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LGMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIAVSAQQGKFLCLLAGAIQARRVLEIGTL GGFSTIWLARGAGPQGRVVTLEYQPKHAEVARVNLQRAGVADRVEVVVGPALDTLPTLAGGPFDLVFIDA DKENNVAYIQWAIRLARRGAVIVVDNVIRGGGILAESDDADAVAARRTLQMMGEHPGLDATAIQTVGRKG WDGFALALVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0187 | - | - | 100% (220) | PROBABLE O-METHYLTRANSFERASE |
| M. tuberculosis H37Rv | Rv1220c | - | 1e-20 | 34.09% (176) | methyltransferase |
| M. tuberculosis H37Rv | Rv1703c | - | 1e-08 | 33.09% (136) | catechol-o-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0193 | - | 1e-122 | 100.00% (220) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_0514 | - | 3e-62 | 59.91% (212) | O-methyltransferase family protein |
| M. leprae Br4923 | MLBr_01075 | - | 2e-18 | 31.67% (180) | putative O-methyltransferase |
| M. abscessus ATCC 19977 | MAB_4548 | - | 3e-59 | 56.94% (209) | O-methyltransferase |
| M. marinum M | MMAR_4217 | - | 4e-18 | 33.77% (154) | methyltransferase |
| M. avium 104 | MAV_4992 | - | 2e-85 | 73.85% (218) | O-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_0224 | - | 3e-70 | 64.95% (214) | O-methyltransferase MdmC |
| M. thermoresistible (build 8) | TH_2678 | - | 2e-70 | 65.44% (217) | PUTATIVE O-methyltransferase MdmC |
| M. ulcerans Agy99 | MUL_4520 | - | 2e-17 | 33.12% (154) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0154 | - | 1e-63 | 59.72% (216) | O-methyltransferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0187|M.tuberculosis_H37Rv -------MGMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIA
Mb0193|M.bovis_AF2122/97 -------MGMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIA
MAV_4992|M.avium_104 ---------MTEKPTPKDVDAFLDSTVVGGDPSVIDALEASSAAGLPPIA
MAB_4548|M.abscessus_ATCC_1997 --------MADADTRWIKIDDYLERTVATDAAELNPIRQAQEDGGLPDIA
MSMEG_0224|M.smegmatis_MC2_155 ------------MAEPSDVDVLFNQLLQTEDQALAAARESTQAAGMPAIE
TH_2678|M.thermoresistible__bu ----------VTEADPRALDALFTELLRTEDEALIAAREAGKAAGMPAIE
Mflv_0514|M.gilvum_PYR-GCK ----------MTTSEWASLDNLFTSVLHSEDDVLRAARESADAAGMPPIE
Mvan_0154|M.vanbaalenii_PYR-1 ----------MTAPDWVSLDELFTSVLHSEDDALREARAAGQAAGMPAIE
MMAR_4217|M.marinum_M MHGTDSSSDTPGQPAPSRAELLSAHAEGSISEDTILKTARDRAVDIGVGA
MUL_4520|M.ulcerans_Agy99 MHGTDSSSDTPGQPAPSRAELLSAHAEGSISEDTILKTARDRAVDIGVGA
MLBr_01075|M.leprae_Br4923 MYGTGNNAVTPDQAAASRADSLFAHAEGSISEDAILASARERSEEIGARA
. : :
Rv0187|M.tuberculosis_H37Rv VSAQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLARGAGPQGRVVTLEY
Mb0193|M.bovis_AF2122/97 VSAQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLARGAGPQGRVVTLEY
MAV_4992|M.avium_104 VSVQQGKFLSLLATAMGARRILELGTLGGFSTIWLARGAGPQGRVVTLEY
MAB_4548|M.abscessus_ATCC_1997 VSATQGKFLYLLATIAKARRVLEIGTLGGYSTAWLAKAVGPEGAVVTLEF
MSMEG_0224|M.smegmatis_MC2_155 VSAQHGKLLSLLAGISGARRVLEIGTLAGYSTINLARGVGADGRVVTCEY
TH_2678|M.thermoresistible__bu VSAQHGKLLSLLTRISGARRVLEIGTLAGYSTINLARGAGADGHVVTLEY
Mflv_0514|M.gilvum_PYR-GCK VSAQHAKLLSLLVRMSRARRVLEIGTLAGYSTIALARAVGEGGTVVTLEF
Mvan_0154|M.vanbaalenii_PYR-1 VSAQHAKLLSLLVAISGARRVLEIGTLAGYSTIALARAVGPDGTVVTLEY
MMAR_4217|M.marinum_M VTPAVGALLSMLAKLSGGKAVAEVGTGAGVSGLWLLSGMSDDGVLTTIDI
MUL_4520|M.ulcerans_Agy99 VTPAVGALLSMLAKLSGGKAVAEVGTGAGVSGLWLLSGMSDDGVLTTIDI
MLBr_01075|M.leprae_Br4923 VTPAVGALLSLLTKLSGGKAVAEVGTGAGVSGLWLLSGMSYDGVLTTIDI
*: . :* :*. .: : *:** .* * * . . * :.* :
Rv0187|M.tuberculosis_H37Rv QPKHAEVARVNLQRAGVA-DRVEVVVGPALDTLPTLAGG--PFDLVFIDA
Mb0193|M.bovis_AF2122/97 QPKHAEVARVNLQRAGVA-DRVEVVVGPALDTLPTLAGG--PFDLVFIDA
MAV_4992|M.avium_104 EPKHAEVARANLQRAGLA-DRVEVIVGAALDTLPSVTG---PFDLVFIDA
MAB_4548|M.abscessus_ATCC_1997 DPKHAAVAQASLVEAGLG-DRVRVLVGAALESLPAVEG---PFDLVFIDA
MSMEG_0224|M.smegmatis_MC2_155 EPRHAEVARANLERAGVA-GRVEILVGTALDTLPKLAERGDVFDLVFIDA
TH_2678|M.thermoresistible__bu EPAHAEVARANLERAGVA-DRVEIIVGAALDTLPTLAGR-DPFDLVFIDA
Mflv_0514|M.gilvum_PYR-GCK EQRHAEVAGQNLERAGVA-DKVEIIVGAALDSLPTLQQRGESFDLVFIDA
Mvan_0154|M.vanbaalenii_PYR-1 EPAHAQVARRNLERAGVS-DRVEIVVGAALESLPTLQQRGETFDLVFIDA
MMAR_4217|M.marinum_M EPEHLRVAKQAFTEAGIGPSRTRLISGRAQEVLTRLADD--SYDLVFVDA
MUL_4520|M.ulcerans_Agy99 EPEHLRVAKQAFTEAGIGPSRTRLISGRAQEVLTRLADD--SYDLVFVDA
MLBr_01075|M.leprae_Br4923 EPEYLRLAKQAFSEAGIGPSRTRLISGRGQDVLTRLADE--SYDLVFIDA
: : :* : .**:. .:..:: * . : *. : :****:**
Rv0187|M.tuberculosis_H37Rv DKENNVAYIQWAIRLARRGAVIVVDNVIRGGGILAESDDA-DAVAARRTL
Mb0193|M.bovis_AF2122/97 DKENNVAYIQWAIRLARRGAVIVVDNVIRGGGILAESDDA-DAVAARRTL
MAV_4992|M.avium_104 DKENYPAYLDWAVRLARPGAVIVADNVIRQGQILEPEADA-LARAVRQTL
MAB_4548|M.abscessus_ATCC_1997 DKSNNPGYLDWALRLTEPGAVIVVDNVIR----WIGEEGP-NAEGTRAAL
MSMEG_0224|M.smegmatis_MC2_155 DKENNVAYVEWAIKLGHPGTVVVVDNVTRFGRVLEPAPDDLQARGVRDML
TH_2678|M.thermoresistible__bu DKENNSAYVQWAIRLGRSGTVIVVDNIARMGRVLDPAPDDQQARAVRDML
Mflv_0514|M.gilvum_PYR-GCK DKENNVSYVEWAITLGHPGTVIVVDNIARSGRVLDPAPDDAQATAIRAMF
Mvan_0154|M.vanbaalenii_PYR-1 DKENNVSYVEWAVTLGRPGTVIVVDNIARNGRVLDPAPDDEQARAVRAMF
MMAR_4217|M.marinum_M DPIDQPDYVVEGVRLLRSGGVIVVHRAALGGRAGDPAARDAEVTAVREAA
MUL_4520|M.ulcerans_Agy99 DPIDQPDYVVEGVRLLRSGGVIVVHRAALGDRAGDPAVRDAEVTAVREAA
MLBr_01075|M.leprae_Br4923 DPIDQPAYVVEGVRLLRSCGIIVVHRAALGGRAGDPAARDAEVTAVREAA
* : *: .: * . ::*... . . *
Rv0187|M.tuberculosis_H37Rv QMMGEHPGLDATAIQTVGRKGWDGFALALVR
Mb0193|M.bovis_AF2122/97 QMMGEHPGLDATAIQTVGRKGWDGFALALVR
MAV_4992|M.avium_104 QAMGEHPRLDTAVIQTVGAKHWDGFAFAVVR
MAB_4548|M.abscessus_ATCC_1997 ERLGSDPRLDATALQTVGVKGWDGLAIAVVR
MSMEG_0224|M.smegmatis_MC2_155 QMMGEHPRLDAAAIQTVGAKGWDGFAVAVIS
TH_2678|M.thermoresistible__bu AMMGEHPRLDTAAIQTVGAKNWDGFAVAVVR
Mflv_0514|M.gilvum_PYR-GCK DMMGADPRLDTAAIQTVGTKGWDGFAVALVR
Mvan_0154|M.vanbaalenii_PYR-1 DMMGANPRLDTAAIQTVGAKGWDGFAVAVVS
MMAR_4217|M.marinum_M RLIAEDERLTPALVPLG-----DGVLAAVRD
MUL_4520|M.ulcerans_Agy99 RLIAEDERLTPALVPLG-----DGVLAAVRD
MLBr_01075|M.leprae_Br4923 RLIAENERLTPALVPLG-----DGLLAAVRE
:. . * .: : **. *: