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VVGAGPNGLAAAIQLARRGVEVQVLEAGETPGGGARSSELTVPGVIHDLCSATHPFGVGSPFWKEIDLPS YGLVWKWPQIDCAHPLDDGSAGVLYRSIEQTTAGMGPDATRWRRAVGDLAAGFDQLASDLMRPVLRVPHH PVRLARFGPRALLPATVLARWFHTEQARALFGGAAAHIYTRLDRPLTASLGLLFLASGHRYGWPVAEGGS GSIIHALVAALRAHGGDVATGVTVSDRRDIPDADIVMLDLTPAAALRLYGELMPARIARSYRRYRQGSSA FKVDFAVEGDIPWTNPHCARAGSVHLGGSFAEIADTERQRAQGKLAPRPFVLVGQQYLADPSRSAGGINP IWAYAHVPFGYTGDATALVVDQIERFAPGFRDRVVATVSRGTADLAAYNANYIGGDILGGANDGLQVILR PRVSVSPYATGVPGVYLCSQSTPPGPGIHGLCGYHAAEAALGWLRRRGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3342 | - | - | 100% (470) | dehydrogenase |
| M. avium 104 | MAV_3848 | - | e-102 | 42.98% (463) | P49 protein |
| M. avium 104 | MAV_5090 | - | 1e-16 | 24.06% (532) | putative dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1467 | - | 0.0 | 80.13% (468) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4235 | - | 1e-99 | 42.76% (463) | hypothetical protein Mflv_4235 |
| M. tuberculosis H37Rv | Rv1432 | - | 0.0 | 80.13% (468) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4734 | - | 1e-157 | 55.58% (466) | dehydrogenase |
| M. marinum M | MMAR_2237 | - | 0.0 | 81.20% (468) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2377 | - | 1e-98 | 41.68% (463) | P49 protein |
| M. thermoresistible (build 8) | TH_4571 | - | 1e-157 | 56.65% (466) | PUTATIVE dehydrogenase |
| M. ulcerans Agy99 | MUL_1826 | - | 0.0 | 80.77% (468) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2127 | - | 1e-102 | 43.41% (463) | hypothetical protein Mvan_2127 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2237|M.marinum_M ------------------------MTKAVVVGAGPNGLAAAIQLARHGVE
MUL_1826|M.ulcerans_Agy99 ------------------------MTKAVVVGAGPNGLAAAIQLARHGVE
Mb1467|M.bovis_AF2122/97 ------------------------MTTAVVVGAGPNGLAAAIHLARHGVD
Rv1432|M.tuberculosis_H37Rv ------------------------MTTAVVVGAGPNGLAAAIHLARHGVD
MAV_3342|M.avium_104 ----------------------------MVVGAGPNGLAAAIQLARRGVE
MAB_4734|M.abscessus_ATCC_1997 ------------------------MSTAVIVGGGPNGLTAAILLAQQGVH
TH_4571|M.thermoresistible__bu VAAERSGADHGHLVPVPRRAGGGGVTTATVVGSGPNGLAAAVTLAKAGVA
Mflv_4235|M.gilvum_PYR-GCK -------------------MGSNGQVELTVVGSGPNGLAAAVICARAGVS
Mvan_2127|M.vanbaalenii_PYR-1 -------------------MGSNVQVELTVVGSGPNGLAAAVICARAGLS
MSMEG_2377|M.smegmatis_MC2_155 -------------------------MDVTVVGSGPNGLTAAVICARAGLA
:**.*****:**: *: *:
MMAR_2237|M.marinum_M VQVLEAHDTIGGGARSG-ELTVPGVIHDHCSAFHPLGVGSPFWNEIDLQS
MUL_1826|M.ulcerans_Agy99 VQVLEAHDTIGGGARSG-ELTVPGVIHDHCSAFHPLGVGSPFWNEIDLQS
Mb1467|M.bovis_AF2122/97 VQVLEARDTIGGGARSG-ELTVPGVIHDHCSAFHPLGVGSPFWAAIDLQR
Rv1432|M.tuberculosis_H37Rv VQVLEARDTIGGGARSG-ELTVPGVIHDHCSAFHPLGVGSPFWAAIDLQR
MAV_3342|M.avium_104 VQVLEAGETPGGGARSS-ELTVPGVIHDLCSATHPFGVGSPFWKEIDLPS
MAB_4734|M.abscessus_ATCC_1997 VTVLEAADSVGGGVRSG-AATGPGLIHDYCSAIHPMAVGSPVLAGLDLEK
TH_4571|M.thermoresistible__bu VTVLEAADEIGGGTRSF-EAIVPGLLHDHCSAIHPMAVGSPFINEFGLDR
Mflv_4235|M.gilvum_PYR-GCK VRVVEAQPTAGGGARTLPDPEFSGVSHDICSAVHPLALASPFFAAFDLRA
Mvan_2127|M.vanbaalenii_PYR-1 VRVVEAQPTPGGGARTLPDPEFSGVSHDICSAVHPLALASPFFAEFDLQA
MSMEG_2377|M.smegmatis_MC2_155 VRVIEAQTTPGGGARTLPDPEFGGVSHDICSAVHPLALASPFFSAYDLTA
* *:** ***.*: *: ** *** **:.:.**. .*
MMAR_2237|M.marinum_M YGLTWNWPEVDCAHPLDDGTAGVLHQSIEHTAAGMGPDGKRWRRAVGDLA
MUL_1826|M.ulcerans_Agy99 YGLTWNWPEVDCAHPLDDGTAGVLHQSIERTAAGMGPDGKRWRCAVGDLA
Mb1467|M.bovis_AF2122/97 YGLTWKWPDVDCAHPLDDGTAGVLYRSIEATAAGLGPDGKRWQRAVGDLA
Rv1432|M.tuberculosis_H37Rv YGLTWKWPDVDCAHPLDDGTAGVLYRSIEATAAGLGPDGKRWQRAVGDLA
MAV_3342|M.avium_104 YGLVWKWPQIDCAHPLDDGSAGVLYRSIEQTTAGMGPDATRWRRAVGDLA
MAB_4734|M.abscessus_ATCC_1997 HGLQWLWPEVDCAHPLDDGSCGVLYRDVAATANGLGRDGRRWRALFERPA
TH_4571|M.thermoresistible__bu HGLRWRWPDIDCVHPLDDGTAGVLRRSVDHTAAGLGPDGRVWRALFGRPV
Mflv_4235|M.gilvum_PYR-GCK RGVTLEVPEVSYGNPLPGRRAAIGYLDIDRTCAELE-DGEPWRRLLGPLA
Mvan_2127|M.vanbaalenii_PYR-1 RGVTLAVPEVSYGNPLPGRPAAVGYRDIERTCAELD-DGASWRRLLGPLA
MSMEG_2377|M.smegmatis_MC2_155 HGVRLAVPEIAYANPLVERPAAIGYRDIDRTCAELD-DGRSWRRLLGPLA
*: *:: :** ..: .: * : *. *: . .
MMAR_2237|M.marinum_M AGFDELAGDLLRPVLGVPRHPLRLAAFGPRAALPATMMARWFRTEQARAL
MUL_1826|M.ulcerans_Agy99 AGFDELAGDLLRPVLGVPRHPLRPAAFGPRAALPATMMARWFRTEQARAL
Mb1467|M.bovis_AF2122/97 AGFDELAEDLLRPVLNMPRHPIRLARFGPRAALPATAMARRFHTERARAL
Rv1432|M.tuberculosis_H37Rv AGFDELAEDLLRPVLNMPRHPIRLARFGPRAALPATAMARRFHTERARAL
MAV_3342|M.avium_104 AGFDQLASDLMRPVLRVPHHPVRLARFGPRALLPATVLARWFHTEQARAL
MAB_4734|M.abscessus_ATCC_1997 RNFDLLTADIMGPLLRIPRHPLALTRFGVPTVLPAAATAQLFRTRQARAL
TH_4571|M.thermoresistible__bu DRFDAVNDAVMGPLLRVPKHPLTLARFGAPTVLPASALARVFRTPAARAL
Mflv_4235|M.gilvum_PYR-GCK ADCDGVVGLLLGDKRSIPPSIPAALRVAPRLLAQGTPAWGTLLGEDARAL
Mvan_2127|M.vanbaalenii_PYR-1 DDCDGVVGLLLGDKRSIPPSIPAAVRVAPRLLAQGSPAWGTLAGEDARAL
MSMEG_2377|M.smegmatis_MC2_155 DDCDGVVGLMLGDKRSLPPSIPAALRVAPRMLGQGTALWRLLRGDDARAL
* : :: :* .. .: : ****
MMAR_2237|M.marinum_M FGGAAAHVYTRLDRPLTASLGLMILASGHRYGWPVAQGGSGSITAALGAA
MUL_1826|M.ulcerans_Agy99 FGGAAAHVYTRLDRPLTASLGLMILASGHRYGWPVAQGGSGSITAALGAA
Mb1467|M.bovis_AF2122/97 FGGAAAHVYTRLDRPLTASLGLMILASGHRHGWPVARGGSGSITKALAAA
Rv1432|M.tuberculosis_H37Rv FGGAAAHVYTRLDRPLTASLGLMILASGHRHGWPVARGGSGSITKALAAA
MAV_3342|M.avium_104 FGGAAAHIYTRLDRPLTASLGLLFLASGHRYGWPVAEGGSGSIIHALVAA
MAB_4734|M.abscessus_ATCC_1997 FGGIAAHAFRPLHYPMTSAIGLGIITAGHRHGWPVAAGGSQSITDALSSL
TH_4571|M.thermoresistible__bu WGGVAAHAFRPLHLPMTSAIGVGIITAGHRHGWAVAEGGSRAITDAMAAR
Mflv_4235|M.gilvum_PYR-GCK FTGVAAHTISRMPSLVASGAGLMLSTLAHAVGWPIPVGGSQAIPDALIAD
Mvan_2127|M.vanbaalenii_PYR-1 FTGVAAHTISRMPSLVSAGAGLMLATLGHTVGWPVPSGGSQAIPDALLAD
MSMEG_2377|M.smegmatis_MC2_155 FSGVAAHTISPMPSLVSAGAGLMLATLAHAVGWPIPIGGSQAIPDALIAD
: * *** : :::. *: : : .* **.:. *** :* *: :
MMAR_2237|M.marinum_M LDALGGVVATGITVTSRRDIPDADIVMLDLSPANVLTLYGDAMPARIKRS
MUL_1826|M.ulcerans_Agy99 LDALGGVVATGITVTSRRDIPDADIVMLDLSPANVLTLYGDEMPARIKRS
Mb1467|M.bovis_AF2122/97 LDAYGGTVATGVTVTSRRDIPDADIVMLDLSPAAVLGIYGDVMPTRINRS
Rv1432|M.tuberculosis_H37Rv LDAYGGTVATGVTVTSRRDIPDADIVMLDLSPAAVLGIYGDVMPTRINRS
MAV_3342|M.avium_104 LRAHGGDVATGVTVSDRRDIPDADIVMLDLTPAAALRLYGELMPARIARS
MAB_4734|M.abscessus_ATCC_1997 LAQFGGRIETGVHVTSFTQLPTADVTLFDLSPTQVADILRDHLPTSVARG
TH_4571|M.thermoresistible__bu LRELGGTIETGVRVRDIADLPPTTITVFDLAPEAVAEILGDRLPPRVARA
Mflv_4235|M.gilvum_PYR-GCK LRAHGGELVVGEEVST----PPSGVVLYDTAPTALLDIYGDRLPSRYART
Mvan_2127|M.vanbaalenii_PYR-1 LQAHGGELVLGEEVTS----PPSGVVLYDTAPTALLRIYGDRLPPGYAKT
MSMEG_2377|M.smegmatis_MC2_155 LRAHGGELVLGEEVTE----PPSGVVVYDTAPTALLSIYRDAVPPRYAKA
* ** : * * * : :.: * :* : : :*. :
MMAR_2237|M.marinum_M YRRYREGSSAFKVDFAIEGDIPWTNPDCRRAGTVHLGGTFAEIADTERQR
MUL_1826|M.ulcerans_Agy99 YRRYREGSSAFKVDFAIEGDIPWTNPDCRRAGTVHLGGTFAEIADTERQR
Mb1467|M.bovis_AF2122/97 YRRYRAGSSAFKVDFAIEGDVGWTNPDCRRAGTVHLGGTFAEIADTERQR
Rv1432|M.tuberculosis_H37Rv YRRYRAGSSAFKVDFAIEGDVGWTNPDCRRAGTVHLGGTFAEIADTERQR
MAV_3342|M.avium_104 YRRYRQGSSAFKVDFAVEGDIPWTNPHCARAGSVHLGGSFAEIADTERQR
MAB_4734|M.abscessus_ATCC_1997 LSRFRYGPGAFKVDFAIEDGVPWTNPDAGRAGTVHLGGTFAEVASTERAV
TH_4571|M.thermoresistible__bu YRAFRRGPGAFKVDFAVEGGVPWCNPDAHRAGTVHVGGTFEEIAATERDV
Mflv_4235|M.gilvum_PYR-GCK LRRYRYGPGVAKVDFVLSGEIPWRDKRLASAPTLHMGGDRATMALAEKDI
Mvan_2127|M.vanbaalenii_PYR-1 LRRYRYGPGVAKVDFVLSGEIPWRDPRLANAPTLHLGGDRATMARAEKDV
MSMEG_2377|M.smegmatis_MC2_155 LRNYTYGSGVAKVDFVLSGEIPWRDPRLAQSPTLHLGGSREQMALAESEV
: *... ****.:.. : * : : ::*:** :* :*
MMAR_2237|M.marinum_M AQGRMVQRPFVLIGQQYLADPSRS-AGNINPIWAYAHVPFGYAGDATAAV
MUL_1826|M.ulcerans_Agy99 AQGRMVQRPFVLIGQQYLADPSRS-AGNINPIWAYAHVPFGYAGDATAAV
Mb1467|M.bovis_AF2122/97 AQGTMVQRPFVLVGQQYLADPSRS-VGNINPIWAYAHVPFGYTGDATAAV
Rv1432|M.tuberculosis_H37Rv AQGTMVQRPFVLVGQQYLADPSRS-VGNINPIWAYAHVPFGYTGDATAAV
MAV_3342|M.avium_104 AQGKLAPRPFVLVGQQYLADPSRS-AGGINPIWAYAHVPFGYTGDATALV
MAB_4734|M.abscessus_ATCC_1997 HAGRMPERPFVLVGQQYLADPGRS-NGNIHPLWTYAHVPHGFTGDATQAL
TH_4571|M.thermoresistible__bu NAGRMPERPFVLVAQQYVADPGRS-VGDIHPVWSYAHVPHGYPGDATEAV
Mflv_4235|M.gilvum_PYR-GCK AEGRHAQWPMVLASLPHLADPGRIDAAGRRPLWTYAHVPAGSTVDMAETI
Mvan_2127|M.vanbaalenii_PYR-1 AAGRHAEWPMVLASLPHLADPGRVDPQGRRPLWTYAHVPAGSTVDMAEAV
MSMEG_2377|M.smegmatis_MC2_155 ARGRHAEWPMVLAASPHIADPGRIDARGRRPLWTYAHVPSGSPVDMADTV
* *:** . ::***.* . .*:*:***** * . * : :
MMAR_2237|M.marinum_M IDQIERFAPGFRDRITATVSKSTAELQAYNRNFIGGDIIGGANDGLQVIF
MUL_1826|M.ulcerans_Agy99 IDQIERFAPGFRDRITATVSKSTAELQAYNRNFIGGDIIGGANDGLQVIF
Mb1467|M.bovis_AF2122/97 IDQIERFAPGFRDRIVATVSTSTTELQTYNRNFIGGDIIGGANDRLQVIF
Rv1432|M.tuberculosis_H37Rv IDQIERFAPGFRDRIVATVSTSTTELQTYNRNFIGGDIIGGANDRLQVIF
MAV_3342|M.avium_104 VDQIERFAPGFRDRVVATVSRGTADLAAYNANYIGGDILGGANDGLQVIL
MAB_4734|M.abscessus_ATCC_1997 IDQIERFAPGFRDRIVATAVRSTTDMTVYNPNYVGGDIVTGAKDIRQLVF
TH_4571|M.thermoresistible__bu VAQIERFAPGFRDRIVGYRTESAEGMARFNANFTGGDILTGAKDIRQLTF
Mflv_4235|M.gilvum_PYR-GCK TGVFERFAPGFRDLVVGVRSVPAARLADHNANLVGGDIGVGGNNMFSALT
Mvan_2127|M.vanbaalenii_PYR-1 TEVIERFAPGFRDVVVGVRSVPAARLSAHNANLVGGDIGVGGNNMVSALT
MSMEG_2377|M.smegmatis_MC2_155 TSILERFAPGFRDLVVAVRSVPASQMSHHNANLIGGDIGVGGNNMISALT
:********* :.. : : .* * **** *.:: .
MMAR_2237|M.marinum_M RPRIALDPYAIGVPGVYLCSQSAPPGAGIHGLCGYHAAESALQGLRKRR-
MUL_1826|M.ulcerans_Agy99 RPRIALDPYAIGVPGVYLCSQSAPPGAGIHGLCGYHAAESALQGLRKRR-
Mb1467|M.bovis_AF2122/97 RPRVAVDPYAIGVPGVYLCSQSAPPGAGIHGLCGYHAAESALRWLRKRR-
Rv1432|M.tuberculosis_H37Rv RPRVAVDPYAIGVPGVYLCSQSAPPGAGIHGLCGYHAAESALRWLRKRR-
MAV_3342|M.avium_104 RPRVSVSPYATGVPGVYLCSQSTPPGPGIHGLCGYHAAEAALGWLRRRGG
MAB_4734|M.abscessus_ATCC_1997 GPRTTAHPYRLGIPGMYICSAATPPGPGAHGMCGAHAAAEALRHLRASI-
TH_4571|M.thermoresistible__bu GPRITLSPYATGAPGYYICSAATPPGPGAHGMCGYHAAQTALRELAR---
Mflv_4235|M.gilvum_PYR-GCK GPALRWNPWATPIPRTYLCSSATPPGGGVHGMAGYYAARTVLRREFGIRE
Mvan_2127|M.vanbaalenii_PYR-1 GPALRWNPWSTPIPKAYLCSSATPPGGGVHGMAGFYAARTVLRREFGIRE
MSMEG_2377|M.smegmatis_MC2_155 GPTPRVNPWTTPIPKAYLCSSATPPGSGVHGMSGFYAARTVLRREFGLG-
* *: * *:** ::*** * **:.* :** .*
MMAR_2237|M.marinum_M ------
MUL_1826|M.ulcerans_Agy99 ------
Mb1467|M.bovis_AF2122/97 ------
Rv1432|M.tuberculosis_H37Rv ------
MAV_3342|M.avium_104 ------
MAB_4734|M.abscessus_ATCC_1997 ------
TH_4571|M.thermoresistible__bu ------
Mflv_4235|M.gilvum_PYR-GCK MPPLAP
Mvan_2127|M.vanbaalenii_PYR-1 LPPLAP
MSMEG_2377|M.smegmatis_MC2_155 LPALR-