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MAPSNAAAGTTAVADLLDTDSMLNPEELELRSTVRRFGEQRLRPFVAEWFESGSVPVRELATEFGKLGLL GMHLEGYGCGGSSATAYGVACQELEAVDSGLRSMVSVQGSLAMFAIHAHGSEEQREQWLPRMATGEVIGC FGLTEPDFGSNPSGMRTTARRDGSDWILNGSKMWITNGSVADVAIVWARSEDGILGFVVPTDTPGFVGRE MKHKLSLRASNTSELHLDDVRLPAEAQLPNARGLSGPLACLSEARFGIVFGSVGAARDCLEATLDYVGTR EVFDKTLASYQITQTKIADMAVELSKAQLLALHLGRLKDAGRISPEQVSVGKLNNVREALEIARQCRTLL GANGITLEYPVLRHANNLESVLTYEGTSEVHQMVIAQALTGVSAFR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5267 | - | - | 100% (396) | glutaryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6686 | - | e-155 | 67.59% (395) | glutaryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2466 | - | e-153 | 67.80% (382) | glutaryl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0406c | fadE7 | 1e-146 | 65.01% (383) | acyl-CoA dehydrogenase FADE7 |
| M. gilvum PYR-GCK | Mflv_4513 | - | 1e-151 | 66.08% (395) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0400c | fadE7 | 1e-146 | 65.01% (383) | acyl-CoA dehydrogenase FADE7 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-43 | 30.13% (375) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0822 | - | 1e-151 | 67.28% (382) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_0698 | fadE7 | 1e-145 | 65.27% (383) | acyl-CoA dehydrogenase FadE7 |
| M. avium 104 | MAV_4767 | - | 1e-151 | 67.80% (382) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2172 | - | 0.0 | 85.71% (385) | glutaryl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2825 | fadE7 | 1e-145 | 65.27% (383) | acyl-CoA dehydrogenase FadE7 |
| M. vanbaalenii PYR-1 | Mvan_4671 | - | 0.0 | 80.62% (387) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0406c|M.bovis_AF2122/97 ----MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHVAA
Rv0400c|M.tuberculosis_H37Rv ----MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHVAA
MMAR_0698|M.marinum_M ----MSTETPPTFDPHDPLGLDASLSDDEIAVRDTVRKFCAEHITAHVAE
MUL_2825|M.ulcerans_Agy99 ----MSTETPPTFDPHDPLGLDASLSDDEIAVRDTVRKFCAEHITAHVAE
MAV_4767|M.avium_104 MSTETSTKTPPAFDRYDPLGLDALLSDDERAVRDTVRGFCAEHVLPHVAE
MSMEG_5267|M.smegmatis_MC2_155 --MAPSNAAAGTTAVADLLDTDSMLNPEELELRSTVRRFGEQRLRPFVAE
TH_2172|M.thermoresistible__bu --------------VDDLLDLDALLTPEDIELRDTVRRFGEQRLRPHVAD
Mvan_4671|M.vanbaalenii_PYR-1 --MPAHQPLPTTTTIENLLDLDSLLSAEDRDLRTMVRGFGEQRLRPQIAE
Mflv_4513|M.gilvum_PYR-GCK MSTTTAPATKAVYAPLELFDTARLLEQDEREIAATVRKFVDSELKPNVED
MAB_0822|M.abscessus_ATCC_1997 MSTAVTPSPEMCSTPLELFDTDRRLDQDERDIAATVRKFVDTKLRPNIAE
MLBr_00737|M.leprae_Br4923 ----------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAAD
: : * :. : :* : .: .
Mb0406c|M.bovis_AF2122/97 WFEDGDLPVARDLAKQFGELGLLGMQL-HGHGCGGASAVHYGLACRELEA
Rv0400c|M.tuberculosis_H37Rv WFEDGDLPVARDLAKQFGELGLLGMQL-HGHGCGGASAVHYGLACRELEA
MMAR_0698|M.marinum_M WFENGDLPAARDLAKQLGGLGLLGMHL-QGYGCGGASAVHYGLACLELEA
MUL_2825|M.ulcerans_Agy99 WFENGDLPAARDLAKQLGGLGLLGMHL-QGYGCGGASAVHYGLACLELEA
MAV_4767|M.avium_104 WFEIGDLP-VRELAREFGRLGLLGMHL-HGYGCGGASAVHYGLACVELEA
MSMEG_5267|M.smegmatis_MC2_155 WFESGSVP-VRELATEFGKLGLLGMHL-EGYGCGGSSATAYGVACQELEA
TH_2172|M.thermoresistible__bu WFESGQIP-VRELAADLGKLGLLGMHL-QGYGCSGSTATAYGLVCQELEA
Mvan_4671|M.vanbaalenii_PYR-1 WFEAGQVP-VRELAAEIGKLGLLGMHL-QGYGCSGSTATAYGLVCQELEA
Mflv_4513|M.gilvum_PYR-GCK WFESATLP--KELGKRFGELGLLGMHL-QGYGCAGTNAVSYGLACMELEA
MAB_0822|M.abscessus_ATCC_1997 WFESATLP--RDLARQFGELGVLGMHL-DGYGCAGTNAVSYGLACLELEA
MLBr_00737|M.leprae_Br4923 VDQRARFP--EEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVAR
: . .* .: :. *. .::: . :* *: :. :. *:
Mb0406c|M.bovis_AF2122/97 ADSGIRSLVSVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGCFGLTEP
Rv0400c|M.tuberculosis_H37Rv ADSGIRSLVSVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGCFGLTEP
MMAR_0698|M.marinum_M ADSGIRSLVSVQGSLAMFAIAHFGSEEHKQRWLPPMAAGELIGCFGLTEP
MUL_2825|M.ulcerans_Agy99 ADSGIRSLVSVQGSLAMFAIAHFGSEEHKQRWLPPMAAGELIGCFGLTEP
MAV_4767|M.avium_104 ADSGLRSMVSVQGSLAMFAIWNFGSEEQKRQWLPGMATGEMLGCFGLTEP
MSMEG_5267|M.smegmatis_MC2_155 VDSGLRSMVSVQGSLAMFAIHAHGSEEQREQWLPRMATGEVIGCFGLTEP
TH_2172|M.thermoresistible__bu VDSGLRSLVSVQGSLAMFAIYRHGSEEQRRHWLPPMATGEVIGCFGLTEP
Mvan_4671|M.vanbaalenii_PYR-1 VDSGLRSLVSVQGSLAMFAIHRWGSEEQRTRWLPGMAAGELIGCFGLTEP
Mflv_4513|M.gilvum_PYR-GCK GDSGFRSFVSVQGSLSMFSIHRYGSEEQKNEWLPRLASGDAIGCFGLTEP
MAB_0822|M.abscessus_ATCC_1997 GDSGLRSFVSVQGSLSMYSIHRYGSEEQKQEWLPQLASGHAIGCFGLTEP
MLBr_00737|M.leprae_Br4923 VDASASLIPAVN-KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSER
*:. : :*: .*. .: **:* : . ** :*: :..:.*:*
Mb0406c|M.bovis_AF2122/97 DVGSDPAAMKTRARRDGP----DWVITGGKMWITNGSVADVAIVWAAT--
Rv0400c|M.tuberculosis_H37Rv DVGSDPAAMKTRARRDGP----DWVITGGKMWITNGSVADVAIVWAAT--
MMAR_0698|M.marinum_M DVGSDPAAMKTRARRDGS----DWVLNGRKMWITNGSIADVAIVWAAT--
MUL_2825|M.ulcerans_Agy99 DVGSDPAAMKTRARRDGS----DWVLNGRKMWITNGSIADVAIVWAAT--
MAV_4767|M.avium_104 DVGSDPAAMKTRARRDGS----DWVLDGRKLWITNGSVADVAVVWAGT--
MSMEG_5267|M.smegmatis_MC2_155 DFGSNPSGMRTTARRDGS----DWILNGSKMWITNGSVADVAIVWARS--
TH_2172|M.thermoresistible__bu DFGSNPAGMRTTARRDGS----DWILNGSKMWITNGSVADVAIVWARSA-
Mvan_4671|M.vanbaalenii_PYR-1 DFGSNPGGMRTTARRDGS----DWILNGSKMWITNASVADVAIIWARS--
Mflv_4513|M.gilvum_PYR-GCK DFGSNPAGMRTRGKRDGSGENADWILNGTKMWITNGNLADVATVWAQT--
MAB_0822|M.abscessus_ATCC_1997 DFGSNPGGMRTRARRDGK----DWILDGTKMWITNGNLADVATVWAQT--
MLBr_00737|M.leprae_Br4923 EAGSDAASMRTRAKADGD----DWILNGFKCWITNGGKSTWYTVMAVTDP
: **:...*:* .: ** **:: * * ****.. : : * :
Mb0406c|M.bovis_AF2122/97 ---DDGIRGFIVPTDTPGFTANTIGHKLSLRASITSELVLDNVRLPADAM
Rv0400c|M.tuberculosis_H37Rv ---DDGIRGFIVPTDTPGFTANTIGHKLSLRASITSELVLDNVRLPADAM
MMAR_0698|M.marinum_M ---EEGIRGFVVPTETAGFAANTIHHKLSLRASITSELVLDDVRLPAEAM
MUL_2825|M.ulcerans_Agy99 ---EEGIRGFVVPTETAGFAANTIHHKLSLRASITSELVLDDVRLPAEAM
MAV_4767|M.avium_104 ---DDGIRGFLVPTDTPGFTANTIHHKLSLRASITSELVLDDVRLPGEAM
MSMEG_5267|M.smegmatis_MC2_155 ---EDGILGFVVPTDTPGFVGREMKHKLSLRASNTSELHLDDVRLPAEAQ
TH_2172|M.thermoresistible__bu ---DDGILGFVVPTDTPGFTAREMTRKLSLRASVTSELHLDDVRLPADAR
Mvan_4671|M.vanbaalenii_PYR-1 ---KEGVLGFAVPTSTPGFHATEMTRKLSLRASVTSEIHLDDVRVPEDAR
Mflv_4513|M.gilvum_PYR-GCK ---DEGIRGFLVPTDTPGFTANAIHRKLSLRASITSELVLDNVRLPASAQ
MAB_0822|M.abscessus_ATCC_1997 ---DDGVRGFVVPTATKGFAANVIHKKLSLRASVTSELVLDGVRLPDSAE
MLBr_00737|M.leprae_Br4923 DKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRI
:*: .* * . ** :**.::.* *:*: :* *:* .
Mb0406c|M.bovis_AF2122/97 LPG-ATGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQRTQFGRP
Rv0400c|M.tuberculosis_H37Rv LPG-ATGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQRTQFGRP
MMAR_0698|M.marinum_M LPG-ATGVRGPLTCLSEARYGIVWGAMGAARSAWQCALDYAKERTQFGRP
MUL_2825|M.ulcerans_Agy99 LPG-ATGVRGPLTCLSEARYGIVWGAMGAARSAWQCALDYAKERTQFGRP
MAV_4767|M.avium_104 LPG-ATGLRGPLSCLSEARYGIIWGAMGAARSAWQAALDYATQRTQFGRP
MSMEG_5267|M.smegmatis_MC2_155 LPN-ARGLSGPLACLSEARFGIVFGSVGAARDCLEATLDYVGTREVFDKT
TH_2172|M.thermoresistible__bu LPG-ARGLSGPLACLSEARFGIVFGSVGAARDCLETTLDYVATREVFDKP
Mvan_4671|M.vanbaalenii_PYR-1 LPE-AQGLKAPLSCLSEARFGIVFGAVGAARDCLQTTLDYVGTRAVFDRP
Mflv_4513|M.gilvum_PYR-GCK LPE-AVGLSAPLSCLNEARFGIVFGALGAARDSLETTIAYTQTREVFDRP
MAB_0822|M.abscessus_ATCC_1997 LPG-ARGLSAPLSCLNEARFGIVFGALGAARDSLQAALDYTRTREVFGRP
MLBr_00737|M.leprae_Br4923 IGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGES
: . *. .*: *..:* * ::* *:.. : :: *. * *...
Mb0406c|M.bovis_AF2122/97 IAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRVGLRPDQVSFG-KLNN
Rv0400c|M.tuberculosis_H37Rv IAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRVGLRPDQVSFG-KLNN
MMAR_0698|M.marinum_M IAGFQLTQAKLVDMAVELHKGQLLALQLGRLKDSVGLRPEQVSFG-KLNN
MUL_2825|M.ulcerans_Agy99 IAGFQLTQAKLVDMAVELHKGQLLALQLGRLKDSVGLRPEQVSFG-KLNN
MAV_4767|M.avium_104 IAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDSTGLRPEQVSFG-KLNN
MSMEG_5267|M.smegmatis_MC2_155 LASYQITQTKIADMAVELSKAQLLALHLGRLKDAGRISPEQVSVG-KLNN
TH_2172|M.thermoresistible__bu LAGYQITQTKLADMAVELGKAQLLALHLGRLKDGGTIRPEQISVG-KLNN
Mvan_4671|M.vanbaalenii_PYR-1 LAGYQLTQAKIADMAVELGKAQLLALHLGRLKDEGRIRPEQVSVG-KLNN
Mflv_4513|M.gilvum_PYR-GCK LAGYQLTQEKLANMTVELGKGMLLAIHLGRIKDAEGVRPEQVSLG-KLNN
MAB_0822|M.abscessus_ATCC_1997 LSSYQLSQEKLANMTVQLGMGMLLALHLGRIKDSVGLRPEQVSLG-KLNN
MLBr_00737|M.leprae_Br4923 ISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFA
:: :* * :.:*:::: . *: . : :* . *
Mb0406c|M.bovis_AF2122/97 TREALKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVL
Rv0400c|M.tuberculosis_H37Rv TREALKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVL
MMAR_0698|M.marinum_M TREAIKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVL
MUL_2825|M.ulcerans_Agy99 TREAIKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVL
MAV_4767|M.avium_104 TREAIEICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVL
MSMEG_5267|M.smegmatis_MC2_155 VREALEIARQCRTLLGANGITLEYPVLRHANNLESVLTYEGTSEVHQMVI
TH_2172|M.thermoresistible__bu VREALRIARECRTLLGANGVTLEYPVLRHANNLESVLTYEGTSEVHQLVI
Mvan_4671|M.vanbaalenii_PYR-1 VREAIKIARQCRTLLGANGITLEYPVLRHANNLESVLTYEGTSEVHQLVI
Mflv_4513|M.gilvum_PYR-GCK VREAIAIARECRTLLGGSGITLEYSPLRHANNLESVLTYEGTSEMHLLSI
MAB_0822|M.abscessus_ATCC_1997 VREALNIARECRTLLGASGITLEYSPLRHANNLESVLTYEGTSEMHLLSI
MLBr_00737|M.leprae_Br4923 SDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVM
*: : . ::*. * : ::. *. : : . **** ::: : :
Mb0406c|M.bovis_AF2122/97 GQAFTGLAAFR-
Rv0400c|M.tuberculosis_H37Rv GQAFTGLAAFR-
MMAR_0698|M.marinum_M GQAFTGLAAFR-
MUL_2825|M.ulcerans_Agy99 GQAFTGLAAFR-
MAV_4767|M.avium_104 GQAFTGADAFR-
MSMEG_5267|M.smegmatis_MC2_155 AQALTGVSAFR-
TH_2172|M.thermoresistible__bu GQTMTGLSAFR-
Mvan_4671|M.vanbaalenii_PYR-1 GEALTGVGAFR-
Mflv_4513|M.gilvum_PYR-GCK GKALTGHAAFRA
MAB_0822|M.abscessus_ATCC_1997 GRALTGQAAFR-
MLBr_00737|M.leprae_Br4923 SRALLR------
..::