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MTTTLTSDPVSTVLHGLLRAEQDGDAAAFAEVGEFPLDAAPAERAEVLKNVYMSVSQTGGELLYLLARAT GARTVVEYGTSFGVSTIYLASAVRDNGGGTVITTELQPGKAAAAQRSFDTAGLGDLIDLRIGDARDTLVH VPRPVDLVLLDGWPDLALPVLKVLEPHLRAGTLILVDDVNLDFGGRDLHGALLDHLATCGHYRTLTLPIG DGIEACVRLSDGAKG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5003 | - | - | 100% (225) | O-methyltransferase, family protein 3 |
| M. smegmatis MC2 155 | MSMEG_4739 | - | 3e-13 | 32.12% (137) | hypothetical protein MSMEG_4739 |
| M. smegmatis MC2 155 | MSMEG_0224 | - | 6e-12 | 33.33% (144) | O-methyltransferase MdmC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0193 | - | 9e-14 | 34.59% (159) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_0514 | - | 3e-12 | 35.19% (162) | O-methyltransferase family protein |
| M. tuberculosis H37Rv | Rv0187 | - | 9e-14 | 34.59% (159) | O-methyltransferase |
| M. leprae Br4923 | MLBr_01075 | - | 2e-08 | 29.95% (207) | putative O-methyltransferase |
| M. abscessus ATCC 19977 | MAB_3463 | - | 4e-36 | 42.62% (183) | O-methyltransferase family protein |
| M. marinum M | MMAR_0313 | - | 7e-36 | 54.41% (136) | O-methyltransferase |
| M. avium 104 | MAV_5200 | - | 5e-38 | 45.00% (180) | O-methyltransferase, family protein 3 |
| M. thermoresistible (build 8) | TH_2678 | - | 2e-13 | 36.43% (129) | PUTATIVE O-methyltransferase MdmC |
| M. ulcerans Agy99 | MUL_4809 | - | 4e-35 | 53.68% (136) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0154 | - | 5e-13 | 36.15% (130) | O-methyltransferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0514|M.gilvum_PYR-GCK ----------MTTSEWASLDNLFTSVLHSEDDVLRAA-----------RE
Mvan_0154|M.vanbaalenii_PYR-1 ----------MTAPDWVSLDELFTSVLHSEDDALREA-----------RA
TH_2678|M.thermoresistible__bu ----------VTEADPRALDALFTELLRTEDEALIAA-----------RE
Mb0193|M.bovis_AF2122/97 -------MGMDQQPNPPDVDAFLDSTLVGDDPALAAA-----------LA
Rv0187|M.tuberculosis_H37Rv -------MGMDQQPNPPDVDAFLDSTLVGDDPALAAA-----------LA
MLBr_01075|M.leprae_Br4923 MYGTGNNAVTPDQAAASRADSLFAHAEGSISEDAILA-----------SA
MMAR_0313|M.marinum_M -----MGTTLQDAKVAAALDRMYAAAANEMTALRERRAEIERLWSGDAQQ
MUL_4809|M.ulcerans_Agy99 -----MGTTLQDAKVAAALDRMYAAAANEMTALRERRAEIERLWSGDAQQ
MAV_5200|M.avium_104 -----MTTTLQDPRVASALDRMYSESKNQMSLLRQRRGTFDQPMT--AQQ
MAB_3463|M.abscessus_ATCC_1997 -----MTATLHEPKFAAIIDRLFRNAAN--DPIPTDRDTFHKKSV---EE
MSMEG_5003|M.smegmatis_MC2_155 -----MTTTLTSDPVSTVLHGLLRAEQDGDAAAFAEVGEFPLDAAP--AE
. :
Mflv_0514|M.gilvum_PYR-GCK SADAAGMPPIEVSAQHAKLLSLLVRMSRARRVLEIGTLAGYSTIALARAV
Mvan_0154|M.vanbaalenii_PYR-1 AGQAAGMPAIEVSAQHAKLLSLLVAISGARRVLEIGTLAGYSTIALARAV
TH_2678|M.thermoresistible__bu AGKAAGMPAIEVSAQHGKLLSLLTRISGARRVLEIGTLAGYSTINLARGA
Mb0193|M.bovis_AF2122/97 ASDAAELPRIAVSAQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLARGA
Rv0187|M.tuberculosis_H37Rv ASDAAELPRIAVSAQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLARGA
MLBr_01075|M.leprae_Br4923 RERSEEIGARAVTPAVGALLSLLTKLSGGKAVAEVGTGAGVSGLWLLSGM
MMAR_0313|M.marinum_M RADAMSEFYIPVTPEAGRLMYALVRAIRPTTVVEFGMSFGISTIHLAAAV
MUL_4809|M.ulcerans_Agy99 RADAMSEFYIPVTPEAGRLMYALVRAIRPTTVVEFGMSFGISTIHLAAAV
MAV_5200|M.avium_104 RADAMIEFYIPVTPEAGRLLYSLVRATRPATVVEFGMSFGISAVHLAAAV
MAB_3463|M.abscessus_ATCC_1997 RIELFENIYVPVAPDAGRLLYSLVRAIKPRTIVEYGLSYGISTLHSAAAV
MSMEG_5003|M.smegmatis_MC2_155 RAEVLKNVYMSVSQTGGELLYLLARATGARTVVEYGTSFGVSTIYLASAV
*: . :: *. : * * * * : .
Mflv_0514|M.gilvum_PYR-GCK GEGG--TVVTLEFEQRHAEVAGQNLERAGVA-DKVEIIVGAALDSLPTLQ
Mvan_0154|M.vanbaalenii_PYR-1 GPDG--TVVTLEYEPAHAQVARRNLERAGVS-DRVEIVVGAALESLPTLQ
TH_2678|M.thermoresistible__bu GADG--HVVTLEYEPAHAEVARANLERAGVA-DRVEIIVGAALDTLPTLA
Mb0193|M.bovis_AF2122/97 GPQG--RVVTLEYQPKHAEVARVNLQRAGVA-DRVEVVVGPALDTLPTLA
Rv0187|M.tuberculosis_H37Rv GPQG--RVVTLEYQPKHAEVARVNLQRAGVA-DRVEVVVGPALDTLPTLA
MLBr_01075|M.leprae_Br4923 SYDG--VLTTIDIEPEYLRLAKQAFSEAGIGPSRTRLISGRGQDVLTRLA
MMAR_0313|M.marinum_M RDNGSGRVVTTELNASKIAAAKQTFADTGLA-DVITVAEGDALATLTTVP
MUL_4809|M.ulcerans_Agy99 RDNGSGRVVTTELNASKIAAAKQTFADTELA-DVITVAEGDALATLTTVP
MAV_5200|M.avium_104 RDNGSGRVVTTELSDTKIAAAKKTFAETGLD-DVITILHGDALTTLADLP
MAB_3463|M.abscessus_ATCC_1997 RDNGFGRIITTEMNTAKIAASRATFAEAGVS-DLITILEGDARETLKTID
MSMEG_5003|M.smegmatis_MC2_155 RDNGGGTVITTELQPGKAAAAQRSFDTAGLG-DLIDLRIGDARDTLVHVP
* : * : . : : : : . : * . * :
Mflv_0514|M.gilvum_PYR-GCK QRGESFDLVFIDADKENNVSYVEWAITLGHPGTVIVVDNIARSGRVLDPA
Mvan_0154|M.vanbaalenii_PYR-1 QRGETFDLVFIDADKENNVSYVEWAVTLGRPGTVIVVDNIARNGRVLDPA
TH_2678|M.thermoresistible__bu GR-DPFDLVFIDADKENNSAYVQWAIRLGRSGTVIVVDNIARMGRVLDPA
Mb0193|M.bovis_AF2122/97 GG--PFDLVFIDADKENNVAYIQWAIRLARRGAVIVVDNVIRGGGILAES
Rv0187|M.tuberculosis_H37Rv GG--PFDLVFIDADKENNVAYIQWAIRLARRGAVIVVDNVIRGGGILAES
MLBr_01075|M.leprae_Br4923 DE--SYDLVFIDADPIDQPAYVVEGVRLLRSCGIIVVHRAALGGRAGDPA
MMAR_0313|M.marinum_M GP---VQFVLLDGWKDLYLPVVRLLEPVLPAGALILADNTESAGSR----
MUL_4809|M.ulcerans_Agy99 GP---VQFVLLDGWKDLYLPVVRLLEPVLPAGALILADNTESAGSR----
MAV_5200|M.avium_104 GP---VDFVLLDGWKDLYLPVLELLEPRLSPGVLVVADNTSAADTQ----
MAB_3463|M.abscessus_ATCC_1997 SP---IDFLLLDGWPDLDLTILNIVEDKLAPGALVIADNVGFESSK----
MSMEG_5003|M.smegmatis_MC2_155 RP---VDLVLLDGWPDLALPVLKVLEPHLRAGTLILVDDVNLDFGGRDLH
:::::*. . : :::..
Mflv_0514|M.gilvum_PYR-GCK PDDAQATAIRAMFDMMGADPRLDTAAIQTVGTKGWDGFAVALVR
Mvan_0154|M.vanbaalenii_PYR-1 PDDEQARAVRAMFDMMGANPRLDTAAIQTVGAKGWDGFAVAVVS
TH_2678|M.thermoresistible__bu PDDQQARAVRDMLAMMGEHPRLDTAAIQTVGAKNWDGFAVAVVR
Mb0193|M.bovis_AF2122/97 -DDADAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGFALALVR
Rv0187|M.tuberculosis_H37Rv -DDADAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGFALALVR
MLBr_01075|M.leprae_Br4923 ARDAEVTAVREAARLIAENERLTPALVPLG-----DGLLAAVRE
MMAR_0313|M.marinum_M -PYLDYIRDPANGYVSFNFPARSSDSMEISCRTAD---------
MUL_4809|M.ulcerans_Agy99 -PYLDYIRDPANGYVSFNFPARSSDSMEISCRTAD---------
MAV_5200|M.avium_104 -PYLDRVRNPDNGYVSFNFQVRDSDSMEISCRTSG---------
MAB_3463|M.abscessus_ATCC_1997 -PYLEYVRNPENGYVSVASPIGECMELSTSCKK-----------
MSMEG_5003|M.smegmatis_MC2_155 GALLDHLATCG-HYRTLTLPIGDGIEACVRLSDGAKG-------
: