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M. tuberculosis H37Rv Rv0903c (prrA)

annotation: TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA
coordinates: 1005852 - 1006562
length: 236

GGMDTGVTSPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEALRSATENRPDAIVLDINMPVLDGVS
VVTALRAMDNDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATSSSETIT
VGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLR
RKLEAGGGPRLLHTVRGVGFVLRMQ*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv0903c prrA - 100% (236) TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA
M. tuberculosis H37Rv Rv0981 mprA 4e-57 50.67% (225) two component response transcriptional regulatory protein
M. tuberculosis H37Rv Rv3765c - 1e-49 42.34% (222) two component transcriptional regulatory protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0927c prrA 1e-128 100.00% (236) two component response transcriptional regulatory protein
M. gilvum PYR-GCK Mflv_1744 - 1e-118 94.85% (233) two component transcriptional regulator
M. leprae Br4923 MLBr_02123 - 1e-122 95.71% (233) two-component response regulator
M. abscessus ATCC 19977 MAB_0956c - 1e-116 91.85% (233) transcriptional regulatory protein PrrA
M. marinum M MMAR_4633 prrA 1e-125 97.46% (236) two-component response transcriptional regulatory protein
M. avium 104 MAV_1022 - 1e-123 97.00% (233) two component response transcriptional regulatory protein prra
M. smegmatis MC2 155 MSMEG_5662 prrA 1e-119 93.22% (236) DNA-binding response regulator PrrA
M. thermoresistible (build 8) TH_4543 - 1e-114 95.95% (222) PUTATIVE two component transcriptional regulator, winged helix
M. ulcerans Agy99 MUL_0248 prrA 1e-124 97.02% (235) two component response transcriptional regulatory protein
M. vanbaalenii PYR-1 Mvan_5009 - 1e-119 94.42% (233) two component transcriptional regulator

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1744|M.gilvum_PYR-GCK          ---MDS-----GSPRVLVVDDDPDVLASLERGLRLSGFDVFTAVDGAEAL
Mvan_5009|M.vanbaalenii_PYR-1       ---MDSGA---GSPKVLVVDDDPDVLASLERGLRLSGFDVYTAVDGAEAL
MSMEG_5662|M.smegmatis_MC2_155      ---MDSTTSGMASPRVLVVDDDPDVLASLERGLRLSGFDVSTAVDGAEAL
TH_4543|M.thermoresistible__bu      -----------------VVDDDPDVLASLERGLRLSGFEVSTAVDGAEAL
Rv0903c|M.tuberculosis_H37Rv        MGGMDTGVT---SPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEAL
Mb0927c|M.bovis_AF2122/97           MGGMDTGVT---SPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEAL
MMAR_4633|M.marinum_M               MGGMDTGAN---SPRVLVVDDDSDVLASLERGLRLSGFEVSTAVDGAEAL
MUL_0248|M.ulcerans_Agy99           MGGMDTGAN---SPRVLVVDDDSDVLASLERGLRLSGFEVSTAVDGAEAL
MAV_1022|M.avium_104                ---MDTAAS---SPRVLVVDDDSDVLASLERGLRLSGFEVSTAVDGAEAL
MLBr_02123|M.leprae_Br4923          ---MDTGVS---SPRVLVVDDDSDVLASLERGLRLSGFEVSTAIDGAEAL
MAB_0956c|M.abscessus_ATCC_199      ---MVDGQG---SPRVLVVDDDADVLASLERGLRLSGFEVNTASDGAEAL
                                                     *****.***************:* ** ******

Mflv_1744|M.gilvum_PYR-GCK          RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
Mvan_5009|M.vanbaalenii_PYR-1       RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
MSMEG_5662|M.smegmatis_MC2_155      RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
TH_4543|M.thermoresistible__bu      RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
Rv0903c|M.tuberculosis_H37Rv        RSATENRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
Mb0927c|M.bovis_AF2122/97           RSATENRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
MMAR_4633|M.marinum_M               RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
MUL_0248|M.ulcerans_Agy99           RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
MAV_1022|M.avium_104                RSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
MLBr_02123|M.leprae_Br4923          RNATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDR
MAB_0956c|M.abscessus_ATCC_199      RCATEHRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARTSVDDR
                                    * *** **************************************:*****

Mflv_1744|M.gilvum_PYR-GCK          VAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATFSSETITVGPLEV
Mvan_5009|M.vanbaalenii_PYR-1       VAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATFSSETITVGPLEV
MSMEG_5662|M.smegmatis_MC2_155      VAGLEAGADDYLVKPFVLAELVARVKALLRRRGSSATFSSETIQVGPLEV
TH_4543|M.thermoresistible__bu      VAGLEAGADDYLVKPFVLAELVARVKALLRRRGSSATSSSETIVVGPLEV
Rv0903c|M.tuberculosis_H37Rv        VAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEV
Mb0927c|M.bovis_AF2122/97           VAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEV
MMAR_4633|M.marinum_M               VAGLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSETITVGPLEV
MUL_0248|M.ulcerans_Agy99           VAGLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSEIITVGPLEV
MAV_1022|M.avium_104                VAGLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSETITVGPLEV
MLBr_02123|M.leprae_Br4923          VAGLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSETIAVGPLEV
MAB_0956c|M.abscessus_ATCC_199      VAGLEAGADDYLTKPFVLAELVARVKALLRRRGAVATSSTETITVGPLEV
                                    ************.********************: ** *:* * ******

Mflv_1744|M.gilvum_PYR-GCK          DIPGRRARVDGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
Mvan_5009|M.vanbaalenii_PYR-1       DIPGRRARVDGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
MSMEG_5662|M.smegmatis_MC2_155      DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
TH_4543|M.thermoresistible__bu      DIPGRRARVNGQDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
Rv0903c|M.tuberculosis_H37Rv        DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
Mb0927c|M.bovis_AF2122/97           DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
MMAR_4633|M.marinum_M               DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
MUL_0248|M.ulcerans_Agy99           DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
MAV_1022|M.avium_104                DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
MLBr_02123|M.leprae_Br4923          DIPGRRARVNGVDVDLTKREFDLLAVLAEHKTTVLSRAQLLELVWGYDFA
MAB_0956c|M.abscessus_ATCC_199      EIPGRRARINGVEVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFA
                                    :*******::* :*******************:*****************

Mflv_1744|M.gilvum_PYR-GCK          ADTNVVDVFIGYLRRKLEANGAPRLLHTVRGVGFVLRQQ
Mvan_5009|M.vanbaalenii_PYR-1       ADTNVVDVFIGYLRRKLEANGAPRLLHTVRGVGFVLRQQ
MSMEG_5662|M.smegmatis_MC2_155      ADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRTQ
TH_4543|M.thermoresistible__bu      ADTNVVDVFIGYLRRKLEATGAPRLLHTVRGVGFVLRTQ
Rv0903c|M.tuberculosis_H37Rv        ADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ
Mb0927c|M.bovis_AF2122/97           ADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ
MMAR_4633|M.marinum_M               ADTNVVDVFIGYLRRKLEANGGPRLLHTVRGVGFVLRMQ
MUL_0248|M.ulcerans_Agy99           ADTNVVDVFIGYLRRKLEANGGPRLLHTVRGVGFVLRMH
MAV_1022|M.avium_104                ADTNVVDVFIGYLRRKLEANGGPRLLHTVRGVGFVLRMQ
MLBr_02123|M.leprae_Br4923          ADTNVVDVFIGYLRRKLEANSGPRLLHTVRGVGFVLRMQ
MAB_0956c|M.abscessus_ATCC_199      ADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRSQ
                                    ******************* ..*************** :

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv0903c	prrA	-	100% (236)	TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA
M. tuberculosis H37Rv	Rv0981	mprA	4e-57	50.67% (225)	two component response transcriptional regulatory protein
M. tuberculosis H37Rv	Rv3765c	-	1e-49	42.34% (222)	two component transcriptional regulatory protein