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TTKVGEHAVVLGASMGGLLAGRSLADFFDRVTVVERDPLPDAHGARRGVPQGRHLHALLCRGAQAIEELF PGVLDQMVRDGAQYFDGQDLSQLYYNIGGHLMTRSGAAPGLTAYSATRPFLEDHVRGRLRGIPNVTLRDE HCVTRLVSTADRRRVVGAWVADGRTGETTAMPADLVVDATGRAAHTPTWLDSLGYDRPREDRVTVQLTYA SQALRMTGEAPRELGLLIGIVPGRPRGCGLLHCEHDTWLLTVMGVGGEEPATLDLATLCDFIADCAPAHL LAAVRGAEPVGEPVRHRMPCSRWRRYDKLRRFPDGLLVTGDAICSFNPIYGQGMSVAALEALALRDCLSS GTTDLARRFFRAAAAPIRQAWQLSTNPDLALPEIEGTPPLIARAFNKYVDRVLTAAETDTVALNQFIRVT SLVDPATRLLRPSIMWRAARARGADHPGTAGGSGTPSSASTPRANVGKSVMSPSTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0575 | - | - | 100% (477) | hypothetical protein MAV_0575 |
| M. avium 104 | MAV_2316 | - | 4e-91 | 44.00% (450) | hypothetical protein MAV_2316 |
| M. avium 104 | MAV_4218 | - | 2e-71 | 36.77% (465) | hypothetical protein MAV_4218 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3282 | - | 8e-70 | 38.57% (446) | hypothetical protein Mb3282 |
| M. gilvum PYR-GCK | Mflv_4723 | - | 2e-79 | 39.22% (459) | hypothetical protein Mflv_4723 |
| M. tuberculosis H37Rv | Rv3254 | - | 8e-70 | 38.57% (446) | hypothetical protein Rv3254 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1628c | - | 3e-80 | 39.96% (448) | hypothetical protein MAB_1628c |
| M. marinum M | MMAR_1289 | - | 3e-80 | 39.86% (434) | hypothetical protein MMAR_1289 |
| M. smegmatis MC2 155 | MSMEG_3511 | - | 1e-117 | 51.01% (447) | hydroxylase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2598 | - | 2e-80 | 39.86% (434) | hypothetical protein MUL_2598 |
| M. vanbaalenii PYR-1 | Mvan_5929 | - | 1e-127 | 52.86% (437) | hypothetical protein Mvan_5929 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0575|M.avium_104 -------MTTKVGEHAVVLGASMGGLLAGRSLADFFDRVTVVERDPLPDA
MSMEG_3511|M.smegmatis_MC2_155 -----------MAGQAVVLGASMSGLLAARVLADHFDTVAVVERDVLPDG
Mvan_5929|M.vanbaalenii_PYR-1 MNPDGPLVMNNLGDHAVVLGASMGGLLAARVLADFYRTVTIVERDVLPND
MAB_1628c|M.abscessus_ATCC_199 ----MTPHVRDHRDHAVVLGAGMAGLLAARVLSESYASVTVVERDELHKV
Mb3282|M.bovis_AF2122/97 ----------------MVIGASIAGLCAARVLSDFYSTVTVFERDELPEA
Rv3254|M.tuberculosis_H37Rv ----------------MVIGASIAGLCAARVLSDFYSTVTVFERDELPEA
MMAR_1289|M.marinum_M MGASVEKRAVNPAEHATVIGASIGGLCAARVLSDFYSKVIVCERDDLPST
MUL_2598|M.ulcerans_Agy99 MGASVEKRAVNPAEHATVIGASIGGLCAARVLSDFYSKVIVCERDDLPST
Mflv_4723|M.gilvum_PYR-GCK MGR----------KHAIVIGASLGGLCAARVLSSAFDDVTVFERDPLPEG
*:**.:.** *.* *:. : * : *** * .
MAV_0575|M.avium_104 HGARRGVPQGRHLHALLCRGAQAIEELFPGVLDQMVRDGAQYFDGQDLSQ
MSMEG_3511|M.smegmatis_MC2_155 TDQRRGVPQGRHVHGLLCAGASALDALFPGFLDELAADGATRLDERGAHR
Mvan_5929|M.vanbaalenii_PYR-1 PVNRRGVPQGRHVHALLARGSRILEELFPGLLDEVVAGGAPVLDGTDPSE
MAB_1628c|M.abscessus_ATCC_199 AAARSGVPQGHHIHMFMAAGTQGLEQLFPGILDDLRTDGATVCDEGDLSR
Mb3282|M.bovis_AF2122/97 PANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENR-PDC
Rv3254|M.tuberculosis_H37Rv PANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENR-PDC
MMAR_1289|M.marinum_M PSGRGTVPQDQHLHLLMARGAAELDTLFPGLLTDLVAAGVPMLDNR-PDC
MUL_2598|M.ulcerans_Agy99 PSGRGTVPQDQHLHLLMARGAAELDTLFPGLLTDLVAAGVPMLDNR-PDC
Mflv_4723|M.gilvum_PYR-GCK PANRPAVPQGRHVHLLMARGAAEFETLFPGLLDDMVACGVPILENR-PDC
* ***.:*:* ::. *: :: ****.* :: *. :
MAV_0575|M.avium_104 LYYNIGGHLMT---RSGAAPG-LTAYSATRPFLEDHVRGRLRGIPNVTLR
MSMEG_3511|M.smegmatis_MC2_155 LSMMFGGHPLH---FPMSFTRPLVSYLCSRPFLETHVRQRVRSAGNIQIL
Mvan_5929|M.vanbaalenii_PYR-1 GYFRFGGHLLP---RDGRPKDPITLLLPSRPMLEYLVRQKVRGIPNIAML
MAB_1628c|M.abscessus_ATCC_199 IRMLLGTHEMFNRTKKFSDPETFKLYLTTRPFLEFHVRQRVQRLGNVKFL
Mb3282|M.bovis_AF2122/97 IYLGAAGHVLG---TGHTLRKEFTAYVPSRPHLEWQLRRRVLQLSNVQIV
Rv3254|M.tuberculosis_H37Rv IYLGAAGHVLG---TGHTLRKEFTAYVPSRPHLEWQLRRRVLQLSNVQIV
MMAR_1289|M.marinum_M IYLGAAGHVLG---TGAKLRKQYTAYLPSRPHLEWQLRRRVLALGNVEIR
MUL_2598|M.ulcerans_Agy99 IYLGAAGHVLG---TGAKLRKQYTAYLPSRPHLEWQLRRRVLALGNVEIR
Mflv_4723|M.gilvum_PYR-GCK IHFGAAGHLLG---TTHRLQDEFTAYVPSRPHLEWQIRRRVLALDNVRLI
. * : :** ** :* :: *: :
MAV_0575|M.avium_104 DEHCVTRLVSTADRRRVVGAWVADGRTGE----TTAMPADLVVDATGRAA
MSMEG_3511|M.smegmatis_MC2_155 DGHDVADMTMSGDGRRVSGVRIADRAGGA----EQTLDADLVVDATGRSA
Mvan_5929|M.vanbaalenii_PYR-1 EAHDVVDLTSASQQDRVTGARVRARDNGA----ERVLNAELVVDATGRGS
MAB_1628c|M.abscessus_ATCC_199 DGHDVIEPMTAEH--RITGVRVARRSTGL----VTTLICDLVVDATGRTP
Mb3282|M.bovis_AF2122/97 R-RLVTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAAGRGT
Rv3254|M.tuberculosis_H37Rv R-RLVTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAAGRGT
MMAR_1289|M.marinum_M Q-RKVREPHFDPVRQRVTGLLLDDHDGDP-----ELIASGLVIDAAGRGT
MUL_2598|M.ulcerans_Agy99 Q-RKVREPHFDPVRQRVTGLLLDDHDGDP-----ELIASGLVIDAAGRGT
Mflv_4723|M.gilvum_PYR-GCK D-CGVDEPVYDG--HRVTGVRTADG---------ATVDADFVVDATGRGT
* *: * : . :*:**:** .
MAV_0575|M.avium_104 HTPTWLDSLGYDRPREDRVTVQLTYASQALRMTGEAPRELGLLIGIVPGR
MSMEG_3511|M.smegmatis_MC2_155 RTPAFLERHGYPRPVEERIAIQVAYSSQLLRIPRDAVEQILFLIAPAPEL
Mvan_5929|M.vanbaalenii_PYR-1 RTPAFLDHLGYNRPAQDHIDVRLTYSSQLLRLPPGAVKERIVIVGPIPGR
MAB_1628c|M.abscessus_ATCC_199 RTQTFLDRLGFARPAETRVASPVTYASQLLHVSEDTDLDKLTFLNAAPGR
Mb3282|M.bovis_AF2122/97 RLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGASHDQ
Rv3254|M.tuberculosis_H37Rv RLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGASHDQ
MMAR_1289|M.marinum_M RLPVWLTQWGYQRPPEETVDIGINYASQRLRIPDGLMREKIVVTGVGPGQ
MUL_2598|M.ulcerans_Agy99 RLPVWLTQWGYQRPPEETVDIGINYASQRLRIPDGLMRERIVVTGVGPGQ
Mflv_4723|M.gilvum_PYR-GCK RLPTWLSQWGFERPREDTVDVGISYATHQLRIPDGLIDEKVIVVGASRTQ
: .:* *: ** : : : *::: :::. : .
MAV_0575|M.avium_104 PRGCGLLHCEHDTWLLTVMGVGGEEPATLDLATLCDFIADCAPAHLLAAV
MSMEG_3511|M.smegmatis_MC2_155 AAAAVLFAYENDTWMFTAVGLTGNDPPT-DPGGMKAFVAPFAPQALRAAL
Mvan_5929|M.vanbaalenii_PYR-1 PTGMALFGYENATWIFTAIGMAGRESPA-ELTEMLTFVDDFTPPHVAAAL
MAB_1628c|M.abscessus_ATCC_199 PFGGAIARCENDTVMMTLGQFNLDEPPT-TFAEMITLAEQFVPHAVVETL
Mb3282|M.bovis_AF2122/97 SLGLGMLCYEDGTWVLTTFGVADAKPPP-TFDEMRALADKLLPARFTAAL
Rv3254|M.tuberculosis_H37Rv SLGLGMLCYEDGTWVLTTFGVADAKPPP-TFDEMRALADKLLPARFTAAL
MMAR_1289|M.marinum_M SLGLGMLCNEDGSWILTTFGVAKVKPPS-TFGEMRELAYRLLPSRFVAAL
MUL_2598|M.ulcerans_Agy99 SLGLGMLCNEDGSWILTTFGVAKVKPPS-TFGEMRELAYRLLPSRFVAAL
Mflv_4723|M.gilvum_PYR-GCK PRGLGMLYYEDGTWGLTTFGVGKVPAPT-DFNEMRELAEELLPAHIGAAL
. . : *. : :* . ... : : * . ::
MAV_0575|M.avium_104 RGAEPVGEPVRHRMPCSRWRRYDKLRRFPDGLLVTGDAICSFNPIYGQGM
MSMEG_3511|M.smegmatis_MC2_155 DAAQPLSQVSSYRYPASVRRRYDRIRRFPLGLLVTGDAICSFNPAYGQGM
Mvan_5929|M.vanbaalenii_PYR-1 REAEPLADIARHRMPSSQWRRYDKMQRFPAGLLVFGDAICSFNPIYGQGM
MAB_1628c|M.abscessus_ATCC_199 RSAEPVGAVHNFWYRDAVWRRYDEMDGFPEGLLVIGDAVCSLDPIRGQGM
Mb3282|M.bovis_AF2122/97 AQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGM
Rv3254|M.tuberculosis_H37Rv AQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGM
MMAR_1289|M.marinum_M AAAGPIGEPVFHAFPASRWRRYDKLSRFPAGIVALGDAVASFNPTFGQGM
MUL_2598|M.ulcerans_Agy99 AAAGPIGEPVFHAFPASRWRRYDKLSRFPAGIVALGDAVASFNPTFGQGM
Mflv_4723|M.gilvum_PYR-GCK YQTHPLGDVALHKYPTSRWRRFDELDRYPRGILPFGDAVASFNPTFGQGM
: *:. . : **:*.: :* *:: ***:.*::* ****
MAV_0575|M.avium_104 SVAALEALALRDCLSSGT----TDLARRFFRAAAAPIRQAWQLSTNPDLA
MSMEG_3511|M.smegmatis_MC2_155 SVAALEALILRDCLESGT----RDLHRRFQHSAAKLLDRVWQMAAGADLT
Mvan_5929|M.vanbaalenii_PYR-1 TVAALQAEALRKCLQHGA----AGLARRYFRATAKPISVAWRLAAGADLN
MAB_1628c|M.abscessus_ATCC_199 TMALLEAAALRDCLFEGD----ADLARRYFQTVGKRISTAWEHNRMTAPL
Mb3282|M.bovis_AF2122/97 TMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDIS
Rv3254|M.tuberculosis_H37Rv TMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDIS
MMAR_1289|M.marinum_M TMASLQAGHLRRALQSHP----AEPANEFNRATAKTIRPVWTMNALTDLC
MUL_2598|M.ulcerans_Agy99 TMASLQAGHLRRALQSHP----AEPANEFNRATAKTIRPVWTMNALTDLC
Mflv_4723|M.gilvum_PYR-GCK TMTSLQAGHLQRALQEPE------PEATFLAATAKSTWPVWTMNAIGDLT
::: *:* *: .* :.. .*
MAV_0575|M.avium_104 LPEIEGT-PPLIARAFN----KYVDRVLTAAETDTVALNQFIRVTSLVDP
MSMEG_3511|M.smegmatis_MC2_155 FPQVEGP-RPVSIRLNN----WYTDRVLTAAESDTTVSEAFFRVMNLVDP
Mvan_5929|M.vanbaalenii_PYR-1 LHEVEGR-RPPSVRIAN----RYVDRLQRAAESDNVVAEQFVKVTGLIDP
MAB_1628c|M.abscessus_ATCC_199 HSSAPDS-ATFGQRVKWNLMAWWSAKMLMAARNDIAITETILRVNNMQDA
Mb3282|M.bovis_AF2122/97 FHHATAEPLPRWWRPAG----SLFDQFLGAAETDPVLAEWFLRRFSLLDS
Rv3254|M.tuberculosis_H37Rv FHHATAEPLPRWWRPAG----SLFDQFLGAAETDPVLAEWFLRRFSLLDS
MMAR_1289|M.marinum_M FQHAEGR-MPRWYRPVG----GLYDQFLGAAETDPVLAEWFLRRISLLDS
MUL_2598|M.ulcerans_Agy99 FQHAEGR-MPRWYRPVG----GLYDQFLGAAETDPVLAEWFLRRISLLDS
Mflv_4723|M.gilvum_PYR-GCK MHGADGP-APWWYRPVG----ALFDQFLGAAESDPVLAEWFLRRFSLLDS
. * :. **..* . : :.: .: *.
MAV_0575|M.avium_104 ATRLLRPSIMWRAARARGADHPGTAGGSGTPSSASTPRANVGKSVMSPST
MSMEG_3511|M.smegmatis_MC2_155 PTRLLRPSVLARSIAARSHRAPATATGQLSAAPGVTSDR-----------
Mvan_5929|M.vanbaalenii_PYR-1 PARLLHPKILLRVAFTSWRRRGRHR-------------------------
MAB_1628c|M.abscessus_ATCC_199 PRSMRRPTFVLRVLRHCWRRHETSTAPAPQRQLTLSGV------------
Mb3282|M.bovis_AF2122/97 LYMVPSVPIIGRAIAHNLRLWLKEQRERRQPVTTRRSP------------
Rv3254|M.tuberculosis_H37Rv LYMVPSVPIIGRAIAHNLRLWLKEQRERRQPVTTRRSP------------
MMAR_1289|M.marinum_M LYMVPSPLIIGRAVAHNARMWLRQRRPK--PSATSR--------------
MUL_2598|M.ulcerans_Agy99 LYMVPSPLIIGRAVAHNARMWLRQRRPK--PSATSR--------------
Mflv_4723|M.gilvum_PYR-GCK LYMVPSARLIGRTVRHNMTLWARSRRSPGTASSAPAR-------------
: .: *
MAV_0575|M.avium_104 P
MSMEG_3511|M.smegmatis_MC2_155 -
Mvan_5929|M.vanbaalenii_PYR-1 -
MAB_1628c|M.abscessus_ATCC_199 -
Mb3282|M.bovis_AF2122/97 -
Rv3254|M.tuberculosis_H37Rv -
MMAR_1289|M.marinum_M -
MUL_2598|M.ulcerans_Agy99 -
Mflv_4723|M.gilvum_PYR-GCK -