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GTTLQDAKVAAALDRMYAAAANEMTALRERRAEIERLWSGDAQQRADAMSEFYIPVTPEAGRLMYALVRA IRPTTVVEFGMSFGISTIHLAAAVRDNGSGRVVTTELNASKIAAAKQTFADTGLADVITVAEGDALATLT TVPGPVQFVLLDGWKDLYLPVVRLLEPVLPAGALILADNTESAGSRPYLDYIRDPANGYVSFNFPARSSD SMEISCRTAD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0313 | - | - | 100% (221) | O-methyltransferase |
| M. marinum M | MMAR_2507 | - | 4e-10 | 31.58% (152) | O-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0193 | - | 3e-10 | 32.14% (140) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_3499 | - | 2e-09 | 29.41% (153) | catechol O-methyltransferase |
| M. tuberculosis H37Rv | Rv0187 | - | 3e-10 | 32.14% (140) | O-methyltransferase |
| M. leprae Br4923 | MLBr_02669 | - | 1e-11 | 45.74% (94) | hypothetical protein MLBr_02669 |
| M. abscessus ATCC 19977 | MAB_3463 | - | 2e-57 | 46.79% (218) | O-methyltransferase family protein |
| M. avium 104 | MAV_5200 | - | 6e-86 | 70.91% (220) | O-methyltransferase, family protein 3 |
| M. smegmatis MC2 155 | MSMEG_5003 | - | 7e-36 | 54.41% (136) | O-methyltransferase, family protein 3 |
| M. thermoresistible (build 8) | TH_1541 | - | 2e-09 | 28.32% (173) | Probable catechol-o-methyltransferase |
| M. ulcerans Agy99 | MUL_4809 | - | 1e-121 | 99.55% (221) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0154 | - | 2e-06 | 28.25% (177) | O-methyltransferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0313|M.marinum_M -------MGTTLQDAKVAAALDRMYAAAANEMTALRERRAEIERLWSGDA
MUL_4809|M.ulcerans_Agy99 -------MGTTLQDAKVAAALDRMYAAAANEMTALRERRAEIERLWSGDA
MAV_5200|M.avium_104 -------MTTTLQDPRVASALDRMYSESKNQMSLLRQRRGTFDQPMT--A
MAB_3463|M.abscessus_ATCC_1997 -------MTATLHEPKFAAIIDRLFRNAAN--DPIPTDRDTFHKKSV---
MLBr_02669|M.leprae_Br4923 -------MTSYIIHTSIP--------------------------------
MSMEG_5003|M.smegmatis_MC2_155 -------MTTTLTSDPVSTVLHGLLRAEQDGDAAAFAEVGEFPLDAAP--
Mb0193|M.bovis_AF2122/97 --------------------MGMDQQPNPPDVDAFLDSTLVGDDPALAAA
Rv0187|M.tuberculosis_H37Rv --------------------MGMDQQPNPPDVDAFLDSTLVGDDPALAAA
Mvan_0154|M.vanbaalenii_PYR-1 ----------------------MT-APDWVSLDELFTSVLHSEDDALREA
Mflv_3499|M.gilvum_PYR-GCK MNALRRWARLALGMRSFVRTGQMGDGRESACADHVETHAAPGDIDAALSA
TH_1541|M.thermoresistible__bu ---------MTMTQHRLTTTGQIGDGREAAAADYVERHARPGDIDDVLDI
MMAR_0313|M.marinum_M QQRADAMSEFYIPVTPEAGRLMYALVRAIRPTTVVEFGMSFGISTIHLAA
MUL_4809|M.ulcerans_Agy99 QQRADAMSEFYIPVTPEAGRLMYALVRAIRPTTVVEFGMSFGISTIHLAA
MAV_5200|M.avium_104 QQRADAMIEFYIPVTPEAGRLLYSLVRATRPATVVEFGMSFGISAVHLAA
MAB_3463|M.abscessus_ATCC_1997 EERIELFENIYVPVAPDAGRLLYSLVRAIKPRTIVEYGLSYGISTLHSAA
MLBr_02669|M.leprae_Br4923 --------------HPEAGLLLTYWYGLIRTNTVVEFGTSFSSHAIHLAA
MSMEG_5003|M.smegmatis_MC2_155 AERAEVLKNVYMSVSQTGGELLYLLARATGARTVVEYGTSFGVSTIYLAS
Mb0193|M.bovis_AF2122/97 LAASDAAELPRIAVSAQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLAR
Rv0187|M.tuberculosis_H37Rv LAASDAAELPRIAVSAQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLAR
Mvan_0154|M.vanbaalenii_PYR-1 RAAGQAAGMPAIEVSAQHAKLLSLLVAISGARRVLEIGTLAGYSTIALAR
Mflv_3499|M.gilvum_PYR-GCK IDGFAVREAVLVNVGVEKGALLDAAVRRADPALALELGTYCGYSALRIAR
TH_1541|M.thermoresistible__bu IDEYAYRKSFLVNIGDEKGLLLDAAVRRADPELALELGTYCGYGALRIAR
. :: . :* * . :: *
MMAR_0313|M.marinum_M AVR--DNGSGRVVTTELNASKIAAAKQTFADTGLADVITVAEGDALATLT
MUL_4809|M.ulcerans_Agy99 AVR--DNGSGRVVTTELNASKIAAAKQTFADTELADVITVAEGDALATLT
MAV_5200|M.avium_104 AVR--DNGSGRVVTTELSDTKIAAAKKTFAETGLDDVITILHGDALTTLA
MAB_3463|M.abscessus_ATCC_1997 AVR--DNGFGRIITTEMNTAKIAASRATFAEAGVSDLITILEGDARETLK
MLBr_02669|M.leprae_Br4923 VIRPHNDSGDWSVPAELSATKSAGAKQMFNTNGLNYLITVLKERYASNLV
MSMEG_5003|M.smegmatis_MC2_155 AVR--DNGGGTVITTELQPGKAAAAQRSFDTAGLGDLIDLRIGDARDTLV
Mb0193|M.bovis_AF2122/97 GAG----PQGRVVTLEYQPKHAEVARVNLQRAGVADRVEVVVGPALDTLP
Rv0187|M.tuberculosis_H37Rv GAG----PQGRVVTLEYQPKHAEVARVNLQRAGVADRVEVVVGPALDTLP
Mvan_0154|M.vanbaalenii_PYR-1 AVG----PDGTVVTLEYEPAHAQVARRNLERAGVSDRVEIVVGAALESLP
Mflv_3499|M.gilvum_PYR-GCK -AA----PSARVLSVEFSAANAEVARRIWTHAGVADRVTCVVGTLGDGGR
TH_1541|M.thermoresistible__bu -AA----PAARVISVELAEANAQVARRIWAHAGVSDRISCVVGTIDDGGR
:. * : :: : :
MMAR_0313|M.marinum_M TVP----------GPVQFVLLDGWKDLYLPVVRLLEPVL--PAGALILAD
MUL_4809|M.ulcerans_Agy99 TVP----------GPVQFVLLDGWKDLYLPVVRLLEPVL--PAGALILAD
MAV_5200|M.avium_104 DLP----------GPVDFVLLDGWKDLYLPVLELLEPRL--SPGVLVVAD
MAB_3463|M.abscessus_ATCC_1997 TID----------SPIDFLLLDGWPDLDLTILNIVEDKL--APGALVIAD
MLBr_02669|M.leprae_Br4923 KIH----------RSVEFV-------------------------------
MSMEG_5003|M.smegmatis_MC2_155 HVP----------RPVDLVLLDGWPDLALPVLKVLEPHL--RAGTLILVD
Mb0193|M.bovis_AF2122/97 TLA---------GGPFDLVFIDADKENNVAYIQWAIRLA--RRGAVIVVD
Rv0187|M.tuberculosis_H37Rv TLA---------GGPFDLVFIDADKENNVAYIQWAIRLA--RRGAVIVVD
Mvan_0154|M.vanbaalenii_PYR-1 TLQQR-------GETFDLVFIDADKENNVSYVEWAVTLG--RPGTVIVVD
Mflv_3499|M.gilvum_PYR-GCK TLDSLAGEHGVGPGSVDLLFIDHDNSAYLSDLLSIEQRGWLHRGSLVVAD
TH_1541|M.thermoresistible__bu TLEALNREHKVSAAALGLVFLDHNKERYLPDLRTIMDQGWLRPGAVVVAD
: .. ::
MMAR_0313|M.marinum_M NT----ESAGSRPYLDYIRDPANGYVSFNFPARSSDSMEISCRTAD----
MUL_4809|M.ulcerans_Agy99 NT----ESAGSRPYLDYIRDPANGYVSFNFPARSSDSMEISCRTAD----
MAV_5200|M.avium_104 NT----SAADTQPYLDRVRNPDNGYVSFNFQVRDSDSMEISCRTSG----
MAB_3463|M.abscessus_ATCC_1997 NV----GFESSKPYLEYVRNPENGYVSVASPIGECMELSTSCKK------
MLBr_02669|M.leprae_Br4923 --------------------------------------------------
MSMEG_5003|M.smegmatis_MC2_155 DVNLDFGGRDLHGALLDHLATCGHYRTLTLPIGDGIEACVRLSDGAKG--
Mb0193|M.bovis_AF2122/97 NVIRGGGILAES-DDADAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGF
Rv0187|M.tuberculosis_H37Rv NVIRGGGILAES-DDADAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGF
Mvan_0154|M.vanbaalenii_PYR-1 NIARNGRVLDPAPDDEQARAVRAMFDMMGANPRLDTAAIQTVGAKGWDGF
Mflv_3499|M.gilvum_PYR-GCK NVRIPGAPEYRRYMREHEGTRWHTVEHKTHVEYQSLLPDLVLESEYLVGS
TH_1541|M.thermoresistible__bu NVRLPGSPRYRAYMREQQGITWRTTEHKTHGEYGIELPDLVLESVYLGG-
MMAR_0313|M.marinum_M ------
MUL_4809|M.ulcerans_Agy99 ------
MAV_5200|M.avium_104 ------
MAB_3463|M.abscessus_ATCC_1997 ------
MLBr_02669|M.leprae_Br4923 ------
MSMEG_5003|M.smegmatis_MC2_155 ------
Mb0193|M.bovis_AF2122/97 ALALVR
Rv0187|M.tuberculosis_H37Rv ALALVR
Mvan_0154|M.vanbaalenii_PYR-1 AVAVVS
Mflv_3499|M.gilvum_PYR-GCK ------
TH_1541|M.thermoresistible__bu ------