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TESVGQASGSRATLATVAASAGVSIATVSKVLNGRADVAPATRSRVKALLAQHHYVARRTELGDLAAASA DRPGPPTVELLFREDFNAYGIEVVQGLLDAGCAAGVAVVVSRRPDDEGDSDGTAQWVSDLAAAGRRAVIS VADELPEADIAALHRFGLPLVVIDPLNQPTTRITSVGSTNFSGGLAATQHLLSLGHRRIAYVGGPVTAAC NQARLHGYRAAMEEAGAAVVDGYVRTGDFLYDNGLREGSALLDLPEPPTAVFAASDETALGVIEAARSRG LRVPEDLSVVGFDDTQLARLSAPPLTTVRQPLREMGAVAMRTALRLADGDELDSHHVELATQLIARSSTA RL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5143 | - | - | 100% (353) | HTH-type transcriptional regulator DegA |
| M. smegmatis MC2 155 | MSMEG_0491 | - | 2e-30 | 34.20% (348) | transcriptional regulator, LacI family protein |
| M. smegmatis MC2 155 | MSMEG_1708 | - | 1e-29 | 30.95% (349) | ribose operon repressor, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3606c | - | 3e-10 | 25.30% (328) | transcriptional regulatory protein LacI-family |
| M. gilvum PYR-GCK | Mflv_1457 | - | 3e-13 | 26.44% (329) | periplasmic binding protein/LacI transcriptional regulator |
| M. tuberculosis H37Rv | Rv3575c | - | 3e-10 | 25.30% (328) | transcriptional regulatory protein LacI-family |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_5070 | - | 5e-11 | 25.30% (328) | PurR family transcriptional regulator |
| M. avium 104 | MAV_5263 | - | 9e-14 | 28.65% (370) | transcriptional regulator, LacI family protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4146 | - | 2e-11 | 25.61% (328) | PurR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2545 | - | 1e-29 | 32.28% (347) | periplasmic binding protein/LacI transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5070|M.marinum_M ---------MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQ--LSAEL
MUL_4146|M.ulcerans_Agy99 ---------MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQ--LSVEL
Mb3606c|M.bovis_AF2122/97 ---------MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQ--LSADL
Rv3575c|M.tuberculosis_H37Rv ---------MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQ--LSADL
Mflv_1457|M.gilvum_PYR-GCK -------MSRSPTPRRRATLASLAAELKVSRTTVSNAYNRPDQ--LSAEL
Mvan_2545|M.vanbaalenii_PYR-1 -----------MIPKQTVNMTDVARRSGVSIASVSRALRGESG--VSAAT
MSMEG_5143|M.smegmatis_MC2_155 -----MTESVGQASGSRATLATVAASAGVSIATVSKVLNGRAD--VAPAT
MAV_5263|M.avium_104 MTGPQGNGNSSSNKAARPTTADVARLAGVSTATVSYVLNNARGRRISPDT
. : :* ** :::* . . ::
MMAR_5070|M.marinum_M RERVLATAKRMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARD
MUL_4146|M.ulcerans_Agy99 RERVLATAKRMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARD
Mb3606c|M.bovis_AF2122/97 RERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARD
Rv3575c|M.tuberculosis_H37Rv RERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARD
Mflv_1457|M.gilvum_PYR-GCK RERVLSTAKRLGYPGPDPVARSLRTRRAGAVGLVITEPLNYSFSDPAALD
Mvan_2545|M.vanbaalenii_PYR-1 RDRILSAARELAYVVS-PEASRLSGGPTGRVGVIVPRVDAWFYST-----
MSMEG_5143|M.smegmatis_MC2_155 RSRVKALLAQHHYVARRTELGDLAAASADRPGPPTVELLFREDFNAYGIE
MAV_5263|M.avium_104 RDAVYRAAKLLGYRPN-LAARNLARGKSGVVLYVVPHVAVGEMPMQAGSR
*. : * * :. .
MMAR_5070|M.marinum_M FVTGVAQSCEELGQGLLLVAVGASRS----LEDGTAAVLNAGVDGFVVYS
MUL_4146|M.ulcerans_Agy99 FVTGVAQSCEELGQGLLLVAVGASRS----LEDGTAAVLNAGVDGFVVYS
Mb3606c|M.bovis_AF2122/97 FVAGVAQSCEELGQGLQLVSVGSSRS----LADGTAAVLGAGVDGFVVYS
Rv3575c|M.tuberculosis_H37Rv FVAGVAQSCEELGQGLQLVSVGSSRS----LADGTAAVLGAGVDGFVVYS
Mflv_1457|M.gilvum_PYR-GCK FVAGLAESCEAVGQGLLLVAVGPNRS----VAEGSAAVLAAGVDGFVVYS
Mvan_2545|M.vanbaalenii_PYR-1 ILAGIADEFDTVGMDLILCTLPTSAAR---HRFFEALPLRRKVDAAVVVS
MSMEG_5143|M.smegmatis_MC2_155 VVQGLLDAGCAAGVAVVVSRRPDDEGDSDGTAQWVSDLAAAGRRAVISVA
MAV_5263|M.avium_104 MTTALAR------EGLLQVQVFETDD-----DQHVVDAIANLDPVAVTSL
. .: : :
MMAR_5070|M.marinum_M VRDDDPYLQVVLQRRLPVVVVDQP-KELAGVSRVGIDDRAAMRKIADYVL
MUL_4146|M.ulcerans_Agy99 VRDDDPYLQVVLQRRLPVVVVDQP-KELAGVSRVGIDDRAAMRKIADYVL
Mb3606c|M.bovis_AF2122/97 VGDDDPYLQVVLQRRLPVVVVDQP-KDLSGVSRVGIDDRAAMRELAGYVL
Rv3575c|M.tuberculosis_H37Rv VGDDDPYLQVVLQRRLPVVVVDQP-KDLSGVSRVGIDDRAAMRELAGYVL
Mflv_1457|M.gilvum_PYR-GCK ASDDDPYLPAVMERHLPVVVVDQP-RDVPGASQVRIDDRAAMRSLAEHVI
Mvan_2545|M.vanbaalenii_PYR-1 LPLSARERTRLDQLAVPTVFVGGH-RTEDHRPWVGIDDERAAQQAVGHLL
MSMEG_5143|M.smegmatis_MC2_155 DELPEADIAALHRFGLPLVVIDPLNQPTTRITSVGSTNFSGGLAATQHLL
MAV_5263|M.avium_104 FPLSAAARRAVTEAGIPHIEIGTL-------PALNDPHLSVGEMRIAHLV
: . :* : :. . : . :::
MMAR_5070|M.marinum_M GLGHRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEA
MUL_4146|M.ulcerans_Agy99 SLGHRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEA
Mb3606c|M.bovis_AF2122/97 GLGHRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEA
Rv3575c|M.tuberculosis_H37Rv GLGHRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEA
Mflv_1457|M.gilvum_PYR-GCK DLGHREIGLLTMRLGRDWPHGPGPALADPERVRAPNFHVQCERIHGVYDA
Mvan_2545|M.vanbaalenii_PYR-1 RIGHHDIAMIQAADDTD-----------------IPWATDQARIRGFHQT
MSMEG_5143|M.smegmatis_MC2_155 SLGHRRIAYVGG---------------------PVTAACNQARLHGYRAA
MAV_5263|M.avium_104 ERGHRRIAFAYTG------------------------IARWRPLGDYWFE
**: :. : .
MMAR_5070|M.marinum_M MTAAGVDPESLTVVESYEHLPTSGGDAAKVALEANPRITALMCTADILAL
MUL_4146|M.ulcerans_Agy99 MTAAGVDPESLTVVESYEHLPTSGGDAAKVALEANPRITALMCTADILAL
Mb3606c|M.bovis_AF2122/97 MTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILAL
Rv3575c|M.tuberculosis_H37Rv MTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILAL
Mflv_1457|M.gilvum_PYR-GCK MTAAGLDPASLTLVESYEHLPTSGGAGADIALEANPRITALMCTADVLAL
Mvan_2545|M.vanbaalenii_PYR-1 MQEAGLADPTVVTVK---WSVDGGSHGMETLLSRSRPPTAVFCHSDEIAL
MSMEG_5143|M.smegmatis_MC2_155 MEEAGAAVVDG-YVRTGDFLYDNGLREGSALLDLPEPPTAVFAASDETAL
MAV_5263|M.avium_104 GVSRAARLRGLPPVRADEVILDTAASVVSAWVR--DGVTAVCAQSDEIAC
. *. . . : **: . :* *
MMAR_5070|M.marinum_M SAMDYLRGHGIYVPGQMTVTGFDGVPEAISRG--LTTVSQPSLQKGRRAG
MUL_4146|M.ulcerans_Agy99 SAMDYLRGHGIYVPGQMTVTGFDGVPEAISRG--LTTVSQPSLQKGRRAG
Mb3606c|M.bovis_AF2122/97 SAMDYLRAHGIYVPGQMTVTGFDGVPEALSRG--LTTVAQPSLHKGHRAG
Rv3575c|M.tuberculosis_H37Rv SAMDYLRAHGIYVPGQMTVTGFDGVPEALSRG--LTTVAQPSLHKGHRAG
Mflv_1457|M.gilvum_PYR-GCK SAMDHLRAKGIYVPGQMTVTGFDGVPEARQRG--LTTVAQPGVEKGRRAG
Mvan_2545|M.vanbaalenii_PYR-1 GALRTLRRSGISVPQQVSVIGVDDHPAAELSD--LTTVAQPVREQGRIAA
MSMEG_5143|M.smegmatis_MC2_155 GVIEAARSRGLRVPEDLSVVGFDDTQLARLSAPPLTTVRQPLREMGAVAM
MAV_5263|M.avium_104 LVLYGIHQAGLRCPGDLAVMGVDASPMGMVSTPPLTTVQFDPCAVADAAL
.: : *: * :::* *.* . **** . *
MMAR_5070|M.marinum_M ELLQNPPRSG-----LPVVELLDTELIRGRTAGPPA
MUL_4146|M.ulcerans_Agy99 ELLQNPPRSG-----LPVVELLDTELIRGRTAGPPA
Mb3606c|M.bovis_AF2122/97 ELLLKPPRSG-----LPVIEVLDTELVRGRTAGPPA
Rv3575c|M.tuberculosis_H37Rv ELLLKPPRSG-----LPVIEVLDTELVRGRTAGPPA
Mflv_1457|M.gilvum_PYR-GCK ELLHNPPRSG-----LPVVEVLDTEVIRGRTSGPPA
Mvan_2545|M.vanbaalenii_PYR-1 RVVLGGLGDGDASGPPASVTTLPTRLVVRGSTAPPR
MSMEG_5143|M.smegmatis_MC2_155 RTALRLADGDE---LDSHHVELATQLIARSSTARL-
MAV_5263|M.avium_104 AAVFERLGHAAP---PSPELTDIARLVVRSST----
. :.:: ::