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TDFRRVAHDVCNWGRWGEADELGTLNFITADKVAEAASLVKQGKVFALGADFGSAGPQGAFQFRQNPTHV MTVDGGDAATLTKYGPQWLLNSVAHQVSEFFVDNPFRFNDDMIVMPLQAATQWDALSHVYYEDRLYNGFP ADSVTSFGAFHCSIDKVDVKGITSRGVLLDVVRHRGAEVFLEPGNPVTPEELDAVAAAQGVQIRRGDIVV VHTGWWTRFLSAGDGAEPGSGLDWRCASWLHDHEVAAVAADNLMVEDPDPASGVEGTFLPMHMLCLRDMG LMLGEYWDLTALSADCAADGVYEFQLIAPPLRVTGAVGSPVNPIAIK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4861 | - | - | 100% (328) | cyclase |
| M. smegmatis MC2 155 | MSMEG_4048 | - | 4e-64 | 45.20% (323) | cyclase |
| M. smegmatis MC2 155 | MSMEG_3991 | - | 2e-20 | 34.25% (219) | cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1744 | - | 3e-05 | 24.76% (105) | hypothetical protein Mb1744 |
| M. gilvum PYR-GCK | Mflv_2406 | - | 1e-157 | 78.35% (328) | hypothetical protein Mflv_2406 |
| M. tuberculosis H37Rv | Rv1716 | - | 3e-05 | 24.76% (105) | hypothetical protein Rv1716 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3566c | - | 2e-52 | 37.19% (320) | putative cyclase |
| M. marinum M | MMAR_4772 | - | 1e-156 | 77.74% (328) | hypothetical protein MMAR_4772 |
| M. avium 104 | MAV_0883 | - | 1e-148 | 75.91% (328) | putative cyclase superfamily protein |
| M. thermoresistible (build 8) | TH_0900 | - | 1e-176 | 89.63% (328) | cyclase |
| M. ulcerans Agy99 | MUL_0343 | - | 1e-157 | 77.74% (328) | hypothetical protein MUL_0343 |
| M. vanbaalenii PYR-1 | Mvan_4240 | - | 1e-160 | 79.88% (328) | hypothetical protein Mvan_4240 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4861|M.smegmatis_MC2_155 --------MTDFRRVAHDVCNWGRWGEADELGTLNFITADKVAEAASLVK
TH_0900|M.thermoresistible__bu VKPMSTASMTEFRRVADQVRNWGRWGTDDELGTLNFITAEKVTEAAGLVR
Mflv_2406|M.gilvum_PYR-GCK ----MTGTMADFRKAADEVRNWGRWGDDDEVGTLNFITPEKVAEAARLVT
Mvan_4240|M.vanbaalenii_PYR-1 ----MTGTMKDFRRVADEVRNWGRWGDDDEVGTLNFITPAKVAEAAGLVK
MMAR_4772|M.marinum_M -----MADMTEFRRVARELSNWGRWGDADELGTLNFITAEKVQRAASLVR
MUL_0343|M.ulcerans_Agy99 ----MMADMTEFRRVARELSNWGRWGDADELGTLNFITAEKVQRAASLVR
MAV_0883|M.avium_104 -----MASVTDFRRAARDVSNWGRWGDDDELGTLNFITEEKIAQAASLVQ
MAB_3566c|M.abscessus_ATCC_199 ----MGDDLAVLESYIQRCSNWGRWGSQDQLGTVNLITQEKIREAATLVK
Mb1744|M.bovis_AF2122/97 ---------------------------------MTFAWPLGAAEST----
Rv1716|M.tuberculosis_H37Rv ---------------------------------MTFAWPLGAAEST----
:.: .::
MSMEG_4861|M.smegmatis_MC2_155 QGKVFALGADFGSAGPQGAFQFRQNPTHVMTVDGGDAATLTKYGPQWLLN
TH_0900|M.thermoresistible__bu QGKVFALGGDFGSAGPQGAFQFRQNPVHVMTVDGGDINTLAQYGPQWLRN
Mflv_2406|M.gilvum_PYR-GCK QGKVISLGGDFSSGGPQGAFKFRQNPVHVMTVDGGDASTLVEYGPKWLRN
Mvan_4240|M.vanbaalenii_PYR-1 QGKVISLGGDFSSGGPQGAFKFRQNPVHVMTVDGGDASTLVEYGPQWLRN
MMAR_4772|M.marinum_M HGKVFALGVDFGSSGPQGAFGFRHNPIHLMTIDGGDASSLAQYGPGWEQN
MUL_0343|M.ulcerans_Agy99 HGKVFALGVDFGSSGPQGAFGFRHNPIHLMTIDGGDASSLAQYGPGWEQN
MAV_0883|M.avium_104 HGKVFPLGVDFGSSGPQGAFGFRHNPIHVMTVDGGDAATLAQYGPGWDRN
MAB_3566c|M.abscessus_ATCC_199 VGKTISLTMAYDADGPQNGYLGRANP-QLYQLTSGPGYLVGEQ--QQVET
Mb1744|M.bovis_AF2122/97 -LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSR--VLTQKITTVMHS
Rv1716|M.tuberculosis_H37Rv -LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSR--VLTQKITTVMHS
: * :. .* : : :: : . : : .
MSMEG_4861|M.smegmatis_MC2_155 SVAHQVSEFFVDNPFRFNDDMIVMPLQAATQWDALSHVYYEDRLYNGFPA
TH_0900|M.thermoresistible__bu SVAHQVSEFFVDNPFRFNDDMIVMPLQAATQWDALSHVYYDDQLYNGFPA
Mflv_2406|M.gilvum_PYR-GCK AVAADMSAFFADNPFRFNDDIIVMPLQAATQWDAMSHVYYEDKLYNGFPA
Mvan_4240|M.vanbaalenii_PYR-1 AVAADMSAFFADNPFRFNDDIIVMPLQAATQWDAMSHVYYEDKLYNGFPA
MMAR_4772|M.marinum_M PTAREMGKYVVDNPFRFNDDMIIMPLQAATQWDALSHVYYDDQLYNGFPA
MUL_0343|M.ulcerans_Agy99 PTAREMGKYLVDNPFRFNDDMIIMPLQAATQWDALSHVYYDDQLYNGFPA
MAV_0883|M.avium_104 PTAAQMGPYFVDNLFRFNDDMIIMPLQAATQWDALSHVYYDDLLYNGVPA
MAB_3566c|M.abscessus_ATCC_199 QTLTELRKTSGEPTAGYYDDVLVMPTQSGTQWDALCHFFWRGKMYNGHRV
Mb1744|M.bovis_AF2122/97 GTHIDAPAHVVEGTP-FLDEIPLS-------------AFFGTGVVVSIPK
Rv1716|M.tuberculosis_H37Rv GTHIDAPAHVVEGTP-FLDEIPLS-------------AFFGTGVVVSIPK
. : : : *:: : :: : .
MSMEG_4861|M.smegmatis_MC2_155 DSVTSFGAFHCSIDKVDVKGITSRGVLLDVVRHRGAEVFLEPGNPVTPEE
TH_0900|M.thermoresistible__bu GSVTSFGAFHCGIDKVDHKGITSRGVLLDVVRHRGAEVFLEPGQPVTPEE
Mflv_2406|M.gilvum_PYR-GCK DSVTSFGAFHLGIEKVDRKGITSRGVLLDVVAHRGADVFCEPGEPITPDE
Mvan_4240|M.vanbaalenii_PYR-1 DSVTSFGAFHLGIEKVDNKGITSRGVLLDVVAHRGVDTFCQPGAPITPDE
MMAR_4772|M.marinum_M DSVTSLGAYHCGIDKVDVKGITSRGVLLDLVRHRGAEVFLEHGNPITPEE
MUL_0343|M.ulcerans_Agy99 DSVTSLGAYHCGIDKVDVKGITSRGVLLDLVRHRGAEVFLEHGNPITPEE
MAV_0883|M.avium_104 GSVTSLGARRLGIEKVDGKGITSRGVLLDLVRHRGAAVFLEHGNPITPEE
MAB_3566c|M.abscessus_ATCC_199 ADAGTGGSRSNGVQNYTGR-IITRGVFVDLAEYWGVET-LDPGYPITTAD
Mb1744|M.bovis_AF2122/97 GKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYAYSPGFDKK
Rv1716|M.tuberculosis_H37Rv GKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYAYSPGFDKK
. : . : * . . . * .
MSMEG_4861|M.smegmatis_MC2_155 LDAVAAAQGVQIRRGDIVVVHTGWWTRFLSAG--DGAEPGSGLDWRCASW
TH_0900|M.thermoresistible__bu LDEVAAAQGVTIRSGDIVVVHTGWWTRFLSTG--DGAEPGSGLHWRCAIW
Mflv_2406|M.gilvum_PYR-GCK LDEIVARQQVEIRSGDIVVVHTGWWTRFLATR--DGGEAGSGLHWTCAKW
Mvan_4240|M.vanbaalenii_PYR-1 LDEIVARQNVEIRSGDIVVVHTGWWTRFLSTG--DGGEAGSGLHWTCASW
MMAR_4772|M.marinum_M LDDVARSQGVTIESGDIVLIRTGWWTRFLMTA--NKTEPYSGLDWRCAQW
MUL_0343|M.ulcerans_Agy99 LDDVARSQGVTIESGDIVLIRTGWWTRFLMTA--NKTEPYSGLDWRCAQW
MAV_0883|M.avium_104 LDDVVRAQGVTIERGDILLIRTGWWTRYLETG--NKTEPYSGLDWRCAQW
MAB_3566c|M.abscessus_ATCC_199 LDDYLAAKKLEIRSGDALIIRTGFMAARRGNWRDYAGGAAPGLSLHTAPW
Mb1744|M.bovis_AF2122/97 AGEWFAAKGVKAVGTDTQALDHPLATAIAPHG----PAEAQGGLLPWAVR
Rv1716|M.tuberculosis_H37Rv AGEWFAAKGVKAVGTDTQALDHPLATAIAPHS----PAEAQGGLLPWAVR
. : : * : : * *
MSMEG_4861|M.smegmatis_MC2_155 LHDHEVAAVAADNLMVEDPDPASGVEGTFLPMHMLCLRDMGLMLGEYWDL
TH_0900|M.thermoresistible__bu LHEHEVAAVAADNLMVEDPDPANGVEGTFLPMHMLCLRDMGLMLGEYWDL
Mflv_2406|M.gilvum_PYR-GCK LHRHEVAAVASDNLMVEDPNPANGVEGTFLPMHMLCLRDMGLMLGEYWDL
Mvan_4240|M.vanbaalenii_PYR-1 LHEHEVAAVAADNLMVEDPDPGNGVEGTFLPMHMLCLRDMGLMLGEYWDL
MMAR_4772|M.marinum_M LHDHEVAAVASDNLQVEDP--VSGVDGLFLPLHLLCLRDMGLMLGEYWDL
MUL_0343|M.ulcerans_Agy99 LHDHEVAAVASDNLQVEDP--VSGVDGLFLPLHLLCLRDMGLMLGEYWDL
MAV_0883|M.avium_104 LHDHEVAAVASDNLQVEDP--VSGVDGVFLPFHLLTLRDMGLMLGEYWDL
MAB_3566c|M.abscessus_ATCC_199 LRDHDIAAVATDTWGIEVLP--NEID-VWQPLHVVSLVHTGLAFGEMFDL
Mb1744|M.bovis_AF2122/97 EYEAQTGRKVLDDFPDWEP-----CHRAILSQGIYGFENVGGDLDKVTGK
Rv1716|M.tuberculosis_H37Rv EYEAQTGRKVLDDFPDWEP-----CHRAILSQGIYGFENVGGDLDKVTGK
: . . * . . : : . * :.: .
MSMEG_4861|M.smegmatis_MC2_155 TALSADCAADGVYEFQLIAPPLRVTGAVGSPVNPIAIK-
TH_0900|M.thermoresistible__bu TDLAADCAADGVYEFQLIAPPLRVIGAVGSPVNPIAIK-
Mflv_2406|M.gilvum_PYR-GCK GPLAADCAADGVYEFQLVAPPLKVVGAVGAPVSPIAIK-
Mvan_4240|M.vanbaalenii_PYR-1 GPLAADCAADGVYEFQLVAPPLKVVGAVGAPVSPIAIK-
MMAR_4772|M.marinum_M TALAADCAADGVYEFQLVAPPLRFVGAVGSPVNPIAIK-
MUL_0343|M.ulcerans_Agy99 TALAADCAADGVYEFQLVAPPLRFVGAVGSPVNPIAIK-
MAV_0883|M.avium_104 SALAADCAADGVYEFQLVAPPLRFVGAVGSPVNPIAIK-
MAB_3566c|M.abscessus_ATCC_199 DGLSEDTKTDGVYEFMFVASPLPLTGASGSPVSALAIK-
Mb1744|M.bovis_AF2122/97 RVTFAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKAA
Rv1716|M.tuberculosis_H37Rv RVTFAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKAV
* :. : . .. *: .