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MTKAVVVGAGPNGLAAAIQLARHGVEVQVLEAHDTIGGGARSGELTVPGVIHDHCSAFHPLGVGSPFWNE IDLQSYGLTWNWPEVDCAHPLDDGTAGVLHQSIERTAAGMGPDGKRWRCAVGDLAAGFDELAGDLLRPVL GVPRHPLRPAAFGPRAALPATMMARWFRTEQARALFGGAAAHVYTRLDRPLTASLGLMILASGHRYGWPV AQGGSGSITAALGAALDALGGVVATGITVTSRRDIPDADIVMLDLSPANVLTLYGDEMPARIKRSYRRYR EGSSAFKVDFAIEGDIPWTNPDCRRAGTVHLGGTFAEIADTERQRAQGRMVQRPFVLIGQQYLADPSRSA GNINPIWAYAHVPFGYAGDATAAVIDQIERFAPGFRDRITATVSKSTAELQAYNRNFIGGDIIGGANDGL QVIFRPRIALDPYAIGVPGVYLCSQSAPPGAGIHGLCGYHAAESALQGLRKRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1826 | - | - | 100% (473) | dehydrogenase |
| M. ulcerans Agy99 | MUL_0254 | - | 6e-11 | 25.09% (554) | oxidoreductase |
| M. ulcerans Agy99 | MUL_2487 | aofH | 7e-05 | 53.66% (41) | flavin-containing monoamine oxidase AofH (amine oxidase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1467 | - | 0.0 | 88.58% (473) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4235 | - | 5e-95 | 42.06% (466) | hypothetical protein Mflv_4235 |
| M. tuberculosis H37Rv | Rv1432 | - | 0.0 | 88.58% (473) | dehydrogenase |
| M. leprae Br4923 | MLBr_00062 | gltD | 6e-05 | 60.53% (38) | glutamate synthase subunit beta |
| M. abscessus ATCC 19977 | MAB_4734 | - | 1e-164 | 57.66% (470) | dehydrogenase |
| M. marinum M | MMAR_2237 | - | 0.0 | 99.15% (473) | dehydrogenase |
| M. avium 104 | MAV_3342 | - | 0.0 | 80.77% (468) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2377 | - | 7e-92 | 40.13% (466) | P49 protein |
| M. thermoresistible (build 8) | TH_4571 | - | 1e-163 | 56.69% (471) | PUTATIVE dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2127 | - | 1e-97 | 43.56% (466) | hypothetical protein Mvan_2127 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4235|M.gilvum_PYR-GCK -------------------MGSNGQVELTVVGSGPNGLAAAVICARAGVS
Mvan_2127|M.vanbaalenii_PYR-1 -------------------MGSNVQVELTVVGSGPNGLAAAVICARAGLS
MSMEG_2377|M.smegmatis_MC2_155 -------------------------MDVTVVGSGPNGLTAAVICARAGLA
MUL_1826|M.ulcerans_Agy99 ------------------------MTKAVVVGAGPNGLAAAIQLARHGVE
MMAR_2237|M.marinum_M ------------------------MTKAVVVGAGPNGLAAAIQLARHGVE
Mb1467|M.bovis_AF2122/97 ------------------------MTTAVVVGAGPNGLAAAIHLARHGVD
Rv1432|M.tuberculosis_H37Rv ------------------------MTTAVVVGAGPNGLAAAIHLARHGVD
MAV_3342|M.avium_104 ----------------------------MVVGAGPNGLAAAIQLARRGVE
MAB_4734|M.abscessus_ATCC_1997 ------------------------MSTAVIVGGGPNGLTAAILLAQQGVH
TH_4571|M.thermoresistible__bu VAAERSGADHGHLVPVPRRAGGGGVTTATVVGSGPNGLAAAVTLAKAGVA
MLBr_00062|M.leprae_Br4923 ----------------------------MADPAGFLKYTQRELPRRRPVP
.* : : :
Mflv_4235|M.gilvum_PYR-GCK VRVVEAQPTAGGGARTLPDPEFSGVSHD---ICSAVHPLALASPFFAAFD
Mvan_2127|M.vanbaalenii_PYR-1 VRVVEAQPTPGGGARTLPDPEFSGVSHD---ICSAVHPLALASPFFAEFD
MSMEG_2377|M.smegmatis_MC2_155 VRVIEAQTTPGGGARTLPDPEFGGVSHD---ICSAVHPLALASPFFSAYD
MUL_1826|M.ulcerans_Agy99 VQVLEAHDTIGGGARSG-ELTVPGVIHD---HCSAFHPLGVGSPFWNEID
MMAR_2237|M.marinum_M VQVLEAHDTIGGGARSG-ELTVPGVIHD---HCSAFHPLGVGSPFWNEID
Mb1467|M.bovis_AF2122/97 VQVLEARDTIGGGARSG-ELTVPGVIHD---HCSAFHPLGVGSPFWAAID
Rv1432|M.tuberculosis_H37Rv VQVLEARDTIGGGARSG-ELTVPGVIHD---HCSAFHPLGVGSPFWAAID
MAV_3342|M.avium_104 VQVLEAGETPGGGARSS-ELTVPGVIHD---LCSATHPFGVGSPFWKEID
MAB_4734|M.abscessus_ATCC_1997 VTVLEAADSVGGGVRSG-AATGPGLIHD---YCSAIHPMAVGSPVLAGLD
TH_4571|M.thermoresistible__bu VTVLEAADEIGGGTRSF-EAIVPGLLHD---HCSAIHPMAVGSPFINEFG
MLBr_00062|M.leprae_Br4923 LRLRDWKELYEEFDKETLRNQASRCMDCGIPFCHNGCPLGNLIPEWNDLV
: : : : . * *:. *
Mflv_4235|M.gilvum_PYR-GCK LRARGVTLEVPEVSYGNPLPGRRAAIGYLDIDRTCA-ELE-DGEPWRRLL
Mvan_2127|M.vanbaalenii_PYR-1 LQARGVTLAVPEVSYGNPLPGRPAAVGYRDIERTCA-ELD-DGASWRRLL
MSMEG_2377|M.smegmatis_MC2_155 LTAHGVRLAVPEIAYANPLVERPAAIGYRDIDRTCA-ELD-DGRSWRRLL
MUL_1826|M.ulcerans_Agy99 LQSYGLTWNWPEVDCAHPLDDGTAGVLHQSIERTAA-GMGPDGKRWRCAV
MMAR_2237|M.marinum_M LQSYGLTWNWPEVDCAHPLDDGTAGVLHQSIEHTAA-GMGPDGKRWRRAV
Mb1467|M.bovis_AF2122/97 LQRYGLTWKWPDVDCAHPLDDGTAGVLYRSIEATAA-GLGPDGKRWQRAV
Rv1432|M.tuberculosis_H37Rv LQRYGLTWKWPDVDCAHPLDDGTAGVLYRSIEATAA-GLGPDGKRWQRAV
MAV_3342|M.avium_104 LPSYGLVWKWPQIDCAHPLDDGSAGVLYRSIEQTTA-GMGPDATRWRRAV
MAB_4734|M.abscessus_ATCC_1997 LEKHGLQWLWPEVDCAHPLDDGSCGVLYRDVAATAN-GLGRDGRRWRALF
TH_4571|M.thermoresistible__bu LDRHGLRWRWPDIDCVHPLDDGTAGVLRRSVDHTAA-GLGPDGRVWRALF
MLBr_00062|M.leprae_Br4923 RRGR-WHDAVERLHATNNFPDVTGRLCPAPCESACVLGINQDPVTIKQIE
: : : : : : * :
Mflv_4235|M.gilvum_PYR-GCK GPLAADCDGVVGLLLGDKRSIPPSIPAALRVAPRLLAQGTPAWGTLLGED
Mvan_2127|M.vanbaalenii_PYR-1 GPLADDCDGVVGLLLGDKRSIPPSIPAAVRVAPRLLAQGSPAWGTLAGED
MSMEG_2377|M.smegmatis_MC2_155 GPLADDCDGVVGLMLGDKRSLPPSIPAALRVAPRMLGQGTALWRLLRGDD
MUL_1826|M.ulcerans_Agy99 GDLAAGFDELAGDLLRPVLGVPRHPLRPAAFGPRAALPATMMARWFRTEQ
MMAR_2237|M.marinum_M GDLAAGFDELAGDLLRPVLGVPRHPLRLAAFGPRAALPATMMARWFRTEQ
Mb1467|M.bovis_AF2122/97 GDLAAGFDELAEDLLRPVLNMPRHPIRLARFGPRAALPATAMARRFHTER
Rv1432|M.tuberculosis_H37Rv GDLAAGFDELAEDLLRPVLNMPRHPIRLARFGPRAALPATAMARRFHTER
MAV_3342|M.avium_104 GDLAAGFDQLASDLMRPVLRVPHHPVRLARFGPRALLPATVLARWFHTEQ
MAB_4734|M.abscessus_ATCC_1997 ERPARNFDLLTADIMGPLLRIPRHPLALTRFGVPTVLPAAATAQLFRTRQ
TH_4571|M.thermoresistible__bu GRPVDRFDAVNDAVMGPLLRVPKHPLTLARFGAPTVLPASALARVFRTPA
MLBr_00062|M.leprae_Br4923 LEIIDKAFDEGWVQPLPPQQLTGKTVAVVGSGPAGLAAAQQLTRAGHRVT
:. . .
Mflv_4235|M.gilvum_PYR-GCK ARALFTGVAAHTISRMPSLVASGAGLMLSTLAHAVGWPIPVGGSQAIPDA
Mvan_2127|M.vanbaalenii_PYR-1 ARALFTGVAAHTISRMPSLVSAGAGLMLATLGHTVGWPVPSGGSQAIPDA
MSMEG_2377|M.smegmatis_MC2_155 ARALFSGVAAHTISPMPSLVSAGAGLMLATLAHAVGWPIPIGGSQAIPDA
MUL_1826|M.ulcerans_Agy99 ARALFGGAAAHVYTRLDRPLTASLGLMILASGHRYGWPVAQGGSGSITAA
MMAR_2237|M.marinum_M ARALFGGAAAHVYTRLDRPLTASLGLMILASGHRYGWPVAQGGSGSITAA
Mb1467|M.bovis_AF2122/97 ARALFGGAAAHVYTRLDRPLTASLGLMILASGHRHGWPVARGGSGSITKA
Rv1432|M.tuberculosis_H37Rv ARALFGGAAAHVYTRLDRPLTASLGLMILASGHRHGWPVARGGSGSITKA
MAV_3342|M.avium_104 ARALFGGAAAHIYTRLDRPLTASLGLLFLASGHRYGWPVAEGGSGSIIHA
MAB_4734|M.abscessus_ATCC_1997 ARALFGGIAAHAFRPLHYPMTSAIGLGIITAGHRHGWPVAAGGSQSITDA
TH_4571|M.thermoresistible__bu ARALWGGVAAHAFRPLHLPMTSAIGVGIITAGHRHGWAVAEGGSRAITDA
MLBr_00062|M.leprae_Br4923 VFERDDRIGGLLRYGIPEFKMEKRFLERRLDQLRAEGTEFRSGVNVGVDI
. .. : : . .*
Mflv_4235|M.gilvum_PYR-GCK LIADLRAHGGELVVGEEVST----PPSGVVLYDTAPTALLDIYGDRLPSR
Mvan_2127|M.vanbaalenii_PYR-1 LLADLQAHGGELVLGEEVTS----PPSGVVLYDTAPTALLRIYGDRLPPG
MSMEG_2377|M.smegmatis_MC2_155 LIADLRAHGGELVLGEEVTE----PPSGVVVYDTAPTALLSIYRDAVPPR
MUL_1826|M.ulcerans_Agy99 LGAALDALGGVVATGITVTSRRDIPDADIVMLDLSPANVLTLYGDEMPAR
MMAR_2237|M.marinum_M LGAALDALGGVVATGITVTSRRDIPDADIVMLDLSPANVLTLYGDAMPAR
Mb1467|M.bovis_AF2122/97 LAAALDAYGGTVATGVTVTSRRDIPDADIVMLDLSPAAVLGIYGDVMPTR
Rv1432|M.tuberculosis_H37Rv LAAALDAYGGTVATGVTVTSRRDIPDADIVMLDLSPAAVLGIYGDVMPTR
MAV_3342|M.avium_104 LVAALRAHGGDVATGVTVSDRRDIPDADIVMLDLTPAAALRLYGELMPAR
MAB_4734|M.abscessus_ATCC_1997 LSSLLAQFGGRIETGVHVTSFTQLPTADVTLFDLSPTQVADILRDHLPTS
TH_4571|M.thermoresistible__bu MAARLRELGGTIETGVRVRDIADLPPTTITVFDLAPEAVAEILGDRLPPR
MLBr_00062|M.leprae_Br4923 TADQLCADFDAVVLAGGAATWRELPIPGRELDGVHQAMEFLPWVNRVQEG
* . : . . * . : . : :
Mflv_4235|M.gilvum_PYR-GCK YARTLRRYRYGPGVAKVDFVLSGEIPWRDKRLASAPTLHMGGDRATMALA
Mvan_2127|M.vanbaalenii_PYR-1 YAKTLRRYRYGPGVAKVDFVLSGEIPWRDPRLANAPTLHLGGDRATMARA
MSMEG_2377|M.smegmatis_MC2_155 YAKALRNYTYGSGVAKVDFVLSGEIPWRDPRLAQSPTLHLGGSREQMALA
MUL_1826|M.ulcerans_Agy99 IKRSYRRYREGSSAFKVDFAIEGDIPWTNPDCRRAGTVHLGGTFAEIADT
MMAR_2237|M.marinum_M IKRSYRRYREGSSAFKVDFAIEGDIPWTNPDCRRAGTVHLGGTFAEIADT
Mb1467|M.bovis_AF2122/97 INRSYRRYRAGSSAFKVDFAIEGDVGWTNPDCRRAGTVHLGGTFAEIADT
Rv1432|M.tuberculosis_H37Rv INRSYRRYRAGSSAFKVDFAIEGDVGWTNPDCRRAGTVHLGGTFAEIADT
MAV_3342|M.avium_104 IARSYRRYRQGSSAFKVDFAVEGDIPWTNPHCARAGSVHLGGSFAEIADT
MAB_4734|M.abscessus_ATCC_1997 VARGLSRFRYGPGAFKVDFAIEDGVPWTNPDAGRAGTVHLGGTFAEVAST
TH_4571|M.thermoresistible__bu VARAYRAFRRGPGAFKVDFAVEGGVPWCNPDAHRAGTVHVGGTFEEIAAT
MLBr_00062|M.leprae_Br4923 DDVLGDDGQPPITAKDKKVVIIGGG---DTGADCLGAVHRQGAIHVHQLE
. . ...: . : ::* *
Mflv_4235|M.gilvum_PYR-GCK EKDI-AEGRHAQWPMVLASLPHLADPGRIDAAGRRPLWTYAHVPAGSTVD
Mvan_2127|M.vanbaalenii_PYR-1 EKDV-AAGRHAEWPMVLASLPHLADPGRVDPQGRRPLWTYAHVPAGSTVD
MSMEG_2377|M.smegmatis_MC2_155 ESEV-ARGRHAEWPMVLAASPHIADPGRIDARGRRPLWTYAHVPSGSPVD
MUL_1826|M.ulcerans_Agy99 ERQR-AQGRMVQRPFVLIGQQYLADPSRS-AGNINPIWAYAHVPFGYAGD
MMAR_2237|M.marinum_M ERQR-AQGRMVQRPFVLIGQQYLADPSRS-AGNINPIWAYAHVPFGYAGD
Mb1467|M.bovis_AF2122/97 ERQR-AQGTMVQRPFVLVGQQYLADPSRS-VGNINPIWAYAHVPFGYTGD
Rv1432|M.tuberculosis_H37Rv ERQR-AQGTMVQRPFVLVGQQYLADPSRS-VGNINPIWAYAHVPFGYTGD
MAV_3342|M.avium_104 ERQR-AQGKLAPRPFVLVGQQYLADPSRS-AGGINPIWAYAHVPFGYTGD
MAB_4734|M.abscessus_ATCC_1997 ERAV-HAGRMPERPFVLVGQQYLADPGRS-NGNIHPLWTYAHVPHGFTGD
TH_4571|M.thermoresistible__bu ERDV-NAGRMPERPFVLVAQQYVADPGRS-VGDIHPVWSYAHVPHGYPGD
MLBr_00062|M.leprae_Br4923 IMPRPPDARAASTPWPTYPLMYRVSPAHE--EGGERVFSVNTEEFVGKNG
. * : ..*.: . . ::: .
Mflv_4235|M.gilvum_PYR-GCK MAETITGVFERFAPGFRDLVVGVRSVPAARLADHNANLVGGDIGVGGNNM
Mvan_2127|M.vanbaalenii_PYR-1 MAEAVTEVIERFAPGFRDVVVGVRSVPAARLSAHNANLVGGDIGVGGNNM
MSMEG_2377|M.smegmatis_MC2_155 MADTVTSILERFAPGFRDLVVAVRSVPASQMSHHNANLIGGDIGVGGNNM
MUL_1826|M.ulcerans_Agy99 ATAAVIDQIERFAPGFRDRITATVSKSTAELQAYNRNFIGGDIIGGANDG
MMAR_2237|M.marinum_M ATAAVIDQIERFAPGFRDRITATVSKSTAELQAYNRNFIGGDIIGGANDG
Mb1467|M.bovis_AF2122/97 ATAAVIDQIERFAPGFRDRIVATVSTSTTELQTYNRNFIGGDIIGGANDR
Rv1432|M.tuberculosis_H37Rv ATAAVIDQIERFAPGFRDRIVATVSTSTTELQTYNRNFIGGDIIGGANDR
MAV_3342|M.avium_104 ATALVVDQIERFAPGFRDRVVATVSRGTADLAAYNANYIGGDILGGANDG
MAB_4734|M.abscessus_ATCC_1997 ATQALIDQIERFAPGFRDRIVATAVRSTTDMTVYNPNYVGGDIVTGAKDI
TH_4571|M.thermoresistible__bu ATEAVVAQIERFAPGFRDRIVGYRTESAEGMARFNANFTGGDILTGAKDI
MLBr_00062|M.leprae_Br4923 RVHALKAHEVTMQDGRFVKVENSVFELEADLVLLAMGFVGPEKPGLLTDL
. : : * : : . * : .:
Mflv_4235|M.gilvum_PYR-GCK FSALTG--PALRWNPWATPIPRTYLCSSATPPG-----------GGVHGM
Mvan_2127|M.vanbaalenii_PYR-1 VSALTG--PALRWNPWSTPIPKAYLCSSATPPG-----------GGVHGM
MSMEG_2377|M.smegmatis_MC2_155 ISALTG--PTPRVNPWTTPIPKAYLCSSATPPG-----------SGVHGM
MUL_1826|M.ulcerans_Agy99 LQVIFR--PRIALDPYAIGVPGVYLCSQSAPPG-----------AGIHGL
MMAR_2237|M.marinum_M LQVIFR--PRIALDPYAIGVPGVYLCSQSAPPG-----------AGIHGL
Mb1467|M.bovis_AF2122/97 LQVIFR--PRVAVDPYAIGVPGVYLCSQSAPPG-----------AGIHGL
Rv1432|M.tuberculosis_H37Rv LQVIFR--PRVAVDPYAIGVPGVYLCSQSAPPG-----------AGIHGL
MAV_3342|M.avium_104 LQVILR--PRVSVSPYATGVPGVYLCSQSTPPG-----------PGIHGL
MAB_4734|M.abscessus_ATCC_1997 RQLVFG--PRTTAHPYRLGIPGMYICSAATPPG-----------PGAHGM
TH_4571|M.thermoresistible__bu RQLTFG--PRITLSPYATGAPGYYICSAATPPG-----------PGAHGM
MLBr_00062|M.leprae_Br4923 GVKFTDRGNVARGADFDTSVPGVFVAGDMGRGQSLIVWAIAEGRAAAAAV
: * ::.. . .:
Mflv_4235|M.gilvum_PYR-GCK AGYYAARTVLRREFGIREMPPLAP
Mvan_2127|M.vanbaalenii_PYR-1 AGFYAARTVLRREFGIRELPPLAP
MSMEG_2377|M.smegmatis_MC2_155 SGFYAARTVLRREFGLG-LPALR-
MUL_1826|M.ulcerans_Agy99 CGYHAAESALQGLRKRR-------
MMAR_2237|M.marinum_M CGYHAAESALQGLRKRR-------
Mb1467|M.bovis_AF2122/97 CGYHAAESALRWLRKRR-------
Rv1432|M.tuberculosis_H37Rv CGYHAAESALRWLRKRR-------
MAV_3342|M.avium_104 CGYHAAEAALGWLRRRGG------
MAB_4734|M.abscessus_ATCC_1997 CGAHAAAEALRHLRASI-------
TH_4571|M.thermoresistible__bu CGYHAAQTALRELAR---------
MLBr_00062|M.leprae_Br4923 DRFLMGATALPAPVKPSSLPLQ--
. .*