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MNRKRVVVAGLGDVVVLIAIRLSRHCDVVGISAKPALVSGQELGVRLTRPHDWARDYWIAFDKFRRLDRV HTIQAELTGVDLAARSVFVRCDDGTTFAEAYDALVISTGVSNGFWRRPTLQSPADIGAELQAAHHRLAAA ASVIAIGGGAAAVSSAVNMATTWPDKRIDLYFPGERPLTAYHPRAWQRIRGRLTGLGVGLHPGHRAVTPD AFTGDEITNAPVRWTTGQPAAHADAVLWAIGKVRPNTGWLPEQLLDDHGFVRVTPQLRVPGRRDVFAVGD VAASDPLRSSARNRGDALVANNIRAEFTGKPLRSYRAPRRRWGSLLGIQPDGLEVFLPTGHSLRLPSWSV HRVVMPVVVRWGMYRGVRKNHPLT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3173 | ndh1 | - | 100% (374) | NADH dehydrogenase Ndh1 |
| M. ulcerans Agy99 | MUL_3068 | - | 3e-07 | 28.37% (282) | NADH dehydrogenase |
| M. ulcerans Agy99 | MUL_3025 | ndh | 9e-07 | 23.96% (288) | NADH dehydrogenase Ndh |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1885c | ndh | 4e-07 | 24.04% (287) | NADH dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1066 | - | 1e-144 | 67.40% (365) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv1854c | ndh | 4e-07 | 23.96% (288) | NADH dehydrogenase |
| M. leprae Br4923 | MLBr_02061 | - | 9e-07 | 50.00% (54) | putative dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2429c | - | 2e-06 | 23.45% (290) | NADH dehydrogenase (NDH) |
| M. marinum M | MMAR_2587 | ndh1 | 0.0 | 99.20% (374) | NADH dehydrogenase Ndh1 |
| M. avium 104 | MAV_3047 | - | 1e-177 | 79.62% (373) | pyridine nucleotide-disulphide oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_6582 | - | 1e-133 | 63.56% (365) | pyridine nucleotide-disulphide oxidoreductase domain-containing |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_5760 | - | 1e-146 | 66.49% (370) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3173|M.ulcerans_Agy99 ---------------MN-----------RKRVVVAGLGDVVVLIAIRLSR
MMAR_2587|M.marinum_M ---------------MN-----------RKRVVVAGLGDVGVLIAIRLSR
MAV_3047|M.avium_104 ---------------MN-----------RKRVVVAGLGDVGVLAAIRLSR
Mflv_1066|M.gilvum_PYR-GCK ---------------MTQ----------GRRVVIAGLGDVGVLTAIKLAR
Mvan_5760|M.vanbaalenii_PYR-1 ---------------MS-----------GRRVVIAGMGDVGVLTAIKLAD
MSMEG_6582|M.smegmatis_MC2_155 ---------------MTRTTPVGSAVVTPKRVVIAGLGDAGVLTAIRLAR
Mb1885c|M.bovis_AF2122/97 ---------------MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKR
Rv1854c|M.tuberculosis_H37Rv ---------------MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKR
MLBr_02061|M.leprae_Br4923 ---------------MNAQPAATAAQDRRHQVVIIGSGFGGLNAAKKLKR
MAB_2429c|M.abscessus_ATCC_199 MSTTPDAAGAAAPVAANPQPKIQDALTPKHRVVIIGSGFGGLTAAKTLKR
. ::**: * * : * *
MUL_3173|M.ulcerans_Agy99 HCDVVGISAKPALVSGQELGVRLTRPHDWARDYWIAFDKFRRLDR-VHTI
MMAR_2587|M.marinum_M HCDVVGISAKPALVSGQELGVRLTRPHDWARDYWIAFDKFRRLDR-VHTI
MAV_3047|M.avium_104 HADVVGISAKPALVSGQELGVRLSRPHDWARDYWIPFDRFRRLDG-VRTV
Mflv_1066|M.gilvum_PYR-GCK HADVVGISAKPGLVSGQELGWRLARPGDWARHNWIPFSRFRGLDR-VRTV
Mvan_5760|M.vanbaalenii_PYR-1 HADVIGISAKPGLVSGQELGWRLARPDDWARHNWIPFGRFRGLDK-VRTV
MSMEG_6582|M.smegmatis_MC2_155 RHDVVGVSLNPGLVSGQELGVRLARPDDWARDYWISFDRLRALDR-VRTV
Mb1885c|M.bovis_AF2122/97 ADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNVQVL
Rv1854c|M.tuberculosis_H37Rv ADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNVQVL
MLBr_02061|M.leprae_Br4923 ANVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNIQVL
MAB_2429c|M.abscessus_ATCC_199 ANADVTLIARTTHHLFQPLLYQVATGIISEGEIAPPTRQILKDQDNAQVV
: : .. * * ::: . . . : :.:
MUL_3173|M.ulcerans_Agy99 QAELTGVDLAARSVFVRCDDGTTFAEAYDALVISTGVSNGFWRRP-----
MMAR_2587|M.marinum_M QAELTGVDLAARSVFVRCDDGTTFAEAYDALVISTGVSNGFWRRP-----
MAV_3047|M.avium_104 QATLTGVDLAARTVFGRGDDGAPVAEPYDALVICTGVSNGFWRRP-----
Mflv_1066|M.gilvum_PYR-GCK HGTLTAVDLDARTVAVSCADGESTVVPYDVLVIATGVSNGFWRHP-----
Mvan_5760|M.vanbaalenii_PYR-1 HGTLTGVDLTARTVAVTLPDGSSTEVVYDALVVATGVANGFWRQP-----
MSMEG_6582|M.smegmatis_MC2_155 HGALTGADLDTRTITVTDADGTEHHEPYDALVIATGVTNGFWRRP-----
Mb1885c|M.bovis_AF2122/97 LGNVTHIDLAGQCVVS-ELLGHTYQTPYDSLIVAAGAGQSYFGNDHFAEF
Rv1854c|M.tuberculosis_H37Rv LGNVTHIDLAGQCVVS-ELLGHTYQTPYDSLIVAAGAGQSYFGNDHFAEF
MLBr_02061|M.leprae_Br4923 LGNVTHIDLANQCVVS-ELLGHTYETLYDSLIVAAGAGQSYFGNDQFAEF
MAB_2429c|M.abscessus_ATCC_199 LGDVTSIDLEKQVVHS-SLLGHDYSTPYDSLIVAAGAGQSYFGNDHFAEW
. :* ** : : * ** *::.:*. :.:: .
MUL_3173|M.ulcerans_Agy99 -----TLQSPADIGAELQAAHHRLAAAAS---------VIAIGGGAAAVS
MMAR_2587|M.marinum_M -----TLQSPADIGAELQAAHHRLAAAAS---------VIVIGGGAAAVS
MAV_3047|M.avium_104 -----TLQSAAEIGADLRDAHERLAAAGS---------VIVVGGGAAAVS
Mflv_1066|M.gilvum_PYR-GCK -----GLQTSEQVDADLRNPHERLSAAQS---------VAIVGGGAAAVS
Mvan_5760|M.vanbaalenii_PYR-1 -----TLQTAAQIGADLHGPHEKLAAARS---------VIVVGGGAAAVS
MSMEG_6582|M.smegmatis_MC2_155 -----VLQSPDDVHQGLREAHDRLSAATS---------VAVIGGGAAAVS
Mb1885c|M.bovis_AF2122/97 APGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGAGPTGVE
Rv1854c|M.tuberculosis_H37Rv APGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGAGPTGVE
MLBr_02061|M.leprae_Br4923 APGMKSIDDALELRGRILSAFEQAERSNDPERREKLLTFTVVGAGPTGVE
MAB_2429c|M.abscessus_ATCC_199 APGMKSIDDALELRGRILGAFEQAERSSDPVRRRKLMTFTVVGAGPTGVE
:: . :: : ...: : . . :*.*.:.*.
MUL_3173|M.ulcerans_Agy99 SAVNMATTWPD-------------KRIDLYFPGERPLTAYHPRAWQRIRG
MMAR_2587|M.marinum_M SAVNMATTWPD-------------KRIDLYFPGERPLTAYHPRAWQRIRG
MAV_3047|M.avium_104 SALNMARTWPD-------------KRIDLYFPGETALSGHHPRAWRRLHA
Mflv_1066|M.gilvum_PYR-GCK SAAQIATTWPD-------------KRVELYFPGDRALAGHHPRTWKTVRR
Mvan_5760|M.vanbaalenii_PYR-1 SAAQIATTWPD-------------KRVELYFPGERALAGHHPRTWTTVRR
MSMEG_6582|M.smegmatis_MC2_155 SAANLAARWPD-------------KHVGLYHPGNEILPQHHRRTRNRITQ
Mb1885c|M.bovis_AF2122/97 MAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLPPMGAKLGQRAAA
Rv1854c|M.tuberculosis_H37Rv MAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLPPMGAKLGQRAAA
MLBr_02061|M.leprae_Br4923 MAGQIAELADHTLKGAFRRIDSTKARVVLLDAAPAVLPPMGEKLGQRAAA
MAB_2429c|M.abscessus_ATCC_199 MAGQIAELANETLKGTFRHIDPTDARVILLDAAPAVLPPFGPKLGDKARK
* ::* . :: * .. *. :
MUL_3173|M.ulcerans_Agy99 RLTGLGVGLHPGHRAVTPDAFTGDEITNAPVRWTTGQPAAHADAVLWAIG
MMAR_2587|M.marinum_M RLTGLGVGLHPGHRAVTPDAFTGDEITNAPVRWTTEQPAAHADAVLWAIG
MAV_3047|M.avium_104 RLTRLGVGVHPGHRAVLPDGFAGDELTSRPVQWSTGQPPAAADAVLWAIG
Mflv_1066|M.gilvum_PYR-GCK RLTEAGVVLRPGHRAQLVPGFTGAELTTDPVQWTTGQDPATADVVLWAIG
Mvan_5760|M.vanbaalenii_PYR-1 RLHEAGVVLRPGHRADLEPGFIGDELTTGPVRWSTGQPPSTADAVLWAIG
MSMEG_6582|M.smegmatis_MC2_155 RLNALGVDVHPGHRAIVPDGFACDEITDDPVHFSTGQSPAKAEAVLWAIG
Mb1885c|M.bovis_AF2122/97 RLQKLGVEIQLGAMVTDVD-RNGITVKDSDGTVRRIESACKVWSAGVSAS
Rv1854c|M.tuberculosis_H37Rv RLQKLGVEIQLGAMVTDVD-RNGITVKDSDGTVRRIESACKVWSAGVSAS
MLBr_02061|M.leprae_Br4923 RLQKMGVEIQLSAMVTDVD-RNGITVQDSDGTVRRIESACKVWSAGVSAS
MAB_2429c|M.abscessus_ATCC_199 RLEKLGVEIQLSAMVTDVD-RNGLTVKHADGSIERIESWCKVWSAGVSAS
** ** :: . . : : . . . : .
MUL_3173|M.ulcerans_Agy99 KVRPNTGWLPEQLLDDHGFVRVTPQLRVPGRRDVFAVGDVAASDPLRSSA
MMAR_2587|M.marinum_M KVRPNTGWLPEQLLDDHGFVRVTPQLRVPGRRDVFAVGDVAASDPLRSSA
MAV_3047|M.avium_104 RVRPNTGWLPAELLDERGFVRVTPQLRVPGHPGVFAVGDVAATDPLRSSA
Mflv_1066|M.gilvum_PYR-GCK RVRPNTGWLPGELLDADGFVRVTPQLQVPGRPEVFAVGDVAATDPLRSSA
Mvan_5760|M.vanbaalenii_PYR-1 RVRPNTGWLPTELLDADGFVRVTPTLQVPGHPEVFAVGDVAATDPLRSSA
MSMEG_6582|M.smegmatis_MC2_155 RVTPNTGWLPRAILDDDGFVRVTPRLQVPGVPGVFAVGDVAATDALRSSA
Mb1885c|M.bovis_AF2122/97 WLGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVEGVPGVA
Rv1854c|M.tuberculosis_H37Rv RLGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVEGVPGVA
MLBr_02061|M.leprae_Br4923 RLGRDLAEQSLVELDWAGRVKVLPDLSIPGYRNVFVVGDMAAIDGVPGVA
MAB_2429c|M.abscessus_ATCC_199 PLGKNLAEQSGVELDRAGRVKVGPDLSIPGHPNVFVVGDMMAVDGVPGVA
: : . . ** * *:* * * :** **.***: * : : . *
MUL_3173|M.ulcerans_Agy99 R--NRGDALVANNIRAEFTGK------PLRSYR----APRRRWGSLLGIQ
MMAR_2587|M.marinum_M R--NRGDALVANNIRAEFTGK------PLRSYR----APRRRWGSLLGIQ
MAV_3047|M.avium_104 R--NRGDALVARNVVAEFTGR------PLRGFR----APRRRWGSLVGIQ
Mflv_1066|M.gilvum_PYR-GCK R--NRADGLLAGNIRAFFDGK------PLRAYR----PPTRRWGSVLGIQ
Mvan_5760|M.vanbaalenii_PYR-1 R--NRADGLLARNIRAAFAGK------PLREYR----APKRRWGSVLGIQ
MSMEG_6582|M.smegmatis_MC2_155 R--NRADALVAHNVAAYFTGG------PMRTYR----PHGRRWGSVLGPQ
Mb1885c|M.bovis_AF2122/97 QGAIQGAKYVASTIKAELAGANPAEREPFQYFDKGSMATVSRFSAVAKIG
Rv1854c|M.tuberculosis_H37Rv QGAIQGAKYVASTIKAELAGANPAEREPFQYFDKGSMATVSRFSAVAKIG
MLBr_02061|M.leprae_Br4923 QGAIQGAKYVANNIKAELGEANPAEREPFQYFDKGSMATVSRFSAVAKIG
MAB_2429c|M.abscessus_ATCC_199 QGAIQGGRYAAKQIKAELKGRSPAERAPFKFFDKGSMATVSRYSAVVKIG
: :. * : * : *:: : . *:.::
MUL_3173|M.ulcerans_Agy99 PDGLEVFLP---------------TGHSLRLPSWSVHRVVMP----VVVR
MMAR_2587|M.marinum_M PDGLEVFLP---------------TGHSLRLPSWSVHRVVMP----VVVR
MAV_3047|M.avium_104 PDGLEVFLP---------------SGHTVRFPSWSVQRVVMP----LIVR
Mflv_1066|M.gilvum_PYR-GCK PDGLEVFAP---------------NGRVFRFPAWAFDRVLMP----VIVR
Mvan_5760|M.vanbaalenii_PYR-1 PDGLEVFAP---------------NGRAFRFPVWAFDRVLMP----GIVR
MSMEG_6582|M.smegmatis_MC2_155 PDGLDVFAP---------------NGFAFHFPGWSIQRVLQP----WIVR
Mb1885c|M.bovis_AF2122/97 PVEFSGFIAWLIWLVLHLAYLIGFKTKITTLLSWTVTFLSTRRGQLTITD
Rv1854c|M.tuberculosis_H37Rv PVEFSGFIAWLIWLVLHLAYLIGFKTKITTLLSWTVTFLSTRRGQLTITD
MLBr_02061|M.leprae_Br4923 PLEFSGFIAWLMWLVLHLMYLIGFKTKITTLLSWTVTFLSTRRGQLTITE
MAB_2429c|M.abscessus_ATCC_199 KIEFSGFIAWLSWLALHLVYLVGFKNRLVTLILWSIAFVTRSRGQMAITE
:. * . . : *:. : :.
MUL_3173|M.ulcerans_Agy99 WGMYRGVRKNHPLT----------------------
MMAR_2587|M.marinum_M WGMYRGVRKNHPLT----------------------
MAV_3047|M.avium_104 WGMYGGVRRNDPLGRETATPPTL-------------
Mflv_1066|M.gilvum_PYR-GCK WGIYRGVRAGGSRR----------------------
Mvan_5760|M.vanbaalenii_PYR-1 WGIYRGVRQDVS------------------------
MSMEG_6582|M.smegmatis_MC2_155 RVIYRGLRDPV-------------------------
Mb1885c|M.bovis_AF2122/97 QQAFARTRLEQLAELAAEAQGSAASAKVAS------
Rv1854c|M.tuberculosis_H37Rv QQAFARTRLEQLAELAAEAQGSAASAKVAS------
MLBr_02061|M.leprae_Br4923 QQAFARTRLEQLAELTAESQSTAAANRATMRAS---
MAB_2429c|M.abscessus_ATCC_199 QQAWARTRLDQLEELVAEKNGDEEPTTQPDKEKAAS
: *