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TSDHQNDSAPAELKREFSLWSAFAFAFAFISPIVAMYGIYGLSLSTAGPGFWWTFVIVGIGQCIVALAFA DLVSRWPFEGSIYQWTKRLAGNVAGWFAGWVYMWALVIIMATVAYAGAGFLAQLVGIESPTAVQQSIVAL FVLLAGTGANILGRGFLKALMAASIGAEIVASIGLGTYLLIFHRHHGFDAIFHGIDLTSGWSWAYVSGPF LAALAFTGWSILGFESAGAIAEEVKEPRRNVPKAMLFSVAFIAIVIAYASLAVTLAVPDFDKIISGEEAD PVAYVLSSALGESAVKPILFAFVIGFLASFLALQASASRVIWSFARDEVLPASKFLVKLSKAEAQPITAI IVTTVIGAFVYLISATDVYSVLVTFTAGGYYLAFLFPLVTGLVARLRGKWVPGPWNLGKFSTPVAVLAVL WAGFEFVNIVWPRTVSDAWYLNWGFFVAMGAILALGAVIVKVRNVADRPAAVDPDTDAPSNDDDDAVVQP A*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4377 | - | - | 100% (492) | amino acid permease family protein, putative |
| M. smegmatis MC2 155 | MSMEG_1069 | - | e-150 | 56.65% (466) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_6735 | - | 3e-97 | 38.21% (458) | amino acid permease, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3281c | - | 8e-20 | 22.58% (465) | cationic amino acid transport integral membrane protein |
| M. gilvum PYR-GCK | Mflv_0800 | - | 1e-147 | 55.83% (480) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv3253c | - | 8e-20 | 22.58% (465) | cationic amino acid transport integral membrane protein |
| M. leprae Br4923 | MLBr_01305 | ansP2 | 2e-11 | 23.91% (322) | putative L-asparagine permease |
| M. abscessus ATCC 19977 | MAB_4090 | - | 4e-51 | 29.52% (481) | putative amino-acid permease |
| M. marinum M | MMAR_2243 | - | 8e-29 | 24.89% (470) | cationic amino acid transport integral membrane protein |
| M. avium 104 | MAV_4216 | - | 5e-20 | 22.82% (482) | cationic amino acid transporter |
| M. thermoresistible (build 8) | TH_0471 | - | 7e-21 | 22.36% (483) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_2597 | - | 2e-19 | 22.84% (464) | cationic amino acid transport integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_0043 | - | 1e-147 | 54.85% (485) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3281c|M.bovis_AF2122/97 -----MAGRRRMKSVEQSIADTD-----EPTTRLRKDLTWWDLVVFGVSV
Rv3253c|M.tuberculosis_H37Rv -----MAGRRRMKSVEQSIADTD-----EPTTRLRKDLTWWDLVVFGVSV
MUL_2597|M.ulcerans_Agy99 -----MAGGLRTKSVEQSIADTD-----EPETRLRKDLTWRDLVVFGVSV
MAV_4216|M.avium_104 -----MASRWRTKSVEQSIADTD-----EPDTRLRKDLTWWDLVVFGVAV
TH_0471|M.thermoresistible__bu -----MTDRLRVKSVEQSIADTD-----EPDSRLRKDLSWWDLTVFGVSV
Mflv_0800|M.gilvum_PYR-GCK ---------------MSSLVSPA-----EQQPQLRREFSLGSAFAFAFAF
Mvan_0043|M.vanbaalenii_PYR-1 ---------------MSISVSPA-----EQPPQLRREFSLGSAFAFAFAF
MSMEG_4377|M.smegmatis_MC2_155 ---------------MTSDHQND-----SAPAELKREFSLWSAFAFAFAF
MAB_4090|M.abscessus_ATCC_1997 MNASTATGTAAPSAAISAASDSDDLAAFGYKPQLHRSLGKFASFAAGFSF
MMAR_2243|M.marinum_M ----------------MSQPTGE--------PRLRRALGVAGLVAFGLAY
MLBr_01305|M.leprae_Br4923 -----MATLAESPEPKSGASRAG---VLGEEAGYHKGLKPRQLQMIGIGG
. :: : ...
Mb3281c|M.bovis_AF2122/97 VIGAGIFTVTASTAGDITGPAIWISFLIAAATCALAALCYAEFASTLPVA
Rv3253c|M.tuberculosis_H37Rv VIGAGIFTVTASTAGDITGPAIWISFLIAAATCALAALCYAEFASTLPVA
MUL_2597|M.ulcerans_Agy99 VIGAGIFTVTASTAGDITGPAIWISFLIAAGTCALAALCYAEFASTLPVA
MAV_4216|M.avium_104 VIGAGIFTVTASTTGDITGPAIWVSFVIAAGTCALAALCYAEFASTLPVA
TH_0471|M.thermoresistible__bu VIGAGIFTVTASTAGNITGPAISVSFIIAAIACGLAALCYAEFASTVPVA
Mflv_0800|M.gilvum_PYR-GCK ISPIVALYGIFGLALSAAGPSFWWGFGLVFAGQFLVALVFATLVSRWPLE
Mvan_0043|M.vanbaalenii_PYR-1 ISPIVALYGIFGLALSAAGPSFWWGFALVFAGQFLVALVFAALVSRWPLE
MSMEG_4377|M.smegmatis_MC2_155 ISPIVAMYGIYGLSLSTAGPGFWWTFVIVGIGQCIVALAFADLVSRWPFE
MAB_4090|M.abscessus_ATCC_1997 VSILTTIFQLFAFGFSFGGPAFFWTWPIVFLGQYMVALNFAELAARYPIS
MMAR_2243|M.marinum_M IDPLAMFDTFGVVSQTTHG-HVPTAYVVTFVAMLFTAASYAVLVHAYPSA
MLBr_01305|M.leprae_Br4923 AIGTGLFLGAGG-RLAKAGPGLFLVYAVCGVFVFLILRALGELVLHRPSS
: * . : : : . :. *
Mb3281c|M.bovis_AF2122/97 GSAYTFSYATFGEFLAWVIGWNLVLELAMGAAVVAKGWSSYLG--TVFG-
Rv3253c|M.tuberculosis_H37Rv GSAYTFSYATFGEFLAWVIGWNLVLELAMGAAVVAKGWSSYLG--TVFG-
MUL_2597|M.ulcerans_Agy99 GSAYTFSYATFGEFLAWVIGWNLVLELAIGAAVVAKGWSSYLG--TVFG-
MAV_4216|M.avium_104 GSAYTFSYATFGEFLAWIIGWNLLLELAIGAAVVAKGWSSYLG--TVFG-
TH_0471|M.thermoresistible__bu GSAYTFSYATFGEFVAWIIGWDLILEFSVAAAVVAKGWSSYLG--EVFE-
Mflv_0800|M.gilvum_PYR-GCK GSIYQWSRRLLGTAYGWFAGWVYMWTLVIAMATVALGAAGFTA--NIVG-
Mvan_0043|M.vanbaalenii_PYR-1 GSIYQWSRRLLGSTYGWFAGWVYMWTLVIAMATVALGAAGFVA--HIVG-
MSMEG_4377|M.smegmatis_MC2_155 GSIYQWTKRLAGNVAGWFAGWVYMWALVIIMATVAYAGAGFLA--QLVG-
MAB_4090|M.abscessus_ATCC_1997 GAIYQWARRLGGAAVGWFAGWFMIIAQIVTASAAAIALQVVLP--TVWSG
MMAR_2243|M.marinum_M GSAYTFARRSFGGNVGFLTGWALMLDYLLLPLVNYLLIGIYLN--AQFP-
MLBr_01305|M.leprae_Br4923 GSFVSYAREFFGEKAAYVVGWLYFLDWAMTAIVDTTAIATYLHRWTIFT-
*: :: * .:. ** . : .
Mb3281c|M.bovis_AF2122/97 -FGNGTGHLGSLQLDWGALVIVTLVATLIALGTKLSSR--FSAVVTAIKV
Rv3253c|M.tuberculosis_H37Rv -FGNGTGHLGSLQLDWGALVIVTLVATLIALGTKLSSR--FSAVVTAIKV
MUL_2597|M.ulcerans_Agy99 -FSGGTADFGSIRLDWGALLSVSIVSLLVAYGTKLSSR--FSAVVTTIKV
MAV_4216|M.avium_104 -FSGGTVKFGAAQLDWGALVIVGGVATLIALGTKLSSR--FSAVITGIKV
TH_0471|M.thermoresistible__bu -FAGATTRLGPITLDWGALLIIGFVTVLLATGTKLSAN--VSLAITVIKV
Mflv_0800|M.gilvum_PYR-GCK -IEEPSG---------GTLALIALVILLAGTAVNLIGRQALKIFMIGSII
Mvan_0043|M.vanbaalenii_PYR-1 -IEEASG---------GTLAWIALLILLAGTAVNLVGRQALKIFMIGSII
MSMEG_4377|M.smegmatis_MC2_155 -IESPTA---------VQQSIVALFVLLAGTGANILGRGFLKALMAASIG
MAB_4090|M.abscessus_ATCC_1997 FQLIGTDSSLTSVSGASNAVLLGSLLLVATTAINAVGVNWMSRINSIGVT
MMAR_2243|M.marinum_M ---------------AVPAPVFCLAAIALVTTVNIVGVVIMNRLNFALVG
MLBr_01305|M.leprae_Br4923 ------------ALPQWTLALLALAVVLVMNLISVEWFGELEFWAALIKV
. . ..
Mb3281c|M.bovis_AF2122/97 SVVVLVVVVGAFYIRAANYSPFIPEPEVQHHG-GGLDQSVFSLLTGAQGS
Rv3253c|M.tuberculosis_H37Rv SVVVLVVVVGAFYIRAANYSPFIPEPEVQHHG-GGLDQSVFSLLTGAQGS
MUL_2597|M.ulcerans_Agy99 AVVILVVVVGAFYVKAANYSPFIPEPEAGPEG-RGADQSLLSLLTGAPGS
MAV_4216|M.avium_104 SVVVFVVVVGVFYIKRANYSPFIPKPEAGGQA-KGIDQSVLSLLTGAHTS
TH_0471|M.thermoresistible__bu GVVLLVVIVGAFFIKAANYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGS
Mflv_0800|M.gilvum_PYR-GCK AEVIGSVVLGTWLLIFHRQNSISVLFEGGGAD----VDL-GAYLGGP---
Mvan_0043|M.vanbaalenii_PYR-1 AEVVGSVVLGTWLLLFHRQNSLSVLFEGGGTD----VDL-WSYLGGP---
MSMEG_4377|M.smegmatis_MC2_155 AEIVASIGLGTYLLIFHRHHGFDAIFHGIDLT----SGWSWAYVSGP---
MAB_4090|M.abscessus_ATCC_1997 CEIVGVVAVVGMLFGHAERGPSVVLHTGDAGS-----GYPWAFLAAG---
MMAR_2243|M.marinum_M LQLAFVLVFITVSLLYLRDHPDASLLQPLYSA---------GFRGGD---
MLBr_01305|M.leprae_Br4923 CALMAFLVVGTIFLGGRYPVDGHNTGLSLWTS----HGGLFPTGVAP---
: : . . .
Mb3281c|M.bovis_AF2122/97 HYGWYGVLAGASIVFFAFIGFDIVATMAEETKRPQRDVPRGILASLGVVT
Rv3253c|M.tuberculosis_H37Rv HYGWYGVLAGASIVFFAFIGFDIVATMAEETKRPQRDVPRGILASLGVVT
MUL_2597|M.ulcerans_Agy99 HYGWYGVLAGASIVFFAFIGFDIVATMAEETKHPQRDVPRGILVSLGVVT
MAV_4216|M.avium_104 HYGWYGVLAGASIVFFAFIGFDIVATMAEETKHPQRDVPRGILASLGIVT
TH_0471|M.thermoresistible__bu SYGWYGLLAGASIVFFAFIGFDIIATTAEETKNPQRDVARGIMATLGIVT
Mflv_0800|M.gilvum_PYR-GCK ------FLLAVAFIGWSFVGFESAGSIAEEVHNPRRDLPKAVLFSIAFIA
Mvan_0043|M.vanbaalenii_PYR-1 ------FLLAVAFIGWSFVGFESAGSIAEEVHNPGRDLPKAVLFSLAFIA
MSMEG_4377|M.smegmatis_MC2_155 ------FLAALAFTGWSILGFESAGAIAEEVKEPRRNVPKAMLFSVAFIA
MAB_4090|M.abscessus_ATCC_1997 -----------LMAAYVLVGFGSASELAEETRNPRRVAPRTILSAIVVSA
MMAR_2243|M.marinum_M ------ILGGAAVVALSFVGFDAVSTMAEEARNPRRTVPLAIILTVLIGG
MLBr_01305|M.leprae_Br4923 ------LIVVSSGVMFAYAAVELVGTAAGETVEPKKIMPRAINSVIARIA
.. . * *. .* : . : :
Mb3281c|M.bovis_AF2122/97 LLYVAVSVVLSGMVPYTQLRTVPGRGPANLATAFQANGVYWASGIISVGA
Rv3253c|M.tuberculosis_H37Rv LLYVAVSVVLSGMVPYTQLRTVPGRGPANLATAFQANGVYWASGIISVGA
MUL_2597|M.ulcerans_Agy99 LLYVAVSIVLSGMVSYTQLRTVSGGGHANLATAFKANGVYWASGIISVGA
MAV_4216|M.avium_104 LLYVAVAVVLSGMVSYTQLKTMPGRGQANLATAFTANGIHWASKIISIGA
TH_0471|M.thermoresistible__bu VLYVAVSLVLTGMVHYTELRAAG--ENANLATAFAANGIDWAAKVISIGA
Mflv_0800|M.gilvum_PYR-GCK LVVGYSALAIILAIPDLDAVAEGAVADPVYDTLTTALGAG-IAKPVQVMF
Mvan_0043|M.vanbaalenii_PYR-1 LVVGYSSLAIILAIPDLDAVAEGAVSDPVYETLTTALGAG-IAKPVQVLF
MSMEG_4377|M.smegmatis_MC2_155 IVIAYASLAVTLAVPDFDKIISGEEADPVAYVLSSALGES-AVKPILFAF
MAB_4090|M.abscessus_ATCC_1997 IG---GALMILGALMAAPSLTDGQLATGGLPYVLDSKLASPFGTLLLIDV
MMAR_2243|M.marinum_M ATFLSVSYCATLVEPDYRAITTP---NSAALQIVVSAGGHSLQTFFIIAY
MLBr_01305|M.leprae_Br4923 IFYVGSVILLALLLPYSAFKASE----SPFVTFFSKVGFYGAGDLMNIVV
. .
Mb3281c|M.bovis_AF2122/97 LAGLTTVVMVLMLGQCRVLFAMARDGLVPRQLA-KTGSRGTPVRVTVLVA
Rv3253c|M.tuberculosis_H37Rv LAGLTTVVMVLMLGQCRVLFAMARDGLVPRQLA-KTGSRGTPVRVTVLVA
MUL_2597|M.ulcerans_Agy99 LAGLTTVVMVLMLGQCRVLFAMARDGLLPRQLA-KTGARGTPVRITVLVA
MAV_4216|M.avium_104 LAGLTTVVMVLMLGQCRVLFAMARDGLLPRALA-KTGSRGTPVRITVLVA
TH_0471|M.thermoresistible__bu LAGLTTVVIVLVLGQTRVLFAMSRDGLLPRPLS-KTGPRGTPVRITVLVG
Mflv_0800|M.gilvum_PYR-GCK VIGFLASFLALQTSASRVIWAYSRDGALPAAGT-LVQLRGKARIPVAAIL
Mvan_0043|M.vanbaalenii_PYR-1 VIGFLASFLALQTSASRVIWAYARDGALPAAGT-LVQLRGRARIPVVAIL
MSMEG_4377|M.smegmatis_MC2_155 VIGFLASFLALQASASRVIWSFARDEVLPASKF-LVKLSKAEAQPITAII
MAB_4090|M.abscessus_ATCC_1997 AIAVFVCTLAIQTAASRLMFSMARDGKLPFSAV-LSHVNPRTGTPIAPAV
MMAR_2243|M.marinum_M MCACSAAALSSQVSVTRILYAMGRDGVLPRAVFGRISRRFRTPIGAALVV
MLBr_01305|M.leprae_Br4923 LTAALSSLNAGLYATGRVMHSIAINGSGPKFTA-RMSKNGVPYGGILLAA
. . *:: : . : *
Mb3281c|M.bovis_AF2122/97 VLVATTASVFPITKLEEMVNVGTLFAFILVS-AGVVVLRRTRPDLQRGF-
Rv3253c|M.tuberculosis_H37Rv VLVATTASVFPITKLEEMVNVGTLFAFILVS-AGVVVLRRTRPDLQRGF-
MUL_2597|M.ulcerans_Agy99 VVVGATASVFPITKLEEMVNVGTLFAFVLVS-AGVIVLRKKRPDLERGF-
MAV_4216|M.avium_104 LVVAVTASVFPITKLEEMVNVGTLFAFVLVS-AGVMVLRRTRPDLERGF-
TH_0471|M.thermoresistible__bu ALVAIAASVFPVGNLEEMVNIGTLFAFALVS-AGVIVLRRTRPDLKRGF-
Mflv_0800|M.gilvum_PYR-GCK VTTVIGAALFLLSIVAGDIYS-LMVNFTAGG-FYLAFLFPLIGFLVVLL-
Mvan_0043|M.vanbaalenii_PYR-1 VTTVIGAGLFLLSIVAGDIYS-LMVNFTAGG-FYLAFLFPLIGFLVVVL-
MSMEG_4377|M.smegmatis_MC2_155 VTTVIGAFVYLIS--ATDVYS-VLVTFTAGG-YYLAFLFPLVTGLVARL-
MAB_4090|M.abscessus_ATCC_1997 VVGVCCVLILAVNFGNAALFT-SLCSVCIAL-IYLAYLMVTTPLLLRRLG
MMAR_2243|M.marinum_M SAVSTLALIADLETMASIVSFGALAAFTLVH-LAVTKHFLIDQRRRGWR-
MLBr_01305|M.leprae_Br4923 VICLCGVALNAFNPGQAFEIVLSVAALGIIAGWGTIVLCQLRLHKMAKAG
. : . : .
Mb3281c|M.bovis_AF2122/97 --TAPWVP-----------------LLPIAAVCACLWLMLNLTALTWIR-
Rv3253c|M.tuberculosis_H37Rv --TAPWVP-----------------LLPIAAVCACLWLMLNLTALTWIR-
MUL_2597|M.ulcerans_Agy99 --RAPWVP-----------------VLPIASLCACLWLMLNLTALTWIR-
MAV_4216|M.avium_104 --KAPWVP-----------------VLPIASIGACVWLMLNLTALTWVR-
TH_0471|M.thermoresistible__bu --RVPFVP-----------------WLPLAAIAACLWLMLNLTGLTWVR-
Mflv_0800|M.gilvum_PYR-GCK --RKTWKPGS----------FSLRAATMPVAAVAVVWAVLQFLNIAWPRV
Mvan_0043|M.vanbaalenii_PYR-1 --RKVWKPAS----------FSLRGWTLPVAVVAVVWAVLQFLNIAWPRV
MSMEG_4377|M.smegmatis_MC2_155 --RGKWVPGP----------WNLGKFSTPVAVLAVLWAGFEFVNIVWPRT
MAB_4090|M.abscessus_ATCC_1997 IGGSTWDANLGQTDADGRKLFSLGRCGLPINILAVGYGAFMILNLSWPRP
MMAR_2243|M.marinum_M ----SWALYA---------------AMPAVGVVLTGWLWTSLSVGAFAIG
MLBr_01305|M.leprae_Br4923 IMRRPRFRMP---------------LAPYSGYLTLAFLFAVLVVMAFDKP
: : :
Mb3281c|M.bovis_AF2122/97 --------FGIWLVAGTAIYVGYGRR---------HSAQGLRQARESATR
Rv3253c|M.tuberculosis_H37Rv --------FGIWLVAGTAIYVGYGRR---------HSAQGLRQARESATR
MUL_2597|M.ulcerans_Agy99 --------FGVWLLVGTVIYVGYGRK---------HSMVGRRQLAEAAMD
MAV_4216|M.avium_104 --------FGIWLVVGTAIYAGYGYW---------HSVQGRRDAGEPDRS
TH_0471|M.thermoresistible__bu --------FLGWMALGLVLYFFYGRH---------HSMLGRGMTDISARR
Mflv_0800|M.gilvum_PYR-GCK AFEQRYLDWSVWIGVVVLGIIGAALY---------ASVKSRIVAPRDHDE
Mvan_0043|M.vanbaalenii_PYR-1 AFEQRYLDWSVWIGVVVLGMIGAVLF---------ATVKSRIAAPQDQDD
MSMEG_4377|M.smegmatis_MC2_155 VSDAWYLNWGFFVAMGAILALGAVIVKVRNVADRPAAVDPDTDAPSNDDD
MAB_4090|M.abscessus_ATCC_1997 AVFDPTGEHPYLVWMAPICIIAVLLAG--------LVAYPRHTASTTEET
MMAR_2243|M.marinum_M ---------FAWLGIGTSYLAVLTRG----FRKPAPAVDFDADAAPIQTE
MLBr_01305|M.leprae_Br4923 IG---TWTVASLIVIVPALIAGWYSIRKRVMTIARERMGYTGPFPAIANP
:
Mb3281c|M.bovis_AF2122/97 RC-----------
Rv3253c|M.tuberculosis_H37Rv RC-----------
MUL_2597|M.ulcerans_Agy99 K------------
MAV_4216|M.avium_104 DALAADPNSPVP-
TH_0471|M.thermoresistible__bu TG-----------
Mflv_0800|M.gilvum_PYR-GCK PALADD-------
Mvan_0043|M.vanbaalenii_PYR-1 RALVDD-------
MSMEG_4377|M.smegmatis_MC2_155 DAVVQPA------
MAB_4090|M.abscessus_ATCC_1997 VR-----------
MMAR_2243|M.marinum_M IDLTKEGTLQ---
MLBr_01305|M.leprae_Br4923 PVQPSERSHSQNP