For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTQGRRVVIAGLGDVGVLTAIKLARHADVVGISAKPGLVSGQELGWRLARPGDWARHNWIPFSRFRGLDR VRTVHGTLTAVDLDARTVAVSCADGESTVVPYDVLVIATGVSNGFWRHPGLQTSEQVDADLRNPHERLSA AQSVAIVGGGAAAVSSAAQIATTWPDKRVELYFPGDRALAGHHPRTWKTVRRRLTEAGVVLRPGHRAQLV PGFTGAELTTDPVQWTTGQDPATADVVLWAIGRVRPNTGWLPGELLDADGFVRVTPQLQVPGRPEVFAVG DVAATDPLRSSARNRADGLLAGNIRAFFDGKPLRAYRPPTRRWGSVLGIQPDGLEVFAPNGRVFRFPAWA FDRVLMPVIVRWGIYRGVRAGGSRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1066 | - | - | 100% (375) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3459 | - | 1e-12 | 26.48% (287) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3348 | - | 5e-10 | 25.74% (338) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0398c | ndhA | 8e-11 | 27.59% (319) | membrane NADH dehydrogenase |
| M. tuberculosis H37Rv | Rv0392c | ndhA | 6e-11 | 26.50% (317) | membrane NADH dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2429c | - | 3e-12 | 25.78% (353) | NADH dehydrogenase (NDH) |
| M. marinum M | MMAR_2587 | ndh1 | 1e-144 | 67.40% (365) | NADH dehydrogenase Ndh1 |
| M. avium 104 | MAV_3047 | - | 1e-150 | 70.14% (365) | pyridine nucleotide-disulphide oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_6582 | - | 1e-137 | 66.58% (365) | pyridine nucleotide-disulphide oxidoreductase domain-containing |
| M. thermoresistible (build 8) | TH_1143 | - | 2e-10 | 27.72% (303) | dehydrogenase |
| M. ulcerans Agy99 | MUL_3173 | ndh1 | 1e-144 | 67.40% (365) | NADH dehydrogenase Ndh1 |
| M. vanbaalenii PYR-1 | Mvan_5760 | - | 0.0 | 84.97% (366) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1066|M.gilvum_PYR-GCK ---------MTQ-------------------------GRRVVIAGLGDVG
Mvan_5760|M.vanbaalenii_PYR-1 ---------MS--------------------------GRRVVIAGMGDVG
MMAR_2587|M.marinum_M ---------MN--------------------------RKRVVVAGLGDVG
MUL_3173|M.ulcerans_Agy99 ---------MN--------------------------RKRVVVAGLGDVV
MAV_3047|M.avium_104 ---------MN--------------------------RKRVVVAGLGDVG
MSMEG_6582|M.smegmatis_MC2_155 ---------MTRTTP---------------VGSAVVTPKRVVIAGLGDAG
Mb0398c|M.bovis_AF2122/97 ---------MTLS---SGEPSAVGG------------RHRVVIIGSGFGG
Rv0392c|M.tuberculosis_H37Rv ---------MTLS---SGEPSAVGG------------RHRVVIIGSGFGG
MAB_2429c|M.abscessus_ATCC_199 ---------MSTTPDAAGAAAPVAANPQPKIQDALTPKHRVVIIGSGFGG
TH_1143|M.thermoresistible__bu VACVTLKVVLSHLRRDRDLKGMTGHNARTPEIGRDTRGPKVVVIGGGYAG
:. :**: * *
Mflv_1066|M.gilvum_PYR-GCK VLTAIKLARHADVVGISAKPGLVSGQELGWRLARPGDWARHNWIPFSR--
Mvan_5760|M.vanbaalenii_PYR-1 VLTAIKLADHADVIGISAKPGLVSGQELGWRLARPDDWARHNWIPFGR--
MMAR_2587|M.marinum_M VLIAIRLSRHCDVVGISAKPALVSGQELGVRLTRPHDWARDYWIAFDK--
MUL_3173|M.ulcerans_Agy99 VLIAIRLSRHCDVVGISAKPALVSGQELGVRLTRPHDWARDYWIAFDK--
MAV_3047|M.avium_104 VLAAIRLSRHADVVGISAKPALVSGQELGVRLSRPHDWARDYWIPFDR--
MSMEG_6582|M.smegmatis_MC2_155 VLTAIRLARRHDVVGVSLNPGLVSGQELGVRLARPDDWARDYWISFDR--
Mb0398c|M.bovis_AF2122/97 LNAAKALKRADVDITLISKTTTHLFQPLLYQVATG-ILSEGDIAPTTRLI
Rv0392c|M.tuberculosis_H37Rv LNAAKALKRADVDITLISKTTTHLFQPLLYQVATG-ILSEGDIAPTTRLI
MAB_2429c|M.abscessus_ATCC_199 LTAAKTLKRANADVTLIARTTHHLFQPLLYQVATG-IISEGEIAPPTRQI
TH_1143|M.thermoresistible__bu TLAANRLQRRADVDITLVNARPTMVQRLQLHRLAAGTADADEVTADYRGL
* * .. * * : . :
Mflv_1066|M.gilvum_PYR-GCK FRGLDRVRTVHGTLTAVDLDARTVAVSCADGESTVVPYDVLVIATGVSNG
Mvan_5760|M.vanbaalenii_PYR-1 FRGLDKVRTVHGTLTGVDLTARTVAVTLPDGSSTEVVYDALVVATGVANG
MMAR_2587|M.marinum_M FRRLDRVHTIQAELTGVDLAARSVFVRCDDGTTFAEAYDALVISTGVSNG
MUL_3173|M.ulcerans_Agy99 FRRLDRVHTIQAELTGVDLAARSVFVRCDDGTTFAEAYDALVISTGVSNG
MAV_3047|M.avium_104 FRRLDGVRTVQATLTGVDLAARTVFGRGDDGAPVAEPYDALVICTGVSNG
MSMEG_6582|M.smegmatis_MC2_155 LRALDRVRTVHGALTGADLDTRTITVTDADGTEHHEPYDALVIATGVTNG
Mb0398c|M.bovis_AF2122/97 LRRQKNVRVLLGEVNAIDLKAQTVTSKLMD-MTTVTPYDSLIVAAGAQQS
Rv0392c|M.tuberculosis_H37Rv LRRQKNVRVLLGEVNAIDLKAQTVTSKLMD-MTTVTPYDSLIVAAGAQQS
MAB_2429c|M.abscessus_ATCC_199 LKDQDNAQVVLGDVTSIDLEKQVVHSSLLG-HDYSTPYDSLIVAAGAGQS
TH_1143|M.thermoresistible__bu LGAR--VRLVVGEATRIDTAARRVQLRSGAPLEYDYLIYAVGSTSAVPES
: .: : . . * : : : :.. :.
Mflv_1066|M.gilvum_PYR-GCK FWRHP----------GLQTSEQVDADLRNPHERLSAAQS---------VA
Mvan_5760|M.vanbaalenii_PYR-1 FWRQP----------TLQTAAQIGADLHGPHEKLAAARS---------VI
MMAR_2587|M.marinum_M FWRRP----------TLQSPADIGAELQAAHHRLAAAAS---------VI
MUL_3173|M.ulcerans_Agy99 FWRRP----------TLQSPADIGAELQAAHHRLAAAAS---------VI
MAV_3047|M.avium_104 FWRRP----------TLQSAAEIGADLRDAHERLAAAGS---------VI
MSMEG_6582|M.smegmatis_MC2_155 FWRRP----------VLQSPDDVHQGLREAHDRLSAATS---------VA
Mb0398c|M.bovis_AF2122/97 YFGNDEFATFAPGMKTIDDALELRGRILGAFEAAEVSTDHAERERRLTFV
Rv0392c|M.tuberculosis_H37Rv YFGNDEFATFAPGMKTIDDALELRGRILGAFEAAEVSTDHAERERRLTFV
MAB_2429c|M.abscessus_ATCC_199 YFGNDHFAEWAPGMKSIDDALELRGRILGAFEQAERSSDPVRRRKLMTFT
TH_1143|M.thermoresistible__bu VPGAAEFA-------YPMADFESAQRLRAVVDELPAQAW---------IT
: : . .
Mflv_1066|M.gilvum_PYR-GCK IVGGGAAAVSSAAQIATTWP-------------DKRVELYFPGDRALAGH
Mvan_5760|M.vanbaalenii_PYR-1 VVGGGAAAVSSAAQIATTWP-------------DKRVELYFPGERALAGH
MMAR_2587|M.marinum_M VIGGGAAAVSSAVNMATTWP-------------DKRIDLYFPGERPLTAY
MUL_3173|M.ulcerans_Agy99 AIGGGAAAVSSAVNMATTWP-------------DKRIDLYFPGERPLTAY
MAV_3047|M.avium_104 VVGGGAAAVSSALNMARTWP-------------DKRIDLYFPGETALSGH
MSMEG_6582|M.smegmatis_MC2_155 VIGGGAAAVSSAANLAARWP-------------DKHVGLYHPGNEILPQH
Mb0398c|M.bovis_AF2122/97 VVGAGPTGVEVAGQIVELAERTLAGAFRTITPSECRVILLDAAPAVLPPM
Rv0392c|M.tuberculosis_H37Rv VVGAGPTGVEVAGQIVELAERTLAGAFRTITPSECRVILLDAAPAVLPPM
MAB_2429c|M.abscessus_ATCC_199 VVGAGPTGVEMAGQIAELANETLKGTFRHIDPTDARVILLDAAPAVLPPF
TH_1143|M.thermoresistible__bu VVGAGLTGIEIAAELAEQDR----------------TVSLVCGGRLAPAF
:*.* :.:. * ::. . .
Mflv_1066|M.gilvum_PYR-GCK HPRTWKTVRRRLTEAGVVLRPGHRAQLVP--GFTGAELTTDPVQWTTGQD
Mvan_5760|M.vanbaalenii_PYR-1 HPRTWTTVRRRLHEAGVVLRPGHRADLEP--GFIGDELTTGPVRWSTGQP
MMAR_2587|M.marinum_M HPRAWQRIRGRLTGLGVGLHPGHRAVTPD--AFTGDEITNAPVRWTTEQP
MUL_3173|M.ulcerans_Agy99 HPRAWQRIRGRLTGLGVGLHPGHRAVTPD--AFTGDEITNAPVRWTTGQP
MAV_3047|M.avium_104 HPRAWRRLHARLTRLGVGVHPGHRAVLPD--GFAGDELTSRPVQWSTGQP
MSMEG_6582|M.smegmatis_MC2_155 HRRTRNRITQRLNALGVDVHPGHRAIVPD--GFACDEITDDPVHFSTGQS
Mb0398c|M.bovis_AF2122/97 GPKLGLKAQRRLEKMDAEVQLNAMVTAVDYKGITIKEKDGGERRIECACK
Rv0392c|M.tuberculosis_H37Rv GPKLGLKAQRRLEKMDVEVQLNAMVTAVDYKGITIKEKDGGERRIECACK
MAB_2429c|M.abscessus_ATCC_199 GPKLGDKARKRLEKLGVEIQLSAMVTDVDRNGLTVKHADGSIERIESWCK
TH_1143|M.thermoresistible__bu GEPARRSIAAWLTAHHVAVLEDDSVVEVR----------PDAVVFADG-A
* . : . .
Mflv_1066|M.gilvum_PYR-GCK PATADVVLWAIGRVRPNTGWLPGELLDADGFVRVTPQLQVPGRPEVFAVG
Mvan_5760|M.vanbaalenii_PYR-1 PSTADAVLWAIGRVRPNTGWLPTELLDADGFVRVTPTLQVPGHPEVFAVG
MMAR_2587|M.marinum_M AAHADAVLWAIGKVRPNTGWLPEQLLDDHGFVRVTPQLRVPGRRDVFAVG
MUL_3173|M.ulcerans_Agy99 AAHADAVLWAIGKVRPNTGWLPEQLLDDHGFVRVTPQLRVPGRRDVFAVG
MAV_3047|M.avium_104 PAAADAVLWAIGRVRPNTGWLPAELLDERGFVRVTPQLRVPGHPGVFAVG
MSMEG_6582|M.smegmatis_MC2_155 PAKAEAVLWAIGRVTPNTGWLPRAILDDDGFVRVTPRLQVPGVPGVFAVG
Mb0398c|M.bovis_AF2122/97 VWAAGVAASPLG--KMIAEGSDGTEIDRAGRVIVEPDLTVKGHPNVFVVG
Rv0392c|M.tuberculosis_H37Rv VWAAGVAASPLG--KMIAEGSDGTEIDRAGRVIVEPDLTVKGHPNVFVVG
MAB_2429c|M.abscessus_ATCC_199 VWSAGVSASPLG--KNLAEQS-GVELDRAGRVKVGPDLSIPGHPNVFVVG
TH_1143|M.thermoresistible__bu VRPSAVTVWAGGFGVPQLAAASGLSTDALGRLRTDDTLTSVDDDRIVGAG
: . . * * * : . * . :. .*
Mflv_1066|M.gilvum_PYR-GCK DVAATDPLRSSAR--NRADGLLAGNIRAFFDGKPLRAYRPPTRRWG--SV
Mvan_5760|M.vanbaalenii_PYR-1 DVAATDPLRSSAR--NRADGLLARNIRAAFAGKPLREYRAPKRRWG--SV
MMAR_2587|M.marinum_M DVAASDPLRSSAR--NRGDALVANNIRAEFTGKPLRSYRAPRRRWG--SL
MUL_3173|M.ulcerans_Agy99 DVAASDPLRSSAR--NRGDALVANNIRAEFTGKPLRSYRAPRRRWG--SL
MAV_3047|M.avium_104 DVAATDPLRSSAR--NRGDALVARNVVAEFTGRPLRGFRAPRRRWG--SL
MSMEG_6582|M.smegmatis_MC2_155 DVAATDALRSSAR--NRADALVAHNVAAYFTGGPMRTYRPHGRRWG--SV
Mb0398c|M.bovis_AF2122/97 DLMFVPGVPGVAQGAIQGARYATTVIKHMVKGNDDPANRKPFHYFNKGSM
Rv0392c|M.tuberculosis_H37Rv DLMFVPGVPGVAQGAIQGARYATTVIKHMVKGNDDPANRKPFHYFNKGSM
MAB_2429c|M.abscessus_ATCC_199 DMMAVDGVPGVAQGAIQGGRYAAKQIKAELKGRS-PAERAPFKFFDKGSM
TH_1143|M.thermoresistible__bu DAVTSSATPLRMS--CYAAAPTAATAADTVLSRLDGAEPAPFALAYVGST
* . : . . *
Mflv_1066|M.gilvum_PYR-GCK LGIQPDGLEVFAPNGRVFRFPAWAFDRVLMPVIVR-----------WGIY
Mvan_5760|M.vanbaalenii_PYR-1 LGIQPDGLEVFAPNGRAFRFPVWAFDRVLMPGIVR-----------WGIY
MMAR_2587|M.marinum_M LGIQPDGLEVFLPTGHSLRLPSWSVHRVVMPVVVR-----------WGMY
MUL_3173|M.ulcerans_Agy99 LGIQPDGLEVFLPTGHSLRLPSWSVHRVVMPVVVR-----------WGMY
MAV_3047|M.avium_104 VGIQPDGLEVFLPSGHTVRFPSWSVQRVVMPLIVR-----------WGMY
MSMEG_6582|M.smegmatis_MC2_155 LGPQPDGLDVFAPNGFAFHFPGWSIQRVLQPWIVR-----------RVIY
Mb0398c|M.bovis_AF2122/97 ATISRHSAVAQVGKLEFAGYFAWLAWLVLHLVYLVGYRNRIAALFAWGIS
Rv0392c|M.tuberculosis_H37Rv ATISRHSAVAQVGKLEFAGYFAWLAWLVLHLVYLVGYRNRIAALFAWGIS
MAB_2429c|M.abscessus_ATCC_199 ATVSRYSAVVKIGKIEFSGFIAWLSWLALHLVYLVGFKNRLVTLILWSIA
TH_1143|M.thermoresistible__bu VGLGRRAAVAQFTRADDSPLRAHLRGRIPALIKDAVVKG-----TLWSIR
. . :
Mflv_1066|M.gilvum_PYR-GCK RGVRAGGSRR---------------------------------------
Mvan_5760|M.vanbaalenii_PYR-1 RGVRQDVS-----------------------------------------
MMAR_2587|M.marinum_M RGVRKNHPLT---------------------------------------
MUL_3173|M.ulcerans_Agy99 RGVRKNHPLT---------------------------------------
MAV_3047|M.avium_104 GGVRRNDPLGRETATPPTL------------------------------
MSMEG_6582|M.smegmatis_MC2_155 RGLRDPV------------------------------------------
Mb0398c|M.bovis_AF2122/97 FMGRARGQMAITSQMIYARLVMTLMEQQAQGALAAAEQAEHAEQEAAG-
Rv0392c|M.tuberculosis_H37Rv FMGRARGQMAITSQMIYARLVMTLMEQQAQGALAAAEQAEHAEQEAAG-
MAB_2429c|M.abscessus_ATCC_199 FVTRSRGQMAITEQQAWARTRLDQLEELVAEKNGDEEPTTQPDKEKAAS
TH_1143|M.thermoresistible__bu REARKPGATIWYRGRRSAAPAPVPEPETVR-------------------
*