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MAGQAVVLGASMSGLLAARVLADHFDTVAVVERDVLPDGTDQRRGVPQGRHVHGLLCAGASALDALFPGF LDELAADGATRLDERGAHRLSMMFGGHPLHFPMSFTRPLVSYLCSRPFLETHVRQRVRSAGNIQILDGHD VADMTMSGDGRRVSGVRIADRAGGAEQTLDADLVVDATGRSARTPAFLERHGYPRPVEERIAIQVAYSSQ LLRIPRDAVEQILFLIAPAPELAAAAVLFAYENDTWMFTAVGLTGNDPPTDPGGMKAFVAPFAPQALRAA LDAAQPLSQVSSYRYPASVRRRYDRIRRFPLGLLVTGDAICSFNPAYGQGMSVAALEALILRDCLESGTR DLHRRFQHSAAKLLDRVWQMAAGADLTFPQVEGPRPVSIRLNNWYTDRVLTAAESDTTVSEAFFRVMNLV DPPTRLLRPSVLARSIAARSHRAPATATGQLSAAPGVTSDR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3511 | - | - | 100% (461) | hydroxylase |
| M. smegmatis MC2 155 | MSMEG_5801 | - | e-120 | 50.68% (442) | hydroxylase |
| M. smegmatis MC2 155 | MSMEG_1837 | - | 5e-74 | 37.27% (432) | secreted protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3282 | - | 2e-67 | 35.60% (441) | hypothetical protein Mb3282 |
| M. gilvum PYR-GCK | Mflv_4723 | - | 5e-74 | 38.41% (453) | hypothetical protein Mflv_4723 |
| M. tuberculosis H37Rv | Rv3254 | - | 2e-67 | 35.60% (441) | hypothetical protein Rv3254 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1628c | - | 9e-88 | 43.15% (438) | hypothetical protein MAB_1628c |
| M. marinum M | MMAR_1288 | - | 3e-73 | 36.80% (462) | hypothetical protein MMAR_1288 |
| M. avium 104 | MAV_0575 | - | 1e-117 | 51.01% (447) | hypothetical protein MAV_0575 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2598 | - | 2e-72 | 37.16% (436) | hypothetical protein MUL_2598 |
| M. vanbaalenii PYR-1 | Mvan_5929 | - | 1e-121 | 51.61% (434) | hypothetical protein Mvan_5929 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3511|M.smegmatis_MC2_155 -----------MAGQAVVLGASMSGLLAARVLADHFDTVAVVERDVLPDG
MAV_0575|M.avium_104 -------MTTKVGEHAVVLGASMGGLLAGRSLADFFDRVTVVERDPLPDA
Mvan_5929|M.vanbaalenii_PYR-1 MNPDGPLVMNNLGDHAVVLGASMGGLLAARVLADFYRTVTIVERDVLPND
MAB_1628c|M.abscessus_ATCC_199 ----MTPHVRDHRDHAVVLGAGMAGLLAARVLSESYASVTVVERDELHKV
Mb3282|M.bovis_AF2122/97 ----------------MVIGASIAGLCAARVLSDFYSTVTVFERDELPEA
Rv3254|M.tuberculosis_H37Rv ----------------MVIGASIAGLCAARVLSDFYSTVTVFERDELPEA
MMAR_1288|M.marinum_M ----MRGTLSTSNNHALVIGASIAGLCAARVLSDFFHRVTLIERDELPSA
MUL_2598|M.ulcerans_Agy99 MGASVEKRAVNPAEHATVIGASIGGLCAARVLSDFYSKVIVCERDDLPST
Mflv_4723|M.gilvum_PYR-GCK ----------MGRKHAIVIGASLGGLCAARVLSSAFDDVTVFERDPLPEG
*:**.:.** *.* *:. : * : *** * .
MSMEG_3511|M.smegmatis_MC2_155 TDQRRGVPQGRHVHGLLCAGASALDALFPGFLDELAADGATRLDERGAHR
MAV_0575|M.avium_104 HGARRGVPQGRHLHALLCRGAQAIEELFPGVLDQMVRDGAQYFDGQDLSQ
Mvan_5929|M.vanbaalenii_PYR-1 PVNRRGVPQGRHVHALLARGSRILEELFPGLLDEVVAGGAPVLDGTDPSE
MAB_1628c|M.abscessus_ATCC_199 AAARSGVPQGHHIHMFMAAGTQGLEQLFPGILDDLRTDGATVCDEGDLSR
Mb3282|M.bovis_AF2122/97 PANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENR-PDC
Rv3254|M.tuberculosis_H37Rv PANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENR-PDC
MMAR_1288|M.marinum_M PHGRATVPQDRHLHMLMARGANEFENLFPGLLTDMVAAGVPMLENR-PDC
MUL_2598|M.ulcerans_Agy99 PSGRGTVPQDQHLHLLMARGAAELDTLFPGLLTDLVAAGVPMLDNR-PDC
Mflv_4723|M.gilvum_PYR-GCK PANRPAVPQGRHVHLLMARGAAEFETLFPGLLDDMVACGVPILENR-PDC
* ***.:*:* ::. *: :: ****.* :: *. :
MSMEG_3511|M.smegmatis_MC2_155 LSMMFGGHPLH---FPMSFTRPLVSYLCSRPFLETHVRQRVRSAGNIQIL
MAV_0575|M.avium_104 LYYNIGGHLMT---RSGAAPG-LTAYSATRPFLEDHVRGRLRGIPNVTLR
Mvan_5929|M.vanbaalenii_PYR-1 GYFRFGGHLLP---RDGRPKDPITLLLPSRPMLEYLVRQKVRGIPNIAML
MAB_1628c|M.abscessus_ATCC_199 IRMLLGTHEMFNRTKKFSDPETFKLYLTTRPFLEFHVRQRVQRLGNVKFL
Mb3282|M.bovis_AF2122/97 IYLGAAGHVLG---TGHTLRKEFTAYVPSRPHLEWQLRRRVLQLSNVQIV
Rv3254|M.tuberculosis_H37Rv IYLGAAGHVLG---TGHTLRKEFTAYVPSRPHLEWQLRRRVLQLSNVQIV
MMAR_1288|M.marinum_M IYFAAAGHALG---TGHTLRKEFTAYVPSRPHLEWQLRRRVLELDNIEIV
MUL_2598|M.ulcerans_Agy99 IYLGAAGHVLG---TGAKLRKQYTAYLPSRPHLEWQLRRRVLALGNVEIR
Mflv_4723|M.gilvum_PYR-GCK IHFGAAGHLLG---TTHRLQDEFTAYVPSRPHLEWQIRRRVLALDNVRLI
. * : :** ** :* :: *: :
MSMEG_3511|M.smegmatis_MC2_155 DGHDVADMTMSGDGRRVSGVRIADR----AGGAEQTLDADLVVDATGRSA
MAV_0575|M.avium_104 DEHCVTRLVSTADRRRVVGAWVADG----RTGETTAMPADLVVDATGRAA
Mvan_5929|M.vanbaalenii_PYR-1 EAHDVVDLTSASQQDRVTGARVRAR----DNGAERVLNAELVVDATGRGS
MAB_1628c|M.abscessus_ATCC_199 DGHDVIEPMTAEH--RITGVRVARR----STGLVTTLICDLVVDATGRTP
Mb3282|M.bovis_AF2122/97 RRL-VTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAAGRGT
Rv3254|M.tuberculosis_H37Rv RRL-VTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAAGRGT
MMAR_1288|M.marinum_M RGL-VIEPRFEPTTQTVSGVLVAPPDD-DDGAEPQFLAADLVVDAAGRGT
MUL_2598|M.ulcerans_Agy99 QRK-VREPHFDPVRQRVTGLLLD-----DHDGDPELIASGLVIDAAGRGT
Mflv_4723|M.gilvum_PYR-GCK DCG-VDEPVYDG--HRVTGVRTA---------DGATVDADFVVDATGRGT
* : * : . :*:**:** .
MSMEG_3511|M.smegmatis_MC2_155 RTPAFLERHGYPRPVEERIAIQVAYSSQLLRIPRDAVEQILFLIAPAPEL
MAV_0575|M.avium_104 HTPTWLDSLGYDRPREDRVTVQLTYASQALRMTGEAPRELGLLIGIVPGR
Mvan_5929|M.vanbaalenii_PYR-1 RTPAFLDHLGYNRPAQDHIDVRLTYSSQLLRLPPGAVKERIVIVGPIPGR
MAB_1628c|M.abscessus_ATCC_199 RTQTFLDRLGFARPAETRVASPVTYASQLLHVSEDTDLDKLTFLNAAPGR
Mb3282|M.bovis_AF2122/97 RLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGASHDQ
Rv3254|M.tuberculosis_H37Rv RLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGASHDQ
MMAR_1288|M.marinum_M RLPVWLSKWGYQRPAEQSMDIGINYASQQLRIPDGLIQEKVVVAGVAHDR
MUL_2598|M.ulcerans_Agy99 RLPVWLTQWGYQRPPEETVDIGINYASQRLRIPDGLMRERIVVTGVGPGQ
Mflv_4723|M.gilvum_PYR-GCK RLPTWLSQWGFERPREDTVDVGISYATHQLRIPDGLIDEKVIVVGASRTQ
: .:* *: ** : : : *::: :::. : .
MSMEG_3511|M.smegmatis_MC2_155 AAAAVLFAYENDTWMFTAVGLTGNDPPT-DPGGMKAFVAPFAPQALRAAL
MAV_0575|M.avium_104 PRGCGLLHCEHDTWLLTVMGVGGEEPATLDLATLCDFIADCAPAHLLAAV
Mvan_5929|M.vanbaalenii_PYR-1 PTGMALFGYENATWIFTAIGMAGRESPA-ELTEMLTFVDDFTPPHVAAAL
MAB_1628c|M.abscessus_ATCC_199 PFGGAIARCENDTVMMTLGQFNLDEPPT-TFAEMITLAEQFVPHAVVETL
Mb3282|M.bovis_AF2122/97 SLGLGMLCYEDGTWVLTTFGVADAKPPP-TFDEMRALADKLLPARFTAAL
Rv3254|M.tuberculosis_H37Rv SLGLGMLCYEDGTWVLTTFGVADAKPPP-TFDEMRALADKLLPARFTAAL
MMAR_1288|M.marinum_M SLGLGMLCYEDGTWVMTTFGVAGAKPPP-TFGEMRALAERLLPARFNAAL
MUL_2598|M.ulcerans_Agy99 SLGLGMLCNEDGSWILTTFGVAKVKPPS-TFGEMRELAYRLLPSRFVAAL
Mflv_4723|M.gilvum_PYR-GCK PRGLGMLYYEDGTWGLTTFGVGKVPAPT-DFNEMRELAEELLPAHIGAAL
. . : *. : :* . ... : : * . ::
MSMEG_3511|M.smegmatis_MC2_155 DAAQPLSQVSSYRYPASVRRRYDRIRRFPLGLLVTGDAICSFNPAYGQGM
MAV_0575|M.avium_104 RGAEPVGEPVRHRMPCSRWRRYDKLRRFPDGLLVTGDAICSFNPIYGQGM
Mvan_5929|M.vanbaalenii_PYR-1 REAEPLADIARHRMPSSQWRRYDKMQRFPAGLLVFGDAICSFNPIYGQGM
MAB_1628c|M.abscessus_ATCC_199 RSAEPVGAVHNFWYRDAVWRRYDEMDGFPEGLLVIGDAVCSLDPIRGQGM
Mb3282|M.bovis_AF2122/97 AQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGM
Rv3254|M.tuberculosis_H37Rv AQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGM
MMAR_1288|M.marinum_M AQSEPIGAPMFHAFPASKWRRYDKLDRFPAGIVPFGDAVASFNPTFGQGM
MUL_2598|M.ulcerans_Agy99 AAAGPIGEPVFHAFPASRWRRYDKLSRFPAGIVALGDAVASFNPTFGQGM
Mflv_4723|M.gilvum_PYR-GCK YQTHPLGDVALHKYPTSRWRRFDELDRYPRGILPFGDAVASFNPTFGQGM
: *:. . : **:*.: :* *:: ***:.*::* ****
MSMEG_3511|M.smegmatis_MC2_155 SVAALEALILRDCLESG----TRDLHRRFQHSAAKLLDRVWQMAAGADLT
MAV_0575|M.avium_104 SVAALEALALRDCLSSG----TTDLARRFFRAAAAPIRQAWQLSTNPDLA
Mvan_5929|M.vanbaalenii_PYR-1 TVAALQAEALRKCLQHG----AAGLARRYFRATAKPISVAWRLAAGADLN
MAB_1628c|M.abscessus_ATCC_199 TMALLEAAALRDCLFEG----DADLARRYFQTVGKRISTAWEHNRMTAPL
Mb3282|M.bovis_AF2122/97 TMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDIS
Rv3254|M.tuberculosis_H37Rv TMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDIS
MMAR_1288|M.marinum_M TMTSLQAGHLRRALQSP----HGDLATQLNRATAKTTYPVWTMNAIGDIS
MUL_2598|M.ulcerans_Agy99 TMASLQAGHLRRALQSH----PAEPANEFNRATAKTIRPVWTMNALTDLC
Mflv_4723|M.gilvum_PYR-GCK TMTSLQAGHLQRALQEP------EPEATFLAATAKSTWPVWTMNAIGDLT
::: *:* *: .* :.. .*
MSMEG_3511|M.smegmatis_MC2_155 FPQVEGP-RPVSIRLNN----WYTDRVLTAAESDTTVSEAFFRVMNLVDP
MAV_0575|M.avium_104 LPEIEGT-PPLIARAFN----KYVDRVLTAAETDTVALNQFIRVTSLVDP
Mvan_5929|M.vanbaalenii_PYR-1 LHEVEGR-RPPSVRIAN----RYVDRLQRAAESDNVVAEQFVKVTGLIDP
MAB_1628c|M.abscessus_ATCC_199 HSSAPDS-ATFGQRVKWNLMAWWSAKMLMAARNDIAITETILRVNNMQDA
Mb3282|M.bovis_AF2122/97 FHHATAEPLPRWWRPAG----SLFDQFLGAAETDPVLAEWFLRRFSLLDS
Rv3254|M.tuberculosis_H37Rv FHHATAEPLPRWWRPAG----SLFDQFLGAAETDPVLAEWFLRRFSLLDS
MMAR_1288|M.marinum_M FHHGLTQSPPAWWRPAG----ALFDQFLGAAETDPVLAEWFLRRFSLLDS
MUL_2598|M.ulcerans_Agy99 FQHAEGR-MPRWYRPVG----GLYDQFLGAAETDPVLAEWFLRRISLLDS
Mflv_4723|M.gilvum_PYR-GCK MHGADGP-APWWYRPVG----ALFDQFLGAAESDPVLAEWFLRRFSLLDS
. * :. **..* . : :.: .: *.
MSMEG_3511|M.smegmatis_MC2_155 PTRLLRPSVLARSIAARSHRAPATATG----QLSAAPGVTSDR-------
MAV_0575|M.avium_104 ATRLLRPSIMWRAARARGADHPGTAGG----SGTPSSASTPRANVGKSVM
Mvan_5929|M.vanbaalenii_PYR-1 PARLLHPKILLRVAFTSWRRRGRHR-------------------------
MAB_1628c|M.abscessus_ATCC_199 PRSMRRPTFVLRVLRHCWRRHETSTAP----APQRQLTLSGV--------
Mb3282|M.bovis_AF2122/97 LYMVPSVPIIGRAIAHNLRLWLKEQRE----RRQPVTTRRSP--------
Rv3254|M.tuberculosis_H37Rv LYMVPSVPIIGRAIAHNLRLWLKEQRE----RRQPVTTRRSP--------
MMAR_1288|M.marinum_M LYIVPPPRLIGRTIAHNVGLWLRERRQSASSRGRTLTAPRSP--------
MUL_2598|M.ulcerans_Agy99 LYMVPSPLIIGRAVAHNARMWLRQRRP------KPSATSR----------
Mflv_4723|M.gilvum_PYR-GCK LYMVPSARLIGRTVRHNMTLWARSRRS-------PGTASSAPAR------
: .: *
MSMEG_3511|M.smegmatis_MC2_155 -----
MAV_0575|M.avium_104 SPSTP
Mvan_5929|M.vanbaalenii_PYR-1 -----
MAB_1628c|M.abscessus_ATCC_199 -----
Mb3282|M.bovis_AF2122/97 -----
Rv3254|M.tuberculosis_H37Rv -----
MMAR_1288|M.marinum_M -----
MUL_2598|M.ulcerans_Agy99 -----
Mflv_4723|M.gilvum_PYR-GCK -----