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MNPDGPLVMNNLGDHAVVLGASMGGLLAARVLADFYRTVTIVERDVLPNDPVNRRGVPQGRHVHALLARG SRILEELFPGLLDEVVAGGAPVLDGTDPSEGYFRFGGHLLPRDGRPKDPITLLLPSRPMLEYLVRQKVRG IPNIAMLEAHDVVDLTSASQQDRVTGARVRARDNGAERVLNAELVVDATGRGSRTPAFLDHLGYNRPAQD HIDVRLTYSSQLLRLPPGAVKERIVIVGPIPGRPTGMALFGYENATWIFTAIGMAGRESPAELTEMLTFV DDFTPPHVAAALREAEPLADIARHRMPSSQWRRYDKMQRFPAGLLVFGDAICSFNPIYGQGMTVAALQAE ALRKCLQHGAAGLARRYFRATAKPISVAWRLAAGADLNLHEVEGRRPPSVRIANRYVDRLQRAAESDNVV AEQFVKVTGLIDPPARLLHPKILLRVAFTSWRRRGRHR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5929 | - | - | 100% (458) | hypothetical protein Mvan_5929 |
| M. vanbaalenii PYR-1 | Mvan_3995 | - | 1e-54 | 30.72% (446) | hypothetical protein Mvan_3995 |
| M. vanbaalenii PYR-1 | Mvan_4003 | - | 7e-48 | 31.33% (450) | oxidoreductase FAD-binding subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3282 | - | 3e-86 | 40.47% (425) | hypothetical protein Mb3282 |
| M. gilvum PYR-GCK | Mflv_4723 | - | 1e-92 | 41.39% (447) | hypothetical protein Mflv_4723 |
| M. tuberculosis H37Rv | Rv3254 | - | 3e-86 | 40.47% (425) | hypothetical protein Rv3254 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1628c | - | 2e-88 | 41.85% (454) | hypothetical protein MAB_1628c |
| M. marinum M | MMAR_1288 | - | 5e-91 | 41.14% (457) | hypothetical protein MMAR_1288 |
| M. avium 104 | MAV_0575 | - | 1e-127 | 52.86% (437) | hypothetical protein MAV_0575 |
| M. smegmatis MC2 155 | MSMEG_5801 | - | 1e-124 | 51.12% (448) | hydroxylase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2598 | - | 9e-90 | 40.98% (449) | hypothetical protein MUL_2598 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5929|M.vanbaalenii_PYR-1 MNPDGPLVMNNLGDHAVVLGASMGGLLAARVLADFYRTVTIVERDVLPND
MSMEG_5801|M.smegmatis_MC2_155 --------MSRIGARAVVLGASISGLLGARVLSEYYDEVVVVERDTLTVD
MAV_0575|M.avium_104 -------MTTKVGEHAVVLGASMGGLLAGRSLADFFDRVTVVERDPLPDA
MAB_1628c|M.abscessus_ATCC_199 ----MTPHVRDHRDHAVVLGAGMAGLLAARVLSESYASVTVVERDELHKV
Mb3282|M.bovis_AF2122/97 ----------------MVIGASIAGLCAARVLSDFYSTVTVFERDELPEA
Rv3254|M.tuberculosis_H37Rv ----------------MVIGASIAGLCAARVLSDFYSTVTVFERDELPEA
MMAR_1288|M.marinum_M ----MRGTLSTSNNHALVIGASIAGLCAARVLSDFFHRVTLIERDELPSA
MUL_2598|M.ulcerans_Agy99 MGASVEKRAVNPAEHATVIGASIGGLCAARVLSDFYSKVIVCERDDLPST
Mflv_4723|M.gilvum_PYR-GCK ----------MGRKHAIVIGASLGGLCAARVLSSAFDDVTVFERDPLPEG
*:**.:.** ..* *:. : * : *** *
Mvan_5929|M.vanbaalenii_PYR-1 PVNRRGVPQGRHVHALLARGSRILEELFPGLLDEVVAGGAPVLDGTDPSE
MSMEG_5801|M.smegmatis_MC2_155 AMPRRGAPQARHGHALQSGGAEVLDRLFPGLLAELSASGAIVLENGGLSR
MAV_0575|M.avium_104 HGARRGVPQGRHLHALLCRGAQAIEELFPGVLDQMVRDGAQYFDGQDLSQ
MAB_1628c|M.abscessus_ATCC_199 AAARSGVPQGHHIHMFMAAGTQGLEQLFPGILDDLRTDGATVCDEGDLSR
Mb3282|M.bovis_AF2122/97 PANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENR-PDC
Rv3254|M.tuberculosis_H37Rv PANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENR-PDC
MMAR_1288|M.marinum_M PHGRATVPQDRHLHMLMARGANEFENLFPGLLTDMVAAGVPMLENR-PDC
MUL_2598|M.ulcerans_Agy99 PSGRGTVPQDQHLHLLMARGAAELDTLFPGLLTDLVAAGVPMLDNR-PDC
Mflv_4723|M.gilvum_PYR-GCK PANRPAVPQGRHVHLLMARGAAEFETLFPGLLDDMVACGVPILENR-PDC
* .** :* * : . *: :: ****:* :: *. : .
Mvan_5929|M.vanbaalenii_PYR-1 GYFRFGGHLLP---RDGRPKDPITLLLPSRPMLEYLVRQKVRGIPNIAML
MSMEG_5801|M.smegmatis_MC2_155 VKLCLQGHWLK---TSGVMNRPVTIYSVSRPFLEMTIRRRVFGIPNVKVL
MAV_0575|M.avium_104 LYYNIGGHLMT---RSGAAPG-LTAYSATRPFLEDHVRGRLRGIPNVTLR
MAB_1628c|M.abscessus_ATCC_199 IRMLLGTHEMFNRTKKFSDPETFKLYLTTRPFLEFHVRQRVQRLGNVKFL
Mb3282|M.bovis_AF2122/97 IYLGAAGHVLG---TGHTLRKEFTAYVPSRPHLEWQLRRRVLQLSNVQIV
Rv3254|M.tuberculosis_H37Rv IYLGAAGHVLG---TGHTLRKEFTAYVPSRPHLEWQLRRRVLQLSNVQIV
MMAR_1288|M.marinum_M IYFAAAGHALG---TGHTLRKEFTAYVPSRPHLEWQLRRRVLELDNIEIV
MUL_2598|M.ulcerans_Agy99 IYLGAAGHVLG---TGAKLRKQYTAYLPSRPHLEWQLRRRVLALGNVEIR
Mflv_4723|M.gilvum_PYR-GCK IHFGAAGHLLG---TTHRLQDEFTAYVPSRPHLEWQIRRRVLALDNVRLI
* : . :** ** :* :: : *: .
Mvan_5929|M.vanbaalenii_PYR-1 EAHDVVDLTSASQQDRVTGARVRA----RDNGAERVLNAELVVDATGRGS
MSMEG_5801|M.smegmatis_MC2_155 DAHDAVDILAATP-ERITGVRVTN----RHGGEEHVIEADLVLDALGRGG
MAV_0575|M.avium_104 DEHCVTRLVSTADRRRVVGAWVAD----GRTGETTAMPADLVVDATGRAA
MAB_1628c|M.abscessus_ATCC_199 DGHDVIEPMTAEH--RITGVRVAR----RSTGLVTTLICDLVVDATGRTP
Mb3282|M.bovis_AF2122/97 RRL-VTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAAGRGT
Rv3254|M.tuberculosis_H37Rv RRL-VTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAAGRGT
MMAR_1288|M.marinum_M RGL-VIEPRFEPTTQTVSGVLVAPPDD-DDGAEPQFLAADLVVDAAGRGT
MUL_2598|M.ulcerans_Agy99 QRK-VREPHFDPVRQRVTGLLLD-----DHDGDPELIASGLVIDAAGRGT
Mflv_4723|M.gilvum_PYR-GCK DCG-VDEPVYDG--HRVTGVRTA---------DGATVDADFVVDATGRGT
. : * : . :*:** **
Mvan_5929|M.vanbaalenii_PYR-1 RTPAFLDHLGYNRPAQDHIDVRLTYSSQLLRLPPGAVKERIVIVGPIPGR
MSMEG_5801|M.smegmatis_MC2_155 RTPALLESLGYGRPAEDSLTVNVNYVSQMLRLPAGLVDEAMILVGATPER
MAV_0575|M.avium_104 HTPTWLDSLGYDRPREDRVTVQLTYASQALRMTGEAPRELGLLIGIVPGR
MAB_1628c|M.abscessus_ATCC_199 RTQTFLDRLGFARPAETRVASPVTYASQLLHVSEDTDLDKLTFLNAAPGR
Mb3282|M.bovis_AF2122/97 RLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGASHDQ
Rv3254|M.tuberculosis_H37Rv RLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGASHDQ
MMAR_1288|M.marinum_M RLPVWLSKWGYQRPAEQSMDIGINYASQQLRIPDGLIQEKVVVAGVAHDR
MUL_2598|M.ulcerans_Agy99 RLPVWLTQWGYQRPPEETVDIGINYASQRLRIPDGLMRERIVVTGVGPGQ
Mflv_4723|M.gilvum_PYR-GCK RLPTWLSQWGFERPREDTVDVGISYATHQLRIPDGLIDEKVIVVGASRTQ
: . * *: ** : : :.* :: :::. : . . :
Mvan_5929|M.vanbaalenii_PYR-1 PTGMALFGYENATWIFTAIGMAGRESP-AELTEMLTFVDDFTPPHVAAAL
MSMEG_5801|M.smegmatis_MC2_155 PTGASLFAYENDTWMLTVAGIAGTEPP-ADLAGRQRFVAELGVPQLDAAL
MAV_0575|M.avium_104 PRGCGLLHCEHDTWLLTVMGVGGEEPATLDLATLCDFIADCAPAHLLAAV
MAB_1628c|M.abscessus_ATCC_199 PFGGAIARCENDTVMMTLGQFNLDEPP-TTFAEMITLAEQFVPHAVVETL
Mb3282|M.bovis_AF2122/97 SLGLGMLCYEDGTWVLTTFGVADAKPP-PTFDEMRALADKLLPARFTAAL
Rv3254|M.tuberculosis_H37Rv SLGLGMLCYEDGTWVLTTFGVADAKPP-PTFDEMRALADKLLPARFTAAL
MMAR_1288|M.marinum_M SLGLGMLCYEDGTWVMTTFGVAGAKPP-PTFGEMRALAERLLPARFNAAL
MUL_2598|M.ulcerans_Agy99 SLGLGMLCNEDGSWILTTFGVAKVKPP-STFGEMRELAYRLLPSRFVAAL
Mflv_4723|M.gilvum_PYR-GCK PRGLGMLYYEDGTWGLTTFGVGKVPAP-TDFNEMRELAEELLPAHIGAAL
. * .: *. : :* . .. : : . ::
Mvan_5929|M.vanbaalenii_PYR-1 REAEPLADIARHRMPSSQWRRYDKMQRFPAGLLVFGDAICSFNPIYGQGM
MSMEG_5801|M.smegmatis_MC2_155 RDGTPLTEPHRHRLPNSRRRRYEAMRRFPAGLLVLGDAICSFNPIYGQGM
MAV_0575|M.avium_104 RGAEPVGEPVRHRMPCSRWRRYDKLRRFPDGLLVTGDAICSFNPIYGQGM
MAB_1628c|M.abscessus_ATCC_199 RSAEPVGAVHNFWYRDAVWRRYDEMDGFPEGLLVIGDAVCSLDPIRGQGM
Mb3282|M.bovis_AF2122/97 AQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGM
Rv3254|M.tuberculosis_H37Rv AQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGM
MMAR_1288|M.marinum_M AQSEPIGAPMFHAFPASKWRRYDKLDRFPAGIVPFGDAVASFNPTFGQGM
MUL_2598|M.ulcerans_Agy99 AAAGPIGEPVFHAFPASRWRRYDKLSRFPAGIVALGDAVASFNPTFGQGM
Mflv_4723|M.gilvum_PYR-GCK YQTHPLGDVALHKYPTSRWRRFDELDRYPRGILPFGDAVASFNPTFGQGM
*: . : **:: : :* *:: ***:.*::* ****
Mvan_5929|M.vanbaalenii_PYR-1 TVAALQAEALRKCLQHG----AAGLARRYFRATAKPISVAWRLAAGADLN
MSMEG_5801|M.smegmatis_MC2_155 SVAAYEAHALRDLLREG----DRDLARRFFRAAAEYVDQAWRMAVNSDLA
MAV_0575|M.avium_104 SVAALEALALRDCLSSG----TTDLARRFFRAAAAPIRQAWQLSTNPDLA
MAB_1628c|M.abscessus_ATCC_199 TMALLEAAALRDCLFEG----DADLARRYFQTVGKRISTAWEHNRMTAPL
Mb3282|M.bovis_AF2122/97 TMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDIS
Rv3254|M.tuberculosis_H37Rv TMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDIS
MMAR_1288|M.marinum_M TMTSLQAGHLRRALQSP----HGDLATQLNRATAKTTYPVWTMNAIGDIS
MUL_2598|M.ulcerans_Agy99 TMASLQAGHLRRALQSH----PAEPANEFNRATAKTIRPVWTMNALTDLC
Mflv_4723|M.gilvum_PYR-GCK TMTSLQAGHLQRALQEP------EPEATFLAATAKSTWPVWTMNAIGDLT
::: :* *: * :.. .*
Mvan_5929|M.vanbaalenii_PYR-1 LHEVEGR-RPPSVRIAN----RYVDRLQRAAESDNVVAEQFVKVTGLIDP
MSMEG_5801|M.smegmatis_MC2_155 LPQVPGR-RTAGVRLSN----WLTGQVLATAAVDDGVAEQFLRVMSMLDP
MAV_0575|M.avium_104 LPEIEGT-PPLIARAFN----KYVDRVLTAAETDTVALNQFIRVTSLVDP
MAB_1628c|M.abscessus_ATCC_199 HSSAPDS-ATFGQRVKWNLMAWWSAKMLMAARNDIAITETILRVNNMQDA
Mb3282|M.bovis_AF2122/97 FHHATAEPLPRWWRPAG----SLFDQFLGAAETDPVLAEWFLRRFSLLDS
Rv3254|M.tuberculosis_H37Rv FHHATAEPLPRWWRPAG----SLFDQFLGAAETDPVLAEWFLRRFSLLDS
MMAR_1288|M.marinum_M FHHGLTQSPPAWWRPAG----ALFDQFLGAAETDPVLAEWFLRRFSLLDS
MUL_2598|M.ulcerans_Agy99 FQHAEGR-MPRWYRPVG----GLYDQFLGAAETDPVLAEWFLRRISLLDS
Mflv_4723|M.gilvum_PYR-GCK MHGADGP-APWWYRPVG----ALFDQFLGAAESDPVLAEWFLRRFSLLDS
. * :. :* * : ::: .: *.
Mvan_5929|M.vanbaalenii_PYR-1 PARLLHPKILLRVAFT---------------SWRRRGRHR----------
MSMEG_5801|M.smegmatis_MC2_155 PTRLFRPSVLWRVAEH---------------SQRRRRRVP----------
MAV_0575|M.avium_104 ATRLLRPSIMWRAARARGADHPGTAGGSGTPSSASTPRANVGKSVMSPST
MAB_1628c|M.abscessus_ATCC_199 PRSMRRPTFVLRVLRH---------------CWRRHETSTAPAPQRQLTL
Mb3282|M.bovis_AF2122/97 LYMVPSVPIIGRAIAHN------------LRLWLKEQRE----RRQPVTT
Rv3254|M.tuberculosis_H37Rv LYMVPSVPIIGRAIAHN------------LRLWLKEQRE----RRQPVTT
MMAR_1288|M.marinum_M LYIVPPPRLIGRTIAHN------------VGLWLRERRQSASSRGRTLTA
MUL_2598|M.ulcerans_Agy99 LYMVPSPLIIGRAVAHN------------ARMWLRQRRP------KPSAT
Mflv_4723|M.gilvum_PYR-GCK LYMVPSARLIGRTVRHN------------MTLWARSRRS-------PGTA
: .: *.
Mvan_5929|M.vanbaalenii_PYR-1 ------
MSMEG_5801|M.smegmatis_MC2_155 ------
MAV_0575|M.avium_104 P-----
MAB_1628c|M.abscessus_ATCC_199 SGV---
Mb3282|M.bovis_AF2122/97 RRSP--
Rv3254|M.tuberculosis_H37Rv RRSP--
MMAR_1288|M.marinum_M PRSP--
MUL_2598|M.ulcerans_Agy99 SR----
Mflv_4723|M.gilvum_PYR-GCK SSAPAR