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TRTTPVGSAVVTPKRVVIAGLGDAGVLTAIRLARRHDVVGVSLNPGLVSGQELGVRLARPDDWARDYWIS FDRLRALDRVRTVHGALTGADLDTRTITVTDADGTEHHEPYDALVIATGVTNGFWRRPVLQSPDDVHQGL REAHDRLSAATSVAVIGGGAAAVSSAANLAARWPDKHVGLYHPGNEILPQHHRRTRNRITQRLNALGVDV HPGHRAIVPDGFACDEITDDPVHFSTGQSPAKAEAVLWAIGRVTPNTGWLPRAILDDDGFVRVTPRLQVP GVPGVFAVGDVAATDALRSSARNRADALVAHNVAAYFTGGPMRTYRPHGRRWGSVLGPQPDGLDVFAPNG FAFHFPGWSIQRVLQPWIVRRVIYRGLRDPV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6582 | - | - | 100% (382) | pyridine nucleotide-disulphide oxidoreductase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3457 | - | 1e-10 | 25.42% (295) | DoxD family protein/pyridine nucleotide-disulfide |
| M. smegmatis MC2 155 | MSMEG_4433 | - | 2e-07 | 25.27% (368) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1885c | ndh | 2e-09 | 24.39% (287) | NADH dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1066 | - | 1e-137 | 66.58% (365) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv1854c | ndh | 2e-09 | 23.93% (280) | NADH dehydrogenase |
| M. leprae Br4923 | MLBr_02061 | - | 2e-06 | 22.83% (276) | putative dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2429c | - | 2e-08 | 24.49% (343) | NADH dehydrogenase (NDH) |
| M. marinum M | MMAR_2587 | ndh1 | 1e-133 | 63.84% (365) | NADH dehydrogenase Ndh1 |
| M. avium 104 | MAV_3047 | - | 1e-139 | 65.95% (370) | pyridine nucleotide-disulphide oxidoreductase, putative |
| M. thermoresistible (build 8) | TH_2218 | - | 3e-09 | 24.58% (301) | dehydrogenase |
| M. ulcerans Agy99 | MUL_3173 | ndh1 | 1e-133 | 63.56% (365) | NADH dehydrogenase Ndh1 |
| M. vanbaalenii PYR-1 | Mvan_5760 | - | 1e-133 | 64.40% (368) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2587|M.marinum_M ---------------MN-----------RKRVVVAGLGDVGVLIAIRLSR
MUL_3173|M.ulcerans_Agy99 ---------------MN-----------RKRVVVAGLGDVVVLIAIRLSR
MAV_3047|M.avium_104 ---------------MN-----------RKRVVVAGLGDVGVLAAIRLSR
Mflv_1066|M.gilvum_PYR-GCK ---------------MTQ----------GRRVVIAGLGDVGVLTAIKLAR
Mvan_5760|M.vanbaalenii_PYR-1 ---------------MS-----------GRRVVIAGMGDVGVLTAIKLAD
MSMEG_6582|M.smegmatis_MC2_155 ---------------MTRTTPVGSAVVTPKRVVIAGLGDAGVLTAIRLAR
Mb1885c|M.bovis_AF2122/97 ---------------MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKR
Rv1854c|M.tuberculosis_H37Rv ---------------MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKR
MLBr_02061|M.leprae_Br4923 ---------------MNAQPAATAAQDRRHQVVIIGSGFGGLNAAKKLKR
MAB_2429c|M.abscessus_ATCC_199 MSTTPDAAGAAAPVAANPQPKIQDALTPKHRVVIIGSGFGGLTAAKTLKR
TH_2218|M.thermoresistible__bu ----------------------------MTSVVIVGSGFAGFECARHLSD
**: * * . * *
MMAR_2587|M.marinum_M ------HCDVVGISAKPALVSGQELGVRLTRPHDWARDYWIAFDKFRRLD
MUL_3173|M.ulcerans_Agy99 ------HCDVVGISAKPALVSGQELGVRLTRPHDWARDYWIAFDKFRRLD
MAV_3047|M.avium_104 ------HADVVGISAKPALVSGQELGVRLSRPHDWARDYWIPFDRFRRLD
Mflv_1066|M.gilvum_PYR-GCK ------HADVVGISAKPGLVSGQELGWRLARPGDWARHNWIPFSRFRGLD
Mvan_5760|M.vanbaalenii_PYR-1 ------HADVIGISAKPGLVSGQELGWRLARPDDWARHNWIPFGRFRGLD
MSMEG_6582|M.smegmatis_MC2_155 ------RHDVVGVSLNPGLVSGQELGVRLARPDDWARDYWISFDRLRALD
Mb1885c|M.bovis_AF2122/97 ------ADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQ
Rv1854c|M.tuberculosis_H37Rv ------ADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQ
MLBr_02061|M.leprae_Br4923 ------ANVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQ
MAB_2429c|M.abscessus_ATCC_199 ------ANADVTLIARTTHHLFQPLLYQVATGIISEGEIAPPTRQILKDQ
TH_2218|M.thermoresistible__bu KLRRQQAPVDITMISPVDYMLYTPLLPDVAGGVVDARFVTVPLANTLRGV
: : * :: .
MMAR_2587|M.marinum_M R-VHTIQAELTGVDLAARSVFVRCDDGTTFAEAYDALVISTGVSNGFWRR
MUL_3173|M.ulcerans_Agy99 R-VHTIQAELTGVDLAARSVFVRCDDGTTFAEAYDALVISTGVSNGFWRR
MAV_3047|M.avium_104 G-VRTVQATLTGVDLAARTVFGRGDDGAPVAEPYDALVICTGVSNGFWRR
Mflv_1066|M.gilvum_PYR-GCK R-VRTVHGTLTAVDLDARTVAVSCADGESTVVPYDVLVIATGVSNGFWRH
Mvan_5760|M.vanbaalenii_PYR-1 K-VRTVHGTLTGVDLTARTVAVTLPDGSSTEVVYDALVVATGVANGFWRQ
MSMEG_6582|M.smegmatis_MC2_155 R-VRTVHGALTGADLDTRTITVTDADGTEHHEPYDALVIATGVTNGFWRR
Mb1885c|M.bovis_AF2122/97 RNVQVLLGNVTHIDLAGQCVVS-ELLGHTYQTPYDSLIVAAGAGQSYFGN
Rv1854c|M.tuberculosis_H37Rv RNVQVLLGNVTHIDLAGQCVVS-ELLGHTYQTPYDSLIVAAGAGQSYFGN
MLBr_02061|M.leprae_Br4923 RNIQVLLGNVTHIDLANQCVVS-ELLGHTYETLYDSLIVAAGAGQSYFGN
MAB_2429c|M.abscessus_ATCC_199 DNAQVVLGDVTSIDLEKQVVHS-SLLGHDYSTPYDSLIVAAGAGQSYFGN
TH_2218|M.thermoresistible__bu R---TARGWVDSVDFDARTVSFTDPEDRTHTVAWDRLVLTPGSVTRLFDI
. . : *: : : . :* *:: .* :
MMAR_2587|M.marinum_M P----------TLQSPADIGAELQAAHHRLAAAAS---------VIVIGG
MUL_3173|M.ulcerans_Agy99 P----------TLQSPADIGAELQAAHHRLAAAAS---------VIAIGG
MAV_3047|M.avium_104 P----------TLQSAAEIGADLRDAHERLAAAGS---------VIVVGG
Mflv_1066|M.gilvum_PYR-GCK P----------GLQTSEQVDADLRNPHERLSAAQS---------VAIVGG
Mvan_5760|M.vanbaalenii_PYR-1 P----------TLQTAAQIGADLHGPHEKLAAARS---------VIVVGG
MSMEG_6582|M.smegmatis_MC2_155 P----------VLQSPDDVHQGLREAHDRLSAATS---------VAVIGG
Mb1885c|M.bovis_AF2122/97 DHFAEFAPGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGA
Rv1854c|M.tuberculosis_H37Rv DHFAEFAPGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGA
MLBr_02061|M.leprae_Br4923 DQFAEFAPGMKSIDDALELRGRILSAFEQAERSNDPERREKLLTFTVVGA
MAB_2429c|M.abscessus_ATCC_199 DHFAEWAPGMKSIDDALELRGRILGAFEQAERSSDPVRRRKLMTFTVVGA
TH_2218|M.thermoresistible__bu PGLAEHARGLKSTAEALYLRDHFLQQLQLSCIDDDPDEIAARRTVVVVGA
. : : . . . :*.
MMAR_2587|M.marinum_M GAAAVSSAVNMATTWPD-------------KRIDLYFPGERPLTAYHPRA
MUL_3173|M.ulcerans_Agy99 GAAAVSSAVNMATTWPD-------------KRIDLYFPGERPLTAYHPRA
MAV_3047|M.avium_104 GAAAVSSALNMARTWPD-------------KRIDLYFPGETALSGHHPRA
Mflv_1066|M.gilvum_PYR-GCK GAAAVSSAAQIATTWPD-------------KRVELYFPGDRALAGHHPRT
Mvan_5760|M.vanbaalenii_PYR-1 GAAAVSSAAQIATTWPD-------------KRVELYFPGERALAGHHPRT
MSMEG_6582|M.smegmatis_MC2_155 GAAAVSSAANLAARWPD-------------KHVGLYHPGNEILPQHHRRT
Mb1885c|M.bovis_AF2122/97 GPTGVEMAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLPPMGAKL
Rv1854c|M.tuberculosis_H37Rv GPTGVEMAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLPPMGAKL
MLBr_02061|M.leprae_Br4923 GPTGVEMAGQIAELADHTLKGAFRRIDSTKARVVLLDAAPAVLPPMGEKL
MAB_2429c|M.abscessus_ATCC_199 GPTGVEMAGQIAELANETLKGTFRHIDPTDARVILLDAAPAVLPPFGPKL
TH_2218|M.thermoresistible__bu SYSGTELVAQLRALADTAAEQMG--FDPAEVRFVLLDLAEQVMPEVGEKL
. :... . :: :. * . :. :
MMAR_2587|M.marinum_M WQRIRGRLTGLGVGLHPGHRAVTPDAFTGDEITNAPVRWTTEQPAAHADA
MUL_3173|M.ulcerans_Agy99 WQRIRGRLTGLGVGLHPGHRAVTPDAFTGDEITNAPVRWTTGQPAAHADA
MAV_3047|M.avium_104 WRRLHARLTRLGVGVHPGHRAVLPDGFAGDELTSRPVQWSTGQPPAAADA
Mflv_1066|M.gilvum_PYR-GCK WKTVRRRLTEAGVVLRPGHRAQLVPGFTGAELTTDPVQWTTGQDPATADV
Mvan_5760|M.vanbaalenii_PYR-1 WTTVRRRLHEAGVVLRPGHRADLEPGFIGDELTTGPVRWSTGQPPSTADA
MSMEG_6582|M.smegmatis_MC2_155 RNRITQRLNALGVDVHPGHRAIVPDGFACDEITDDPVHFSTGQSPAKAEA
Mb1885c|M.bovis_AF2122/97 GQRAAARLQKLGVEIQLGAMVTDVD-RNGITVKDSDGTVRRIESACKVWS
Rv1854c|M.tuberculosis_H37Rv GQRAAARLQKLGVEIQLGAMVTDVD-RNGITVKDSDGTVRRIESACKVWS
MLBr_02061|M.leprae_Br4923 GQRAAARLQKMGVEIQLSAMVTDVD-RNGITVQDSDGTVRRIESACKVWS
MAB_2429c|M.abscessus_ATCC_199 GDKARKRLEKLGVEIQLSAMVTDVD-RNGLTVKHADGSIERIESWCKVWS
TH_2218|M.thermoresistible__bu GTAAMQVLRHRGIDVRLGLTLSEVH-ADHVVLSDG----SRVGTRTVAWL
* *: :: . : .
MMAR_2587|M.marinum_M VLWAIGKVRPNTGWLPEQLLDDHGFVRVTPQLRVPGRRDVFAVGDVAASD
MUL_3173|M.ulcerans_Agy99 VLWAIGKVRPNTGWLPEQLLDDHGFVRVTPQLRVPGRRDVFAVGDVAASD
MAV_3047|M.avium_104 VLWAIGRVRPNTGWLPAELLDERGFVRVTPQLRVPGHPGVFAVGDVAATD
Mflv_1066|M.gilvum_PYR-GCK VLWAIGRVRPNTGWLPGELLDADGFVRVTPQLQVPGRPEVFAVGDVAATD
Mvan_5760|M.vanbaalenii_PYR-1 VLWAIGRVRPNTGWLPTELLDADGFVRVTPTLQVPGHPEVFAVGDVAATD
MSMEG_6582|M.smegmatis_MC2_155 VLWAIGRVTPNTGWLPRAILDDDGFVRVTPRLQVPGVPGVFAVGDVAATD
Mb1885c|M.bovis_AF2122/97 AGVSASWLGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVE
Rv1854c|M.tuberculosis_H37Rv AGVSASRLGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVE
MLBr_02061|M.leprae_Br4923 AGVSASRLGRDLAEQSLVELDWAGRVKVLPDLSIPGYRNVFVVGDMAAID
MAB_2429c|M.abscessus_ATCC_199 AGVSASPLGKNLAEQSGVELDRAGRVKVGPDLSIPGHPNVFVVGDMMAVD
TH_2218|M.thermoresistible__bu TGVTAAPLIETLG-----LPTTKGRLEVDAELRVPDRPDVFAAGDAAAVP
. : . : . * :.* . * :*. **..** *
MMAR_2587|M.marinum_M PLRS---------SAR--NRGDALVANNIRAEFTGK------PLRSYR--
MUL_3173|M.ulcerans_Agy99 PLRS---------SAR--NRGDALVANNIRAEFTGK------PLRSYR--
MAV_3047|M.avium_104 PLRS---------SAR--NRGDALVARNVVAEFTGR------PLRGFR--
Mflv_1066|M.gilvum_PYR-GCK PLRS---------SAR--NRADGLLAGNIRAFFDGK------PLRAYR--
Mvan_5760|M.vanbaalenii_PYR-1 PLRS---------SAR--NRADGLLARNIRAAFAGK------PLREYR--
MSMEG_6582|M.smegmatis_MC2_155 ALRS---------SAR--NRADALVAHNVAAYFTGG------PMRTYR--
Mb1885c|M.bovis_AF2122/97 GVPG---------VAQGAIQGAKYVASTIKAELAGANPAEREPFQYFDKG
Rv1854c|M.tuberculosis_H37Rv GVPG---------VAQGAIQGAKYVASTIKAELAGANPAEREPFQYFDKG
MLBr_02061|M.leprae_Br4923 GVPG---------VAQGAIQGAKYVANNIKAELGEANPAEREPFQYFDKG
MAB_2429c|M.abscessus_ATCC_199 GVPG---------VAQGAIQGGRYAAKQIKAELKGRSPAERAPFKFFDKG
TH_2218|M.thermoresistible__bu DLAQPDPERITPPTAQHATRQGKVLANNVAASLGYG------RMKQYRHR
: *: : * : * : :: :
MMAR_2587|M.marinum_M --APRRRWG---SLLGIQPDGLEVFLP---------------TGHSLRLP
MUL_3173|M.ulcerans_Agy99 --APRRRWG---SLLGIQPDGLEVFLP---------------TGHSLRLP
MAV_3047|M.avium_104 --APRRRWG---SLVGIQPDGLEVFLP---------------SGHTVRFP
Mflv_1066|M.gilvum_PYR-GCK --PPTRRWG---SVLGIQPDGLEVFAP---------------NGRVFRFP
Mvan_5760|M.vanbaalenii_PYR-1 --APKRRWG---SVLGIQPDGLEVFAP---------------NGRAFRFP
MSMEG_6582|M.smegmatis_MC2_155 --PHGRRWG---SVLGPQPDGLDVFAP---------------NGFAFHFP
Mb1885c|M.bovis_AF2122/97 SMATVSRFS---AVAKIGPVEFSGFIAWLIWLVLHLAYLIGFKTKITTLL
Rv1854c|M.tuberculosis_H37Rv SMATVSRFS---AVAKIGPVEFSGFIAWLIWLVLHLAYLIGFKTKITTLL
MLBr_02061|M.leprae_Br4923 SMATVSRFS---AVAKIGPLEFSGFIAWLMWLVLHLMYLIGFKTKITTLL
MAB_2429c|M.abscessus_ATCC_199 SMATVSRYS---AVVKIGKIEFSGFIAWLSWLALHLVYLVGFKNRLVTLI
TH_2218|M.thermoresistible__bu NMGLVVDLGPRYAVANPLNVHLSGFPAKAVARGYHLYAIPRFVNRWAVAL
. :: :. * .
MMAR_2587|M.marinum_M SWSVHRVVMP----VVVRWGMYRGVRKNHPLT------------------
MUL_3173|M.ulcerans_Agy99 SWSVHRVVMP----VVVRWGMYRGVRKNHPLT------------------
MAV_3047|M.avium_104 SWSVQRVVMP----LIVRWGMYGGVRRNDPLGRETATPPTL---------
Mflv_1066|M.gilvum_PYR-GCK AWAFDRVLMP----VIVRWGIYRGVRAGGSRR------------------
Mvan_5760|M.vanbaalenii_PYR-1 VWAFDRVLMP----GIVRWGIYRGVRQDVS--------------------
MSMEG_6582|M.smegmatis_MC2_155 GWSIQRVLQP----WIVRRVIYRGLRDPV---------------------
Mb1885c|M.bovis_AF2122/97 SWTVTFLSTRRGQLTITDQQAFARTRLEQLAELAAEAQGSAASAKVAS--
Rv1854c|M.tuberculosis_H37Rv SWTVTFLSTRRGQLTITDQQAFARTRLEQLAELAAEAQGSAASAKVAS--
MLBr_02061|M.leprae_Br4923 SWTVTFLSTRRGQLTITEQQAFARTRLEQLAELTAESQSTAAANRATMRA
MAB_2429c|M.abscessus_ATCC_199 LWSIAFVTRSRGQMAITEQQAWARTRLDQLEELVAEKNGDEEPTTQPDKE
TH_2218|M.thermoresistible__bu AYLTDALFDR----SVVSIGLSSKEDASFAVSQRIPPPKQPTPGD-----
: : :.
MMAR_2587|M.marinum_M ----
MUL_3173|M.ulcerans_Agy99 ----
MAV_3047|M.avium_104 ----
Mflv_1066|M.gilvum_PYR-GCK ----
Mvan_5760|M.vanbaalenii_PYR-1 ----
MSMEG_6582|M.smegmatis_MC2_155 ----
Mb1885c|M.bovis_AF2122/97 ----
Rv1854c|M.tuberculosis_H37Rv ----
MLBr_02061|M.leprae_Br4923 S---
MAB_2429c|M.abscessus_ATCC_199 KAAS
TH_2218|M.thermoresistible__bu ----