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DATGTGPSVGVMTRPRLILNAFTMNTATHVAYGAWRNPETRSVEFDQLDPWVELVKLLERGKFDSIFFAD VVGLYDDYRGGWETYLREGLQIPNHDPSAIVSALALSTEHLGLVITSSVLQDHPFSFARKISTLDHASKG RIGWNVVTSALQNSARNFGLPEREEHDERYQWAEEYTEVVYKLWEGSWDDGALLRDRERGIHADPDKVHK IHHIGKRYRVEGPHLSFPSPQRTPVLFQAGTSTAGRAFAARHAEGVFINAASPKGARVVIDDTRDRAVAA GRRREDIKFFQGLSFVVGSTEVEARARAAELDEYLSVDALIAHRSGGIGVDLGGLDHHTPIGDLAPTVQG TRSTIEALIAAAPPGTNPTIADLVRQQQESTRIVGTPEQIADALEEWQDAGVDGLNIRYITTPGSFADFI DHVVPELQSRGLAQTEYAPGTLREKLFGNGPHLPERHPARHWRGRFREADVAARAVSESV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2841 | - | - | 100% (481) | putative monooxygenase |
| M. smegmatis MC2 155 | MSMEG_4083 | - | e-143 | 54.29% (455) | putative monooxygenase |
| M. smegmatis MC2 155 | MSMEG_5810 | - | e-130 | 49.67% (461) | putative monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_1269 | - | 1e-117 | 46.41% (459) | putative monooxygenase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3401 | - | 1e-105 | 44.87% (448) | putative monooxygenase |
| M. marinum M | MMAR_0703 | - | 3e-54 | 33.72% (427) | FMNH2-utilizing oxygenase |
| M. avium 104 | MAV_4059 | - | 1e-101 | 43.83% (454) | monoxygenase |
| M. thermoresistible (build 8) | TH_4268 | - | 1e-110 | 45.95% (444) | PUTATIVE putative monooxygenase |
| M. ulcerans Agy99 | MUL_4782 | - | 2e-05 | 26.52% (181) | coenzyme F420-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3887 | - | 1e-130 | 48.40% (469) | putative monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 MTLTSPAAASAGDLPARPGLRTVAAGSMIGTTIEWYDFYLYATASALVFK
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4782|M.ulcerans_Agy99 --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 PLFFPNISPSAGTLASFATYAAGFGARPLGAVLSGHFGDRLGRKTVLVAA
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4782|M.ulcerans_Agy99 --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 LLVMGLVTTAIGALPTYAEAGLAAPALLASLRVVQGLAVGAEWGGAAVLS
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4782|M.ulcerans_Agy99 --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 VEHAPPGRRGLFGSFTQLGSPAGMLLATSVFFGVRKATGPAAFLGFGWRI
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4782|M.ulcerans_Agy99 --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 PFLLSIFLVAVGLFVRLRLTDAEVFDRLRSRDELARLPIVQVLRTDARNV
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4782|M.ulcerans_Agy99 --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 VITTGLRLSQIGLFVLLTTYSLSYLQDSFGKGSGVGLVAVLISSALGFLS
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4782|M.ulcerans_Agy99 --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 TPGWALLSDRVGRRPPYLFGALASVVALVLFFVAAGTGSAVLVVVAIVFG
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4782|M.ulcerans_Agy99 --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 VNVVHDAMYGPQAAWFAELFDTRVRYSGSSLGYHIGAVLSGGFAPLIAAS
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MUL_4782|M.ulcerans_Agy99 --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 -----------------------------------------MTRVIRFNA
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 LLVAGGGRPWLIVGYFAVLAAITVGAACAGPGDARGADRMSAARRIYLNA
MSMEG_2841|M.smegmatis_MC2_155 ----------------------------MDATGTGPSVGVMTRPRLILNA
Mvan_3887|M.vanbaalenii_PYR-1 ----------------------------------------MTKRPLYYSA
Mflv_1269|M.gilvum_PYR-GCK ----------------------------------MYSIQGMTQR-MIFTL
MMAR_0703|M.marinum_M ----------------------------------------MIRKPVHLAA
MUL_4782|M.ulcerans_Agy99 --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 FDMNCVAHQSPGLWRHPDDQSWRYKDLSYWTNLATLLERGRFDGLFIADV
TH_4268|M.thermoresistible__bu --MNCVAHQSPGLWKHPEDQSWRYKDLEYWTELARLLERGRFDGLFIADV
MAV_4059|M.avium_104 FDMACVGHQSAGLWRHPDDQGHRYRELSYWTELARTLEAGGFDALFLADV
MSMEG_2841|M.smegmatis_MC2_155 FTMNTATHVAYGAWRNPETRSVEFDQLDPWVELVKLLERGKFDSIFFADV
Mvan_3887|M.vanbaalenii_PYR-1 FVMNTASHVLHGLWRAPDAQNHRFNSLRHWTSLAAEVDKAGYDVLFFADV
Mflv_1269|M.gilvum_PYR-GCK LVMDSIGHNFHGSWRHPAARNREFKGFDMWVDLARKAEQAKVDAFFFTDV
MMAR_0703|M.marinum_M HFP---GVNNTTVWADPGAGS--QIEFESFVHLARTAERGLFDFFFLAEG
MUL_4782|M.ulcerans_Agy99 ------------MRTATTVELSGGKDGKDTVDFVVEAEKLGLHTCWVAEA
. . :. : . :.::
MAB_3401|M.abscessus_ATCC_1997 LGTYDIYGASDEAAIRQAAQIPVADPLLLVSAMALVTEHLGFGV-TTGTG
TH_4268|M.thermoresistible__bu LGTYDVYGAGDEAAIRQAAQIPVNDPMMLVSAMALVTEHLGFGI-TTGTG
MAV_4059|M.avium_104 LGVYDIYGASRDAAVVDAAQFPVNEPSAAVSAMAAVTETLGFGI-TLSLT
MSMEG_2841|M.smegmatis_MC2_155 VGLYDDYRGGWETYLREGLQIPNHDPSAIVSALALSTEHLGLVI-TSSVL
Mvan_3887|M.vanbaalenii_PYR-1 FGLRAPWNGNWRKAVEGGIQVPVNDPSVLASAIAAATENLGIVF-TSSIV
Mflv_1269|M.gilvum_PYR-GCK MGVQGEYNGKRDIVFEMAMNVPIGDCTMLIPALAQQTRDLGFLY-TSSVI
MMAR_0703|M.marinum_M LRLREHRG-----RIHDLDVVGRPDTFTLLAALAGVTDRIGLTG-TINTT
MUL_4782|M.ulcerans_Agy99 WG---------------------SDAPSALGYIAARTERMQLGSGVLQVG
: :* * : : .
MAB_3401|M.abscessus_ATCC_1997 FEHPYPFARRLSTLDHLTGGRVGWNVVTGYLPAAARNMGQTDQPAHDARY
TH_4268|M.thermoresistible__bu FEHPYPFARRMSTLDHLTKGRIGWNVVTGYLPAAARNMGQSDQPAHDARY
MAV_4059|M.avium_104 YEQPYALARRLSTLDHLTGGRVAWNIVTSYLDSAARNLGLDAQIPHDQRY
MSMEG_2841|M.smegmatis_MC2_155 QDHPFSFARKISTLDHASKGRIGWNVVTSALQNSARNFGLPEREEHDERY
Mvan_3887|M.vanbaalenii_PYR-1 QDHPFNFARRMSSLDHYTDGRLGWNIVTSFNANMFRSFGHEGTLAHDQRY
Mflv_1269|M.gilvum_PYR-GCK SHHPFVFARAASTLDNLSNGRIGWNIVTSANEKAFRNLGLPGNLSHDERY
MMAR_0703|M.marinum_M FNEPFEVARQFATLDHLSEGRAGWNIVTSSDAFTGANFRRGGYLDHADRY
MUL_4782|M.ulcerans_Agy99 TRSPVLVAQTAITLSNLSCGRFLLGLGASGPRVIEGLHG----VAFDRPL
* .*: :*.: : ** .: :. .
MAB_3401|M.abscessus_ATCC_1997 DHADEYLEVLYKLWEGSWEDDAVVRDAARGVFTDPDKVHHIGHEGTHFTV
TH_4268|M.thermoresistible__bu DHADEYLEVLYKLWEGSWEDDAVIRDRERGVFTDPDKVHHIGHRGRHFSV
MAV_4059|M.avium_104 EIADEYLEVCYKLWEGSWEAGAVLRDRQRGVFTDPAKVHDIEHKGRYFSV
MSMEG_2841|M.smegmatis_MC2_155 QWAEEYTEVVYKLWEGSWDDGALLRDRERGIHADPDKVHKIHHIGKRYRV
Mvan_3887|M.vanbaalenii_PYR-1 EWANEYVDVTYKLWEGSWDDDALVQDKERSVHSDPSKIHKINHVGRRYTV
Mflv_1269|M.gilvum_PYR-GCK VWAQEYVDVTYKLWEGSWDVDAIVDDPASGVYADPSKVHDINHKGARYSV
MMAR_0703|M.marinum_M QRAEEFLTVARKFWD-SWAPGAVLADIENGDYVDPERIRSVEHSGPQFEV
MUL_4782|M.ulcerans_Agy99 ARLKETVEIVRQVFAGGKVTYSGSE-------------FQIPRRG---GE
.* : :.: . : : : *
MAB_3401|M.abscessus_ATCC_1997 PGVHLVEPSPQRTPVIYQAGSSPRGVRFAAENAEAVFTAAPTKELL-RQT
TH_4268|M.thermoresistible__bu PGVHLSEPSPQRTPVIYQAGSSPRGVRFAAENAEAIFTASPTKEIL-RRT
MAV_4059|M.avium_104 PGPFLCEPSPQRTPVLFQAGASPRGIRFAAAHAEAVFVSGPTAQVV-REP
MSMEG_2841|M.smegmatis_MC2_155 EGPHLSFPSPQRTPVLFQAGTSTAGRAFAARHAEGVFINAASPKGA-RVV
Mvan_3887|M.vanbaalenii_PYR-1 EGPHFTSPSPQRTPVLFQAGSSPAGQLFSARNAEGVYISSPTPADA-HKL
Mflv_1269|M.gilvum_PYR-GCK EGFNLMEPSPQRTPVLAQAGGSPAGLAFAGKHAELMFLSAYSLETI-AAQ
MMAR_0703|M.marinum_M RGFATLPAGPQGHPVLLQAGDSEQGRAFGARHADAMFTLHSSLRDG-QRY
MUL_4782|M.ulcerans_Agy99 ARPMRLSTRPEYDIPIYLAALSPAMLRLTGRIADGWLGTSFVPEGAGDAY
. *: : *. * : . *:
MAB_3401|M.abscessus_ATCC_1997 VTTIRRELELAGRDPYSAKIFNLTTVVTGENSEAAHAKHAELLGYGSA-E
TH_4268|M.thermoresistible__bu VSTIRQELEIAGRDPYSVKIFNLTTIITAETDEEAHARHAEYLAYGDP-E
MAV_4059|M.avium_104 VRALRTAAAQLGRDPRAVKVFTMVTPVVAETHDAAVAKLAEYRRFVSP-R
MSMEG_2841|M.smegmatis_MC2_155 IDDTRDRAVAAGRRREDIKFFQGLSFVVGSTEVEARARAAELDEYLSV-D
Mvan_3887|M.vanbaalenii_PYR-1 TGETRALAAANGRDPQDITFAQGLSFVIGDTHAEAVRRNDELKRYLDV-E
Mflv_1269|M.gilvum_PYR-GCK VGAVREQARTNGRRDGDILFLQGMMFVIGSTDEEAYRKWGELEEWRSP-E
MMAR_0703|M.marinum_M YADVKGRARSYGRDPDQLKVFPAATFVIGDTPDQAGEKARQISYQQVSGA
MUL_4782|M.ulcerans_Agy99 FTHLDAGLAAAGRSRADIDFCQGAEVAFASG-------VEELRDMVAARK
** . .. :
MAB_3401|M.abscessus_ATCC_1997 GALVFMSGWMGVDLARYGLDEPIGNVD--SNAILSA----------VAAF
TH_4268|M.thermoresistible__bu GALTFMSGWMGVDLARYGLDEPVGNVD--SNAILSA----------VAAF
MAV_4059|M.avium_104 GALALFGGWTGVDLAELDPDEPLTYVE--TDANRSA----------LASF
MSMEG_2841|M.smegmatis_MC2_155 ALIAHRSGGIGVDLGGLDHHTPIGDLAPTVQGTRST----------IEAL
Mvan_3887|M.vanbaalenii_PYR-1 GVALHALGDAGIDAGNLPLDTPISALG-EFTGIQS-----------FSRW
Mflv_1269|M.gilvum_PYR-GCK AQTAYFSSLSGMDLGRYDPGTPLENILDEIPGIQGA----------FLAV
MMAR_0703|M.marinum_M TAIAMLEQVWGRDLSDYDPDGPLPDIDPIADAAISQGRVRHADPVAVARR
MUL_4782|M.ulcerans_Agy99 TELAFSLGGMGSASTNYYNQAYSRQGWSEVAAAVRER------------W
* .
MAB_3401|M.abscessus_ATCC_1997 QAATADGREWKVRDIAEWGEIGGMGPRIVGSGTEVADTLQEWVEETDVDG
TH_4268|M.thermoresistible__bu QSADPDGREWAVRDIAEWGKIGGMGPRIVGSGFTVADTLQEWVEETDVDG
MAV_4059|M.avium_104 TTA---GRAWTVAELAAEIGIGGRGPVLVGSPTEVADELERWVDDADVDG
MSMEG_2841|M.smegmatis_MC2_155 IAAAPPGTNPTIADLVRQQQES---TRIVGTPEQIADALEEWQDAG-VDG
Mvan_3887|M.vanbaalenii_PYR-1 AAEISGNDEPTIRDMAWALEGA---NRVVGTPKEIADRLEEWREAG-VDG
Mflv_1269|M.gilvum_PYR-GCK INAWPDGSKPTIKDFLTSLSLP---QMVVGSPETIAGRLLEYQGAG-VNG
MMAR_0703|M.marinum_M YRERSQAENLSIRELVIAVTSR---QQFVGTPSHIADEIDRYVQADACDG
MUL_4782|M.ulcerans_Agy99 QRGDREGAARLVTDEMVLA------TTLIGTEEMVRSRLVAWRDAG----
: : .:*: : . : :
MAB_3401|M.abscessus_ATCC_1997 FNLAYAITPGTFEDFIEYVVPVLTERGAYQSSYTPGTLRHKLLGHGDRLP
TH_4268|M.thermoresistible__bu FNLAYAITPGSFAQFIEHVVPVLTERGAYQPAYTPGTLRHKLFGKGDRLP
MAV_4059|M.avium_104 FNVAYVTTPGTFVDFAKFVVPELRRRGHVPEQVPGSTLRERLGAAGPLLG
MSMEG_2841|M.smegmatis_MC2_155 LNIRYITTPGSFADFIDHVVPELQSRGLAQTEYAPGTLREKLFGNGPHLP
Mvan_3887|M.vanbaalenii_PYR-1 INVYHATLPASFREVADRLFPTLRERGLIGTDKS-GTLRHKLLGRGDRLP
Mflv_1269|M.gilvum_PYR-GCK VQVMNALLPNSYAEFFEHLVPVLQDKGIMQKEYQPGTLRQKLFGSGPDIS
MMAR_0703|M.marinum_M FILVPHLTPHGLDEFVDRVVPLLQERGAFRTAYTGQTLRDHLGLAG--LP
MUL_4782|M.ulcerans_Agy99 ---VNTVRLYPAGDTMDAKLSTLGRAIELVRAVR----------------
: . .. *
MAB_3401|M.abscessus_ATCC_1997 EEHRGAKYRIGGPLSTIIDRPSTVPSSSGSTAPAPTPGR
TH_4268|M.thermoresistible__bu DDHRGSRYRVGGPLSTIIDRPSTLPSSPASAASQPISGR
MAV_4059|M.avium_104 DDHPGAAYRLRR------DR-------------------
MSMEG_2841|M.smegmatis_MC2_155 ERHPARHWRGRFREADVAARAVSESV-------------
Mvan_3887|M.vanbaalenii_PYR-1 DTHPAARYRGAFSDNSLADR-VPETVGSV----------
Mflv_1269|M.gilvum_PYR-GCK ERHPAHGYRGMFC--------------------------
MMAR_0703|M.marinum_M S--------------------------------------
MUL_4782|M.ulcerans_Agy99 ---------------------------------------