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KAGDVMGLVDRIERKLESTVGDAFARVFGGSIVPQEVEVALRREAETRARTVAGGQVLAPNDYVITLSGT DYQKVRADTDLTSTTFAKHLKGYIHDQGWQTYGEVVVRFEQSPNLHTGQFRARGAVNPDSTAGESARAPR DHAFTAESGEPPMTDNPNYRGGQGPARPGDEYYDERYGRQDDPRGGQYPPEQGGYPPQDQGGYPPRGGGY PDQGGYPDQGGYPDQGGYPDQGGYPPQSYEQRPPAGYGPPPQGGGYDRGYGQPAGGYPPAGPPAGPPPGG QPGYGGADYDYGRQAPRHDDYGRPDPRQGYPEQGGYPEQGGYGGQAYGRPDYGQPDYGQQPGRGYPEQGG YPEQGGYGEPAGRDYEYGGDYGAPAGQGGYGGGYGADYPAGGTTVTLQLDDGSGRTYQLREGANVIGRGQ DAQFRLPDTGVSRRHLEIRWDGQVALLSDLNSTNGTTVNNAPVQEWQLADGDVIRLGHSEIIVRVH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0035 | - | - | 100% (487) | FHA domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_5268 | - | 1e-20 | 40.83% (169) | hypothetical protein MSMEG_5268 |
| M. smegmatis MC2 155 | MSMEG_2420 | - | 7e-15 | 44.23% (104) | hypothetical protein MSMEG_2420 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0020c | TB39.8 | 1e-167 | 60.41% (543) | hypothetical protein Mb0020c |
| M. gilvum PYR-GCK | Mflv_0806 | - | 0.0 | 71.83% (497) | FHA domain-containing protein |
| M. tuberculosis H37Rv | Rv0020c | TB39.8 | 1e-168 | 60.15% (547) | hypothetical protein Rv0020c |
| M. leprae Br4923 | MLBr_00022 | - | 1e-156 | 59.50% (516) | hypothetical protein MLBr_00022 |
| M. abscessus ATCC 19977 | MAB_0039c | - | 1e-137 | 57.79% (507) | hypothetical protein MAB_0039c |
| M. marinum M | MMAR_0022 | - | 1e-177 | 60.92% (563) | hypothetical protein MMAR_0022 |
| M. avium 104 | MAV_0024 | - | 1e-171 | 60.62% (546) | xyppx repeat-containing protein |
| M. thermoresistible (build 8) | TH_2237 | - | 0.0 | 69.57% (529) | CONSERVED HYPOTHETICAL PROTEIN TB39.8 |
| M. ulcerans Agy99 | MUL_0024 | - | 1e-177 | 62.11% (549) | hypothetical protein MUL_0024 |
| M. vanbaalenii PYR-1 | Mvan_0029 | - | 0.0 | 73.83% (493) | FHA domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0806|M.gilvum_PYR-GCK ------MGLVDRFERKLEDSVGDAFARVFGGSIVPREVEVLLRREAETGA
Mvan_0029|M.vanbaalenii_PYR-1 ------MGLVGRFERKLEDKVGDAFARVFGGSIVPQEVESLLRREADAGV
TH_2237|M.thermoresistible__bu ------MGLADRIERKLEATVGDAFARVFGGSIVPQEVEARLRREAQAGA
MSMEG_0035|M.smegmatis_MC2_155 MKAGDVMGLVDRIERKLESTVGDAFARVFGGSIVPQEVEVALRREAETRA
MMAR_0022|M.marinum_M --MGSQKGLVQRIERKLESTVGDAFARMFGGSIVPQEVEALLRREAADGV
MUL_0024|M.ulcerans_Agy99 --MGSQKGLVQRIERKLESTVGDAFARMFGGSIVPQEVEALLRREAADGV
Mb0020c|M.bovis_AF2122/97 --MGSQKRLVQRVERKLEQTVGDAFARIFGGSIVPQEVEALLRREAADRI
Rv0020c|M.tuberculosis_H37Rv --MGSQKRLVQRVERKLEQTVGDAFARIFGGSIVPQEVEALLRREAADGI
MLBr_00022|M.leprae_Br4923 --MDNQKELIQRIERKLESSIDDAFARMFGGSIVPQEVEALLRREASDGV
MAV_0024|M.avium_104 --MSSQRGLVARIERKLEATVDNAFARVFGGPIVPQEVEALLCREARDGV
MAB_0039c|M.abscessus_ATCC_199 ------MGIVQRFERKLEDVVGDAFARVFGGSIVPQEVQASLRREAADGV
: *.***** :.:****:***.***:**: * ***
Mflv_0806|M.gilvum_PYR-GCK RKVPGGHILAPNDYVITLSVPDFQKVNADPDITATTFAKHLEGYIHEQGW
Mvan_0029|M.vanbaalenii_PYR-1 RELHGGRILAPNDYVITLSVPDYRKVSADPDITATTFAKHLEGYIHEQGW
TH_2237|M.thermoresistible__bu RDVGGGRILAPNDYVITLSESDYRKVSADPDRTSTTFAKHLEGYIHDQGW
MSMEG_0035|M.smegmatis_MC2_155 RTVAGGQVLAPNDYVITLSGTDYQKVRADTDLTSTTFAKHLKGYIHDQGW
MMAR_0022|M.marinum_M RSLPGNRLLAPNEYIITLSVHDAEELGADPHLTSSEFARYLADYIHEQGW
MUL_0024|M.ulcerans_Agy99 RSLPGNRLLAPNEYIITLSVHDAEELGADPHLTSSEFARYLADYIHEQGW
Mb0020c|M.bovis_AF2122/97 QSLQGNRLLAPNEYIITLGVHDFEKLGADPELKSTGFARDLADYIQEQGW
Rv0020c|M.tuberculosis_H37Rv QSLQGNRLLAPNEYIITLGVHDFEKLGADPELKSTGFARDLADYIQEQGW
MLBr_00022|M.leprae_Br4923 RSLQGNRLLAPNEYIITLGVHDLEKMKADPDLTSSAFASDLADYIHEQGW
MAV_0024|M.avium_104 QKLHGNRLLAPNEYIITLGMHDFEKVSADPDLTSSAFARYLADYIHEQGW
MAB_0039c|M.abscessus_ATCC_199 RSAGQGRLLAPNEFFVLLSTADHEKAADDRDLNPDTFAELLREYIRDQGW
: .::****::.: *. * .: * . .. ** * **::***
Mflv_0806|M.gilvum_PYR-GCK QTYGDVVVRFEQSPNLHTGQFRARGAVNPDA----TTVEPAPPSRDATSQ
Mvan_0029|M.vanbaalenii_PYR-1 QTYGDVVVRFEQSPNLHTGQFRARAAVNPDA----TTVEPAPPPRDVTSQ
TH_2237|M.thermoresistible__bu QTYGDVVVRFEQSSNLHTGQFRARGLVNPDT----TTGEPAQAQQDRAYT
MSMEG_0035|M.smegmatis_MC2_155 QTYGEVVVRFEQSPNLHTGQFRARGAVNPDS----TAGESARAPRDHAFT
MMAR_0022|M.marinum_M QTYGDVVVRFEQSSSLHTGQFRARGAVNPDVEPRPTVNDSAQPQSNDAFG
MUL_0024|M.ulcerans_Agy99 QTYADVVVRFEQSSSLHTGQFRARGAVNPDVEPRPTVNDSAQPQSNDAFG
Mb0020c|M.bovis_AF2122/97 QTYGDVVVRFEQSSNLHTGQFRARGTVNPDVETHPPVIDCARPQSNHAFG
Rv0020c|M.tuberculosis_H37Rv QTYGDVVVRFEQSSNLHTGQFRARGTVNPDVETHPPVIDCARPQSNHAFG
MLBr_00022|M.leprae_Br4923 QTYGDVVVRFDQSSSLHTGQIRARSVVNPDVEPRPTVNDPVRTQSNQAFS
MAV_0024|M.avium_104 QTYGEVVVRFEQSSSLRTGQYRACGAVNPDVQPRPTVDDPVRPQSNNAFG
MAB_0039c|M.abscessus_ATCC_199 QTYGEVVVRFEQSPNLHTGQFRTRGVVNPDS--KRDRPHGAVTTAPPTPD
***.:*****:**..*:*** *: . **** . . . :
Mflv_0806|M.gilvum_PYR-GCK AEPGVPAMTDNPSYRGGPGQGRP-DEY--YN----RPPENRPEDEGGYNR
Mvan_0029|M.vanbaalenii_PYR-1 AEPGVPPMTDNPTYRGGQGPGRPADDY--YN----RPEDERP--------
TH_2237|M.thermoresistible__bu AEPGVPPMSDNPSYRGGQGPGRPADDE--YDDRYGRPDDPRGQ----YPP
MSMEG_0035|M.smegmatis_MC2_155 AESGEPPMTDNPNYRGGQGPARPGDEY--YDERYGRQDDPRG--------
MMAR_0022|M.marinum_M AEPGVPPMTDNSSYRGGQGQGRPDE-Y--YDERYARPQEDPRGGP-----
MUL_0024|M.ulcerans_Agy99 AEPGVPPMTDNSSYRGGQGQGRPDE-Y--YDERYARPQEDPRGGP-----
Mb0020c|M.bovis_AF2122/97 AEPGVAPMSDNSSYRGGQGQGRPDE-Y--YDDRYARPQEDPRGGPD----
Rv0020c|M.tuberculosis_H37Rv AEPGVAPMSDNSSYRGGQGQGRPDE-Y--YDDRYARPQEDPRGGPD----
MLBr_00022|M.leprae_Br4923 AEPGVPPMTDNSSYRGGQGQGRPS------DDYYGRPQDDPRGAD-----
MAV_0024|M.avium_104 EERGVAPMTDNSSYRGAQGPGRPGDEY--YDERYGRPQDDARGGSE----
MAB_0039c|M.abscessus_ATCC_199 PQPG-APMTDNP----GPQQGRPGEEYGREDDRYGRPDQDPR--------
: * ..*:**. . .** : * :
Mflv_0806|M.gilvum_PYR-GCK PENRGDEQRGGYPHGDQGGYP--AQDQGYP-----PRGGYPEQG------
Mvan_0029|M.vanbaalenii_PYR-1 --NRGDEPRGGYPPADQGGYPPPADQGGYP-----PRGGYPEHGGYPEHG
TH_2237|M.thermoresistible__bu ADQGGYPPRGGYPEQPGGGYP--EQQGGYPE----QQGGYPDQGGYPPRG
MSMEG_0035|M.smegmatis_MC2_155 --GQYPPEQGGYPPQDQGGYP--PRGGGYP-----DQGGYPDQG------
MMAR_0022|M.marinum_M --HGGPDPRGGYPP-EAGGYP---PQPGYPPPRPQDQGGYPEQGGYPEQG
MUL_0024|M.ulcerans_Agy99 --HGGPDPRGGYPP-EAGGYP---PQPGYPPPRPQDQGGYPEQGGYPDQR
Mb0020c|M.bovis_AF2122/97 -PQGGSDPRGGYPP-ETGGYP---PQPGYPRPRHPGQGDYPEQIGYPDQG
Rv0020c|M.tuberculosis_H37Rv -PQGGSDPRGGYPP-ETGGYP---PQPGYPRPRHPDQGDYPEQIGYPDQG
MLBr_00022|M.leprae_Br4923 -PQGGQDPRGCYPP-KPGSYP---QQAGHPPLHRPDQGGYPGQGGYE---
MAV_0024|M.avium_104 -PQGAPDQRGGYPP-EQGGYP---PQQGYPPPRHPEQGGYPEQGGYPPPQ
MAB_0039c|M.abscessus_ATCC_199 ----GQQPQG------GQGYP--PRQGGYE------GGGYGQGQ------
:* .** *: *.*
Mflv_0806|M.gilvum_PYR-GCK GYQDQGGYQ---------GQGGYP--------------------PQSYEQ
Mvan_0029|M.vanbaalenii_PYR-1 GYPDQGGYP---------EQGGYP--------------------PQSYEQ
TH_2237|M.thermoresistible__bu GYPDQGGYP---------EQGGYPDQG---------------GYPPSYEQ
MSMEG_0035|M.smegmatis_MC2_155 GYPDQGGYP---------DQGGYP--------------------PQSYEQ
MMAR_0022|M.marinum_M GYPDQRGYQDQRG---YQDQRGYPDQG-GYPDQRGYPE--QGGYPPSYEQ
MUL_0024|M.ulcerans_Agy99 GYPDQRGYQDQRG---YPDQRDYQDQG-GYPDQRGYPE--QGGYPPSYEQ
Mb0020c|M.bovis_AF2122/97 GYPEQRGYP---------DQRGHQDQGRGYPDQG------QGGYPPPYEQ
Rv0020c|M.tuberculosis_H37Rv GYPEQRGYPEQRG---YPDQRGYQDQGRGYPDQG------QGGYPPPYEQ
MLBr_00022|M.leprae_Br4923 ------------------DQRAYHDQG-------------QGGYPSPYEQ
MAV_0024|M.avium_104 SYQEHGGYPDQRGGYPEPGQAGYPPQQHGYPDLRGYPEPAQGGYPQSYEQ
MAB_0039c|M.abscessus_ATCC_199 PYGQDYGRP----------PAGYD--------------------QGGYQQ
: *:*
Mflv_0806|M.gilvum_PYR-GCK RPPAGYGP---PPG-YPDQGYRQGPGGY-------GPPPGG-----APGY
Mvan_0029|M.vanbaalenii_PYR-1 RPPAGYGP---PPGGYPDQGYRQPPPGY-------GPPPGG-----QPGY
TH_2237|M.thermoresistible__bu RPPAGYGP---PPGGGYDQGYRQPPPGY-------GPP-GG-----QPGY
MSMEG_0035|M.smegmatis_MC2_155 RPPAGYGPP--PQGGGYDRGYGQPAGGYPPAGPPAGPPPGG-----QPGY
MMAR_0022|M.marinum_M RPPA-PG---GYGAQGYDQGYRQA-GGY-------GQPPGG-----QPGY
MUL_0024|M.ulcerans_Agy99 CPPA-PG---GYGAQGYDQGYRQG-GGY-------GQPPGG-----QPGY
Mb0020c|M.bovis_AF2122/97 RPPVSPGPAAGYGAPGYDQGYRQS-GGC-------GPSPGGG----QPGY
Rv0020c|M.tuberculosis_H37Rv RPPVSPGPAAGYGAPGYDQGYRQS-GGY-------GPSPGGG----QPGY
MLBr_00022|M.leprae_Br4923 RPAT-PG---GYGSQGHDQGYRP--GSY-------GPPSGG-----QPGY
MAV_0024|M.avium_104 RPPAPPG----YSGQGYDQGYRPP-GGG-------YPPPGGQPAGGPQGY
MAB_0039c|M.abscessus_ATCC_199 RPPQQGG----YDQGGYGAPPQAPQGGGD-----YGRPPAP------PQQ
*. * . . . .
Mflv_0806|M.gilvum_PYR-GCK GGP-AGDYDYGR----RPDDGGYG-------QPP--RPAYPDQGG-YPDQ
Mvan_0029|M.vanbaalenii_PYR-1 GPP-SGDYDYGR----RPDDGGYGP------QGPQGRPSYPDQGG-YPDQ
TH_2237|M.thermoresistible__bu GAPPAGEYDYGRPPGGRPDD--YGR------PGHPDQGGYPDQGGGYPDQ
MSMEG_0035|M.smegmatis_MC2_155 GGA---DYDYGR---QAPRHDDYGR------PDP--RQGYPEQGG-YPEQ
MMAR_0022|M.marinum_M GGY--GEYGREP---ARQDEGAYSAPAAPSAPPEAQRPGYPDQGGGYDQG
MUL_0024|M.ulcerans_Agy99 GGY--GEYGREP---ARQDEGAYSAPAAPSAPPEAQRPGYPDQGGGYDQG
Mb0020c|M.bovis_AF2122/97 GGY--GEYGRGP---ARHEEGSY-VPSGPPGPPE-QRPAYPDQGG-YDQG
Rv0020c|M.tuberculosis_H37Rv GGY--GEYGRGP---ARHEEGSY-VPSGPPGPPE-QRPAYPDQGG-YDQG
MLBr_00022|M.leprae_Br4923 GGY--GDYGRGP---ARPDEGSY-TPSGFPAPPE-QRVAYPDQGGGYDQG
MAV_0024|M.avium_104 GGY--GDYGRGP---ARPDEGGY-------APPE-QRPAYPEQGGGYDQG
MAB_0039c|M.abscessus_ATCC_199 GGG----YGAPP------QQGGYGE------PPRPNYGEY-EQGGGYGGG
* *. . * * :*** *
Mflv_0806|M.gilvum_PYR-GCK ------GGYGAP-GGQQSYGRQDYAQP-DYGRYGEP-----AGYGDQG--
Mvan_0029|M.vanbaalenii_PYR-1 ------GGY----GGQQ-YGRQDYAQP-DYGRYGEAP----AGYQDQG--
TH_2237|M.thermoresistible__bu GYGDQGGGYPDQGYGDQGYGGQPYGRP-DYGQQPGQ-----GDYGAGG--
MSMEG_0035|M.smegmatis_MC2_155 ------GGY-----GGQAYGRPDYGQP-DYGQQPGRGYPEQGGYPEQGG-
MMAR_0022|M.marinum_M --------YQ---QGGAGYGRPEYGQG-DYTQYADTS--SPGGYPPQGAG
MUL_0024|M.ulcerans_Agy99 --------YQ---QGGAGYGRPEYGQG-DYTQYADTS--SPGGYPPQGAG
Mb0020c|M.bovis_AF2122/97 --------YQ---QGATTYGRQDYGGGADYTRYTESP--QVPGYAPQGGG
Rv0020c|M.tuberculosis_H37Rv --------YQ---QGATTYGRQDYGGGADYTRYTESP--RVPGYAPQGGG
MLBr_00022|M.leprae_Br4923 --------YQ---HSGLGYGREDYGRQ-EYTQYAENL--PGGVYAPSSGG
MAV_0024|M.avium_104 --------YP---QGG-GYGRQDYGSA-EYTQYAEHA--QGATYAPPGGG
MAB_0039c|M.abscessus_ATCC_199 -------QYG---GQQGPPPGQDYGRPPAYPQQGGYG------APPQQGG
* *. * :
Mflv_0806|M.gilvum_PYR-GCK YGEQGYGDQGYGD-------QGYGAPA-----------------GQQGGY
Mvan_0029|M.vanbaalenii_PYR-1 YGEP----AGYQD-------PGY---------------------GQGGSY
TH_2237|M.thermoresistible__bu YGDAGGYGAGYGD-------PGRGDYD-----------------YAGAGY
MSMEG_0035|M.smegmatis_MC2_155 YGEPAGRDYEYG--------GDYGAPA-----------------GQGGYG
MMAR_0022|M.marinum_M YADPAGRDYEYCQ----AAAPDYGQAPPDYGQAPSDYGQAPPEYGQPAG-
MUL_0024|M.ulcerans_Agy99 YADPAGRDYEYGQ----AAAPDYGQAPPDY--------------GQPAG-
Mb0020c|M.bovis_AF2122/97 YAEPAGRDYDYGQ----SGAPDY---------------------GQPAP-
Rv0020c|M.tuberculosis_H37Rv YAEPAGRDYDYGQ----SGAPDY---------------------GQPAP-
MLBr_00022|M.leprae_Br4923 YAEPAGRDYDYGQP---GAANDY---------------------SQPVI-
MAV_0024|M.avium_104 YPEAPGSEYEYGQPADYGQQPEYAQP---------------AEYGQPADY
MAB_0039c|M.abscessus_ATCC_199 YGSPEYGDYEQGG-------------------------------YQSSP-
* .
Mflv_0806|M.gilvum_PYR-GCK ----GGYGAG-QGDYPAG----ATVTLQLDDGSGRTYQLREGANVIGRGQ
Mvan_0029|M.vanbaalenii_PYR-1 ----AGYGA--QGDYPAAG---ATVTLQLDDGSGRTYQLREGANVIGRGQ
TH_2237|M.thermoresistible__bu GQD-AGYGRQ-DYQQPPATGRPTTVTLQLDDGSGRTYQLREGANVIGRGQ
MSMEG_0035|M.smegmatis_MC2_155 ----GGYGA----DYPAGG---TTVTLQLDDGSGRTYQLREGANVIGRGQ
MMAR_0022|M.marinum_M ----GGYGGYGQSGYGAAG---SSVILQLDDGSGRTYQLRDGSNIIGRGQ
MUL_0024|M.ulcerans_Agy99 ----GGYGGYGQSGYGAAG---SSVILQLDDGSGRTYQLRDGSNIIGRGQ
Mb0020c|M.bovis_AF2122/97 ----GGYSGYGQGGYGSAG---TSVTLQLDDGSGRTYQLREGSNIIGRGQ
Rv0020c|M.tuberculosis_H37Rv ----GGYSGYGQGGYGSAG---TSVTLQLDDGSGRTYQLREGSNIIGRGQ
MLBr_00022|M.leprae_Br4923 ----GGYG-----GYGALG---SAVILQLDDGSGRTYQLREGSNIVGRGQ
MAV_0024|M.avium_104 GQQAGGYGGYGQGGYGSTG---TTVTLQLDDGSGRTYQLREGSNIIGRGQ
MAB_0039c|M.abscessus_ATCC_199 -----DYGAP-AGGPGGGR---TTVTLQLDDGSGRTYQLREGTNVIGRGQ
.*. ::* **************:*:*::****
Mflv_0806|M.gilvum_PYR-GCK DAQFRLPDTGVSRRHLEIRWDGQVALLSDLNSTNGTTVNNAPVQEWQLAD
Mvan_0029|M.vanbaalenii_PYR-1 DAQFRLPDTGVSRRHLEIRWDGQVALLSDLNSTNGTTVNNAPVQEWQLAD
TH_2237|M.thermoresistible__bu DAQFRLPDTGVSRRHLEIRWDGQVALLSDLNSTNGTTVNNAPVQEWQLAD
MSMEG_0035|M.smegmatis_MC2_155 DAQFRLPDTGVSRRHLEIRWDGQVALLSDLNSTNGTTVNNAPVQEWQLAD
MMAR_0022|M.marinum_M DAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLAD
MUL_0024|M.ulcerans_Agy99 DAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLAD
Mb0020c|M.bovis_AF2122/97 DAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLAD
Rv0020c|M.tuberculosis_H37Rv DAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLAD
MLBr_00022|M.leprae_Br4923 DAQFRLPDTGVSRRHLEIRWDGQVALLSDLNSTNGTTVNNAPVQEWQLAD
MAV_0024|M.avium_104 DAQFRLPDTGVSRRHLEIRWDGQVALLSDLNSTNGTTVNNAPVQEWQLAD
MAB_0039c|M.abscessus_ATCC_199 DAQFRLPDTGVSRRHLEVRFDGHAALLSDLNSTNGTTVNNAPVTEWQLAD
*****************:*:**:.***:*************** ******
Mflv_0806|M.gilvum_PYR-GCK GDVIRLGHSEIIVRVH
Mvan_0029|M.vanbaalenii_PYR-1 GDVIRLGHSEIIVRVH
TH_2237|M.thermoresistible__bu GDVIRLGHSEIIVRMH
MSMEG_0035|M.smegmatis_MC2_155 GDVIRLGHSEIIVRVH
MMAR_0022|M.marinum_M GDVIRLGHSEIIVRIH
MUL_0024|M.ulcerans_Agy99 GDVIRLGHSEIIVRIH
Mb0020c|M.bovis_AF2122/97 GDVIRLGHSEIIVRMH
Rv0020c|M.tuberculosis_H37Rv GDVIRLGHSEIIVRMH
MLBr_00022|M.leprae_Br4923 GDVIRLGHSEIIVRIH
MAV_0024|M.avium_104 GDVIRLGHSEIIVRIH
MAB_0039c|M.abscessus_ATCC_199 GDIIRLGHSEIIVRVQ
**:***********::