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SRIGARAVVLGASISGLLGARVLSEYYDEVVVVERDTLTVDAMPRRGAPQARHGHALQSGGAEVLDRLFP GLLAELSASGAIVLENGGLSRVKLCLQGHWLKTSGVMNRPVTIYSVSRPFLEMTIRRRVFGIPNVKVLDA HDAVDILAATPERITGVRVTNRHGGEEHVIEADLVLDALGRGGRTPALLESLGYGRPAEDSLTVNVNYVS QMLRLPAGLVDEAMILVGATPERPTGASLFAYENDTWMLTVAGIAGTEPPADLAGRQRFVAELGVPQLDA ALRDGTPLTEPHRHRLPNSRRRRYEAMRRFPAGLLVLGDAICSFNPIYGQGMSVAAYEAHALRDLLREGD RDLARRFFRAAAEYVDQAWRMAVNSDLALPQVPGRRTAGVRLSNWLTGQVLATAAVDDGVAEQFLRVMSM LDPPTRLFRPSVLWRVAEHSQRRRRRVP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5801 | - | - | 100% (449) | hydroxylase |
| M. smegmatis MC2 155 | MSMEG_3511 | - | e-120 | 50.68% (442) | hydroxylase |
| M. smegmatis MC2 155 | MSMEG_1837 | - | 9e-75 | 38.02% (434) | secreted protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3282 | - | 3e-71 | 36.01% (461) | hypothetical protein Mb3282 |
| M. gilvum PYR-GCK | Mflv_4723 | - | 2e-71 | 37.08% (445) | hypothetical protein Mflv_4723 |
| M. tuberculosis H37Rv | Rv3254 | - | 3e-71 | 36.01% (461) | hypothetical protein Rv3254 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1628c | - | 1e-79 | 40.90% (445) | hypothetical protein MAB_1628c |
| M. marinum M | MMAR_1289 | - | 4e-78 | 38.15% (443) | hypothetical protein MMAR_1289 |
| M. avium 104 | MAV_0575 | - | 1e-108 | 48.52% (439) | hypothetical protein MAV_0575 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2598 | - | 3e-78 | 38.15% (443) | hypothetical protein MUL_2598 |
| M. vanbaalenii PYR-1 | Mvan_5929 | - | 1e-124 | 51.12% (448) | hypothetical protein Mvan_5929 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5801|M.smegmatis_MC2_155 --------MSRIGARAVVLGASISGLLGARVLSEYYDEVVVVERDTLTVD
Mvan_5929|M.vanbaalenii_PYR-1 MNPDGPLVMNNLGDHAVVLGASMGGLLAARVLADFYRTVTIVERDVLPND
MAV_0575|M.avium_104 -------MTTKVGEHAVVLGASMGGLLAGRSLADFFDRVTVVERDPLPDA
MAB_1628c|M.abscessus_ATCC_199 ----MTPHVRDHRDHAVVLGAGMAGLLAARVLSESYASVTVVERDELHKV
Mb3282|M.bovis_AF2122/97 ----------------MVIGASIAGLCAARVLSDFYSTVTVFERDELPEA
Rv3254|M.tuberculosis_H37Rv ----------------MVIGASIAGLCAARVLSDFYSTVTVFERDELPEA
MMAR_1289|M.marinum_M MGASVEKRAVNPAEHATVIGASIGGLCAARVLSDFYSKVIVCERDDLPST
MUL_2598|M.ulcerans_Agy99 MGASVEKRAVNPAEHATVIGASIGGLCAARVLSDFYSKVIVCERDDLPST
Mflv_4723|M.gilvum_PYR-GCK MGR----------KHAIVIGASLGGLCAARVLSSAFDDVTVFERDPLPEG
*:**.:.** ..* *:. : * : *** *
MSMEG_5801|M.smegmatis_MC2_155 AMPRRGAPQARHGHALQSGGAEVLDRLFPGLLAELSASGAIVLENGGLSR
Mvan_5929|M.vanbaalenii_PYR-1 PVNRRGVPQGRHVHALLARGSRILEELFPGLLDEVVAGGAPVLDGTDPSE
MAV_0575|M.avium_104 HGARRGVPQGRHLHALLCRGAQAIEELFPGVLDQMVRDGAQYFDGQDLSQ
MAB_1628c|M.abscessus_ATCC_199 AAARSGVPQGHHIHMFMAAGTQGLEQLFPGILDDLRTDGATVCDEGDLSR
Mb3282|M.bovis_AF2122/97 PANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENR-PDC
Rv3254|M.tuberculosis_H37Rv PANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENR-PDC
MMAR_1289|M.marinum_M PSGRGTVPQDQHLHLLMARGAAELDTLFPGLLTDLVAAGVPMLDNR-PDC
MUL_2598|M.ulcerans_Agy99 PSGRGTVPQDQHLHLLMARGAAELDTLFPGLLTDLVAAGVPMLDNR-PDC
Mflv_4723|M.gilvum_PYR-GCK PANRPAVPQGRHVHLLMARGAAEFETLFPGLLDDMVACGVPILENR-PDC
* .** :* * : . *: :: ****:* :: *. : .
MSMEG_5801|M.smegmatis_MC2_155 VKLCLQGHWLK---TSGVMNRPVTIYSVSRPFLEMTIRRRVFGIPNVKVL
Mvan_5929|M.vanbaalenii_PYR-1 GYFRFGGHLLP---RDGRPKDPITLLLPSRPMLEYLVRQKVRGIPNIAML
MAV_0575|M.avium_104 LYYNIGGHLMT---RSGAAPG-LTAYSATRPFLEDHVRGRLRGIPNVTLR
MAB_1628c|M.abscessus_ATCC_199 IRMLLGTHEMFNRTKKFSDPETFKLYLTTRPFLEFHVRQRVQRLGNVKFL
Mb3282|M.bovis_AF2122/97 IYLGAAGHVLG---TGHTLRKEFTAYVPSRPHLEWQLRRRVLQLSNVQIV
Rv3254|M.tuberculosis_H37Rv IYLGAAGHVLG---TGHTLRKEFTAYVPSRPHLEWQLRRRVLQLSNVQIV
MMAR_1289|M.marinum_M IYLGAAGHVLG---TGAKLRKQYTAYLPSRPHLEWQLRRRVLALGNVEIR
MUL_2598|M.ulcerans_Agy99 IYLGAAGHVLG---TGAKLRKQYTAYLPSRPHLEWQLRRRVLALGNVEIR
Mflv_4723|M.gilvum_PYR-GCK IHFGAAGHLLG---TTHRLQDEFTAYVPSRPHLEWQIRRRVLALDNVRLI
* : . :** ** :* :: : *: .
MSMEG_5801|M.smegmatis_MC2_155 DAHDAVDILAATP-ERITGVRVTNRHGGE----EHVIEADLVLDALGRGG
Mvan_5929|M.vanbaalenii_PYR-1 EAHDVVDLTSASQQDRVTGARVRARDNGA----ERVLNAELVVDATGRGS
MAV_0575|M.avium_104 DEHCVTRLVSTADRRRVVGAWVADGRTGE----TTAMPADLVVDATGRAA
MAB_1628c|M.abscessus_ATCC_199 DGHDVIEPMTAEH--RITGVRVARRSTGL----VTTLICDLVVDATGRTP
Mb3282|M.bovis_AF2122/97 R-RLVTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAAGRGT
Rv3254|M.tuberculosis_H37Rv R-RLVTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAAGRGT
MMAR_1289|M.marinum_M Q-RKVREPHFDPVRQRVTGLLLDDHDGDP-----ELIASGLVIDAAGRGT
MUL_2598|M.ulcerans_Agy99 Q-RKVREPHFDPVRQRVTGLLLDDHDGDP-----ELIASGLVIDAAGRGT
Mflv_4723|M.gilvum_PYR-GCK D-CGVDEPVYDG--HRVTGVRTADG---------ATVDADFVVDATGRGT
. *:.* : . :*:** **
MSMEG_5801|M.smegmatis_MC2_155 RTPALLESLGYGRPAEDSLTVNVNYVSQMLRLPAGLVDEAMILVGATPER
Mvan_5929|M.vanbaalenii_PYR-1 RTPAFLDHLGYNRPAQDHIDVRLTYSSQLLRLPPGAVKERIVIVGPIPGR
MAV_0575|M.avium_104 HTPTWLDSLGYDRPREDRVTVQLTYASQALRMTGEAPRELGLLIGIVPGR
MAB_1628c|M.abscessus_ATCC_199 RTQTFLDRLGFARPAETRVASPVTYASQLLHVSEDTDLDKLTFLNAAPGR
Mb3282|M.bovis_AF2122/97 RLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGASHDQ
Rv3254|M.tuberculosis_H37Rv RLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGASHDQ
MMAR_1289|M.marinum_M RLPVWLTQWGYQRPPEETVDIGINYASQRLRIPDGLMREKIVVTGVGPGQ
MUL_2598|M.ulcerans_Agy99 RLPVWLTQWGYQRPPEETVDIGINYASQRLRIPDGLMRERIVVTGVGPGQ
Mflv_4723|M.gilvum_PYR-GCK RLPTWLSQWGFERPREDTVDVGISYATHQLRIPDGLIDEKVIVVGASRTQ
: . * *: ** : : :.* :: :::. : . . :
MSMEG_5801|M.smegmatis_MC2_155 PTGASLFAYENDTWMLTVAGIAGTEPP-ADLAGRQRFVAELGVPQLDAAL
Mvan_5929|M.vanbaalenii_PYR-1 PTGMALFGYENATWIFTAIGMAGRESP-AELTEMLTFVDDFTPPHVAAAL
MAV_0575|M.avium_104 PRGCGLLHCEHDTWLLTVMGVGGEEPATLDLATLCDFIADCAPAHLLAAV
MAB_1628c|M.abscessus_ATCC_199 PFGGAIARCENDTVMMTLGQFNLDEPP-TTFAEMITLAEQFVPHAVVETL
Mb3282|M.bovis_AF2122/97 SLGLGMLCYEDGTWVLTTFGVADAKPP-PTFDEMRALADKLLPARFTAAL
Rv3254|M.tuberculosis_H37Rv SLGLGMLCYEDGTWVLTTFGVADAKPP-PTFDEMRALADKLLPARFTAAL
MMAR_1289|M.marinum_M SLGLGMLCNEDGSWILTTFGVAKVKPP-STFGEMRELAYRLLPSRFVAAL
MUL_2598|M.ulcerans_Agy99 SLGLGMLCNEDGSWILTTFGVAKVKPP-STFGEMRELAYRLLPSRFVAAL
Mflv_4723|M.gilvum_PYR-GCK PRGLGMLYYEDGTWGLTTFGVGKVPAP-TDFNEMRELAEELLPAHIGAAL
. * .: *. : :* . .. : : . ::
MSMEG_5801|M.smegmatis_MC2_155 RDGTPLTEPHRHRLPNSRRRRYEAMRRFPAGLLVLGDAICSFNPIYGQGM
Mvan_5929|M.vanbaalenii_PYR-1 REAEPLADIARHRMPSSQWRRYDKMQRFPAGLLVFGDAICSFNPIYGQGM
MAV_0575|M.avium_104 RGAEPVGEPVRHRMPCSRWRRYDKLRRFPDGLLVTGDAICSFNPIYGQGM
MAB_1628c|M.abscessus_ATCC_199 RSAEPVGAVHNFWYRDAVWRRYDEMDGFPEGLLVIGDAVCSLDPIRGQGM
Mb3282|M.bovis_AF2122/97 AQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGM
Rv3254|M.tuberculosis_H37Rv AQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGM
MMAR_1289|M.marinum_M AAAGPIGEPVFHAFPASRWRRYDKLSRFPAGIVALGDAVASFNPTFGQGM
MUL_2598|M.ulcerans_Agy99 AAAGPIGEPVFHAFPASRWRRYDKLSRFPAGIVALGDAVASFNPTFGQGM
Mflv_4723|M.gilvum_PYR-GCK YQTHPLGDVALHKYPTSRWRRFDELDRYPRGILPFGDAVASFNPTFGQGM
*: . : **:: : :* *:: ***:.*::* ****
MSMEG_5801|M.smegmatis_MC2_155 SVAAYEAHALRDLLREGD----RDLARRFFRAAAEYVDQAWRMAVNSDLA
Mvan_5929|M.vanbaalenii_PYR-1 TVAALQAEALRKCLQHGA----AGLARRYFRATAKPISVAWRLAAGADLN
MAV_0575|M.avium_104 SVAALEALALRDCLSSGT----TDLARRFFRAAAAPIRQAWQLSTNPDLA
MAB_1628c|M.abscessus_ATCC_199 TMALLEAAALRDCLFEGD----ADLARRYFQTVGKRISTAWEHNRMTAPL
Mb3282|M.bovis_AF2122/97 TMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDIS
Rv3254|M.tuberculosis_H37Rv TMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDIS
MMAR_1289|M.marinum_M TMASLQAGHLRRALQSHP----AEPANEFNRATAKTIRPVWTMNALTDLC
MUL_2598|M.ulcerans_Agy99 TMASLQAGHLRRALQSHP----AEPANEFNRATAKTIRPVWTMNALTDLC
Mflv_4723|M.gilvum_PYR-GCK TMTSLQAGHLQRALQEPE------PEATFLAATAKSTWPVWTMNAIGDLT
::: :* *: * :.. .*
MSMEG_5801|M.smegmatis_MC2_155 LPQVPGR-RTAGVRLSN----WLTGQVLATAAVDDGVAEQFLRVMSMLDP
Mvan_5929|M.vanbaalenii_PYR-1 LHEVEGR-RPPSVRIAN----RYVDRLQRAAESDNVVAEQFVKVTGLIDP
MAV_0575|M.avium_104 LPEIEGT-PPLIARAFN----KYVDRVLTAAETDTVALNQFIRVTSLVDP
MAB_1628c|M.abscessus_ATCC_199 HSSAPDS-ATFGQRVKWNLMAWWSAKMLMAARNDIAITETILRVNNMQDA
Mb3282|M.bovis_AF2122/97 FHHATAEPLPRWWRPAG----SLFDQFLGAAETDPVLAEWFLRRFSLLDS
Rv3254|M.tuberculosis_H37Rv FHHATAEPLPRWWRPAG----SLFDQFLGAAETDPVLAEWFLRRFSLLDS
MMAR_1289|M.marinum_M FQHAEGR-MPRWYRPVG----GLYDQFLGAAETDPVLAEWFLRRISLLDS
MUL_2598|M.ulcerans_Agy99 FQHAEGR-MPRWYRPVG----GLYDQFLGAAETDPVLAEWFLRRISLLDS
Mflv_4723|M.gilvum_PYR-GCK MHGADGP-APWWYRPVG----ALFDQFLGAAESDPVLAEWFLRRFSLLDS
. * :. :* * : ::: .: *.
MSMEG_5801|M.smegmatis_MC2_155 PTRLFRPSVLWRVAEH---------------SQRRRRRVP----------
Mvan_5929|M.vanbaalenii_PYR-1 PARLLHPKILLRVAFT---------------SWRRRGRHR----------
MAV_0575|M.avium_104 ATRLLRPSIMWRAARARGADHPGTAGGSGTPSSASTPRANVGKSVMSPST
MAB_1628c|M.abscessus_ATCC_199 PRSMRRPTFVLRVLRH---------------CWRRHETSTAPAPQRQLTL
Mb3282|M.bovis_AF2122/97 LYMVPSVPIIGRAIAHN------------LRLWLKEQRERRQPVTTRRSP
Rv3254|M.tuberculosis_H37Rv LYMVPSVPIIGRAIAHN------------LRLWLKEQRERRQPVTTRRSP
MMAR_1289|M.marinum_M LYMVPSPLIIGRAVAHN------------ARMWLRQRRPK--PSATSR--
MUL_2598|M.ulcerans_Agy99 LYMVPSPLIIGRAVAHN------------ARMWLRQRRPK--PSATSR--
Mflv_4723|M.gilvum_PYR-GCK LYMVPSARLIGRTVRHN------------MTLWARSRRSPGTASSAPAR-
: .: *.
MSMEG_5801|M.smegmatis_MC2_155 ---
Mvan_5929|M.vanbaalenii_PYR-1 ---
MAV_0575|M.avium_104 P--
MAB_1628c|M.abscessus_ATCC_199 SGV
Mb3282|M.bovis_AF2122/97 ---
Rv3254|M.tuberculosis_H37Rv ---
MMAR_1289|M.marinum_M ---
MUL_2598|M.ulcerans_Agy99 ---
Mflv_4723|M.gilvum_PYR-GCK ---