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AVRILVVDDDRAVRESLRRSLSFNGYSVELAQDGVEALDAITNNRPDALILDVMMPRLDGLEVCRQLRST GDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTVSDDSGDSQKMTFSDLTLDP VTREVTRGGRQISLTRTEFSLLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYIGYLRRKTEAEGE PRLIHTVRGVGYVLRETPP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5488 | - | - | 100% (230) | DNA-binding response regulator |
| M. smegmatis MC2 155 | MSMEG_0244 | - | 3e-60 | 52.44% (225) | two component response transcriptional regulatory protein prra |
| M. smegmatis MC2 155 | MSMEG_5662 | prrA | 2e-59 | 52.02% (223) | DNA-binding response regulator PrrA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1007 | mprA | 1e-115 | 90.43% (230) | two component response transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_1887 | - | 1e-115 | 91.34% (231) | two component transcriptional regulator |
| M. tuberculosis H37Rv | Rv0981 | mprA | 1e-115 | 90.00% (230) | two component response transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_00174 | - | 1e-113 | 89.04% (228) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_1076 | - | 1e-112 | 87.83% (230) | two component response transcriptional regulatory protein MprA |
| M. marinum M | MMAR_4529 | mprA | 1e-114 | 89.66% (232) | two component response transcriptional regulatory protein |
| M. avium 104 | MAV_1094 | - | 1e-116 | 91.67% (228) | two component response transcriptional regulatory protein MprA |
| M. thermoresistible (build 8) | TH_1732 | phoP | 1e-119 | 92.61% (230) | DNA-binding response regulator PhoP |
| M. ulcerans Agy99 | MUL_4701 | mprA | 1e-115 | 89.66% (232) | two component response transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4844 | - | 1e-116 | 91.77% (231) | two component transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5488|M.smegmatis_MC2_155 MAVRILVVDDDRAVRESLRRSLSFNGYSVELAQDGVEALDAITNNRPDAL
TH_1732|M.thermoresistible__bu VAVRILVVDDDRAVRESLRRSLSFNGYSVELAEDGVEALDLIANDRPDAV
Mb1007|M.bovis_AF2122/97 MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDAL
Rv0981|M.tuberculosis_H37Rv MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDAL
MAV_1094|M.avium_104 --MRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDAL
MLBr_00174|M.leprae_Br4923 --MRILAVDDDRAVRESLRRSLSFNGYSVELANDGVEALEMVARDRPDAL
MMAR_4529|M.marinum_M MSVRILVVDDDRAVRESLRRSLSFNGYTVELAHDGVEALEMIASDRPDAL
MUL_4701|M.ulcerans_Agy99 MSVRILVVDDDRAVRESLRRSLSFNGYTVELAHDGVEALEMIASDRPDAL
Mflv_1887|M.gilvum_PYR-GCK MPVRILVVDDDRAVRESLRRSLSFNGYSVELAQDGREALDLIASDRPDAV
Mvan_4844|M.vanbaalenii_PYR-1 MPVRILVVDDDRAVRESLRRSLSFNGYSVELAQDGREALDLIASDRPDAV
MAB_1076|M.abscessus_ATCC_1997 MPVRILVVDDDRAVRESLRRSLSFNGYSVDLAEDGVDALNVIANDRPDAL
:***.********************:*:**.** :**: :: :****:
MSMEG_5488|M.smegmatis_MC2_155 ILDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
TH_1732|M.thermoresistible__bu VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
Mb1007|M.bovis_AF2122/97 VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
Rv0981|M.tuberculosis_H37Rv VLDVMMPRLDGLEVCRQLRGTGDDLPILVLTARDSVSERVAGLDAGADDY
MAV_1094|M.avium_104 VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
MLBr_00174|M.leprae_Br4923 VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
MMAR_4529|M.marinum_M VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
MUL_4701|M.ulcerans_Agy99 VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
Mflv_1887|M.gilvum_PYR-GCK VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
Mvan_4844|M.vanbaalenii_PYR-1 VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
MAB_1076|M.abscessus_ATCC_1997 VLDVMMPKLDGLEVCRRLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
:******:********:**.******************************
MSMEG_5488|M.smegmatis_MC2_155 LPKPFALEELLARMRALLRRTVSDD--SGDSQKMTFSDLTLDPVTREVTR
TH_1732|M.thermoresistible__bu LPKPFALEELLARLRALLRRTTPDD--AADSQKLTFADLTLDPVTREVTR
Mb1007|M.bovis_AF2122/97 LPKPFALEELLARMRALLRRTKPED--AAESMAMRFSDLTLDPVTREVNR
Rv0981|M.tuberculosis_H37Rv LPKPFALEELLARMRALLRRTKPED--AAESMAMRFSDLTLDPVTREVNR
MAV_1094|M.avium_104 LPKPFALEELLARMRALLRRTKPED--DAESVAMTFSDLTLDPVTREVTR
MLBr_00174|M.leprae_Br4923 LPKPFALEELLARIRALLRRTKPDD--AAESVAMSFSDLTLDPVTREVAR
MMAR_4529|M.marinum_M LPKPFALEELLARMRALLRRTKPEDDEAADSVAMTFSDLSLDPVTREVTR
MUL_4701|M.ulcerans_Agy99 LPKPFALEELLARMRALLRRTKLEDDEAADSVAMTFSDLSLDPVTREVTR
Mflv_1887|M.gilvum_PYR-GCK LPKPFALEELLARMRALLRRTSPVDG-DGESAAMTFSDLTLDPVTREVTR
Mvan_4844|M.vanbaalenii_PYR-1 LPKPFALEELLARMRALLRRTTPDDG-AGESAAMTFSDLSLDPVTREVTR
MAB_1076|M.abscessus_ATCC_1997 LPKPFALEELLARMRALLRRTTIDE--SADAATLSFGDLTLDPVTREVHR
*************:******* : .:: : *.**:******** *
MSMEG_5488|M.smegmatis_MC2_155 GGRQISLTRTEFSLLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
TH_1732|M.thermoresistible__bu GNRQISLTRTEFALLELLIANPRRVLSRSRILEEVWGFDFPTSGNALEVY
Mb1007|M.bovis_AF2122/97 GQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
Rv0981|M.tuberculosis_H37Rv GQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
MAV_1094|M.avium_104 GQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
MLBr_00174|M.leprae_Br4923 GQRWISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
MMAR_4529|M.marinum_M GARRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
MUL_4701|M.ulcerans_Agy99 GARRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
Mflv_1887|M.gilvum_PYR-GCK GNRSISLTRTEFSLLEMLITNPRRVLTRSRILEEVWGFDFPTSGNALEVY
Mvan_4844|M.vanbaalenii_PYR-1 GDRPISLTRTEFSLLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
MAB_1076|M.abscessus_ATCC_1997 GTRSISLTRTEFALLEMLMANPRRVLTRSRILEEVWGFDFPTSGNALEVY
* * ********:***:*::******:***********************
MSMEG_5488|M.smegmatis_MC2_155 IGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
TH_1732|M.thermoresistible__bu IGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
Mb1007|M.bovis_AF2122/97 VGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
Rv0981|M.tuberculosis_H37Rv VGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
MAV_1094|M.avium_104 VGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
MLBr_00174|M.leprae_Br4923 VGYLRRKTEADGESRLIHTVRGVGYVLRETPP
MMAR_4529|M.marinum_M VGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
MUL_4701|M.ulcerans_Agy99 VGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
Mflv_1887|M.gilvum_PYR-GCK VGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
Mvan_4844|M.vanbaalenii_PYR-1 VGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
MAB_1076|M.abscessus_ATCC_1997 VGYLRRKTEAEGELRLIHTVRGVGYVLRETPP
:*********:** ******************