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NLELTDEQVALRDTTRRFLAEKAPIAHHVRRLLDDPTGIEPAVWRGLADLGCTGLLVPEQHGGAGMTMVE AGIVAEELGAALYPGPWLSTAVAAPRALIRLCAGGDTAAGLLRGIADGTTHVAVCFLDTPPMAATREGET TVLHGQARAVPDAAAADVLLALAEDAGDTALFGVNTGSAGVAVRPEHHIDPTHKQSRVTFDAAPARRLAT ASADDVAAVVDDVLIAACADALGAARAVMDLAVEYAKTRTQFGQPIGSFQAVQHLCVDMYETVELARSGV IHALWVSDAPDGDERHLAALRAKAFAGRLAGVADTAIQVFGGIGYTWEHDAHLYLKRLLGYSAFLGGPDR YLTEVGARLAKRGSP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1267 | - | - | 100% (366) | acyl-CoA dehydrogenase domain-containing protein |
| M. avium 104 | MAV_1838 | - | 3e-45 | 35.03% (334) | acyl-CoA dehydrogenase protein |
| M. avium 104 | MAV_1618 | - | 6e-42 | 29.95% (364) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1968c | fadE18 | 3e-43 | 35.91% (362) | acyl-CoA dehydrogenase FADE18 |
| M. gilvum PYR-GCK | Mflv_2335 | - | 8e-51 | 36.19% (362) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1933c | fadE18 | 4e-43 | 35.91% (362) | acyl-CoA dehydrogenase FADE18 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-16 | 27.60% (366) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3123 | - | 3e-52 | 37.88% (359) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_2861 | fadE18 | 4e-48 | 37.75% (355) | acyl-CoA dehydrogenase FadE18 |
| M. smegmatis MC2 155 | MSMEG_1905 | - | 2e-50 | 36.31% (347) | acyl-CoA dehydrogenase protein |
| M. thermoresistible (build 8) | TH_0804 | - | 3e-54 | 39.89% (371) | acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2893 | fadE18 | 4e-49 | 38.03% (355) | acyl-CoA dehydrogenase FadE18 |
| M. vanbaalenii PYR-1 | Mvan_0393 | - | 1e-50 | 37.71% (358) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2335|M.gilvum_PYR-GCK --------------------------------MTISVAERAELRTAVGKL
MSMEG_1905|M.smegmatis_MC2_155 --------------------------------MTISVAERAELAAAVREL
MAV_1267|M.avium_104 -------------------------------MNLELTDEQVALRDTTRRF
TH_0804|M.thermoresistible__bu --VAEELAEQPDNAAEELAEQPDNAAGLS--PTFTFTEEQQQLRAAVRR-
Mvan_0393|M.vanbaalenii_PYR-1 -----------------------MADSQG--AEYVFTEEQGQLRAAVRR-
MAB_3123|M.abscessus_ATCC_1997 MSASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDLRSLVRS-
Mb1968c|M.bovis_AF2122/97 -------------------------------MDFRYSTEQDDFRASLRG-
Rv1933c|M.tuberculosis_H37Rv -------------------------------MDFRYSTEQDDFRASLRG-
MMAR_2861|M.marinum_M -------------------------------MDFRYSTEQDDFRESLRG-
MUL_2893|M.ulcerans_Agy99 -------------------------------MDFRYSTEQDDFRESLRG-
MLBr_00737|M.leprae_Br4923 ---------------------MVGWSGNPLFDLFKLPEEHNELRATIRA-
*: :
Mflv_2335|M.gilvum_PYR-GCK LADKC-TEDDVRRVRESDEGFDRDLWRRL-ADQGVLGMLVDSEYGGLGFG
MSMEG_1905|M.smegmatis_MC2_155 LQNEC-TEQDVRQTISSDEGYDPQLWRKL-AAQGVTGLLIDPEYGGVGLG
MAV_1267|M.avium_104 LAEKAPIAHHVRRLLDDPTGIEPAVWRGL-ADLGCTGLLVPEQHGGAGMT
TH_0804|M.thermoresistible__bu FCTEHFDEQTVRRLMESEPRFDPKVWARLGAELGVLGMSVPEADGGVGGT
Mvan_0393|M.vanbaalenii_PYR-1 FCADHIDETAVRAQMASEPRFDPKVWARLGSELGVLGMSVPESHGGAGGT
MAB_3123|M.abscessus_ATCC_1997 WCERVWTPKHVRQIAEAG-SVDLDAWRALGSELGVVGLSLPEQHGGGGLG
Mb1968c|M.bovis_AF2122/97 FLGRGAP---VREMAAAD-GSDRRLWQRLCTELELPALHVPPEHGGLGAT
Rv1933c|M.tuberculosis_H37Rv FLGRGAP---VREMAAAD-GSDRRLWQRLCTELELPALHVPPEHGGLGAT
MMAR_2861|M.marinum_M FLRDQAPPARVRQVAAVG-GHDKKLWHRLCAELELPALHAPPEYGGAGGT
MUL_2893|M.ulcerans_Agy99 FLRDQAPPARVRQVAAVG-GHDKKLWHRLCAELELPALHAPPEYGGAGGT
MLBr_00737|M.leprae_Br4923 LAEKEIAPHAADVDQRAR--FPEEALAAL-NASGFNAIHVPEEYGGQGAD
. * .: ** *
Mflv_2335|M.gilvum_PYR-GCK AQELEAVAEETGAALLPAPFISSAVLT-VALINAVGSDEDKQRLLPGLAD
MSMEG_1905|M.smegmatis_MC2_155 ALELEAVAEETGAALLPAPFIGSAVLA-TALIEAAGTAEDKQRLLPGLAE
MAV_1267|M.avium_104 MVEAGIVAEELGAALYPGPWLSTAVAAPRALIRLCAGGDTAAGLLRGIAD
TH_0804|M.thermoresistible__bu LVDQAVAVEEFGAALACGPFFGTVYLAVPALAA-ASAGPVRDELLGPLLE
Mvan_0393|M.vanbaalenii_PYR-1 LVDQAVAVEQLGAALACGPLFGTVYLAIPALVA-SSQ---PGDLLAPLIE
MAB_3123|M.abscessus_ATCC_1997 VIELSIVAEELGRALACLPWISSAALGATALVS-SGDDSALAEWVPALAA
Mb1968c|M.bovis_AF2122/97 LVETAIAFAELGRALTPIP-FAATVFAIEAILR-MGDDEQRKRLLAGLLT
Rv1933c|M.tuberculosis_H37Rv LVETAIAFAELGRALTPIP-FAATVFAIEAILR-MGDDEQRKRLLAGLLT
MMAR_2861|M.marinum_M LVETAIAFGELGRALTPVP-FAATILAIEAILR-MGDSEQRKGLLSGLLS
MUL_2893|M.ulcerans_Agy99 LVETAIAFGELGRALTPVP-FAATILAIEAILR-MGDSEQRKGLLSGLLS
MLBr_00737|M.leprae_Br4923 SVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPSLAA
. : . . . : :. . : :
Mflv_2335|M.gilvum_PYR-GCK GTAIGTVALTGPAGSWSEDGVDVRAG--ADG-ALDGVAHFVTWGQVADVV
MSMEG_1905|M.smegmatis_MC2_155 GTSIATVAVTGARGTWAKEGVAVKATERADGHTLNGNAHYVLSGQIADVL
MAV_1267|M.avium_104 GTTHVAVCFLDTP--------PMAATREGETTVLHGQARAVPDAAAADVL
TH_0804|M.thermoresistible__bu GARTAAVILADRAGVFDPTAVTV----TTDGATLTGTASQVVDVDAADDL
Mvan_0393|M.vanbaalenii_PYR-1 GIRTAAFAVPDAGGDFDADAVTVEAIPTDQGWTLTGTVQRVVDAGAADVV
MAB_3123|M.abscessus_ATCC_1997 GEKTITLAGGRTR---LADAITVSAESDTDGWKLTGDTEHVPDGATADVI
Mb1968c|M.bovis_AF2122/97 GARIGTIAV---SGHDVASATTVRAVRRDGRPALTGECTPVLHGHVADLF
Rv1933c|M.tuberculosis_H37Rv GARIGTIAV---SGHDVASATTVRAVRRDGRPALTGECTPVLHGHVADLF
MMAR_2861|M.marinum_M GDRIGALAA---AGPDLS-VTSVRAGRRDGRPVLTGECAPVLHGHVADLF
MUL_2893|M.ulcerans_Agy99 GDRIGALAA---AGPDLS-VTSVRAGRRDGRPVLTGECAPVLHGHVADLF
MLBr_00737|M.leprae_Br4923 EGAMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWY
: * * : :
Mflv_2335|M.gilvum_PYR-GCK LVVARTDD-----GVGVFEIATDATGFERTA----ATVFDPTVRLSTYTF
MSMEG_1905|M.smegmatis_MC2_155 LVVARTGGDDVG-GVGIFEVTPDATGLTRAA----ATVFDPSVRLSTFTF
MAV_1267|M.avium_104 LALAEDAG-----DTALFGVNTGSAGVAVRP----EHHIDPTHKQSRVTF
TH_0804|M.thermoresistible__bu LVAADGPD-----GVGLYAVDATGPGVTRTP----LVTMDLTRPQAAVRF
Mvan_0393|M.vanbaalenii_PYR-1 LVAAAGPD-----GLGLYAIEADNIGVQRIP----LTTLDLTRPQATVGL
MAB_3123|M.abscessus_ATCC_1997 LVLADTDS-----GPSLFAVDGDAPGVDRHS----LATLDMTRRQANIHF
Mb1968c|M.bovis_AF2122/97 VVPAVADG-----SIVLHVVAADAPGVTVTP----LPSFDITRPVATLRL
Rv1933c|M.tuberculosis_H37Rv VVPAVADG-----SIVLHVVAADAPGVTVTP----LPSFDITRPVATLRL
MMAR_2861|M.marinum_M VVPAESDG-----AVILYVVDAAAPGVAVVG----LPSFDITRPVAKLRL
MUL_2893|M.ulcerans_Agy99 VVPAESDG-----AVILYVVDAAAPGVAVVG----LPSFDITRPVAKLRL
MLBr_00737|M.leprae_Br4923 TVMAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDK
. * . : *. . .
Mflv_2335|M.gilvum_PYR-GCK AGTP-ARRLGTAG--WEAVREAMDYAVVASAGEQVGGAKRIFDITIAYLK
MSMEG_1905|M.smegmatis_MC2_155 TDTP-ARRIGTAG--WDAVSHALDLAVIALAGEQVGGTRRIFDITIDYLK
MAV_1267|M.avium_104 DAAP-ARRLATAS--ADDVAAVVDDVLIAACADALGAARAVMDLAVEYAK
TH_0804|M.thermoresistible__bu SGAP-ARLVAEPGTAERVITRALQVGAALLAVEQVGAAQHLLDLSVDYAK
Mvan_0393|M.vanbaalenii_PYR-1 FHAP-ARLVAGPAEAERVITHALQIGAALLAVEQVGAAQHLLDLTVDYAK
MAB_3123|M.abscessus_ATCC_1997 NSAP-ARLIGAQGRGAEAVATALDVAATVLAAEQAGIAAHMLDVTTEYAK
Mb1968c|M.bovis_AF2122/97 AGSP-AEPLTAG--TPDDMERVLDVARVLLAAEMLGGAEACLDLAVQYAG
Rv1933c|M.tuberculosis_H37Rv AGSP-AEPLTAG--TPDDMERVLDVARVLLAAEMLGGAEACLDLAVQYAG
MMAR_2861|M.marinum_M VRAP-AEALAAS--SADEVARLLDVARVLLAAEMLGGAEACLDLAIEYAC
MUL_2893|M.ulcerans_Agy99 VRAP-AEALAAS--SADEVARLLDVARVLLAAEMLGGAEACLDLAIEYAC
MLBr_00737|M.leprae_Br4923 CRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTK
* . : :: : * : :* : *
Mflv_2335|M.gilvum_PYR-GCK TRFQFGRAIGSFQALKHMAADLLLEVESATSAAQHAAAVFDD-PE---AR
MSMEG_1905|M.smegmatis_MC2_155 TRIQFGRAIGSFQALKHMAADLLVQVESSTSAAQHAAAEKAAGSD---DA
MAV_1267|M.avium_104 TRTQFGQPIGSFQAVQHLCVDMYETVELARSGVIHALWVSDAPDG---DE
TH_0804|M.thermoresistible__bu SRLQFGRPIGSFQAVKHRLADMLVDVEHARSTAYHAVWALADPAGELDDP
Mvan_0393|M.vanbaalenii_PYR-1 NRLQFGRPIGSFQAVKHRLADDLVALEHARSTAYHAVWALTDGS---DDP
MAB_3123|M.abscessus_ATCC_1997 SRIQFGRIIGSFQAVKHRLADMAAATGNVRGAAYHAAWSHDHPS--LDDP
Mb1968c|M.bovis_AF2122/97 RRTQFDRPIGSFQAVKHACADMMIEIDATRATVMFAAMSAANGD----EL
Rv1933c|M.tuberculosis_H37Rv RRTQFDRPIGSFQAVKHACADMMIEIDATRATVMFAAMSAANGD----EL
MMAR_2861|M.marinum_M SRKQFDRPIGSFQAVKHRCADMMIEIDATRAAVMFAQLCAAGGD----EL
MUL_2893|M.ulcerans_Agy99 SRKQFDRPIGSFQAVKHRCADMMIEIDATRAAVMFAQLCAAGGD----EL
MLBr_00737|M.leprae_Br4923 DRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEP---DL
* **.. *.:**:::. .* . *
Mflv_2335|M.gilvum_PYR-GCK DGAVALAGFACAEAYVKTAMAAVQMHGGIGFTWEHPCHLYVRRARSGLQL
MSMEG_1905|M.smegmatis_MC2_155 AGAIALAGFFCAEAYNTTAMQAVQMHGGIGFTWEHPAHLFVRRARTGLQL
MAV_1267|M.avium_104 RHLAALRAKAFAGRLAGVADTAIQVFGGIGYTWEHDAHLYLKRLLGYSAF
TH_0804|M.thermoresistible__bu ALATGIAQAVCSAAFSRVAADTIQVHGGIGFTWEHSAHLYYKRAATDAAL
Mvan_0393|M.vanbaalenii_PYR-1 ALAVSIAQATCSEALVRVATDTIQVHGGIGFTWEHQAHLYYKRAYTDAAL
MAB_3123|M.abscessus_ATCC_1997 ALATSIAQQVASAGAVEVTAKAIQSHGGIGFTWEHPAHLYYKRAVSNSAL
Mb1968c|M.bovis_AF2122/97 QTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLYYRRAKTTEAL
Rv1933c|M.tuberculosis_H37Rv QTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLYYRRAKTTEAL
MMAR_2861|M.marinum_M HATAPLAKAQAADTYVLCAGSAIQVHGGIAFTWEHDLHLYFRRAKTTEAL
MUL_2893|M.ulcerans_Agy99 HATAPLAKAQAAGTYVLCAGSAIQVHGGIAFTWEHDLHLYFRRAKTTEAL
MLBr_00737|M.leprae_Br4923 GFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIY
: : ::* .*. .:* :. . : :
Mflv_2335|M.gilvum_PYR-GCK FGDSGLHRERYLISKGA----------------
MSMEG_1905|M.smegmatis_MC2_155 FGSSAQHRERYLTAKGA----------------
MAV_1267|M.avium_104 LGGP----DRYLTEVGARLAKRGSP--------
TH_0804|M.thermoresistible__bu LGTAEQHRDRVAALALDTASPDRVPRVATGSG-
Mvan_0393|M.vanbaalenii_PYR-1 LGSAEAHRARVAELVLDVAPRKDAPRVATGMPS
MAB_3123|M.abscessus_ATCC_1997 FGGRAVHAERIAKEVIDA---------------
Mb1968c|M.bovis_AF2122/97 FGSSARNRALLAERAGLVKA-------------
Rv1933c|M.tuberculosis_H37Rv FGSSARNRALLAERAGLVKA-------------
MMAR_2861|M.marinum_M FGSSAHHRSLLADRVGL----------------
MUL_2893|M.ulcerans_Agy99 FGSSAHHRSLLADRVGL----------------
MLBr_00737|M.leprae_Br4923 EGTNQIQRVVMSRALLR----------------
*