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MTDFTTDFSAIHDELRSVAADLLAKDSVDWPLLVQAGWVGLDAPESLGGAGATFAEVAVICEELGRAAAT TGYLGGAVLGVGALLAVAPNTSRDNLLTEVVEGRTRVSLALPGDLVPGDPRVPFTVTTDGRVHGRAAFVP DAGDAHRLLLPARDATGTTVLVDAAATVIEQPVLDETRRLAIVEADGAEARDVWPLEDPHALARRAALAV ACDSLGIAAAMLDATVSYASMRQQFGRPIGSFQAVKHACADMLVQVTAARQLIAGAISAPDAHTVAKAKS YATEAAVGVAGKAMQLHGGIGYTWESGVHTYLKRAALNRSLFGSPREHRTMLSARYRSAPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5618 | - | - | 100% (342) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6016 | - | 9e-40 | 35.89% (326) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6585 | - | 3e-39 | 36.53% (323) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3594 | fadE33 | 2e-39 | 35.26% (329) | acyl-CoA dehydrogenase FADE33 |
| M. gilvum PYR-GCK | Mflv_1795 | - | 1e-93 | 56.98% (344) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3564 | fadE33 | 2e-39 | 35.26% (329) | acyl-CoA dehydrogenase FADE33 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-14 | 32.31% (130) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3123 | - | 7e-37 | 35.81% (310) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_1954 | fadE18_1 | 6e-41 | 37.46% (315) | acyl-CoA dehydrogenase FadE18_1 |
| M. avium 104 | MAV_1267 | - | 6e-41 | 34.96% (349) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_2777 | - | 1e-105 | 61.38% (347) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_2176 | fadE18_1 | 5e-41 | 37.46% (315) | acyl-CoA dehydrogenase FadE18_1 |
| M. vanbaalenii PYR-1 | Mvan_4955 | - | 3e-92 | 55.88% (340) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1795|M.gilvum_PYR-GCK -------------------------------MRAEFAEFHDELRSVASDL
Mvan_4955|M.vanbaalenii_PYR-1 -------------------------------MTHGFSEFHDELRSVAGDL
TH_2777|M.thermoresistible__bu -------------------------------MTDQFTEFHDELRAVAAEV
MSMEG_5618|M.smegmatis_MC2_155 ---------------------------MMTDFTTDFSAIHDELRSVAADL
MAV_1267|M.avium_104 -------------------------------MNLELTDEQVALRDTTRRF
MMAR_1954|M.marinum_M ----------------------------MSTGDLLYSDTEEALRASVGQL
MUL_2176|M.ulcerans_Agy99 ----------------------------MSTGDLLYSDTEEALRASVGQL
Mb3594|M.bovis_AF2122/97 ---------------------------------MTPPEERQMLRETVASL
Rv3564|M.tuberculosis_H37Rv ---------------------------------MTPPEERQMLRETVASL
MAB_3123|M.abscessus_ATCC_1997 MSASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDLRSLVRSW
MLBr_00737|M.leprae_Br4923 ---------------------MVGWSGNPLFDLFKLPEEHNELRATIRAL
. . **
Mflv_1795|M.gilvum_PYR-GCK LAKDG----------------HAPEWRVLADAGWTGLEVPDTLGGAGASF
Mvan_4955|M.vanbaalenii_PYR-1 LAKD-----------------RVVDWSVLVDAGWTGLEVPDGLGGSGATF
TH_2777|M.thermoresistible__bu LAKD-----------------RTVDWPVLADAGWVGLEVADEFGGAGASF
MSMEG_5618|M.smegmatis_MC2_155 LAKD------------------SVDWPLLVQAGWVGLDAPESLGGAGATF
MAV_1267|M.avium_104 LAEKAPIAHHVRRLLDDPTGIEPAVWRGLADLGCTGLLVPEQHGGAGMTM
MMAR_1954|M.marinum_M FAERCPPESVVAAYDSPPADFAKLWRTLAAELGVAGLLVPESLGGAGASA
MUL_2176|M.ulcerans_Agy99 FAERCPPESVVAAYDSPPADFAKLWRTLAAELGVAGLLVPESLGGAGASA
Mb3594|M.bovis_AF2122/97 VAKHAGPAAVRAAMASDRGYDESLWRLLCEQVGAAALVIPEELGGAGGEL
Rv3564|M.tuberculosis_H37Rv VAKHAGPAAVRAAMASDRGYDESLWRLLCEQVGAAALVIPEELGGAGGEL
MAB_3123|M.abscessus_ATCC_1997 CERVWTPKHVRQIAEAG-SVDLDAWRALGSELGVVGLSLPEQHGGGGLGV
MLBr_00737|M.leprae_Br4923 AEKEIAPHAADVDQRAR---FPEEALAALNASGFNAIHVPEEYGGQGADS
. * .: .: ** *
Mflv_1795|M.gilvum_PYR-GCK AESAVILDQIGRAAGVTGYLGGAVLATGVLNLLRPS-DSRDHLLAAVAGG
Mvan_4955|M.vanbaalenii_PYR-1 VETAMILDQIGRAASANRYLGSAVLAVGVLNLLEPS-EIRDELLTAVASG
TH_2777|M.thermoresistible__bu GEVAVICSEMGRAATASSYLGGAVLGVGALNAVQPD-AARDDLLTAVAAG
MSMEG_5618|M.smegmatis_MC2_155 AEVAVICEELGRAAATTGYLGGAVLGVGALLAVAPN-TSRDNLLTEVVEG
MAV_1267|M.avium_104 VEAGIVAEELGAALYPGPWLSTAVAAPRALIRLCAGGDTAAGLLRGIADG
MMAR_1954|M.marinum_M REAAVVMEEVGRAVAPVPFLSSAVLATVALLHSG-----ETETLSELAQG
MUL_2176|M.ulcerans_Agy99 REAAVVMEEVGRAVAPVPFLSSAVLATVALLHSG-----ETETLSELAQG
Mb3594|M.bovis_AF2122/97 ADAAIVVQELGRALVPSPLLG-TTLAELALLAAAKP---DAQALTELAQG
Rv3564|M.tuberculosis_H37Rv ADAAIVVQELGRALVPSPLLG-TTLAELALLAAAKP---DAQALTELAQG
MAB_3123|M.abscessus_ATCC_1997 IELSIVAEELGRALACLPWISSAALGATALVSSGDD-SALAEWVPALAAG
MLBr_00737|M.leprae_Br4923 VAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPSLAAE
:: .::. . : . : :.
Mflv_1795|M.gilvum_PYR-GCK EPRLAVVTG----------DFSMS---------AGKLTGRAEFVPDAVGA
Mvan_4955|M.vanbaalenii_PYR-1 PGRLGVATD----------GFAVN---------GGRLAGRAGFVPDAVGA
TH_2777|M.thermoresistible__bu AERTALVLG----------PFTFT---------GGRLTGRAEFVPDASGA
MSMEG_5618|M.smegmatis_MC2_155 RTRVSLALPGDLVPGDPRVPFTVTT--------DGRVHGRAAFVPDAGDA
MAV_1267|M.avium_104 TTHVAVCFLDTP-------PMAATRE-----GETTVLHGQARAVPDAAAA
MMAR_1954|M.marinum_M ELTAALVVP---------LATAPGDPVAGVSRGSAGLSGRVCGVAGAREA
MUL_2176|M.ulcerans_Agy99 ELTAALVVP---------LATAPGDPVAGASRGSAGLSGRVCGVAGAREA
Mb3594|M.bovis_AF2122/97 SAIGALVLD---------PDYVVN-------------------------G
Rv3564|M.tuberculosis_H37Rv SAIGALVLD---------PDYVVN-------------------------G
MAB_3123|M.abscessus_ATCC_1997 EKTITLAGGRTR----LADAITVSAES---DTDGWKLTGDTEHVPDGATA
MLBr_00737|M.leprae_Br4923 GAMASYALSEREAG----SDAASMRTRAKADGDDWILNGFKCWITNGGKS
.
Mflv_1795|M.gilvum_PYR-GCK DRLLVVTG------PEVAVVETAAATVTAQPVVDETRRL-------ATVA
Mvan_4955|M.vanbaalenii_PYR-1 DRLLVLVD------GAVAVVDAAQMSVVPQPVVDETRQL-------ATVT
TH_2777|M.thermoresistible__bu DRLLVLATDS---DGTPVLTATAAATVTAQPVLDETRRL-------AVVC
MSMEG_5618|M.smegmatis_MC2_155 HRLLLPARDA---TGTTVLVD-AAATVIEQPVLDETRRL-------AIVE
MAV_1267|M.avium_104 DVLLALAEDAGDTALFGVNTGSAGVAVRPEHHIDPTHKQ-------SRVT
MMAR_1954|M.marinum_M DVLVVPVAGADGVELHTVRANAPGVEIVPLLAFDMTRPL-------ADVV
MUL_2176|M.ulcerans_Agy99 DVLVVPVAGADGVELHTVRANAPGVEIVPLLAFDMTRPL-------ADVV
Mb3594|M.bovis_AF2122/97 DIADIVVAATSGQLTRWTRFSAQ-----PVATMDPTRRL-------ARLQ
Rv3564|M.tuberculosis_H37Rv DIADIVVAATSGQLTRWTRFSAQ-----PVATMDPTRRL-------ARLQ
MAB_3123|M.abscessus_ATCC_1997 DVILVLADTDSGPSLFAVDGDAPGVDRHSLATLDMTRRQ-------ANIH
MLBr_00737|M.leprae_Br4923 TWYTVMAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELY
. : : :
Mflv_1795|M.gilvum_PYR-GCK ADSA--TVVDILTFDGNPADAVNALRHRAEIAVACDSLGVAEQMLSDTVD
Mvan_4955|M.vanbaalenii_PYR-1 AEAA--EIAELLTLAGDPAS----VRHRAEVAIACDSLGLAEQMLAATVD
TH_2777|M.thermoresistible__bu AEDS--GVEAVWRFAGDPRAAARRLADRAAVAVAIDSLGLAEAMLSATVS
MSMEG_5618|M.smegmatis_MC2_155 ADGA--EARDVWPLE-DPHA----LARRAALAVACDSLGIAAAMLDATVS
MAV_1267|M.avium_104 FDAA--PARRLATASADDVAA---VVDDVLIAACADALGAARAVMDLAVE
MMAR_1954|M.marinum_M FSGA--ASAPVGLGSAEAALA--EALQTGAALLASEQLGIAQWCFDTTLA
MUL_2176|M.ulcerans_Agy99 FSGA--ASAPVGLGSAEAALA--EALQTGAALLASEQLGIAQWCFDTTLA
Mb3594|M.bovis_AF2122/97 SEET--EPLCPDPG----------IADTAAILLAAEQIGAAERCLQLTVE
Rv3564|M.tuberculosis_H37Rv SEET--EPLCPDPG----------IADTAAILLAAEQIGAAERCLQLTVE
MAB_3123|M.abscessus_ATCC_1997 FNSA--PARLIGAQGRGAEAVA-TALDVAATVLAAEQAGIAAHMLDVTTE
MLBr_00737|M.leprae_Br4923 FDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIV
. : * * : :
Mflv_1795|M.gilvum_PYR-GCK YVKVRHQFGRPIGSFQAVKHACADMLVAVEVSRQLVADAVDVLAG--GGD
Mvan_4955|M.vanbaalenii_PYR-1 YVLVRHQFGRPIGSFQAVKHACADMLVAIEVSRRLVSDAVGVLAE--GGD
TH_2777|M.thermoresistible__bu YAKVRHQFGRPIGSFQAVKHACADMQVQITVARQLVGRAVAALCDPDSDD
MSMEG_5618|M.smegmatis_MC2_155 YASMRQQFGRPIGSFQAVKHACADMLVQVTAARQLIAGAIS-------AP
MAV_1267|M.avium_104 YAKTRTQFGQPIGSFQAVQHLCVDMYETVELARSGVIHALWVSDAP-DGD
MMAR_1954|M.marinum_M YTKQRKQFGRAIGSYQAIKHRLADLWLEVGSARAAARYGADTCARG-DED
MUL_2176|M.ulcerans_Agy99 YTKQRKQFGRAIGSYQAIKHRLADLWLEVGSARAAARYGADTCARG-DED
Mb3594|M.bovis_AF2122/97 YAKSRVQFGRPIGSFQALKHRMADLYVTIAAARAVV---ADACHAP-TPT
Rv3564|M.tuberculosis_H37Rv YAKSRVQFGRPIGSFQALKHRMADLYVTIAAARAVV---ADACHAP-TPT
MAB_3123|M.abscessus_ATCC_1997 YAKSRIQFGRIIGSFQAVKHRLADMAAATGNVRGAAYHAAWSHDHPSLDD
MLBr_00737|M.leprae_Br4923 YTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERG-EPD
*. * ***. *.::*:::. .*: *
Mflv_1795|M.gilvum_PYR-GCK AAIPAAMAKSYVCAAAVEVAGKAMQLHGGIGYTWESGIHTYLKRATLNRS
Mvan_4955|M.vanbaalenii_PYR-1 AATQAAMAKSHACSAAVDVAGKAMQLHGGIGYTWESGIHVYLKRATLNRA
TH_2777|M.thermoresistible__bu TAAAAAMAKSFVCSAAVEVVGKAMQLHGGIGYTWESGVHVYLKRATLNRA
MSMEG_5618|M.smegmatis_MC2_155 DAHTVAKAKSYATEAAVGVAGKAMQLHGGIGYTWESGVHTYLKRAALNRS
MAV_1267|M.avium_104 ERHLAALRAKAFAGRLAGVADTAIQVFGGIGYTWEHDAHLYLKRLLGYSA
MMAR_1954|M.marinum_M AAIAAAIAAAYCGDVAVHAAEECVQLHGGIGMTWEYPAHLYLKRAKSDQL
MUL_2176|M.ulcerans_Agy99 AAIAAAIAAAYCGDVAVHAAEECVQLHGGIGMTWEYPAHLYLKRAKSDQL
Mb3594|M.bovis_AF2122/97 NAATARLAAS---EALSTAAAEGIQLHGGIAITWEHDMHLYFKRAHGSAQ
Rv3564|M.tuberculosis_H37Rv NAATARLAAS---EALSTAAAEGIQLHGGIAITWEHDMHLYFKRAHGSAQ
MAB_3123|M.abscessus_ATCC_1997 PALATSIAQQVASAGAVEVTAKAIQSHGGIGFTWEHPAHLYYKRAVSNSA
MLBr_00737|M.leprae_Br4923 LGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQI
.. :* .** . * : . : :
Mflv_1795|M.gilvum_PYR-GCK LFGSPAAQRRRLSQRYH-----
Mvan_4955|M.vanbaalenii_PYR-1 LFGSPAAQRKRLSQRYSKGI--
TH_2777|M.thermoresistible__bu LYGSPAAHRSQLVSRYR-----
MSMEG_5618|M.smegmatis_MC2_155 LFGSPREHRTMLSARYRSAPG-
MAV_1267|M.avium_104 FLGGPDRYLTEVGARLAKRGSP
MMAR_1954|M.marinum_M ALGTAYRHRGRLAKLVNLPVS-
MUL_2176|M.ulcerans_Agy99 ALGTAYRHRGRLAKLVNLPVS-
Mb3594|M.bovis_AF2122/97 LLESPREVLRRLESEVWESP--
Rv3564|M.tuberculosis_H37Rv LLESPREVLRRLESEVWESP--
MAB_3123|M.abscessus_ATCC_1997 LFGGRAVHAERIAKEVIDA---
MLBr_00737|M.leprae_Br4923 YEGTNQIQRVVMSRALLR----
: