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MRPARIVIVGSGFAGFECARRLSKQLKRHRSEAVVTLISPVDYLLYTPLLPEVAGGATDPRFATVPLNDR LPEVQFIRAYVDSVDLSARSLRCRDQENMSHELSWDRLVLTPGSISRLFDIPGLAEHGRGLKSTAQALFL RDHIIEQFELARIDEDRERANARKTVVVVGSSYSGTELIAQLCAMASVAVHDFGFEPGDVRLILVERSGR LMPEIGPALAVRAEHVLKRRGVRFLTGVTLSRVAADHVILSDGTRIGTYTVAWVAGVVASPLITATGLPT EKGRLKVGPDLQVPGFDGVFAGGDAAAVPDVTNPGTITPPTAQHATRQGKILARNVAASLGYGSAREYRH RDLGTVVDLGPGFAVANPLNIPLSGFLAKLVTRAYHLYAIPRNANRWAVALGYLTNVLFGRPLVSIGFAQ PSWAQFSASEEFMTAPTATQPLDEQMYTDDLRFQEASADRASAPGDRARKAT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4433 | - | - | 100% (472) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3457 | - | 4e-33 | 27.51% (418) | DoxD family protein/pyridine nucleotide-disulfide |
| M. smegmatis MC2 155 | MSMEG_3621 | ndh | 4e-32 | 28.42% (461) | NADH dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1885c | ndh | 2e-33 | 30.12% (405) | NADH dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3459 | - | 7e-33 | 27.75% (418) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv1854c | ndh | 2e-33 | 30.12% (405) | NADH dehydrogenase |
| M. leprae Br4923 | MLBr_02061 | - | 5e-34 | 29.70% (404) | putative dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2429c | - | 3e-38 | 30.28% (459) | NADH dehydrogenase (NDH) |
| M. marinum M | MMAR_2728 | ndh | 1e-33 | 30.50% (400) | NADH dehydrogenase Ndh |
| M. avium 104 | MAV_4103 | - | 1e-156 | 64.39% (424) | dehydrogenase |
| M. thermoresistible (build 8) | TH_2218 | - | 1e-150 | 60.27% (438) | dehydrogenase |
| M. ulcerans Agy99 | MUL_3025 | ndh | 7e-34 | 30.50% (400) | NADH dehydrogenase Ndh |
| M. vanbaalenii PYR-1 | Mvan_2953 | - | 3e-34 | 27.79% (421) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2728|M.marinum_M ---------------MSPQPETTAQARPRHRVVIIGSGFGGLNAAKKLKR
MUL_3025|M.ulcerans_Agy99 ---------------MSPQPETTAQARPRHRVVIIGSGFGGLNAAKKLKR
Mb1885c|M.bovis_AF2122/97 ---------------MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKR
Rv1854c|M.tuberculosis_H37Rv ---------------MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKR
MLBr_02061|M.leprae_Br4923 ---------------MNAQPAATAAQDRRHQVVIIGSGFGGLNAAKKLKR
MAB_2429c|M.abscessus_ATCC_199 MSTTPDAAGAAAPVAANPQPKIQDALTPKHRVVIIGSGFGGLTAAKTLKR
Mflv_3459|M.gilvum_PYR-GCK ------------------------MSAARPRVVIIGGGFGGLFCARRLAR
Mvan_2953|M.vanbaalenii_PYR-1 ------------------------MVGRRLRVVIIGGGFGGLFCARRLAR
MAV_4103|M.avium_104 --------------------------------MIVGSGFTGFTCARRLAK
TH_2218|M.thermoresistible__bu ----------------------------MTSVVIVGSGFAGFECARHLSD
MSMEG_4433|M.smegmatis_MC2_155 --------------------------MRPARIVIVGSGFAGFECARRLSK
:*:*.** *: .*: *
MMAR_2728|M.marinum_M ------ADVDIKLIARTTHHLFQPLLYQVATGIISEGDIAPPTRVVLRRQ
MUL_3025|M.ulcerans_Agy99 ------ADVDIKLIARTTHHLFQPLLYQVATGIISEGDIAPPTRVVLRRQ
Mb1885c|M.bovis_AF2122/97 ------ADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQ
Rv1854c|M.tuberculosis_H37Rv ------ADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQ
MLBr_02061|M.leprae_Br4923 ------ANVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQ
MAB_2429c|M.abscessus_ATCC_199 ------ANADVTLIARTTHHLFQPLLYQVATGIISEGEIAPPTRQILKDQ
Mflv_3459|M.gilvum_PYR-GCK ------VDVDVTLLDRAACHVFQPLLYQCATGTLSIGQISRSLREELEHH
Mvan_2953|M.vanbaalenii_PYR-1 ------ADVDVTVLDRTAGHLFQPLLYQCATGTLSIGHISRPLREEFAGH
MAV_4103|M.avium_104 TLRR--APVDITMISPVDYMLYTPLLPDVAGGVVDARFVAVPLANSLR--
TH_2218|M.thermoresistible__bu KLRRQQAPVDITMISPVDYMLYTPLLPDVAGGVVDARFVTVPLANTLR--
MSMEG_4433|M.smegmatis_MC2_155 QLKRHRSEAVVTLISPVDYLLYTPLLPEVAGGATDPRFATVPLNDRLP--
. :.:: . :: *** : * * . : . :
MMAR_2728|M.marinum_M RNAQVLLGNVTHIDLAKQSVVSDLLG-HTYETPYDTLIVAAGAGQSYFGN
MUL_3025|M.ulcerans_Agy99 RNAQVLLGNVTHIDLAKQSVVSDLLG-HTYETPYDTLIVAAGAGQSYFGN
Mb1885c|M.bovis_AF2122/97 RNVQVLLGNVTHIDLAGQCVVSELLG-HTYQTPYDSLIVAAGAGQSYFGN
Rv1854c|M.tuberculosis_H37Rv RNVQVLLGNVTHIDLAGQCVVSELLG-HTYQTPYDSLIVAAGAGQSYFGN
MLBr_02061|M.leprae_Br4923 RNIQVLLGNVTHIDLANQCVVSELLG-HTYETLYDSLIVAAGAGQSYFGN
MAB_2429c|M.abscessus_ATCC_199 DNAQVVLGDVTSIDLEKQVVHSSLLG-HDYSTPYDSLIVAAGAGQSYFGN
Mflv_3459|M.gilvum_PYR-GCK ENVRTLLGEAIRLDPAGRRVTARRPDDSTFDLDYDYLVIAAGMRQSYFGN
Mvan_2953|M.vanbaalenii_PYR-1 PNITTLLGEAVALDPERRTVTALRPDETTFTIDYDVLVVAAGMQQSYFGK
MAV_4103|M.avium_104 -GMHAVRGRVDAVDFTGRTLTYRDPEERSHSMSWDRLVLTPGSVTKLFDV
TH_2218|M.thermoresistible__bu -GVRTARGWVDSVDFDARTVSFTDPEDRTHTVAWDRLVLTPGSVTRLFDI
MSMEG_4433|M.smegmatis_MC2_155 -EVQFIRAYVDSVDLSARSLRCRDQENMSHELSWDRLVLTPGSISRLFDI
. . :* : : . :* *:::.* *.
MMAR_2728|M.marinum_M DHFAEFAPGMKSIDDALELRGRILSAFEQAERSRDAERRAKLLTFTVVGA
MUL_3025|M.ulcerans_Agy99 DHFAEFAPGMKSIDDALELRGRILSAFEQAERSRDAERRAKLLTFTVVGA
Mb1885c|M.bovis_AF2122/97 DHFAEFAPGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGA
Rv1854c|M.tuberculosis_H37Rv DHFAEFAPGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGA
MLBr_02061|M.leprae_Br4923 DQFAEFAPGMKSIDDALELRGRILSAFEQAERSNDPERREKLLTFTVVGA
MAB_2429c|M.abscessus_ATCC_199 DHFAEWAPGMKSIDDALELRGRILGAFEQAERSSDPVRRRKLMTFTVVGA
Mflv_3459|M.gilvum_PYR-GCK EDFAAWAPGMKTLDDALSIRRRVFAAFEIAETLPPGPERDQWLTFAVTGA
Mvan_2953|M.vanbaalenii_PYR-1 PHFAQWAPGMKTLDDALSIRQRIFTAFEIAETLPPGAERDAWLTFAVTGG
MAV_4103|M.avium_104 PGLARHARGLKTTAEALYLRDHFVEQLELANIEDDPRVAAARRTVVVVGA
TH_2218|M.thermoresistible__bu PGLAEHARGLKSTAEALYLRDHFLQQLQLSCIDDDPDEIAARRTVVVVGA
MSMEG_4433|M.smegmatis_MC2_155 PGLAEHGRGLKSTAQALFLRDHIIEQFELARIDEDRERANARKTVVVVGS
:* . *:*: :** :* :.. :: : *..*.*.
MMAR_2728|M.marinum_M GPTGVEMAGQIAELAEHTLKGAFRHIDSTRARVILLDAAPAVLPPFGDKL
MUL_3025|M.ulcerans_Agy99 GPTGVEMAGQIAELAEHTLKGAFRHIDSTRARVILLDAAPAVLPPFGDKL
Mb1885c|M.bovis_AF2122/97 GPTGVEMAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLPPMGAKL
Rv1854c|M.tuberculosis_H37Rv GPTGVEMAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLPPMGAKL
MLBr_02061|M.leprae_Br4923 GPTGVEMAGQIAELADHTLKGAFRRIDSTKARVVLLDAAPAVLPPMGEKL
MAB_2429c|M.abscessus_ATCC_199 GPTGVEMAGQIAELANETLKGTFRHIDPTDARVILLDAAPAVLPPFGPKL
Mflv_3459|M.gilvum_PYR-GCK GPTGVELAGQIRELATRALANQFHSIEPEDARVLLFDGGDRVLKTFAPDL
Mvan_2953|M.vanbaalenii_PYR-1 GPTGVELAGQIREMATRTLTNEFHSIEPEEARVLLFDGGDRVLKSFAPEL
MAV_4103|M.avium_104 SYSGTELVAQLRALADAAARQMG--FDPGAVRFLLLDLAEQVMPEVGKKL
TH_2218|M.thermoresistible__bu SYSGTELVAQLRALADTAAEQMG--FDPAEVRFVLLDLAEQVMPEVGEKL
MSMEG_4433|M.smegmatis_MC2_155 SYSGTELIAQLCAMASVAVHDFG--FEPGDVRLILVERSGRLMPEIGPAL
. :*.*: .*: :* : ::. .*.:*.: . :: .. *
MMAR_2728|M.marinum_M GERAAARLQKLGVEIQLGAMVTDVDRNGITVKDSDG-TIRRIESACKVWS
MUL_3025|M.ulcerans_Agy99 GERAAARLQKLGVEIQLGAMVTDVDRNGITVKDSDG-TIRRIESACKVWS
Mb1885c|M.bovis_AF2122/97 GQRAAARLQKLGVEIQLGAMVTDVDRNGITVKDSDG-TVRRIESACKVWS
Rv1854c|M.tuberculosis_H37Rv GQRAAARLQKLGVEIQLGAMVTDVDRNGITVKDSDG-TVRRIESACKVWS
MLBr_02061|M.leprae_Br4923 GQRAAARLQKMGVEIQLSAMVTDVDRNGITVQDSDG-TVRRIESACKVWS
MAB_2429c|M.abscessus_ATCC_199 GDKARKRLEKLGVEIQLSAMVTDVDRNGLTVKHADG-SIERIESWCKVWS
Mflv_3459|M.gilvum_PYR-GCK SARAQRVLEDLGVEMRFGVRVSDVRRDGITVSPKDGSPDADVATRTVLWT
Mvan_2953|M.vanbaalenii_PYR-1 SGRAAGTLRSLGVDVRLGVHVTDVQREGVTVAPKSGGSEEYYAVRTVLWT
MAV_4103|M.avium_104 GDAALKVLRRRGIDVRLGTTLKEAHADHVVLSDGSR-----IDTHTIAWV
TH_2218|M.thermoresistible__bu GTAAMQVLRHRGIDVRLGLTLSEVHADHVVLSDGSR-----VGTRTVAWL
MSMEG_4433|M.smegmatis_MC2_155 AVRAEHVLKRRGVRFLTGVTLSRVAADHVILSDGTR-----IGTYTVAWV
. * *. *: . . :. . : : : *
MMAR_2728|M.marinum_M AGVQASRLGRDLAEQSEVELDRAGRVQVLPDLSVPGHPNVFVIGDMAAV-
MUL_3025|M.ulcerans_Agy99 AGVQASRLGRDLAEQSEVELDRAGRVQVLPDLSVPGHPNVFVIGDMAAV-
Mb1885c|M.bovis_AF2122/97 AGVSASWLGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAV-
Rv1854c|M.tuberculosis_H37Rv AGVSASRLGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAV-
MLBr_02061|M.leprae_Br4923 AGVSASRLGRDLAEQSLVELDWAGRVKVLPDLSIPGYRNVFVVGDMAAI-
MAB_2429c|M.abscessus_ATCC_199 AGVSASPLGKNLAEQSGVELDRAGRVKVGPDLSIPGHPNVFVVGDMMAV-
Mflv_3459|M.gilvum_PYR-GCK AGVEAVPFARHAAEVLGATTDRSGRIAVDADLSVPNHREVFVIGDLAGR-
Mvan_2953|M.vanbaalenii_PYR-1 AGVEAVPFAGHLAEVLDVQADRAGRLAVQPDLSVPGHPEIFVIGDLVGR-
MAV_4103|M.avium_104 TGVTGAPLIQDLG-----LPTEKGRLKVQPDLQVPGHPGVFAAGDAAAVP
TH_2218|M.thermoresistible__bu TGVTAAPLIETLG-----LPTTKGRLEVDAELRVPDRPDVFAAGDAAAVP
MSMEG_4433|M.smegmatis_MC2_155 AGVVASPLITATG-----LPTEKGRLKVGPDLQVPGFDGVFAGGDAAAVP
:** . : . **: * .:* :*. :*. ** .
MMAR_2728|M.marinum_M --------EGVPGVAQGAIQGAKYVATTIKSELAGANAAEREPFQYFDKG
MUL_3025|M.ulcerans_Agy99 --------EGVPGVAQGAIQGAKYVATTIKSELAGANAAEREPFQYFDKG
Mb1885c|M.bovis_AF2122/97 --------EGVPGVAQGAIQGAKYVASTIKAELAGANPAEREPFQYFDKG
Rv1854c|M.tuberculosis_H37Rv --------EGVPGVAQGAIQGAKYVASTIKAELAGANPAEREPFQYFDKG
MLBr_02061|M.leprae_Br4923 --------DGVPGVAQGAIQGAKYVANNIKAELGEANPAEREPFQYFDKG
MAB_2429c|M.abscessus_ATCC_199 --------DGVPGVAQGAIQGGRYAAKQIKAELKGRSPAERAPFKFFDKG
Mflv_3459|M.gilvum_PYR-GCK --------DGLPGVAENAMQGGMHAAACMRRDLQGK---RRKNFRYRDLG
Mvan_2953|M.vanbaalenii_PYR-1 --------DDLPGVAENAMQGGLHVAACIRRDLAGR---PRRNYRYRDLG
MAV_4103|M.avium_104 DLTQPG--KITPPTAQHATRQGKVLARNVAASLGHG---SAKEYKHRNLG
TH_2218|M.thermoresistible__bu DLAQPDPERITPPTAQHATRQGKVLANNVAASLGYG---RMKQYRHRNMG
MSMEG_4433|M.smegmatis_MC2_155 DVTNPG--TITPPTAQHATRQGKILARNVAASLGYG---SAREYRHRDLG
* .*: * : . * : .* ::. : *
MMAR_2728|M.marinum_M SMATVSRFSAVAKIGPVEISGFIAWLAWLVLHLVYLVGFKTKVSTLLSWT
MUL_3025|M.ulcerans_Agy99 SMATVSRFSAVAKIGPVEISGFIAWLAWLVLHLVYLVGFKTKVSTLLSWT
Mb1885c|M.bovis_AF2122/97 SMATVSRFSAVAKIGPVEFSGFIAWLIWLVLHLAYLIGFKTKITTLLSWT
Rv1854c|M.tuberculosis_H37Rv SMATVSRFSAVAKIGPVEFSGFIAWLIWLVLHLAYLIGFKTKITTLLSWT
MLBr_02061|M.leprae_Br4923 SMATVSRFSAVAKIGPLEFSGFIAWLMWLVLHLMYLIGFKTKITTLLSWT
MAB_2429c|M.abscessus_ATCC_199 SMATVSRYSAVVKIGKIEFSGFIAWLSWLALHLVYLVGFKNRLVTLILWS
Mflv_3459|M.gilvum_PYR-GCK SAAYISRGHALMQLGPVKLSGLSGWIGWGFIHIAFLTGVRNRFSTVGTWL
Mvan_2953|M.vanbaalenii_PYR-1 SAAYISRGNALLQVGPVKVAGFLGWIAWGLLHIAFLTGVRNRVSTVVTWL
MAV_4103|M.avium_104 LVVDLGPRYAVANPLNIHLSGLPAKAVTRGYHLYAIPRGVNRWAVSLAYL
TH_2218|M.thermoresistible__bu LVVDLGPRYAVANPLNVHLSGFPAKAVARGYHLYAIPRFVNRWAVALAYL
MSMEG_4433|M.smegmatis_MC2_155 TVVDLGPGFAVANPLNIPLSGFLAKLVTRAYHLYAIPRNANRWAVALGYL
. :. *: : : .:*: . *: : .: . :
MMAR_2728|M.marinum_M VTFLSTRR-------GQLTITEQQAFARTR--------------LEQLAE
MUL_3025|M.ulcerans_Agy99 VTFLSTRR-------GQLTITEQQAFARTR--------------LEQLAE
Mb1885c|M.bovis_AF2122/97 VTFLSTRR-------GQLTITDQQAFARTR--------------LEQLAE
Rv1854c|M.tuberculosis_H37Rv VTFLSTRR-------GQLTITDQQAFARTR--------------LEQLAE
MLBr_02061|M.leprae_Br4923 VTFLSTRR-------GQLTITEQQAFARTR--------------LEQLAE
MAB_2429c|M.abscessus_ATCC_199 IAFVTRSR-------GQMAITEQQAWARTR--------------LDQLEE
Mflv_3459|M.gilvum_PYR-GCK ATIARSNRSDRTFILGGSGHPEEPYTWES------------------PVH
Mvan_2953|M.vanbaalenii_PYR-1 ATIARASRYHRAFMLGSVSAPEARYTWSSRDQPTPPQALCEDPRTGHTSH
MAV_4103|M.avium_104 TDALFARS---VVSIGLSSEDDAQFTASEG----------------IPMP
TH_2218|M.thermoresistible__bu TDALFDRS---VVSIGLSSKEDASFAVSQR----------------IPPP
MSMEG_4433|M.smegmatis_MC2_155 TNVLFGRP---LVSIGFAQPSWAQFSASEEF---------------MTAP
*
MMAR_2728|M.marinum_M LASEAQST----------------------EARQAS--------------
MUL_3025|M.ulcerans_Agy99 LASEAQST----------------------EARQAS--------------
Mb1885c|M.bovis_AF2122/97 LAAEAQGS----------------------AASAKVAS------------
Rv1854c|M.tuberculosis_H37Rv LAAEAQGS----------------------AASAKVAS------------
MLBr_02061|M.leprae_Br4923 LTAESQST----------------------AAANRATMRAS---------
MAB_2429c|M.abscessus_ATCC_199 LVAEKNGD----------------------EEPTTQPDKEKAAS------
Mflv_3459|M.gilvum_PYR-GCK QGGSSRDN----------------------SGEDKTA-------------
Mvan_2953|M.vanbaalenii_PYR-1 MTISAQDVRRLLDAEHDSTLVLIEGRTEVITGQQKSSDQYRGAFEVISRD
MAV_4103|M.avium_104 KTG-----------------------------------------------
TH_2218|M.thermoresistible__bu KQPTPGD-------------------------------------------
MSMEG_4433|M.smegmatis_MC2_155 TATQPLDEQMYTDDLR-----------FQEASADRASAPGDRARKAT---
MMAR_2728|M.marinum_M ---------------------------------
MUL_3025|M.ulcerans_Agy99 ---------------------------------
Mb1885c|M.bovis_AF2122/97 ---------------------------------
Rv1854c|M.tuberculosis_H37Rv ---------------------------------
MLBr_02061|M.leprae_Br4923 ---------------------------------
MAB_2429c|M.abscessus_ATCC_199 ---------------------------------
Mflv_3459|M.gilvum_PYR-GCK ---------------------------------
Mvan_2953|M.vanbaalenii_PYR-1 ELLSRTGGAAHLTDDQISAQAAALDTAVNELGG
MAV_4103|M.avium_104 ---------------------------------
TH_2218|M.thermoresistible__bu ---------------------------------
MSMEG_4433|M.smegmatis_MC2_155 ---------------------------------