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M. vanbaalenii PYR-1 Mvan_4671 (-)

annotation: acyl-CoA dehydrogenase domain-containing protein
coordinates: 5010390 - 5011580
length: 396

MPAHQPLPTTTTIENLLDLDSLLSAEDRDLRTMVRGFGEQRLRPQIAEWFEAGQVPVRELAAEIGKLGLL
GMHLQGYGCSGSTATAYGLVCQELEAVDSGLRSLVSVQGSLAMFAIHRWGSEEQRTRWLPGMAAGELIGC
FGLTEPDFGSNPGGMRTTARRDGSDWILNGSKMWITNASVADVAIIWARSKEGVLGFAVPTSTPGFHATE
MTRKLSLRASVTSEIHLDDVRVPEDARLPEAQGLKAPLSCLSEARFGIVFGAVGAARDCLQTTLDYVGTR
AVFDRPLAGYQLTQAKIADMAVELGKAQLLALHLGRLKDEGRIRPEQVSVGKLNNVREAIKIARQCRTLL
GANGITLEYPVLRHANNLESVLTYEGTSEVHQLVIGEALTGVGAFR

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. vanbaalenii PYR-1 Mvan_4671 - - 100% (396) acyl-CoA dehydrogenase domain-containing protein
M. vanbaalenii PYR-1 Mvan_1857 - e-147 66.23% (385) acyl-CoA dehydrogenase domain-containing protein
M. vanbaalenii PYR-1 Mvan_4089 - 4e-45 32.52% (369) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0406c fadE7 1e-144 63.27% (392) acyl-CoA dehydrogenase FADE7
M. gilvum PYR-GCK Mflv_4513 - 1e-151 67.53% (385) acyl-CoA dehydrogenase domain-containing protein
M. tuberculosis H37Rv Rv0400c fadE7 1e-144 63.27% (392) acyl-CoA dehydrogenase FADE7
M. leprae Br4923 MLBr_00737 fadE25 3e-40 29.07% (375) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_4609c - 1e-150 66.58% (386) putative acyl-CoA dehydrogenase FadE
M. marinum M MMAR_0698 fadE7 1e-145 65.38% (390) acyl-CoA dehydrogenase FadE7
M. avium 104 MAV_4767 - 1e-150 67.11% (380) putative acyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_5267 - 0.0 80.62% (387) glutaryl-CoA dehydrogenase
M. thermoresistible (build 8) TH_2172 - 0.0 83.38% (385) glutaryl-CoA dehydrogenase
M. ulcerans Agy99 MUL_2825 fadE7 1e-145 65.38% (390) acyl-CoA dehydrogenase FadE7

CLUSTAL 2.0.9 multiple sequence alignment


Mb0406c|M.bovis_AF2122/97           ----MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHVAA
Rv0400c|M.tuberculosis_H37Rv        ----MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHVAA
MMAR_0698|M.marinum_M               ----MSTETPPTFDPHDPLGLDASLSDDEIAVRDTVRKFCAEHITAHVAE
MUL_2825|M.ulcerans_Agy99           ----MSTETPPTFDPHDPLGLDASLSDDEIAVRDTVRKFCAEHITAHVAE
MAV_4767|M.avium_104                MSTETSTKTPPAFDRYDPLGLDALLSDDERAVRDTVRGFCAEHVLPHVAE
MSMEG_5267|M.smegmatis_MC2_155      MAPSNAAAGTTAVA--DLLDTDSMLNPEELELRSTVRRFGEQRLRPFVAE
TH_2172|M.thermoresistible__bu      ------------VD--DLLDLDALLTPEDIELRDTVRRFGEQRLRPHVAD
Mvan_4671|M.vanbaalenii_PYR-1       MPAHQPLPTTTTIE--NLLDLDSLLSAEDRDLRTMVRGFGEQRLRPQIAE
Mflv_4513|M.gilvum_PYR-GCK          MSTTTAPATKAVYAPLELFDTARLLEQDEREIAATVRKFVDSELKPNVED
MAB_4609c|M.abscessus_ATCC_199      MATDAAPTNP---D--ELFGIDALLSDEERAIRDSVRALVQARVVPNVQR
MLBr_00737|M.leprae_Br4923          ---------MVGWSGNPLFDLFKLPEEHN-ELRATIRALAEKEIAPHAAD
                                                      :.       .:  :   :* :   .: .    

Mb0406c|M.bovis_AF2122/97           WFEDGDLPVARDLAKQFGELGLLGMQL-HGHGCGGASAVHYGLACRELEA
Rv0400c|M.tuberculosis_H37Rv        WFEDGDLPVARDLAKQFGELGLLGMQL-HGHGCGGASAVHYGLACRELEA
MMAR_0698|M.marinum_M               WFENGDLPAARDLAKQLGGLGLLGMHL-QGYGCGGASAVHYGLACLELEA
MUL_2825|M.ulcerans_Agy99           WFENGDLPAARDLAKQLGGLGLLGMHL-QGYGCGGASAVHYGLACLELEA
MAV_4767|M.avium_104                WFEIGDLP-VRELAREFGRLGLLGMHL-HGYGCGGASAVHYGLACVELEA
MSMEG_5267|M.smegmatis_MC2_155      WFESGSVP-VRELATEFGKLGLLGMHL-EGYGCGGSSATAYGVACQELEA
TH_2172|M.thermoresistible__bu      WFESGQIP-VRELAADLGKLGLLGMHL-QGYGCSGSTATAYGLVCQELEA
Mvan_4671|M.vanbaalenii_PYR-1       WFEAGQVP-VRELAAEIGKLGLLGMHL-QGYGCSGSTATAYGLVCQELEA
Mflv_4513|M.gilvum_PYR-GCK          WFESATLP--KELGKRFGELGLLGMHL-QGYGCAGTNAVSYGLACMELEA
MAB_4609c|M.abscessus_ATCC_199      WYEHGDLP-VRKLALELGKIGVLGMHL-HGYGCSGTSSLAYGLACMELEA
MLBr_00737|M.leprae_Br4923          VDQRARFP--EEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVAR
                                      : . .*  ..    :.  *. .::: . :*  *: :    :.  *:  

Mb0406c|M.bovis_AF2122/97           ADSGIRSLVSVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGCFGLTEP
Rv0400c|M.tuberculosis_H37Rv        ADSGIRSLVSVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGCFGLTEP
MMAR_0698|M.marinum_M               ADSGIRSLVSVQGSLAMFAIAHFGSEEHKQRWLPPMAAGELIGCFGLTEP
MUL_2825|M.ulcerans_Agy99           ADSGIRSLVSVQGSLAMFAIAHFGSEEHKQRWLPPMAAGELIGCFGLTEP
MAV_4767|M.avium_104                ADSGLRSMVSVQGSLAMFAIWNFGSEEQKRQWLPGMATGEMLGCFGLTEP
MSMEG_5267|M.smegmatis_MC2_155      VDSGLRSMVSVQGSLAMFAIHAHGSEEQREQWLPRMATGEVIGCFGLTEP
TH_2172|M.thermoresistible__bu      VDSGLRSLVSVQGSLAMFAIYRHGSEEQRRHWLPPMATGEVIGCFGLTEP
Mvan_4671|M.vanbaalenii_PYR-1       VDSGLRSLVSVQGSLAMFAIHRWGSEEQRTRWLPGMAAGELIGCFGLTEP
Mflv_4513|M.gilvum_PYR-GCK          GDSGFRSFVSVQGSLSMFSIHRYGSEEQKNEWLPRLASGDAIGCFGLTEP
MAB_4609c|M.abscessus_ATCC_199      GDSGIRSLVSVQGSLAMYAIYAYGSDAQKQKWLPRMATGEELGCFGLTEP
MLBr_00737|M.leprae_Br4923          VDASASLIPAVN-KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSER
                                     *:.   : :*: .*.  .:   **:  : . ** :*:   :..:.*:* 

Mb0406c|M.bovis_AF2122/97           DVGSDPAAMKTRARRDGP----DWVITGGKMWITNGSVADVAIVWAAT--
Rv0400c|M.tuberculosis_H37Rv        DVGSDPAAMKTRARRDGP----DWVITGGKMWITNGSVADVAIVWAAT--
MMAR_0698|M.marinum_M               DVGSDPAAMKTRARRDGS----DWVLNGRKMWITNGSIADVAIVWAAT--
MUL_2825|M.ulcerans_Agy99           DVGSDPAAMKTRARRDGS----DWVLNGRKMWITNGSIADVAIVWAAT--
MAV_4767|M.avium_104                DVGSDPAAMKTRARRDGS----DWVLDGRKLWITNGSVADVAVVWAGT--
MSMEG_5267|M.smegmatis_MC2_155      DFGSNPSGMRTTARRDGS----DWILNGSKMWITNGSVADVAIVWARS--
TH_2172|M.thermoresistible__bu      DFGSNPAGMRTTARRDGS----DWILNGSKMWITNGSVADVAIVWARSA-
Mvan_4671|M.vanbaalenii_PYR-1       DFGSNPGGMRTTARRDGS----DWILNGSKMWITNASVADVAIIWARS--
Mflv_4513|M.gilvum_PYR-GCK          DFGSNPAGMRTRGKRDGSGENADWILNGTKMWITNGNLADVATVWAQT--
MAB_4609c|M.abscessus_ATCC_199      DFGSNPGGMRTHARRDGS----DWVLNGTKMWITNGSIADVAVIWAQT--
MLBr_00737|M.leprae_Br4923          EAGSDAASMRTRAKADGD----DWILNGFKCWITNGGKSTWYTVMAVTDP
                                    : **:...*:* .: **     **:: * * ****.. :    : * :  

Mb0406c|M.bovis_AF2122/97           ---DDGIRGFIVPTDTPGFTANTIGHKLSLRASITSELVLDNVRLPADAM
Rv0400c|M.tuberculosis_H37Rv        ---DDGIRGFIVPTDTPGFTANTIGHKLSLRASITSELVLDNVRLPADAM
MMAR_0698|M.marinum_M               ---EEGIRGFVVPTETAGFAANTIHHKLSLRASITSELVLDDVRLPAEAM
MUL_2825|M.ulcerans_Agy99           ---EEGIRGFVVPTETAGFAANTIHHKLSLRASITSELVLDDVRLPAEAM
MAV_4767|M.avium_104                ---DDGIRGFLVPTDTPGFTANTIHHKLSLRASITSELVLDDVRLPGEAM
MSMEG_5267|M.smegmatis_MC2_155      ---EDGILGFVVPTDTPGFVGREMKHKLSLRASNTSELHLDDVRLPAEAQ
TH_2172|M.thermoresistible__bu      ---DDGILGFVVPTDTPGFTAREMTRKLSLRASVTSELHLDDVRLPADAR
Mvan_4671|M.vanbaalenii_PYR-1       ---KEGVLGFAVPTSTPGFHATEMTRKLSLRASVTSEIHLDDVRVPEDAR
Mflv_4513|M.gilvum_PYR-GCK          ---DEGIRGFLVPTDTPGFTANAIHRKLSLRASITSELVLDNVRLPASAQ
MAB_4609c|M.abscessus_ATCC_199      ---DEGVRGFLVSTDSAGFDAQTIHSKMSLRASVTAELNLVDVWVPEKNR
MLBr_00737|M.leprae_Br4923          DKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRI
                                        :*: .* * ..  **       *:.::.* *:*: : .  :* .  

Mb0406c|M.bovis_AF2122/97           LPG-ATGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQRTQFGRP
Rv0400c|M.tuberculosis_H37Rv        LPG-ATGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQRTQFGRP
MMAR_0698|M.marinum_M               LPG-ATGVRGPLTCLSEARYGIVWGAMGAARSAWQCALDYAKERTQFGRP
MUL_2825|M.ulcerans_Agy99           LPG-ATGVRGPLTCLSEARYGIVWGAMGAARSAWQCALDYAKERTQFGRP
MAV_4767|M.avium_104                LPG-ATGLRGPLSCLSEARYGIIWGAMGAARSAWQAALDYATQRTQFGRP
MSMEG_5267|M.smegmatis_MC2_155      LPN-ARGLSGPLACLSEARFGIVFGSVGAARDCLEATLDYVGTREVFDKT
TH_2172|M.thermoresistible__bu      LPG-ARGLSGPLACLSEARFGIVFGSVGAARDCLETTLDYVATREVFDKP
Mvan_4671|M.vanbaalenii_PYR-1       LPE-AQGLKAPLSCLSEARFGIVFGAVGAARDCLQTTLDYVGTRAVFDRP
Mflv_4513|M.gilvum_PYR-GCK          LPE-AVGLSAPLSCLNEARFGIVFGALGAARDSLETTIAYTQTREVFDRP
MAB_4609c|M.abscessus_ATCC_199      LPL-AVGLKAPLSCLNEARFGIIFGSMGAARECLRTALEYAQTREQFDRP
MLBr_00737|M.leprae_Br4923          IGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGES
                                    :   . *.  .*: *..:*  *   ::* *: .   :: *.  *  *...

Mb0406c|M.bovis_AF2122/97           IAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRVGLRPDQVSFG-KLNN
Rv0400c|M.tuberculosis_H37Rv        IAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRVGLRPDQVSFG-KLNN
MMAR_0698|M.marinum_M               IAGFQLTQAKLVDMAVELHKGQLLALQLGRLKDSVGLRPEQVSFG-KLNN
MUL_2825|M.ulcerans_Agy99           IAGFQLTQAKLVDMAVELHKGQLLALQLGRLKDSVGLRPEQVSFG-KLNN
MAV_4767|M.avium_104                IAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDSTGLRPEQVSFG-KLNN
MSMEG_5267|M.smegmatis_MC2_155      LASYQITQTKIADMAVELSKAQLLALHLGRLKDAGRISPEQVSVG-KLNN
TH_2172|M.thermoresistible__bu      LAGYQITQTKLADMAVELGKAQLLALHLGRLKDGGTIRPEQISVG-KLNN
Mvan_4671|M.vanbaalenii_PYR-1       LAGYQLTQAKIADMAVELGKAQLLALHLGRLKDEGRIRPEQVSVG-KLNN
Mflv_4513|M.gilvum_PYR-GCK          LAGYQLTQEKLANMTVELGKGMLLAIHLGRIKDAEGVRPEQVSLG-KLNN
MAB_4609c|M.abscessus_ATCC_199      IAGFQLTQEKLANMALEYGKGVLLALHLGRRKDADTLATPQVSLG-KLNN
MLBr_00737|M.leprae_Br4923          ISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFA
                                    :: :*  *  :.:*:::   . *:    .   :        :* . *   

Mb0406c|M.bovis_AF2122/97           TREALKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVL
Rv0400c|M.tuberculosis_H37Rv        TREALKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVL
MMAR_0698|M.marinum_M               TREAIKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVL
MUL_2825|M.ulcerans_Agy99           TREAIKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVL
MAV_4767|M.avium_104                TREAIEICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVL
MSMEG_5267|M.smegmatis_MC2_155      VREALEIARQCRTLLGANGITLEYPVLRHANNLESVLTYEGTSEVHQMVI
TH_2172|M.thermoresistible__bu      VREALRIARECRTLLGANGVTLEYPVLRHANNLESVLTYEGTSEVHQLVI
Mvan_4671|M.vanbaalenii_PYR-1       VREAIKIARQCRTLLGANGITLEYPVLRHANNLESVLTYEGTSEVHQLVI
Mflv_4513|M.gilvum_PYR-GCK          VREAIAIARECRTLLGGSGITLEYSPLRHANNLESVLTYEGTSEMHLLSI
MAB_4609c|M.abscessus_ATCC_199      VREAIEIARTARTILGANGISGEYPVMRHANNLESVLTYEGTSEMHTLVI
MLBr_00737|M.leprae_Br4923          SDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVM
                                       *: :   .  ::*. * : ::.  *.  : : .  **** ::: : :

Mb0406c|M.bovis_AF2122/97           GQAFTGLAAFR-
Rv0400c|M.tuberculosis_H37Rv        GQAFTGLAAFR-
MMAR_0698|M.marinum_M               GQAFTGLAAFR-
MUL_2825|M.ulcerans_Agy99           GQAFTGLAAFR-
MAV_4767|M.avium_104                GQAFTGADAFR-
MSMEG_5267|M.smegmatis_MC2_155      AQALTGVSAFR-
TH_2172|M.thermoresistible__bu      GQTMTGLSAFR-
Mvan_4671|M.vanbaalenii_PYR-1       GEALTGVGAFR-
Mflv_4513|M.gilvum_PYR-GCK          GKALTGHAAFRA
MAB_4609c|M.abscessus_ATCC_199      GQALTGIAAFR-
MLBr_00737|M.leprae_Br4923          SRALLR------
                                    ..::

species	id	gene	e-value	identity (len)	annotation
M. vanbaalenii PYR-1	Mvan_4671	-	-	100% (396)	acyl-CoA dehydrogenase domain-containing protein
M. vanbaalenii PYR-1	Mvan_1857	-	e-147	66.23% (385)	acyl-CoA dehydrogenase domain-containing protein
M. vanbaalenii PYR-1	Mvan_4089	-	4e-45	32.52% (369)	acyl-CoA dehydrogenase domain-containing protein