------------------------
MUL_0480|M.ulcerans_Agy99 --------------------------------------------------
MAV_0716|M.avium_104 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1221|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK LAVAGSADSPTPPESLRRIASDVKDGDVVVLEGVGHLAPAEAPERVAGLI
Mvan_0563|M.vanbaalenii_PYR-1 LAVAGSVDVPTPPESLRRIASDVKDGDLVVLEGVGHLAPAEAPQRVAGLI
MSMEG_6797|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4925|M.marinum_M -------------MDELRRKGLDKMNEVYGWEMPN--------IEGDAYF
MUL_0480|M.ulcerans_Agy99 -------------MDELRRKGLDKMNEVYGWEMPN--------IEGDAYF
MAV_0716|M.avium_104 ------------MMDERRRKGLEKMNEVYGWEMPN--------VEGDAYF
Mb0794|M.bovis_AF2122/97 ------------MMDELRRTGLDKMNEVYAWDMPD--------MPG-EFF
Rv0771|M.tuberculosis_H37Rv ------------MMDELRRTGLDKMNEVYAWDMPD--------MPG-EFF
MAB_1221|M.abscessus_ATCC_1997 ---MVCHTRKGQVMDELRRQGLDKMKEVYGWDMPD--------IPG-DYF
TH_0621|M.thermoresistible__bu ----------------MREQGLQVFRELLPGVLPDGDVDFRDGSFGDELL
Mflv_0527|M.gilvum_PYR-GCK AEIVGVPQPPSKTLEDVHRAGMAVRREVLGHAHVDRAVAG-TTDLTADFQ
Mvan_0563|M.vanbaalenii_PYR-1 AEIVGVPQPPSKTLEDVHRAGMAVRREVLGEAHVDRAVAG-TTDLTADFQ
MSMEG_6797|M.smegmatis_MC2_155 --MTDPRIDPTETTAMRRARGEAIVTQLSGGTRPAS--LDALDHEHPFLS
: * ::
MMAR_4925|M.marinum_M DLTVDHLFGTIWTRPGLSMRDRRLMTLTAVTAIGNRDLAEIQINAALLNG
MUL_0480|M.ulcerans_Agy99 DLTVDHLFGTIWTRPGLSMRDRRLMTLTAVTAIGNRDLAEIQINAAPLNG
MAV_0716|M.avium_104 DLTVDHLFGSIWTRPGLSMRDKRIMTLTAVTAIGNRDLAEIQINAALLNG
Mb0794|M.bovis_AF2122/97 ALTVDHLFGRIWTRPGLSMRDRRMAVIAVLTAQGQSDLLEVQVNAVLHND
Rv0771|M.tuberculosis_H37Rv ALTVDHLFGRIWTRPGLSMRDRRMAVIAVLTAQGQSDLLEVQVNAVLHND
MAB_1221|M.abscessus_ATCC_1997 KYTIDHLFGTIWTRPELSMRDRRLLLLGAVSALGLDEILEIQTSAALKNG
TH_0621|M.thermoresistible__bu EIGIDNVFGRLWTRDGLSRRDRSLVTLGILIALRATDELRFHVQIARNNG
Mflv_0527|M.gilvum_PYR-GCK HMITQYAWGSIWTRPGLDFRSRSMITLTALVARGHHEELAMHLRAARRNG
Mvan_0563|M.vanbaalenii_PYR-1 HMITQYAWGTIWTRPGLDLRSRSMITLTALVARGHHEELAMHLRAARRNG
MSMEG_6797|M.smegmatis_MC2_155 HAVNAFAVGEIFDRDVLDVRTRQLALVAAFATLGLTDFIKIHGAYALGAG
* :: * *. * : : : . : : .: . .
MMAR_4925|M.marinum_M ELTEAELKEMAVFLTHYLGFPLGSGLNGAVDTVVARRKKAAAKGAGEDKK
MUL_0480|M.ulcerans_Agy99 ELTEAELKEMAVFLTHYLGFPLGSGLNGAVDTVVARRKKAAAKGAGEDKK
MAV_0716|M.avium_104 ELTETELKEMAVFLTHYLGFPLGSALNGAVDAVVAKRRKAAAKGAGEDKK
Mb0794|M.bovis_AF2122/97 ELTIDELRELAVFITHYVGFPLGSRLNSAIERVAAKRKQAAENGSLPDTK
Rv0771|M.tuberculosis_H37Rv ELTIDELRELAVFITHYVGFPLGSRLNSAIERVAAKRKQAAENGSLPDTK
MAB_1221|M.abscessus_ATCC_1997 ELTEAELREVAIFITHYVGWPLGQRVNKHVEMAVAKQNEARR------TK
TH_0621|M.thermoresistible__bu -LTEDEIAEVIYHATGYAGFPNASTAMKVAKEVLAEEHSRAADADKQSRL
Mflv_0527|M.gilvum_PYR-GCK -LSNDEIKELLLQTAIYCGVPDANSAFRIAAEVLPEFDEHPGAPS-----
Mvan_0563|M.vanbaalenii_PYR-1 -LSNDEIKELLMQTAIYCGVPDANSAFRIAAEVLPEFDEHPGAPS-----
MSMEG_6797|M.smegmatis_MC2_155 -ATEDELKEIAVLTLIPGGFPRAIQASQAISALLAERKDHAR--------
: *: *: * * . .. .
MMAR_4925|M.marinum_M GNVDDALKMHSGGKPD
MUL_0480|M.ulcerans_Agy99 GNVDDALKMHSGSKPD
MAV_0716|M.avium_104 ANVDAALKMHSGGERG
Mb0794|M.bovis_AF2122/97 ANVAEVLAKESGKSS-
Rv0771|M.tuberculosis_H37Rv ANVAEVLAKESGKSS-
MAB_1221|M.abscessus_ATCC_1997 ESSDD-----------
TH_0621|M.thermoresistible__bu GESNP-----------
Mflv_0527|M.gilvum_PYR-GCK ----------------
Mvan_0563|M.vanbaalenii_PYR-1 ----------------
MSMEG_6797|M.smegmatis_MC2_155 ----------------