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TYPPSSPGYPPAPQSGSQYGATQPFGKPAETAPAGESSLPQILLGVAAAAGLIAYFVSYGIEDAQFAVGA PIVQVIVVAALAGALLAGVSLLPKQKNHAGVASVLALVAFLQSVYLVILAGSDSGWAFITILVLTLIQAG AALTVLLFDSGILTPPPPKPAYEQQPQYGQYGAPSQYYGQQPGQQPGQQPGQHGQQPGQQQGQPSYQQGQ RPGYPSQYGGYSAGPSTGGFPTPGSQPGGQQHGQQSGPPTPPTGFPTYGQPQQSSGPSSAPTSQVPAQPQ QQQPGQQPSSPQSGQSSS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5518 | - | - | 100% (299) | antigen 34 kDa |
| M. smegmatis MC2 155 | MSMEG_3884 | - | 7e-11 | 49.44% (89) | hypothetical protein MSMEG_3884 |
| M. smegmatis MC2 155 | MSMEG_0035 | - | 2e-09 | 31.25% (144) | FHA domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0979 | - | 2e-47 | 39.49% (314) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1872 | - | 2e-62 | 46.65% (313) | hypothetical protein Mflv_1872 |
| M. tuberculosis H37Rv | Rv0954 | - | 2e-47 | 39.49% (314) | transmembrane protein |
| M. leprae Br4923 | MLBr_00158 | - | 7e-41 | 37.38% (313) | 34 kDa antigen |
| M. abscessus ATCC 19977 | MAB_1061 | - | 4e-27 | 31.41% (347) | 34 kDa antigenic protein |
| M. marinum M | MMAR_4545 | - | 3e-45 | 37.38% (321) | transmembrane protein |
| M. avium 104 | MAV_1078 | - | 2e-55 | 43.87% (310) | 34 kDa antigenic protein |
| M. thermoresistible (build 8) | TH_0991 | ftsH | 1e-10 | 38.68% (106) | MEMBRANE-BOUND PROTEASE FTSH (CELL DIVISION PROTEIN) |
| M. ulcerans Agy99 | MUL_4715 | - | 1e-44 | 38.01% (321) | transmembrane protein |
| M. vanbaalenii PYR-1 | Mvan_4859 | - | 2e-55 | 42.72% (316) | hypothetical protein Mvan_4859 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1872|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4859|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5518|M.smegmatis_MC2_155 --------------------------------------------------
Mb0979|M.bovis_AF2122/97 --------------------------------------------------
Rv0954|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4545|M.marinum_M --------------------------------------------------
MUL_4715|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00158|M.leprae_Br4923 --------------------------------------------------
MAV_1078|M.avium_104 --------------------------------------------------
MAB_1061|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0991|M.thermoresistible__bu MNRKTVIRTLTIVAVVLLLGWSFFYFGDDTREYKPVDTSVALAQIQADNV
Mflv_1872|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4859|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5518|M.smegmatis_MC2_155 --------------------------------------------------
Mb0979|M.bovis_AF2122/97 --------------------------------------------------
Rv0954|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4545|M.marinum_M --------------------------------------------------
MUL_4715|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00158|M.leprae_Br4923 --------------------------------------------------
MAV_1078|M.avium_104 --------------------------------------------------
MAB_1061|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0991|M.thermoresistible__bu DSAQIDDREQQVRLDLKNANSDTGDSDKIIAKYPTGYAVPLFDALQDKNA
Mflv_1872|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4859|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5518|M.smegmatis_MC2_155 --------------------------------------------------
Mb0979|M.bovis_AF2122/97 --------------------------------------------------
Rv0954|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4545|M.marinum_M --------------------------------------------------
MUL_4715|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00158|M.leprae_Br4923 --------------------------------------------------
MAV_1078|M.avium_104 --------------------------------------------------
MAB_1061|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0991|M.thermoresistible__bu KVNTVVNQGSVLGTLLIYMLPLLLLVALFVFFMRMQSGGRMGFGFGKSKA
Mflv_1872|M.gilvum_PYR-GCK -----------------------------------------------MTY
Mvan_4859|M.vanbaalenii_PYR-1 -----------------------------------------------MSY
MSMEG_5518|M.smegmatis_MC2_155 -----------------------------------------------MTY
Mb0979|M.bovis_AF2122/97 -----------------------------------------------MTY
Rv0954|M.tuberculosis_H37Rv -----------------------------------------------MTY
MMAR_4545|M.marinum_M -----------------------------------------------MTY
MUL_4715|M.ulcerans_Agy99 -----------------------------------------------MTY
MLBr_00158|M.leprae_Br4923 ------------------------------MHCSSGAVTALEITGGVMTY
MAV_1078|M.avium_104 -----------------------------------------------MTY
MAB_1061|M.abscessus_ATCC_1997 -----------------------------------------------MTY
TH_0991|M.thermoresistible__bu KQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIPKGVL
Mflv_1872|M.gilvum_PYR-GCK PQGAPGG--FPPAQQPTNQFSAPTQQFSTLPPDNEQSQAGANKLPTYLAG
Mvan_4859|M.vanbaalenii_PYR-1 PQGAPGGQGFPPGQQPTTQFSAPTQQFNRVP-DADPVAEGPSKLPVYLSA
MSMEG_5518|M.smegmatis_MC2_155 PPSSPGY---PPAPQSGSQYGA-TQPFGKPA---ETAPAGESSLPQILLG
Mb0979|M.bovis_AF2122/97 SPGNPGY----PQAQPAGSYGGVTPSFAHAD-------EGASKLPMYLNI
Rv0954|M.tuberculosis_H37Rv SPGNPGY----PQAQPAGSYGGVTPSFAHAD-------EGASKLPMYLNI
MMAR_4545|M.marinum_M TPGSPGY----PPAQSGGSYGGATPSFAQAD-------DAASKLPMYLNV
MUL_4715|M.ulcerans_Agy99 TPGSPGY----PPAQSGGSYGGATPSFAQAD-------DAASKLPMYLNV
MLBr_00158|M.leprae_Br4923 LPGSPGY----PLVQPAGSYPGATPSFVKSD-------VGESQLYHYLTI
MAV_1078|M.avium_104 SPGSPGY----PPAQSGGTYAGATPSFAKDD-------DGKSKLPLYLNI
MAB_1061|M.abscessus_ATCC_1997 STGGPGY----QPAQPSNPYGT--PSFVAEP--------NTGALGVYLPG
TH_0991|M.thermoresistible__bu LYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDLFEQ
. ** : . : :
Mflv_1872|M.gilvum_PYR-GCK ATALLGLLTYLASFGPKLSLDD--AQIDVSL-------------------
Mvan_4859|M.vanbaalenii_PYR-1 AVVALGLLVYMSSFGPHFTASDFSAFGELTG-------------------
MSMEG_5518|M.smegmatis_MC2_155 VAAAAGLIAYFVSYG----IED----AQFAV-------------------
Mb0979|M.bovis_AF2122/97 AVAVLGLAAYFASFGPMFTLST-ELGGGDGA-------------------
Rv0954|M.tuberculosis_H37Rv AVAVLGLAAYFASFGPMFTLST-ELGGGDGA-------------------
MMAR_4545|M.marinum_M AVAVLGFLAYLASFGPMFTISS-ELGGGSSE-------------------
MUL_4715|M.ulcerans_Agy99 AVAVLGFLAYLASFGPMFTISS-ELGGGSSE-------------------
MLBr_00158|M.leprae_Br4923 AVVVLGLAVYLGNFGPTFTSSS-DIGPGSGG-------------------
MAV_1078|M.avium_104 AVVALGFAAYLLNFGPTFTIGA-DLGPGIGG-------------------
MAB_1061|M.abscessus_ATCC_1997 GVLVLSLIGFIAGFGPFYTGKASSGTSGSFGGFDLL--------------
TH_0991|M.thermoresistible__bu AKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFGDRQ
:. .
Mflv_1872|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4859|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5518|M.smegmatis_MC2_155 --------------------------------------------------
Mb0979|M.bovis_AF2122/97 --------------------------------------------------
Rv0954|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4545|M.marinum_M --------------------------------------------------
MUL_4715|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00158|M.leprae_Br4923 --------------------------------------------------
MAV_1078|M.avium_104 --------------------------------------------------
MAB_1061|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0991|M.thermoresistible__bu GVILIAATNRPDILDPALLRPGRFDRQIPVTNPDLAGRKAVLRVHAQGKP
Mflv_1872|M.gilvum_PYR-GCK --------SPVRLDLALVAAVLAGLIAGVGLLPRQTPRPALV------AV
Mvan_4859|M.vanbaalenii_PYR-1 --------SSFGVILAVISAITAGLFAAVGLLPRQNNFTAVA------AV
MSMEG_5518|M.smegmatis_MC2_155 --------GAPIVQVIVVAALAGALLAGVSLLPKQKNHAGVA------SV
Mb0979|M.bovis_AF2122/97 --------VSGDTGLPVGVALLAALLAGVALVPKAKSHVTVV------AV
Rv0954|M.tuberculosis_H37Rv --------VSGDTGLPVGVALLAALLAGVALVPKAKSHVTVV------AV
MMAR_4545|M.marinum_M --------ASGDTVLAVGMALLAGLLAGVSLLPKVKSYGAVV------AV
MUL_4715|M.ulcerans_Agy99 --------ASGDTVLAVGMALLAGLLAGVSLLPKVKSYGAVV------AV
MLBr_00158|M.leprae_Br4923 --------FAGDAGTAVVVALLAALLAGLDLLPKAKSSAGVV------GA
MAV_1078|M.avium_104 --------RAGDAGTAVVVALLAALLAGLGLLPKAKSYVGVV------AV
MAB_1061|M.abscessus_ATCC_1997 -------ALSPVFGFAQFALLIAGLTAGVSLLSGKDDKQAPV------AI
TH_0991|M.thermoresistible__bu LAPDVDLDGLAKRTVGMSGADLANVINEAALLTARENGTMITGPALEEAV
. : *:. . .
Mflv_1872|M.gilvum_PYR-GCK LSLLGFLIALATLFDGFEGTTV----------GWGVYLVIAFTLLQAAVA
Mvan_4859|M.vanbaalenii_PYR-1 AAVLALLLVVAEIINKPAEASI----------GWGLYLVIAFILLQAAVS
MSMEG_5518|M.smegmatis_MC2_155 LALVAFLQSVYLVI--LAGSDS----------GWAFITILVLTLIQAGAA
Mb0979|M.bovis_AF2122/97 LGVLGVFLMVSATFNKPSAYST----------GWALWVVLAFIVFQAVAA
Rv0954|M.tuberculosis_H37Rv LGVLGVFLMVSATFNKPSAYST----------GWALWVVLAFIVFQAVAA
MMAR_4545|M.marinum_M VSILGVFLMISSTFNKPSAFST----------GWALWIVLVCIVFQAVAA
MUL_4715|M.ulcerans_Agy99 VSILGVFLMISSTFNKPSAFST----------GWALWIVLVCIVFQAVAA
MLBr_00158|M.leprae_Br4923 IAVLGALLAISEMINMPAGFSI----------GWAMWFILVCSVLQAIAA
MAV_1078|M.avium_104 VAVLGALLAITETINLPAGFAI----------GWAMWPLVACVVLQAIAA
MAB_1061|M.abscessus_ATCC_1997 LSIVGFLFVLGGLFGNPFAAAVGEVG-----IGWGLITLAVVSGLQAAVS
TH_0991|M.thermoresistible__bu DRVVGGPRRKSRLISELEKKITAYHEGGHTLAAWAMPDIEPIYKVTILAR
::. : .*.. : . .
Mflv_1872|M.gilvum_PYR-GCK -----------------------VVCLLFDSG-------IITPPVPRPKY
Mvan_4859|M.vanbaalenii_PYR-1 -----------------------VVVLLFDAG-------IITPPVPRPKY
MSMEG_5518|M.smegmatis_MC2_155 -----------------------LTVLLFDSG-------ILTPPPPKPAY
Mb0979|M.bovis_AF2122/97 -----------------------VLALLVETG-------AITAPAPRPKF
Rv0954|M.tuberculosis_H37Rv -----------------------VLALLVETG-------AITAPAPRPKF
MMAR_4545|M.marinum_M -----------------------VGALLLETG-------VVSAPAPRPKF
MUL_4715|M.ulcerans_Agy99 -----------------------VGALLLETG-------VVSAPAPRPKF
MLBr_00158|M.leprae_Br4923 -----------------------VAALLLEAG-------IITAPAPRLSY
MAV_1078|M.avium_104 -----------------------VVVVLLDAG-------VITAPAPRPKY
MAB_1061|M.abscessus_ATCC_1997 -----------------------VYSLLSEVG-------VIKAKTASPAA
TH_0991|M.thermoresistible__bu GRTGGHAVAVPEDDKGLMTRSEMIARLVFAMGGRAAEELVFREPTTGAVS
: :: * . .
Mflv_1872|M.gilvum_PYR-GCK DQHQQQYGQYSGG------------YYGQQHGQQHGQQHGGPQQQGSQQQ
Mvan_4859|M.vanbaalenii_PYR-1 EQ-PQSYGQYPG-------------YYGQPPTQGGSGQH----QQGPQQQ
MSMEG_5518|M.smegmatis_MC2_155 EQ-QPQYGQYGAPSQ----------YYGQQPGQQPGQQPGQHGQQPGQQQ
Mb0979|M.bovis_AF2122/97 DP-YGQYGRYGQYGQYGVQPGG---YYGQQGAQ----QAAGLQSPGPQQS
Rv0954|M.tuberculosis_H37Rv DP-YGQYGRYGQYGQYGVQPGG---YYGQQGAQ----QAAGLQSPGPQQS
MMAR_4545|M.marinum_M DP-YGQYGQYGQYGQYGGQPGG---YYGQPGAQ----QSA----PNPQQS
MUL_4715|M.ulcerans_Agy99 DP-YGQYGQYGQY---GGQPGG---YYGQPGAQ----QSA----PNPQQS
MLBr_00158|M.leprae_Br4923 DP-YLQYGQY------GAQS-----YYGQPNRQ----LQVGLNAHSPQQS
MAV_1078|M.avium_104 DP-YAQYGQYGQYGQYGQQP-----YYGQPGGQP--GGQPGGQQHGQQHS
MAB_1061|M.abscessus_ATCC_1997 NPFGNQYQPQQSYYTPAQQQPQ---QQLPKQGQG---QSYGQAQGYGQQQ
TH_0991|M.thermoresistible__bu DIEQATKIARAMVTEYGMSSKLGAVRYGTEHGDPFLGRTMGTHADYSHEV
: : :.
Mflv_1872|M.gilvum_PYR-GCK GLQ-----------------------------------------------
Mvan_4859|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5518|M.smegmatis_MC2_155 GQPSYQQG------------------------------------------
Mb0979|M.bovis_AF2122/97 PQ------------------------------------------------
Rv0954|M.tuberculosis_H37Rv PQ------------------------------------------------
MMAR_4545|M.marinum_M PQQ-----------------------------------------------
MUL_4715|M.ulcerans_Agy99 PQQ-----------------------------------------------
MLBr_00158|M.leprae_Br4923 PA------------------------------------------------
MAV_1078|M.avium_104 PQ------------------------------------------------
MAB_1061|M.abscessus_ATCC_1997 GYG-----------------------------------------------
TH_0991|M.thermoresistible__bu ARDIDDEIRKLIEAAHTEAWEILTEYRDVLDVLAGELLEKETLHRRELEV
Mflv_1872|M.gilvum_PYR-GCK --------QRPGYPTPYGGYSG----------------------------
Mvan_4859|M.vanbaalenii_PYR-1 --------QRPGYPTPYGGYPG----------------------------
MSMEG_5518|M.smegmatis_MC2_155 --------QRPGYPSQYGGYS-----------------------------
Mb0979|M.bovis_AF2122/97 ---------PPGYGSQYGGYSSSPS-------------------------
Rv0954|M.tuberculosis_H37Rv ---------PPGYGSQYGGYSSSPS-------------------------
MMAR_4545|M.marinum_M ---------PSGYGSQYGGFTSS---------------------------
MUL_4715|M.ulcerans_Agy99 ---------PSGYGSQYGGFTSS---------------------------
MLBr_00158|M.leprae_Br4923 -----------GYGAQYGAYTS----------------------------
MAV_1078|M.avium_104 -----------GYGSQYGGYGQG---------------------------
MAB_1061|M.abscessus_ATCC_1997 ----------QQQPAQGYGQSGAQA-------------------------
TH_0991|M.thermoresistible__bu ILADVKKRPRLTMFDDFGGRTPSDKPPIKTPGELAMERGEPWPKPEPEPA
.
Mflv_1872|M.gilvum_PYR-GCK ----SGQTTGGFPA-----------AQSGPPTP-----------------
Mvan_4859|M.vanbaalenii_PYR-1 ----SGPGTGGFPAG----------AQSGPPTP-----------------
MSMEG_5518|M.smegmatis_MC2_155 ----AGPSTGGFPTPGSQPGGQQHGQQSGPPTP-----------------
Mb0979|M.bovis_AF2122/97 -QSGSGYTAQPPAQPPAQSG--SQQSHQGPSTP-----------------
Rv0954|M.tuberculosis_H37Rv -QSGSGYTAQPPAQPPAQSG--SQQSHQGPSTP-----------------
MMAR_4545|M.marinum_M --QGSNPSSGGFSAPQAQSA--PQPMHQTPSTP-----------------
MUL_4715|M.ulcerans_Agy99 --QGSNPSSGGFSAPQAQSA--PQPMHQTPSTP-----------------
MLBr_00158|M.leprae_Br4923 ---SPTQIQAGMPATGGFSA--QHSAQQGPSTP-----------------
MAV_1078|M.avium_104 --GAPTGGFGAQPSPQSGPQ--QSAQQQGPSTP-----------------
MAB_1061|M.abscessus_ATCC_1997 -APGYGQQQSAPAAPPSYGGYGQQQPQSAPPTP-----------------
TH_0991|M.thermoresistible__bu FKVAIAEATRAAEAASGQNGQNGHNGTPGPTGPNGTPSAPAQQPAPVVPD
*. *
Mflv_1872|M.gilvum_PYR-GCK ---PTGFPTYGQPPANN----TPTTQVPTQ--QQSPPQS-----------
Mvan_4859|M.vanbaalenii_PYR-1 ---PTGFPTYGQPPASN----TPTSQAPAP--HQSPS-------------
MSMEG_5518|M.smegmatis_MC2_155 ---PTGFPTYGQPQQSSGPSSAPTSQVPAQPQQQQPGQQ-----------
Mb0979|M.bovis_AF2122/97 ---PTGFPSFSPPPPVSAGTGSQAGSAPVNYSNPSG--------------
Rv0954|M.tuberculosis_H37Rv ---PTGFPSFSPPPPVSAGTGSQAGSAPVNYSNPSG--------------
MMAR_4545|M.marinum_M ---PTGFPSFSPPPSVSAGTGSQGGSAPVNYGNPGGGQQNYGQ-------
MUL_4715|M.ulcerans_Agy99 ---PTGFPSFSPPPSVSAGTGSQGGSAPVNYANPSGAQQNYGQ-------
MLBr_00158|M.leprae_Br4923 ---PTGFPSFSPPPSVGAAAGSQAGSAPVSYSNPTDSKQGFGQGR-----
MAV_1078|M.avium_104 ---PTGFPSFSPPPNVG--GGSDSGSATANYSEQAGGQQSYGQ-------
MAB_1061|M.abscessus_ATCC_1997 ---PQGFSSSGFTPPSSQPAQQAASSQPTQQYPTFGAASGQAAGG-----
TH_0991|M.thermoresistible__bu YGAPAGWHAPGWPPQPTPQQQPPPYQQPHGQWYPPQQQPGWQQQQQPYPS
* *: : . . . .
Mflv_1872|M.gilvum_PYR-GCK ------------GQSSQSGQSSPSGQSSP-----------
Mvan_4859|M.vanbaalenii_PYR-1 --------------SSQPGQSSS-----------------
MSMEG_5518|M.smegmatis_MC2_155 ------------PSSPQSGQSSS-----------------
Mb0979|M.bovis_AF2122/97 -----------GEQSSSPGGAPV-----------------
Rv0954|M.tuberculosis_H37Rv -----------GEQSSSPGGAPV-----------------
MMAR_4545|M.marinum_M -----------GQQSSSPGSAPV-----------------
MUL_4715|M.ulcerans_Agy99 -----------GQQSSSPGSAPV-----------------
MLBr_00158|M.leprae_Br4923 -----------ESTSSSSGSAPV-----------------
MAV_1078|M.avium_104 ------------EPSSPSGPTPA-----------------
MAB_1061|M.abscessus_ATCC_1997 -----------EQQSSAGAGGGSASASGDDLFGTSRPSN-
TH_0991|M.thermoresistible__bu QYSPYQPYPQPSPPAPPGGAAPNDQESGQDPNRTNPPGQG
:. .