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VTSVGFVGLGIMGRPMALNLAWSGTPLVVWNRTLERCLPVEAAGARVASHVGEVFDRCETVILMLADESA IDDVLGCQTSAFDGLVRRHTIVQMGTVDPGYSRRLADRVAGAGGCYVEAPVSGSRGPAEAGELVAMLAGA PEDCTHVRAIIAPMCRAVFDCGTPPHALLTKFAVNLFMIAMVTGLAEAYHFAEGHGVDPALLDRILDASP MASTVSRAKSAKLARRDFEVQAGLADVHKNTDLITRAARSRGIASPVLDACHALYGEAVALGHPTEDMAA VIHAVRARTAAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5463 | - | - | 100% (292) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. smegmatis MC2 155 | MSMEG_5477 | - | 7e-29 | 27.40% (292) | 2-hydroxy-3-oxopropionate reductase |
| M. smegmatis MC2 155 | MSMEG_2170 | - | 3e-24 | 30.18% (285) | 3-hydroxyisobutyrate dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0773c | mmsB | 3e-16 | 25.17% (302) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. gilvum PYR-GCK | Mflv_5012 | - | 9e-17 | 24.57% (293) | 3-hydroxyisobutyrate dehydrogenase |
| M. tuberculosis H37Rv | Rv0751c | mmsB | 3e-16 | 25.17% (302) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1043c | - | 1e-22 | 29.63% (297) | putative oxidoreductase |
| M. marinum M | MMAR_1077 | mmsB | 4e-16 | 24.49% (294) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. avium 104 | MAV_0931 | - | 1e-21 | 28.72% (282) | 3-hydroxyisobutyrate dehydrogenase |
| M. thermoresistible (build 8) | TH_2512 | - | 6e-16 | 25.71% (210) | PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 2e-16 | 24.49% (294) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_5187 | - | 2e-18 | 29.62% (260) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0773c|M.bovis_AF2122/97 MTT---IAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAV
Rv0751c|M.tuberculosis_H37Rv MTT---IAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAV
MMAR_1077|M.marinum_M MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASAAAAKGATM
MUL_0835|M.ulcerans_Agy99 MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATAAKGATM
Mflv_5012|M.gilvum_PYR-GCK MTT---IAFLGLGNMGGPMAANLVAAGHTVHAFDVVPELRDAAEAKGANV
MAB_1043c|M.abscessus_ATCC_199 MST---IAVIGLGAMGKAMADNLVQAGHQVSVWNRSPAPVAELAAVGARP
Mvan_5187|M.vanbaalenii_PYR-1 -MK---IGFIGLGNMGSAMAANLLSAGHEVLAYNRSRDRVVALAERGATP
MAV_0931|M.avium_104 MT----IGFIGLGNMGFPMASRLIREQHDVVAFDSRREALERLVAAGARP
MSMEG_5463|M.smegmatis_MC2_155 MTS---VGFVGLGIMGRPMALNLAWSGTPLVVWNRTLERCLPVEAAGARV
TH_2512|M.thermoresistible__bu MR----VGFIGLGSQGGPMARRIAENGYETTLWARRAATLEPFADTPAKT
:..:*** * .*: .: : .
Mb0773c|M.bovis_AF2122/97 FRSAPEAVAEADVVITMLPTGEVVRRCY---TDVLAAARPATLFIDSSTI
Rv0751c|M.tuberculosis_H37Rv FRSAPEAVAEADVVITMLPTGEVVRRCY---TDVLAAARPATLFIDSSTI
MMAR_1077|M.marinum_M FDSAAEAVAGADVVITMLPNGAVVKRCY---AEVLPAARSGALFIDSSTI
MUL_0835|M.ulcerans_Agy99 FDSAAEAVARADVVITMLPNGAVVKRCY---AEVLPAARSGALFIDSSTI
Mflv_5012|M.gilvum_PYR-GCK FDSAAAAVADADVVVTSLPNGAVVKAVY---DEVVPAAKAGALLIDTSTI
MAB_1043c|M.abscessus_ATCC_199 LDSVAQAFDSGVVFSVLADDHAVTETLL---TPEVLAAGHGALHVNLATV
Mvan_5187|M.vanbaalenii_PYR-1 VPTVAAACEGDVVFTMLADDTAVESVTFGD-TGIVAALAPGAIHVSASTI
MAV_0931|M.avium_104 ASSPKEVADGAETVLASLPTPGASLEVATG-TAGVIEGARVKRYVDLSTV
MSMEG_5463|M.smegmatis_MC2_155 ASHVGEVFDRCETVILMLADESAIDDVLGCQTSAFDGLVRRHTIVQMGTV
TH_2512|M.thermoresistible__bu AGSPAELGAASDLVCLCVVGDDDVREVLYGDTGVLAGLAPGGVVAIHSTV
. . .*:
Mb0773c|M.bovis_AF2122/97 SVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRA
Rv0751c|M.tuberculosis_H37Rv SVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRA
MMAR_1077|M.marinum_M SVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSALAQA
MUL_0835|M.ulcerans_Agy99 SVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSALAQA
Mflv_5012|M.gilvum_PYR-GCK SVDDARAIHEQATAGGLAQIDAPVSGGIKGATAGTLAFMVGGDDEAFERA
MAB_1043c|M.abscessus_ATCC_199 SARLADRATALHDEHGVGYVAAPVFGRVPVAQAGQLQVLAAGAAAQIDKA
Mvan_5187|M.vanbaalenii_PYR-1 SVALSEKLTAAHAEAGQMFVSAPVFGRPEAAAAAKLFVVAAGPHDAVTSL
MAV_0931|M.avium_104 GSRTAMRIHDLLARRNIVAIDSPVSGGVGGAEQGTLALMVSGPRGEFDVI
MSMEG_5463|M.smegmatis_MC2_155 DPGYSRRLADRVAGAGGCYVEAPVSGSRGPAEAGELVAMLAGAPEDCTHV
TH_2512|M.thermoresistible__bu HPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGKLLVMVGGDEEVVERC
. : :** * . . * : .*
Mb0773c|M.bovis_AF2122/97 RPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLG
Rv0751c|M.tuberculosis_H37Rv RPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLG
MMAR_1077|M.marinum_M RPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIGEAFVLAENLG
MUL_0835|M.ulcerans_Agy99 RPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIGEAFVLAENLG
Mflv_5012|M.gilvum_PYR-GCK KPVLEPMAGKIIHCG-ASGAGQAAKLCNNMVLAVQQIAIGEAFVLAEKLG
MAB_1043c|M.abscessus_ATCC_199 QSFFDVIGARTWRLGDAPRQANVVKIIGNFLIASAIQSLSEAVSMAERSG
Mvan_5187|M.vanbaalenii_PYR-1 QPAFEAIGQRTYVMSEEPKTANLVKLSGNFLIASVIESLGEAMALVSKAG
MAV_0931|M.avium_104 RTTLEALG-RPFYVGDKPGAAQTMKLANNILAANVLAATAEVVVMGVKAG
MSMEG_5463|M.smegmatis_MC2_155 RAIIAPMCRAVFDCG-TPPHALLTKFAVNLFMIAMVTGLAEAYHFAEGHG
TH_2512|M.thermoresistible__bu RPVFASYADPIVHLG-PLGSGQVTKILNNLLFTANLGSALSTLELGESLG
:. : . . *. *:. . .. : *
Mb0773c|M.bovis_AF2122/97 LSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMNK
Rv0751c|M.tuberculosis_H37Rv LSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMNK
MMAR_1077|M.marinum_M LDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATALMNK
MUL_0835|M.ulcerans_Agy99 LDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATALMNK
Mflv_5012|M.gilvum_PYR-GCK LPAQSLFDVITGATGNCWSVHTNCPVPGPVPTSPANNDFKPGFATALMNK
MAB_1043c|M.abscessus_ATCC_199 VDSALLVELLTSTLFQGPAYSSYGKLIATSAYEPAG------FTTTLGRK
Mvan_5187|M.vanbaalenii_PYR-1 VDRQTYLELLTSTLFAAPAYQTYGGLLARKQFEPAG------FAAHLGLK
MAV_0931|M.avium_104 LDPAVMIEVLNAGSGATSASRDKFPRAILPRSFDYG------FATGLMVK
MSMEG_5463|M.smegmatis_MC2_155 VDPALLDRILDASPMASTVSRAKSAKLARRDFEVQAG-------LADVHK
TH_2512|M.thermoresistible__bu IPRVKLAEVLNGGSATSKALGSISVFGGTVEGLAPIAG-------ALLQK
: :: . *
Mb0773c|M.bovis_AF2122/97 DLGLAMDAVAATGATAPLGSHAADIYAKFAAD-HADLDFSAVIHTLRARA
Rv0751c|M.tuberculosis_H37Rv DLGLAMDAVAATGATAPLGSHAADIYAKFAAD-HADLDFSAVIHTLRARA
MMAR_1077|M.marinum_M DLGLAMDAVTSTGSAAPLGSHAAEIYAKFAAD-HADQDFSAVIEMLRGS-
MUL_0835|M.ulcerans_Agy99 DLGLAMDAVTSTASAAPLGSHAAEIYAKFATD-HADQDFSAVIEMLRGS-
Mflv_5012|M.gilvum_PYR-GCK DLGLAMAAVESSGAKAPLGTHAAEIYSDFAKE-HAGKDFSAIIEALRD--
MAB_1043c|M.abscessus_ATCC_199 DVGLALEVAADTGLRLPFGEILRTVFDEALAGGHANLDWSSIADLQRARD
Mvan_5187|M.vanbaalenii_PYR-1 DVRLVLAAGEQLEVPLPVASLIRDRFLTLLAGGGRDLDWSALGALADWEA
MAV_0931|M.avium_104 DVRLYLDEAKALGVPAEVAETIARLWETAAREEGPEADFTTVIKPLERAA
MSMEG_5463|M.smegmatis_MC2_155 NTDLITRAARSRGIASPVLDACHALYGEAVALGHPTEDMAAVIHAVRART
TH_2512|M.thermoresistible__bu DVRHAANIAASASVPEGTVFTVADTALTAMGHARR---------------
:
Mb0773c|M.bovis_AF2122/97 DA-------
Rv0751c|M.tuberculosis_H37Rv DA-------
MMAR_1077|M.marinum_M ---------
MUL_0835|M.ulcerans_Agy99 ---------
Mflv_5012|M.gilvum_PYR-GCK ---------
MAB_1043c|M.abscessus_ATCC_199 AE-------
Mvan_5187|M.vanbaalenii_PYR-1 GGPRPGSG-
MAV_0931|M.avium_104 GVTVGRSAR
MSMEG_5463|M.smegmatis_MC2_155 AAA------
TH_2512|M.thermoresistible__bu ---------