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GASVEKRAVNPAEHATVIGASIGGLCAARVLSDFYSKVIVCERDDLPSTPSGRGTVPQDQHLHLLMARGA AELDTLFPGLLTDLVAAGVPMLDNRPDCIYLGAAGHVLGTGAKLRKQYTAYLPSRPHLEWQLRRRVLALG NVEIRQRKVREPHFDPVRQRVTGLLLDDHDGDPELIASGLVIDAAGRGTRLPVWLTQWGYQRPPEETVDI GINYASQRLRIPDGLMREKIVVTGVGPGQSLGLGMLCNEDGSWILTTFGVAKVKPPSTFGEMRELAYRLL PSRFVAALAAAGPIGEPVFHAFPASRWRRYDKLSRFPAGIVALGDAVASFNPTFGQGMTMASLQAGHLRR ALQSHPAEPANEFNRATAKTIRPVWTMNALTDLCFQHAEGRMPRWYRPVGGLYDQFLGAAETDPVLAEWF LRRISLLDSLYMVPSPLIIGRAVAHNARMWLRQRRPKPSATSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1289 | - | - | 100% (464) | hypothetical protein MMAR_1289 |
| M. marinum M | MMAR_1288 | - | 0.0 | 70.33% (455) | hypothetical protein MMAR_1288 |
| M. marinum M | MMAR_2865 | - | 2e-35 | 27.49% (451) | oxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3282 | - | 0.0 | 70.81% (459) | hypothetical protein Mb3282 |
| M. gilvum PYR-GCK | Mflv_4723 | - | 1e-159 | 61.78% (450) | hypothetical protein Mflv_4723 |
| M. tuberculosis H37Rv | Rv3254 | - | 0.0 | 70.81% (459) | hypothetical protein Rv3254 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1628c | - | 2e-57 | 32.90% (462) | hypothetical protein MAB_1628c |
| M. avium 104 | MAV_4218 | - | 1e-180 | 68.37% (449) | hypothetical protein MAV_4218 |
| M. smegmatis MC2 155 | MSMEG_1837 | - | 1e-141 | 54.42% (441) | secreted protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2598 | - | 0.0 | 99.78% (464) | hypothetical protein MUL_2598 |
| M. vanbaalenii PYR-1 | Mvan_5929 | - | 3e-89 | 40.85% (448) | hypothetical protein Mvan_5929 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1289|M.marinum_M ----MGASVEKRAVNPAEHATVIGASIGGLCAARVLSDFYSKVIVCERDD
MUL_2598|M.ulcerans_Agy99 ----MGASVEKRAVNPAEHATVIGASIGGLCAARVLSDFYSKVIVCERDD
Mb3282|M.bovis_AF2122/97 --------------------MVIGASIAGLCAARVLSDFYSTVTVFERDE
Rv3254|M.tuberculosis_H37Rv --------------------MVIGASIAGLCAARVLSDFYSTVTVFERDE
MAV_4218|M.avium_104 --------MPDGKANAREHALVIGGSIAGLCAARVLSESYSAVTVCERDE
Mflv_4723|M.gilvum_PYR-GCK --------------MGRKHAIVIGASLGGLCAARVLSSAFDDVTVFERDP
MSMEG_1837|M.smegmatis_MC2_155 MFPLPWQSMSTTLEHSSTHAIVIGGSVAGLCAARVLSDHFDRVTVYERDE
MAB_1628c|M.abscessus_ATCC_199 ----MTPH----VRDHRDHAVVLGAGMAGLLAARVLSESYASVTVVERDE
Mvan_5929|M.vanbaalenii_PYR-1 ----MNPDGPLVMNNLGDHAVVLGASMGGLLAARVLADFYRTVTIVERDV
*:*..:.** *****:. : * : ***
MMAR_1289|M.marinum_M LPSTPSGRGTVPQDQHLHLLMARGAAELDTLFPGLLTDLVAAGVPMLD-N
MUL_2598|M.ulcerans_Agy99 LPSTPSGRGTVPQDQHLHLLMARGAAELDTLFPGLLTDLVAAGVPMLD-N
Mb3282|M.bovis_AF2122/97 LPEAPANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLE-N
Rv3254|M.tuberculosis_H37Rv LPEAPANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLE-N
MAV_4218|M.avium_104 LPAAPASRATVPQDRHLHLLMARGAIEFEKLFPGLLDDMTAAGVPRLH-N
Mflv_4723|M.gilvum_PYR-GCK LPEGPANRPAVPQGRHVHLLMARGAAEFETLFPGLLDDMVACGVPILE-N
MSMEG_1837|M.smegmatis_MC2_155 LPTEPVNRSAVPQGQHVHLLMARGAQELEAIFPGMLDDMARAGVPVVQ-N
MAB_1628c|M.abscessus_ATCC_199 LHKVAAARSGVPQGHHIHMFMAAGTQGLEQLFPGILDDLRTDGATVCDEG
Mvan_5929|M.vanbaalenii_PYR-1 LPNDPVNRRGVPQGRHVHALLARGSRILEELFPGLLDEVVAGGAPVLDGT
* . * ***.:*:* ::* *: :: :***:* :: *.. .
MMAR_1289|M.marinum_M RPDCIYLGAAGHVLG-TGAKLRKQ--YTAYLPSRPHLEWQLRRRVLALGN
MUL_2598|M.ulcerans_Agy99 RPDCIYLGAAGHVLG-TGAKLRKQ--YTAYLPSRPHLEWQLRRRVLALGN
Mb3282|M.bovis_AF2122/97 RPDCIYLGAAGHVLG-TGHTLRKE--FTAYVPSRPHLEWQLRRRVLQLSN
Rv3254|M.tuberculosis_H37Rv RPDCIYLGAAGHVLG-TGHTLRKE--FTAYVPSRPHLEWQLRRRVLQLSN
MAV_4218|M.avium_104 RPECIHLGAAGHVLG-TGQTLRDE--FTAYVPSRPQLEWQLRKRVHAIGN
Mflv_4723|M.gilvum_PYR-GCK RPDCIHFGAAGHLLG-TTHRLQDE--FTAYVPSRPHLEWQIRRRVLALDN
MSMEG_1837|M.smegmatis_MC2_155 QPESIHFTAGGHLLG-TGQTLESN--FTAYVPTRGRLEWQIRERVLALPT
MAB_1628c|M.abscessus_ATCC_199 DLSRIRMLLGTHEMFNRTKKFSDPETFKLYLTTRPFLEFHVRQRVQRLGN
Mvan_5929|M.vanbaalenii_PYR-1 DPSEGYFRFGGHLLP-RDGRPKDP--ITLLLPSRPMLEYLVRQKVRGIPN
. : . * : . . :.:* **: :*.:* : .
MMAR_1289|M.marinum_M VEIRQ-RKVREPHFDPVRQRVTGLLLDDHDGDP-----ELIASGLVIDAA
MUL_2598|M.ulcerans_Agy99 VEIRQ-RKVREPHFDPVRQRVTGLLLDDHDGDP-----ELIASGLVIDAA
Mb3282|M.bovis_AF2122/97 VQIVR-RLVTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAA
Rv3254|M.tuberculosis_H37Rv VQIVR-RLVTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAA
MAV_4218|M.avium_104 VTVLR-RSVAQPRFDPARARVTGVWLDPVAGGS----AEFVAADLVVDAA
Mflv_4723|M.gilvum_PYR-GCK VRLID-CGVDEPVYDG--HRVTGVRTADG---------ATVDADFVVDAT
MSMEG_1837|M.smegmatis_MC2_155 VSVLR-GGVAHPEFDAAAQRVTGVVLDNG---------ETVEGDLVVDAS
MAB_1628c|M.abscessus_ATCC_199 VKFLDGHDVIEPMTAEH--RITGVRVARRSTGL----VTTLICDLVVDAT
Mvan_5929|M.vanbaalenii_PYR-1 IAMLEAHDVVDLTSASQQDRVTGARVRARDNGA----ERVLNAELVVDAT
: . * . *:.* : :*:**:
MMAR_1289|M.marinum_M GRGTRLPVWLTQWGYQRPPEETVDIGINYASQRLRIPDGLMREKIVVTGV
MUL_2598|M.ulcerans_Agy99 GRGTRLPVWLTQWGYQRPPEETVDIGINYASQRLRIPDGLMRERIVVTGV
Mb3282|M.bovis_AF2122/97 GRGTRLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGA
Rv3254|M.tuberculosis_H37Rv GRGTRLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGA
MAV_4218|M.avium_104 GRGTRLPVWLSQWGFQRPPEEVIDIGINYATQHFRIPDGLIAQKVVVAGA
Mflv_4723|M.gilvum_PYR-GCK GRGTRLPTWLSQWGFERPREDTVDVGISYATHQLRIPDGLIDEKVIVVGA
MSMEG_1837|M.smegmatis_MC2_155 GRGSRLPVWLEEWGFERPREDSVKIGVTYASHRVRIPEGLMAEKMVLVSA
MAB_1628c|M.abscessus_ATCC_199 GRTPRTQTFLDRLGFARPAETRVASPVTYASQLLHVSEDTDLDKLTFLNA
Mvan_5929|M.vanbaalenii_PYR-1 GRGSRTPAFLDHLGYNRPAQDHIDVRLTYSSQLLRLPPGAVKERIVIVGP
** .* .:* . *: ** : : :.*::: .::. . ::: . .
MMAR_1289|M.marinum_M GPGQSLGLGMLCNEDGSWILTTFGVAKVKPPSTFGEMRELAYRLLPSRFV
MUL_2598|M.ulcerans_Agy99 GPGQSLGLGMLCNEDGSWILTTFGVAKVKPPSTFGEMRELAYRLLPSRFV
Mb3282|M.bovis_AF2122/97 SHDQSLGLGMLCYEDGTWVLTTFGVADAKPPPTFDEMRALADKLLPARFT
Rv3254|M.tuberculosis_H37Rv SHDQSLGLGMLCYEDGTWVLTTFGVADAKPPPTFDEMRALADKLLPARFT
MAV_4218|M.avium_104 SHDEPLGLGMLCYEDRVWVLTTFGVADAKPPRTFPEMLTLARRLLPAHFG
Mflv_4723|M.gilvum_PYR-GCK SRTQPRGLGMLYYEDGTWGLTTFGVGKVPAPTDFNEMRELAEELLPAHIG
MSMEG_1837|M.smegmatis_MC2_155 SHDDGLGMGMLFHEDGIWTVTAFGVAKAEPPKDLDGILAQADTMVPPHIS
MAB_1628c|M.abscessus_ATCC_199 APGRPFGGAIARCENDTVMMTLGQFNLDEPPTTFAEMITLAEQFVPHAVV
Mvan_5929|M.vanbaalenii_PYR-1 IPGRPTGMALFGYENATWIFTAIGMAGRESPAELTEMLTFVDDFTPPHVA
* .: *: .* . .* : : . : * .
MMAR_1289|M.marinum_M AALAAAGPIGEPVFHAFPASRWRRYDKLSRFPAGIVALGDAVASFNPTFG
MUL_2598|M.ulcerans_Agy99 AALAAAGPIGEPVFHAFPASRWRRYDKLSRFPAGIVALGDAVASFNPTFG
Mb3282|M.bovis_AF2122/97 AALAQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFG
Rv3254|M.tuberculosis_H37Rv AALAQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFG
MAV_4218|M.avium_104 DALARAEPLGDPAFHAFPASRWRRYDKLDRVPAGIVALGDAVASFNPTFG
Mflv_4723|M.gilvum_PYR-GCK AALYQTHPLGDVALHKYPTSRWRRFDELDRYPRGILPFGDAVASFNPTFG
MSMEG_1837|M.smegmatis_MC2_155 AALRAGEPVGGMNFHRYPVAKWRRYDKMRRWPAGIMPFGDAVASLNPTYG
MAB_1628c|M.abscessus_ATCC_199 ETLRSAEPVGAVHNFWYRDAVWRRYDEMDGFPEGLLVIGDAVCSLDPIRG
Mvan_5929|M.vanbaalenii_PYR-1 AALREAEPLADIARHRMPSSQWRRYDKMQRFPAGLLVFGDAICSFNPIYG
:* *:. . : ***:*:: * *:: :***:.*::* *
MMAR_1289|M.marinum_M QGMTMASLQAGHLRRALQSHP----AEPANEFNRATAKTIRPVWTMNALT
MUL_2598|M.ulcerans_Agy99 QGMTMASLQAGHLRRALQSHP----AEPANEFNRATAKTIRPVWTMNALT
Mb3282|M.bovis_AF2122/97 QGMTMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIG
Rv3254|M.tuberculosis_H37Rv QGMTMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIG
MAV_4218|M.avium_104 QGMTMTALQAGHLRRALRCPD----DRLAAALYRATAKTTFPVWTMNAIG
Mflv_4723|M.gilvum_PYR-GCK QGMTMTSLQAGHLQRALQEPE------PEATFLAATAKSTWPVWTMNAIG
MSMEG_1837|M.smegmatis_MC2_155 QGVTMTALQAANLRTVLSVGK----QDLVSRLAYRTARTTFPVWMMNAVA
MAB_1628c|M.abscessus_ATCC_199 QGMTMALLEAAALRDCLFEGD----ADLARRYFQTVGKRISTAWEHNRMT
Mvan_5929|M.vanbaalenii_PYR-1 QGMTVAALQAEALRKCLQHGA----AGLARRYFRATAKPISVAWRLAAG-
**:*:: *:* *: * ..: .*
MMAR_1289|M.marinum_M DLCFQHAEGR-----MPRWYRPVGGLYDQFLGAAETDPVLAEWFLRRISL
MUL_2598|M.ulcerans_Agy99 DLCFQHAEGR-----MPRWYRPVGGLYDQFLGAAETDPVLAEWFLRRISL
Mb3282|M.bovis_AF2122/97 DISFHHATAEP----LPRWWRPAGSLFDQFLGAAETDPVLAEWFLRRFSL
Rv3254|M.tuberculosis_H37Rv DISFHHATAEP----LPRWWRPAGSLFDQFLGAAETDPVLAEWFLRRFSL
MAV_4218|M.avium_104 DVTFHHATTKRP---APWWWRPSGALFDQFLGAAETEPVLAEWFLRRFSL
Mflv_4723|M.gilvum_PYR-GCK DLTMHGADGP-----APWWYRPVGALFDQFLGAAESDPVLAEWFLRRFSL
MSMEG_1837|M.smegmatis_MC2_155 DHVAHGAEGP-----KPWWYRPMYSLFDQFLGAAETDPVLAEWFLRRTSL
MAB_1628c|M.abscessus_ATCC_199 APLHSSAPDSATFGQR-VKWNLMAWWSAKMLMAARNDIAITETILRVNNM
Mvan_5929|M.vanbaalenii_PYR-1 ADLNLHEVE----GRRPPSVRIANRYVDRLQRAAESDNVVAEQFVKVTGL
. :: **..: .::* ::: .:
MMAR_1289|M.marinum_M LDSLYMVPSPLIIGRAVAHNARMWLRQRRPK--PSATSR----
MUL_2598|M.ulcerans_Agy99 LDSLYMVPSPLIIGRAVAHNARMWLRQRRPK--PSATSR----
Mb3282|M.bovis_AF2122/97 LDSLYMVPSVPIIGRAIAHNLRLWLKEQRERRQPVTTRRSP--
Rv3254|M.tuberculosis_H37Rv LDSLYMVPSVPIIGRAIAHNLRLWLKEQRERRQPVTTRRSP--
MAV_4218|M.avium_104 LDSLYLIPPPRIVGRAVGHNMRLWLGQRRGAGRPGTATARPSP
Mflv_4723|M.gilvum_PYR-GCK LDSLYMVPSARLIGRTVRHNMTLWARSRRSPGTASSAPAR---
MSMEG_1837|M.smegmatis_MC2_155 LDSLYLAPSPRVIGRAIRHNASMWLAEKTNRADRDKSLAATG-
MAB_1628c|M.abscessus_ATCC_199 QDAPRSMRRPTFVLRVLRHCWRRHETSTAPAPQRQLTLSGV--
Mvan_5929|M.vanbaalenii_PYR-1 IDPPARLLHPKILLRVAFTSWRRRGRHR---------------
*. .: *.