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MTNSAVAQPRSQRRGADDLIGINAVLSAEEREIRDTVRSVVQRRIKPHIASWYEDGELPARELAVELGEL GLLGMHLKGYGCAGMSAVAYGLACLELEAGDSGIRSLVSVQGSLAMYAIHAFGSDEQKDQWLPDMASGHR IGCFGLTEPDHGSDPAGMRTRATRSGDDWILTGTKMWITNGSVADVAVVWARTDEGIRGFVVPTDTPGFT ANTIKSKMSLRASVTSELVLDGVRLPDSARLPGATSLGAPLRCLNEARFGIVFGALGAARDCLETALAYA CSREQFDRPIGGFQLTQQKLADMTLEYGKGFLLALHLGRQKDAGELAPEQVSLGKLNNVREAIEIARTAR TVLGASGITGEYPVMRHANNLESVLTYEGTSEMHTLIIGQALTGVGAFR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2466 | - | - | 100% (399) | glutaryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6686 | - | e-154 | 70.16% (382) | glutaryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5267 | - | e-153 | 67.80% (382) | glutaryl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0406c | fadE7 | 1e-153 | 69.53% (384) | acyl-CoA dehydrogenase FADE7 |
| M. gilvum PYR-GCK | Mflv_4513 | - | 1e-154 | 70.21% (386) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0400c | fadE7 | 1e-153 | 69.53% (384) | acyl-CoA dehydrogenase FADE7 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 6e-44 | 32.28% (378) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4609c | - | 1e-168 | 74.41% (383) | putative acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_0698 | fadE7 | 1e-148 | 68.67% (383) | acyl-CoA dehydrogenase FadE7 |
| M. avium 104 | MAV_4767 | - | 1e-154 | 69.63% (382) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2172 | - | 1e-157 | 69.01% (384) | glutaryl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2825 | fadE7 | 1e-149 | 68.67% (383) | acyl-CoA dehydrogenase FadE7 |
| M. vanbaalenii PYR-1 | Mvan_1857 | - | 1e-155 | 68.75% (400) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0406c|M.bovis_AF2122/97 ----MSTPTPPALD------RDDPLGLDASLSSDEIAVRDTVRRFCAEHV
Rv0400c|M.tuberculosis_H37Rv ----MSTPTPPALD------RDDPLGLDASLSSDEIAVRDTVRRFCAEHV
MMAR_0698|M.marinum_M ----MSTETPPTFD------PHDPLGLDASLSDDEIAVRDTVRKFCAEHI
MUL_2825|M.ulcerans_Agy99 ----MSTETPPTFD------PHDPLGLDASLSDDEIAVRDTVRKFCAEHI
MAV_4767|M.avium_104 MSTETSTKTPPAFD------RYDPLGLDALLSDDERAVRDTVRGFCAEHV
MSMEG_2466|M.smegmatis_MC2_155 -----MTNSAVAQPRSQRRGADDLIGINAVLSAEEREIRDTVRSVVQRRI
MAB_4609c|M.abscessus_ATCC_199 ----MATDAAPTNP-------DELFGIDALLSDEERAIRDSVRALVQARV
Mflv_4513|M.gilvum_PYR-GCK ----MSTTTAPATK--AVYAPLELFDTARLLEQDEREIAATVRKFVDSEL
Mvan_1857|M.vanbaalenii_PYR-1 -----MTTTAAPQK--AVYSPLELFDTARLLDHDEREIAATVRKFVDTEL
TH_2172|M.thermoresistible__bu --------------------VDDLLDLDALLTPEDIELRDTVRRFGEQRL
MLBr_00737|M.leprae_Br4923 ---------MVGWS-------GNPLFDLFKLPEEHNELRATIRALAEKEI
: : * :. : ::* . .:
Mb0406c|M.bovis_AF2122/97 TPHVAAWFEDGDLPVARDLAKQFGELGLLGMQL-HGHGCGGASAVHYGLA
Rv0400c|M.tuberculosis_H37Rv TPHVAAWFEDGDLPVARDLAKQFGELGLLGMQL-HGHGCGGASAVHYGLA
MMAR_0698|M.marinum_M TAHVAEWFENGDLPAARDLAKQLGGLGLLGMHL-QGYGCGGASAVHYGLA
MUL_2825|M.ulcerans_Agy99 TAHVAEWFENGDLPAARDLAKQLGGLGLLGMHL-QGYGCGGASAVHYGLA
MAV_4767|M.avium_104 LPHVAEWFEIGDLP-VRELAREFGRLGLLGMHL-HGYGCGGASAVHYGLA
MSMEG_2466|M.smegmatis_MC2_155 KPHIASWYEDGELP-ARELAVELGELGLLGMHL-KGYGCAGMSAVAYGLA
MAB_4609c|M.abscessus_ATCC_199 VPNVQRWYEHGDLP-VRKLALELGKIGVLGMHL-HGYGCSGTSSLAYGLA
Mflv_4513|M.gilvum_PYR-GCK KPNVEDWFESATLP--KELGKRFGELGLLGMHL-QGYGCAGTNAVSYGLA
Mvan_1857|M.vanbaalenii_PYR-1 KPNIEGWFESSTLP--RELGRRFGELGVLGMHL-EGYGCAGTNAVSYGLA
TH_2172|M.thermoresistible__bu RPHVADWFESGQIP-VRELAADLGKLGLLGMHL-QGYGCSGSTATAYGLV
MLBr_00737|M.leprae_Br4923 APHAADVDQRARFP--EEALAALNASGFNAIHVPEEYGGQGADSVAACIV
.: : . :* .. :. *. .::: . :* * : :.
Mb0406c|M.bovis_AF2122/97 CRELEAADSGIRSLVSVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGC
Rv0400c|M.tuberculosis_H37Rv CRELEAADSGIRSLVSVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGC
MMAR_0698|M.marinum_M CLELEAADSGIRSLVSVQGSLAMFAIAHFGSEEHKQRWLPPMAAGELIGC
MUL_2825|M.ulcerans_Agy99 CLELEAADSGIRSLVSVQGSLAMFAIAHFGSEEHKQRWLPPMAAGELIGC
MAV_4767|M.avium_104 CVELEAADSGLRSMVSVQGSLAMFAIWNFGSEEQKRQWLPGMATGEMLGC
MSMEG_2466|M.smegmatis_MC2_155 CLELEAGDSGIRSLVSVQGSLAMYAIHAFGSDEQKDQWLPDMASGHRIGC
MAB_4609c|M.abscessus_ATCC_199 CMELEAGDSGIRSLVSVQGSLAMYAIYAYGSDAQKQKWLPRMATGEELGC
Mflv_4513|M.gilvum_PYR-GCK CMELEAGDSGFRSFVSVQGSLSMFSIHRYGSEEQKNEWLPRLASGDAIGC
Mvan_1857|M.vanbaalenii_PYR-1 CLELEAGDSGFRSFVSVQGSLSMYSIYRYGSDEQKNEWLPQLASGEAIGC
TH_2172|M.thermoresistible__bu CQELEAVDSGLRSLVSVQGSLAMFAIYRHGSEEQRRHWLPPMATGEVIGC
MLBr_00737|M.leprae_Br4923 IEEVARVDASASLIPAVN-KLGTMGLILRGSEELKKQVLPSLAAEGAMAS
*: *:. : :*: .*. .: **: : . ** :*: :..
Mb0406c|M.bovis_AF2122/97 FGLTEPDVGSDPAAMKTRARRDGP----DWVITGGKMWITNGSVADVAIV
Rv0400c|M.tuberculosis_H37Rv FGLTEPDVGSDPAAMKTRARRDGP----DWVITGGKMWITNGSVADVAIV
MMAR_0698|M.marinum_M FGLTEPDVGSDPAAMKTRARRDGS----DWVLNGRKMWITNGSIADVAIV
MUL_2825|M.ulcerans_Agy99 FGLTEPDVGSDPAAMKTRARRDGS----DWVLNGRKMWITNGSIADVAIV
MAV_4767|M.avium_104 FGLTEPDVGSDPAAMKTRARRDGS----DWVLDGRKLWITNGSVADVAVV
MSMEG_2466|M.smegmatis_MC2_155 FGLTEPDHGSDPAGMRTRATRSGD----DWILTGTKMWITNGSVADVAVV
MAB_4609c|M.abscessus_ATCC_199 FGLTEPDFGSNPGGMRTHARRDGS----DWVLNGTKMWITNGSIADVAVI
Mflv_4513|M.gilvum_PYR-GCK FGLTEPDFGSNPAGMRTRGKRDGSGENADWILNGTKMWITNGNLADVATV
Mvan_1857|M.vanbaalenii_PYR-1 FGLTEPDFGSNPAGMRTRARRSGAGENADWVLNGTKMWITNGNLADVATV
TH_2172|M.thermoresistible__bu FGLTEPDFGSNPAGMRTTARRDGS----DWILNGSKMWITNGSVADVAIV
MLBr_00737|M.leprae_Br4923 YALSEREAGSDAASMRTRAKADGD----DWILNGFKCWITNGGKSTWYTV
:.*:* : **:...*:* . .* **:: * * *****. : :
Mb0406c|M.bovis_AF2122/97 WAA-----TDDGIRGFIVPTDTPGFTANTIGHKLSLRASITSELVLDNVR
Rv0400c|M.tuberculosis_H37Rv WAA-----TDDGIRGFIVPTDTPGFTANTIGHKLSLRASITSELVLDNVR
MMAR_0698|M.marinum_M WAA-----TEEGIRGFVVPTETAGFAANTIHHKLSLRASITSELVLDDVR
MUL_2825|M.ulcerans_Agy99 WAA-----TEEGIRGFVVPTETAGFAANTIHHKLSLRASITSELVLDDVR
MAV_4767|M.avium_104 WAG-----TDDGIRGFLVPTDTPGFTANTIHHKLSLRASITSELVLDDVR
MSMEG_2466|M.smegmatis_MC2_155 WAR-----TDEGIRGFVVPTDTPGFTANTIKSKMSLRASVTSELVLDGVR
MAB_4609c|M.abscessus_ATCC_199 WAQ-----TDEGVRGFLVSTDSAGFDAQTIHSKMSLRASVTAELNLVDVW
Mflv_4513|M.gilvum_PYR-GCK WAQ-----TDEGIRGFLVPTDTPGFTANAIHRKLSLRASITSELVLDNVR
Mvan_1857|M.vanbaalenii_PYR-1 WAQ-----TDEGIRGFLVPTDTPGFTANAIHRKLSLRASVTSELVLDNVR
TH_2172|M.thermoresistible__bu WARS----ADDGILGFVVPTDTPGFTAREMTRKLSLRASVTSELHLDDVR
MLBr_00737|M.leprae_Br4923 MAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCR
* :*: .*:* .: ** *:.::.* *:** :
Mb0406c|M.bovis_AF2122/97 LPADAMLPG-ATGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQR
Rv0400c|M.tuberculosis_H37Rv LPADAMLPG-ATGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQR
MMAR_0698|M.marinum_M LPAEAMLPG-ATGVRGPLTCLSEARYGIVWGAMGAARSAWQCALDYAKER
MUL_2825|M.ulcerans_Agy99 LPAEAMLPG-ATGVRGPLTCLSEARYGIVWGAMGAARSAWQCALDYAKER
MAV_4767|M.avium_104 LPGEAMLPG-ATGLRGPLSCLSEARYGIIWGAMGAARSAWQAALDYATQR
MSMEG_2466|M.smegmatis_MC2_155 LPDSARLPG-ATSLGAPLRCLNEARFGIVFGALGAARDCLETALAYACSR
MAB_4609c|M.abscessus_ATCC_199 VPEKNRLPL-AVGLKAPLSCLNEARFGIIFGSMGAARECLRTALEYAQTR
Mflv_4513|M.gilvum_PYR-GCK LPASAQLPE-AVGLSAPLSCLNEARFGIVFGALGAARDSLETTIAYTQTR
Mvan_1857|M.vanbaalenii_PYR-1 LPASAQLPD-AVGLSAPLSCLNEARFGIVFGALGAARDSLETTIAYTQTR
TH_2172|M.thermoresistible__bu LPADARLPG-ARGLSGPLACLSEARFGIVFGSVGAARDCLETTLDYVATR
MLBr_00737|M.leprae_Br4923 IPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDR
:* . : . .. .* *..:* * ::* *: . :: *. *
Mb0406c|M.bovis_AF2122/97 TQFGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRVGLRPDQVSF
Rv0400c|M.tuberculosis_H37Rv TQFGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRVGLRPDQVSF
MMAR_0698|M.marinum_M TQFGRPIAGFQLTQAKLVDMAVELHKGQLLALQLGRLKDSVGLRPEQVSF
MUL_2825|M.ulcerans_Agy99 TQFGRPIAGFQLTQAKLVDMAVELHKGQLLALQLGRLKDSVGLRPEQVSF
MAV_4767|M.avium_104 TQFGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDSTGLRPEQVSF
MSMEG_2466|M.smegmatis_MC2_155 EQFDRPIGGFQLTQQKLADMTLEYGKGFLLALHLGRQKDAGELAPEQVSL
MAB_4609c|M.abscessus_ATCC_199 EQFDRPIAGFQLTQEKLANMALEYGKGVLLALHLGRRKDADTLATPQVSL
Mflv_4513|M.gilvum_PYR-GCK EVFDRPLAGYQLTQEKLANMTVELGKGMLLAIHLGRIKDAEGVRPEQVSL
Mvan_1857|M.vanbaalenii_PYR-1 DVFDKPLAGYQLTQEKLANMTVELGKGMLLAIHLGRIKDAEGVRPEQISL
TH_2172|M.thermoresistible__bu EVFDKPLAGYQITQTKLADMAVELGKAQLLALHLGRLKDGGTIRPEQISV
MLBr_00737|M.leprae_Br4923 KQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISA
*...:. :* * *.:*::: . *: . : :*
Mb0406c|M.bovis_AF2122/97 G-KLNNTREALKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPE
Rv0400c|M.tuberculosis_H37Rv G-KLNNTREALKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPE
MMAR_0698|M.marinum_M G-KLNNTREAIKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPE
MUL_2825|M.ulcerans_Agy99 G-KLNNTREAIKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPE
MAV_4767|M.avium_104 G-KLNNTREAIEICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPE
MSMEG_2466|M.smegmatis_MC2_155 G-KLNNVREAIEIARTARTVLGASGITGEYPVMRHANNLESVLTYEGTSE
MAB_4609c|M.abscessus_ATCC_199 G-KLNNVREAIEIARTARTILGANGISGEYPVMRHANNLESVLTYEGTSE
Mflv_4513|M.gilvum_PYR-GCK G-KLNNVREAIAIARECRTLLGGSGITLEYSPLRHANNLESVLTYEGTSE
Mvan_1857|M.vanbaalenii_PYR-1 G-KLNNVREAIAIARECRTLLGGSGITLEYSPLRHANNLESVLTYEGTSE
TH_2172|M.thermoresistible__bu G-KLNNVREALRIARECRTLLGANGVTLEYPVLRHANNLESVLTYEGTSE
MLBr_00737|M.leprae_Br4923 ASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQ
. * *: : . ::*. * : ::. *. : : . **** :
Mb0406c|M.bovis_AF2122/97 MHQLVLGQAFTGLAAFR-
Rv0400c|M.tuberculosis_H37Rv MHQLVLGQAFTGLAAFR-
MMAR_0698|M.marinum_M MHQLVLGQAFTGLAAFR-
MUL_2825|M.ulcerans_Agy99 MHQLVLGQAFTGLAAFR-
MAV_4767|M.avium_104 MHQLVLGQAFTGADAFR-
MSMEG_2466|M.smegmatis_MC2_155 MHTLIIGQALTGVGAFR-
MAB_4609c|M.abscessus_ATCC_199 MHTLVIGQALTGIAAFR-
Mflv_4513|M.gilvum_PYR-GCK MHLLSIGKALTGHAAFRA
Mvan_1857|M.vanbaalenii_PYR-1 MHLLSIGKALTGHAAFRS
TH_2172|M.thermoresistible__bu VHQLVIGQTMTGLSAFR-
MLBr_00737|M.leprae_Br4923 IQRVVMSRALLR------
:: : :.:::