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VSKRPLYFSAFVMNTASHVLHGLWRAPEAQNHRFNELKHWTSVATSVENAGFDLLFFADVFGLRSPWNGN WRKAVEGGIQIPVNDPSVLASALAAATDNLGIVFTSSIVQDHPFNFARRMSSLDHYTDGRLGWNIVTSFN ANVYRSFGHEDVLAHDQRYEWANEYVEVAYKLWEGSWDEDGLVQDKERSIHADPTKIHKINHVGKRFKVE GPHFVSPSPQRTPVLFQAGSSPAGQLFSARHAEGVYISSPSPEAAHGLTTESRALAAANGRDPEDITFAQ GLSFVIGETHRDAVKREDEIKRYLDLEGVALHALGDAGVDAGHLSLDTPISQLGEFKGVQSFKRWAAEHS GNDDPTIRDMAWVLEGANRVVGTAEEIADRLEEWREAGVDGVNVYHATVPGSFLEVSQRLFPTLRERGLI SNDKSGTLRHKLFGRGDRLPGTHPAARYRGAFGDNDLLDGVEEPIAARS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5810 | - | - | 100% (469) | putative monooxygenase |
| M. smegmatis MC2 155 | MSMEG_4083 | - | e-133 | 52.32% (453) | putative monooxygenase |
| M. smegmatis MC2 155 | MSMEG_2841 | - | e-130 | 49.67% (461) | putative monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_1269 | - | 1e-100 | 42.00% (450) | putative monooxygenase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3401 | - | 8e-97 | 41.91% (451) | putative monooxygenase |
| M. marinum M | MMAR_0703 | - | 2e-42 | 29.11% (426) | FMNH2-utilizing oxygenase |
| M. avium 104 | MAV_4059 | - | 2e-93 | 40.58% (451) | monoxygenase |
| M. thermoresistible (build 8) | TH_4268 | - | 2e-97 | 41.40% (442) | PUTATIVE putative monooxygenase |
| M. ulcerans Agy99 | MUL_4507 | fgd2 | 7e-07 | 23.13% (281) | F420-dependent glucose-6-phosphate dehydrogenase Fgd2 |
| M. vanbaalenii PYR-1 | Mvan_3887 | - | 0.0 | 83.51% (467) | putative monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5810|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 MTLTSPAAASAGDLPARPGLRTVAAGSMIGTTIEWYDFYLYATASALVFK
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4507|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5810|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 PLFFPNISPSAGTLASFATYAAGFGARPLGAVLSGHFGDRLGRKTVLVAA
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4507|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5810|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 LLVMGLVTTAIGALPTYAEAGLAAPALLASLRVVQGLAVGAEWGGAAVLS
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4507|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5810|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 VEHAPPGRRGLFGSFTQLGSPAGMLLATSVFFGVRKATGPAAFLGFGWRI
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4507|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5810|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 PFLLSIFLVAVGLFVRLRLTDAEVFDRLRSRDELARLPIVQVLRTDARNV
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4507|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5810|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 VITTGLRLSQIGLFVLLTTYSLSYLQDSFGKGSGVGLVAVLISSALGFLS
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4507|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5810|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 TPGWALLSDRVGRRPPYLFGALASVVALVLFFVAAGTGSAVLVVVAIVFG
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4507|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5810|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 VNVVHDAMYGPQAAWFAELFDTRVRYSGSSLGYHIGAVLSGGFAPLIAAS
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4507|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5810|M.smegmatis_MC2_155 ----------------------------------------MSKRPLYFSA
Mvan_3887|M.vanbaalenii_PYR-1 ----------------------------------------MTKRPLYYSA
Mflv_1269|M.gilvum_PYR-GCK ----------------------------------MYSIQGMTQR-MIFTL
MAB_3401|M.abscessus_ATCC_1997 -----------------------------------------MTRVIRFNA
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 LLVAGGGRPWLIVGYFAVLAAITVGAACAGPGDARGADRMSAARRIYLNA
MMAR_0703|M.marinum_M ----------------------------------------MIRKPVHLAA
MUL_4507|M.ulcerans_Agy99 ------------------------------------------MALLFHWF
MSMEG_5810|M.smegmatis_MC2_155 FVMNTASHVLHGLWRAPEAQNHRFNELKHWTSVATSVENAGFDLLFFADV
Mvan_3887|M.vanbaalenii_PYR-1 FVMNTASHVLHGLWRAPDAQNHRFNSLRHWTSLAAEVDKAGYDVLFFADV
Mflv_1269|M.gilvum_PYR-GCK LVMDSIGHNFHGSWRHPAARNREFKGFDMWVDLARKAEQAKVDAFFFTDV
MAB_3401|M.abscessus_ATCC_1997 FDMNCVAHQSPGLWRHPDDQSWRYKDLSYWTNLATLLERGRFDGLFIADV
TH_4268|M.thermoresistible__bu --MNCVAHQSPGLWKHPEDQSWRYKDLEYWTELARLLERGRFDGLFIADV
MAV_4059|M.avium_104 FDMACVGHQSAGLWRHPDDQGHRYRELSYWTELARTLEAGGFDALFLADV
MMAR_0703|M.marinum_M HFP---GVNNTTVWADPGAG--SQIEFESFVHLARTAERGLFDFFFLAEG
MUL_4507|M.ulcerans_Agy99 LPTYGDSRGLVAGGHGLPMSGNRPATLRYLNQIAAAAESNGFEAVLTP--
. : :* : : .: .
MSMEG_5810|M.smegmatis_MC2_155 FGLRSPWNGNWRKAVEGGIQIPVNDPSVLASALAAATDNLGIVFTSSIVQ
Mvan_3887|M.vanbaalenii_PYR-1 FGLRAPWNGNWRKAVEGGIQVPVNDPSVLASAIAAATENLGIVFTSSIVQ
Mflv_1269|M.gilvum_PYR-GCK MGVQGEYNGKRDIVFEMAMNVPIGDCTMLIPALAQQTRDLGFLYTSSVIS
MAB_3401|M.abscessus_ATCC_1997 LGTYDIYGASDEAAIRQAAQIPVADPLLLVSAMALVTEHLGFGVTTGTGF
TH_4268|M.thermoresistible__bu LGTYDVYGAGDEAAIRQAAQIPVNDPMMLVSAMALVTEHLGFGITTGTGF
MAV_4059|M.avium_104 LGVYDIYGASRDAAVVDAAQFPVNEPSAAVSAMAAVTETLGFGITLSLTY
MMAR_0703|M.marinum_M LRLREHRG-----RIHDLDVVGRPDTFTLLAALAGVTDRIGLTGTINTTF
MUL_4507|M.ulcerans_Agy99 ------------------AGLWCEDAWLTTAMLVGTTKTLKFLVALRPGL
. : . :. * : : :
MSMEG_5810|M.smegmatis_MC2_155 DHPFNFARRMSSLDHYTDGRLGWNIVTSFNANVYRSFGHEDVLAHDQRYE
Mvan_3887|M.vanbaalenii_PYR-1 DHPFNFARRMSSLDHYTDGRLGWNIVTSFNANMFRSFGHEGTLAHDQRYE
Mflv_1269|M.gilvum_PYR-GCK HHPFVFARAASTLDNLSNGRIGWNIVTSANEKAFRNLGLPGNLSHDERYV
MAB_3401|M.abscessus_ATCC_1997 EHPYPFARRLSTLDHLTGGRVGWNVVTGYLPAAARNMGQTDQPAHDARYD
TH_4268|M.thermoresistible__bu EHPYPFARRMSTLDHLTKGRIGWNVVTGYLPAAARNMGQSDQPAHDARYD
MAV_4059|M.avium_104 EQPYALARRLSTLDHLTGGRVAWNIVTSYLDSAARNLGLDAQIPHDQRYE
MMAR_0703|M.marinum_M NEPFEVARQFATLDHLSEGRAGWNIVTSSDAFTGANFRRGGYLDHADRYQ
MUL_4507|M.ulcerans_Agy99 VSPTLAAQMATTFQQQSGGRLLVNVVTGGEAHEQRAYG--DFLDKQQRYR
* *: ::::: : ** *:**. : **
MSMEG_5810|M.smegmatis_MC2_155 WANEYVEVAYKLWEGSWDEDGLVQDKERSIHADPTKIHKINHVGKRFKVE
Mvan_3887|M.vanbaalenii_PYR-1 WANEYVDVTYKLWEGSWDDDALVQDKERSVHSDPSKIHKINHVGRRYTVE
Mflv_1269|M.gilvum_PYR-GCK WAQEYVDVTYKLWEGSWDVDAIVDDPASGVYADPSKVHDINHKGARYSVE
MAB_3401|M.abscessus_ATCC_1997 HADEYLEVLYKLWEGSWEDDAVVRDAARGVFTDPDKVHHIGHEGTHFTVP
TH_4268|M.thermoresistible__bu HADEYLEVLYKLWEGSWEDDAVIRDRERGVFTDPDKVHHIGHRGRHFSVP
MAV_4059|M.avium_104 IADEYLEVCYKLWEGSWEAGAVLRDRQRGVFTDPAKVHDIEHKGRYFSVP
MMAR_0703|M.marinum_M RAEEFLTVARKFWD-SWAPGAVLADIENGDYVDPERIRSVEHSGPQFEVR
MUL_4507|M.ulcerans_Agy99 RTGEFLHVVRQLWASGQP---------------------VTFEGEHIHVH
: *:: * ::* . : . * *
MSMEG_5810|M.smegmatis_MC2_155 GPHFVSPSPQRTPVLFQAGSSPAGQLFSARHAEGVYISSPSPEAAHGLTT
Mvan_3887|M.vanbaalenii_PYR-1 GPHFTSPSPQRTPVLFQAGSSPAGQLFSARNAEGVYISSPTPADAHKLTG
Mflv_1269|M.gilvum_PYR-GCK GFNLMEPSPQRTPVLAQAGGSPAGLAFAGKHAELMFLSAYSLETIAAQVG
MAB_3401|M.abscessus_ATCC_1997 GVHLVEPSPQRTPVIYQAGSSPRGVRFAAENAEAVFTAAPTKELLRQTVT
TH_4268|M.thermoresistible__bu GVHLSEPSPQRTPVIYQAGSSPRGVRFAAENAEAIFTASPTKEILRRTVS
MAV_4059|M.avium_104 GPFLCEPSPQRTPVLFQAGASPRGIRFAAAHAEAVFVSGPTAQVVREPVR
MMAR_0703|M.marinum_M GFATLPAGPQGHPVLLQAGDSEQGRAFGARHADAMFTLHSSLRDGQRYYA
MUL_4507|M.ulcerans_Agy99 QAQLG-RLPDPPPPVFFGGSSESAGAVAARYADTYLTWGEPLSAVGKKID
*: * : .* * . ... *: .
MSMEG_5810|M.smegmatis_MC2_155 ESRALAAANGRDPEDITFAQGLSFVIGETHRDAVKREDEIKRYLDL-EGV
Mvan_3887|M.vanbaalenii_PYR-1 ETRALAAANGRDPQDITFAQGLSFVIGDTHAEAVRRNDELKRYLDV-EGV
Mflv_1269|M.gilvum_PYR-GCK AVREQARTNGRRDGDILFLQGMMFVIGSTDEEAYRKWGELEEWRSP-EAQ
MAB_3401|M.abscessus_ATCC_1997 TIRRELELAGRDPYSAKIFNLTTVVTGENSEAAHAKHAELLGYGSA-EGA
TH_4268|M.thermoresistible__bu TIRQELEIAGRDPYSVKIFNLTTIITAETDEEAHARHAEYLAYGDP-EGA
MAV_4059|M.avium_104 ALRTAAAQLGRDPRAVKVFTMVTPVVAETHDAAVAKLAEYRRFVSP-RGA
MMAR_0703|M.marinum_M DVKGRARSYGRDPDQLKVFPAATFVIGDTPDQAGEKARQISYQQVSGATA
MUL_4507|M.ulcerans_Agy99 WIRGLAADHGR---ALSYGLRIHVITRDTAEEAWRVADRLLAGIDP----
: ** : .. * .
MSMEG_5810|M.smegmatis_MC2_155 ALHALGDAGVDAGHLSLDTPIS-QLGEFKGVQ-----------SFKRWAA
Mvan_3887|M.vanbaalenii_PYR-1 ALHALGDAGIDAGNLPLDTPIS-ALGEFTGIQ-----------SFSRWAA
Mflv_1269|M.gilvum_PYR-GCK TAYFSSLSGMDLGRYDPGTPLENILDEIPGIQG----------AFLAVIN
MAB_3401|M.abscessus_ATCC_1997 LVFMSGWMGVDLARYGLDEPIG--NVDSNAILS----------AVAAFQA
TH_4268|M.thermoresistible__bu LTFMSGWMGVDLARYGLDEPVG--NVDSNAILS----------AVAAFQS
MAV_4059|M.avium_104 LALFGGWTGVDLAELDPDEPLT--YVETDANRS----------ALASFTT
MMAR_0703|M.marinum_M IAMLEQVWGRDLSDYDPDGPLPDIDPIADAAISQGRVRHADPVAVARRYR
MUL_4507|M.ulcerans_Agy99 ---------ADIERMQANLARS----ESEGQRR-----------MAELHG
* . . . .
MSMEG_5810|M.smegmatis_MC2_155 EHSGNDDPTIRDMA-WVLEGAN---RVVGTAEEIADRLEEWREAG-VDGV
Mvan_3887|M.vanbaalenii_PYR-1 EISGNDEPTIRDMA-WALEGAN---RVVGTPKEIADRLEEWREAG-VDGI
Mflv_1269|M.gilvum_PYR-GCK AWPDGSKPTIKDFL-TSLSLPQ---MVVGSPETIAGRLLEYQGAG-VNGV
MAB_3401|M.abscessus_ATCC_1997 ATADGREWKVRDIA-EWGEIGGMGPRIVGSGTEVADTLQEWVEETDVDGF
TH_4268|M.thermoresistible__bu ADPDGREWAVRDIA-EWGKIGGMGPRIVGSGFTVADTLQEWVEETDVDGF
MAV_4059|M.avium_104 A---GRAWTVAELA-AEIGIGGRGPVLVGSPTEVADELERWVDDADVDGF
MMAR_0703|M.marinum_M ERSQAENLSIRELV-IAVTSRQ---QFVGTPSHIADEIDRYVQADACDGF
MUL_4507|M.ulcerans_Agy99 GVLDQLEIAPNLWAGVGLVRGGAGTALVGSHQEVAERIIEYARLG-ISHF
.**: :* : .: . .
MSMEG_5810|M.smegmatis_MC2_155 NVYHATVPGSFLEVSQRLFPTLRERGLISND-KSGTLRHKLFGRGDRLPG
Mvan_3887|M.vanbaalenii_PYR-1 NVYHATLPASFREVADRLFPTLRERGLIGTD-KSGTLRHKLLGRGDRLPD
Mflv_1269|M.gilvum_PYR-GCK QVMNALLPNSYAEFFEHLVPVLQDKGIMQKEYQPGTLRQKLFGSGPDISE
MAB_3401|M.abscessus_ATCC_1997 NLAYAITPGTFEDFIEYVVPVLTERGAYQSSYTPGTLRHKLLGHGDRLPE
TH_4268|M.thermoresistible__bu NLAYAITPGSFAQFIEHVVPVLTERGAYQPAYTPGTLRHKLFGKGDRLPD
MAV_4059|M.avium_104 NVAYVTTPGTFVDFAKFVVPELRRRGHVPEQVPGSTLRERLGAAGPLLGD
MMAR_0703|M.marinum_M ILVPHLTPHGLDEFVDRVVPLLQERGAFRTAYTGQTLRDHLGLAG--LPS
MUL_4507|M.ulcerans_Agy99 ILSGYPHLEEAYWFGEGVLPILERKRLWHRPHGSSPHSAALPVAHSSVN-
: . . :.* * : . * :
MSMEG_5810|M.smegmatis_MC2_155 THPAARYRGAFGDNDLLDGVEEPIAARS----------
Mvan_3887|M.vanbaalenii_PYR-1 THPAARYRGAFSDNSLADRVPETVGSV-----------
Mflv_1269|M.gilvum_PYR-GCK RHPAHGYRGMFC--------------------------
MAB_3401|M.abscessus_ATCC_1997 EHRGAKYRIGGPLSTIIDRPSTVPSSSGSTAPAPTPGR
TH_4268|M.thermoresistible__bu DHRGSRYRVGGPLSTIIDRPSTLPSSPASAASQPISGR
MAV_4059|M.avium_104 DHPGAAYRLRR------DR-------------------
MMAR_0703|M.marinum_M --------------------------------------
MUL_4507|M.ulcerans_Agy99 --------------------------------------