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MTTTLQDPRVASALDRMYSESKNQMSLLRQRRGTFDQPMTAQQRADAMIEFYIPVTPEAGRLLYSLVRAT RPATVVEFGMSFGISAVHLAAAVRDNGSGRVVTTELSDTKIAAAKKTFAETGLDDVITILHGDALTTLAD LPGPVDFVLLDGWKDLYLPVLELLEPRLSPGVLVVADNTSAADTQPYLDRVRNPDNGYVSFNFQVRDSDS MEISCRTSG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5200 | - | - | 100% (219) | O-methyltransferase, family protein 3 |
| M. avium 104 | MAV_4992 | - | 2e-11 | 32.54% (126) | O-methyltransferase |
| M. avium 104 | MAV_3069 | - | 2e-11 | 31.77% (192) | catechol-O-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1729c | - | 1e-13 | 34.93% (146) | catechol-o-methyltransferase |
| M. gilvum PYR-GCK | Mflv_0514 | - | 2e-09 | 31.91% (141) | O-methyltransferase family protein |
| M. tuberculosis H37Rv | Rv1703c | - | 1e-13 | 34.93% (146) | catechol-o-methyltransferase |
| M. leprae Br4923 | MLBr_02669 | - | 2e-11 | 45.74% (94) | hypothetical protein MLBr_02669 |
| M. abscessus ATCC 19977 | MAB_3463 | - | 4e-58 | 48.61% (216) | O-methyltransferase family protein |
| M. marinum M | MMAR_0313 | - | 7e-86 | 70.91% (220) | O-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_5003 | - | 6e-38 | 45.00% (180) | O-methyltransferase, family protein 3 |
| M. thermoresistible (build 8) | TH_1541 | - | 2e-09 | 28.36% (201) | Probable catechol-o-methyltransferase |
| M. ulcerans Agy99 | MUL_4809 | - | 4e-85 | 70.45% (220) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0154 | - | 3e-07 | 30.23% (129) | O-methyltransferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0313|M.marinum_M MGTTLQDAKVAAALDRMYAAAANEMTALRERRAEIERLWSGDAQQRADAM
MUL_4809|M.ulcerans_Agy99 MGTTLQDAKVAAALDRMYAAAANEMTALRERRAEIERLWSGDAQQRADAM
MAV_5200|M.avium_104 MTTTLQDPRVASALDRMYSESKNQMSLLRQRRGTFDQPMT--AQQRADAM
MAB_3463|M.abscessus_ATCC_1997 MTATLHEPKFAAIIDRLFRNAAN--DPIPTDRDTFHKKSV---EERIELF
MLBr_02669|M.leprae_Br4923 MTSYIIHTSIP---------------------------------------
MSMEG_5003|M.smegmatis_MC2_155 MTTTLTSDPVSTVLHGLLRAEQDGDAAAFAEVGEFPLDAAP--AERAEVL
Mb1729c|M.bovis_AF2122/97 ---------------------------------------MLATIDKFAYE
Rv1703c|M.tuberculosis_H37Rv ---------------------------------------MLATIDKFAYE
TH_1541|M.thermoresistible__bu --MTMTQHRLTTTGQIGDGREAAAADYVERHARPGDIDDVLDIIDEYAYR
Mflv_0514|M.gilvum_PYR-GCK ----------------MTTSEWASLDNLFTSVLHSEDDVLRAARESADAA
Mvan_0154|M.vanbaalenii_PYR-1 ----------------MTAPDWVSLDELFTSVLHSEDDALREARAAGQAA
MMAR_0313|M.marinum_M SEFYIPVTPEAGRLMYALVRAIRPTTVVEFGMSFGISTIHLAAAVR--DN
MUL_4809|M.ulcerans_Agy99 SEFYIPVTPEAGRLMYALVRAIRPTTVVEFGMSFGISTIHLAAAVR--DN
MAV_5200|M.avium_104 IEFYIPVTPEAGRLLYSLVRATRPATVVEFGMSFGISAVHLAAAVR--DN
MAB_3463|M.abscessus_ATCC_1997 ENIYVPVAPDAGRLLYSLVRAIKPRTIVEYGLSYGISTLHSAAAVR--DN
MLBr_02669|M.leprae_Br4923 -------HPEAGLLLTYWYGLIRTNTVVEFGTSFSSHAIHLAAVIRPHND
MSMEG_5003|M.smegmatis_MC2_155 KNVYMSVSQTGGELLYLLARATGARTVVEYGTSFGVSTIYLASAVR--DN
Mb1729c|M.bovis_AF2122/97 KSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAA-----
Rv1703c|M.tuberculosis_H37Rv KSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAA-----
TH_1541|M.thermoresistible__bu KSFLVNIGDEKGLLLDAAVRRADPELALELGTYCGYGALRIARAA-----
Mflv_0514|M.gilvum_PYR-GCK GMPPIEVSAQHAKLLSLLVRMSRARRVLEIGTLAGYSTIALARAVG----
Mvan_0154|M.vanbaalenii_PYR-1 GMPAIEVSAQHAKLLSLLVAISGARRVLEIGTLAGYSTIALARAVG----
. *: . :* * . :: * .
MMAR_0313|M.marinum_M GSGRVVTTELNASKIAAAKQTFADTGLADVITVAEG---DALATLTTVP-
MUL_4809|M.ulcerans_Agy99 GSGRVVTTELNASKIAAAKQTFADTELADVITVAEG---DALATLTTVP-
MAV_5200|M.avium_104 GSGRVVTTELSDTKIAAAKKTFAETGLDDVITILHG---DALTTLADLP-
MAB_3463|M.abscessus_ATCC_1997 GFGRIITTEMNTAKIAASRATFAEAGVSDLITILEG---DARETLKTID-
MLBr_02669|M.leprae_Br4923 SGDWSVPAELSATKSAGAKQMFNTNGLNYLITVLKE---RYASNLVKIH-
MSMEG_5003|M.smegmatis_MC2_155 GGGTVITTELQPGKAAAAQRSFDTAGLGDLIDLRIG---DARDTLVHVP-
Mb1729c|M.bovis_AF2122/97 PEARVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALT-
Rv1703c|M.tuberculosis_H37Rv PEARVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALT-
TH_1541|M.thermoresistible__bu PAARVISVELAEANAQVARRIWAHAGVSDRISCVVGTIDDGGRTLEALNR
Mflv_0514|M.gilvum_PYR-GCK EGGTVVTLEFEQRHAEVAGQNLERAGVADKVEIIVGAALDSLPTLQQRG-
Mvan_0154|M.vanbaalenii_PYR-1 PDGTVVTLEYEPAHAQVARRNLERAGVSDRVEIVVGAALESLPTLQQRG-
. * : : : : .*
MMAR_0313|M.marinum_M ------GPVQFVLLDGWKDLYLPVVR--LLEPVLPAGALILADNT----E
MUL_4809|M.ulcerans_Agy99 ------GPVQFVLLDGWKDLYLPVVR--LLEPVLPAGALILADNT----E
MAV_5200|M.avium_104 ------GPVDFVLLDGWKDLYLPVLE--LLEPRLSPGVLVVADNT----S
MAB_3463|M.abscessus_ATCC_1997 ------SPIDFLLLDGWPDLDLTILN--IVEDKLAPGALVIADNV----G
MLBr_02669|M.leprae_Br4923 ------RSVEFV--------------------------------------
MSMEG_5003|M.smegmatis_MC2_155 ------RPVDLVLLDGWPDLALPVLK--VLEPHLRAGTLILVDDVNLDFG
Mb1729c|M.bovis_AF2122/97 EHGFATGTLDFVFLDHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGA
Rv1703c|M.tuberculosis_H37Rv EHGFATGTLDFVFLDHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGA
TH_1541|M.thermoresistible__bu EHKVSAAALGLVFLDHNKERYLPDLRTIMDQGWLRPGAVVVADNVRLPGS
Mflv_0514|M.gilvum_PYR-GCK ------ESFDLVFIDADKENNVSYVEWAITLG--HPGTVIVVDNIARSGR
Mvan_0154|M.vanbaalenii_PYR-1 ------ETFDLVFIDADKENNVSYVEWAVTLG--RPGTVIVVDNIARNGR
.. ::
MMAR_0313|M.marinum_M SAGSRPYLDYIRDPANGYVSFNFPARSSDSMEISCRTAD----------
MUL_4809|M.ulcerans_Agy99 SAGSRPYLDYIRDPANGYVSFNFPARSSDSMEISCRTAD----------
MAV_5200|M.avium_104 AADTQPYLDRVRNPDNGYVSFNFQVRDSDSMEISCRTSG----------
MAB_3463|M.abscessus_ATCC_1997 FESSKPYLEYVRNPENGYVSVASPIGECMELSTSCKK------------
MLBr_02669|M.leprae_Br4923 -------------------------------------------------
MSMEG_5003|M.smegmatis_MC2_155 GRDLHGALLDHLATCGHYRTLTLPIGDGIEACVRLSDGAKG--------
Mb1729c|M.bovis_AF2122/97 PKYRAYMRRQQGMSWNTIEHK-THLEYQTLVPDLVLESEYLG-------
Rv1703c|M.tuberculosis_H37Rv PKYRAYMRRQQGMSWNTIEHK-THLEYQTLVPDLVLESEYLG-------
TH_1541|M.thermoresistible__bu PRYRAYMREQQGITWRTTEHK-THGEYGIELPDLVLESVYLGG------
Mflv_0514|M.gilvum_PYR-GCK VLDPAPDDAQATAIRAMFDMMGADPRLDTAAIQTVGTKGWDGFAVALVR
Mvan_0154|M.vanbaalenii_PYR-1 VLDPAPDDEQARAVRAMFDMMGANPRLDTAAIQTVGAKGWDGFAVAVVS