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VNASLLDALAAARPRIIDLAQPLQEGMPCSPTHPGFRMALSRRHGDVARPDGMTGSHEMLVLGGHVGTHM DALAHVAVDGYFHGGTPVTVTDGRYASHGIDEVPPLVCRGVLVDVPKLRGVDRLPPGEPVTAADLRDADI RHGDVVLIRTGWAQLWHNPDAYIGTDSGVPGLTTDGARHLVAAGARVVGADTLALEHIPPGAGFANLPVH RILLQDSGMNIIEAMNLEALAHTGAREFVFVGAPLPVVGATGAPIRPLALVEEQHVGSGGQT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3991 | - | - | 100% (272) | cyclase |
| M. smegmatis MC2 155 | MSMEG_4048 | - | 5e-22 | 35.75% (207) | cyclase |
| M. smegmatis MC2 155 | MSMEG_4861 | - | 1e-20 | 34.25% (219) | cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1744 | - | 1e-11 | 31.52% (184) | hypothetical protein Mb1744 |
| M. gilvum PYR-GCK | Mflv_2406 | - | 4e-20 | 33.33% (219) | hypothetical protein Mflv_2406 |
| M. tuberculosis H37Rv | Rv1716 | - | 1e-11 | 31.52% (184) | hypothetical protein Rv1716 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3566c | - | 1e-20 | 33.80% (216) | putative cyclase |
| M. marinum M | MMAR_4772 | - | 2e-20 | 34.39% (221) | hypothetical protein MMAR_4772 |
| M. avium 104 | MAV_0883 | - | 2e-19 | 33.48% (221) | putative cyclase superfamily protein |
| M. thermoresistible (build 8) | TH_0900 | - | 3e-21 | 34.23% (222) | cyclase |
| M. ulcerans Agy99 | MUL_0343 | - | 1e-20 | 34.39% (221) | hypothetical protein MUL_0343 |
| M. vanbaalenii PYR-1 | Mvan_4240 | - | 5e-21 | 34.23% (222) | hypothetical protein Mvan_4240 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2406|M.gilvum_PYR-GCK ----MTGTMADFRKAADEVRNWGRWGDDDEVGTLNFITPEKVAEAARLVT
Mvan_4240|M.vanbaalenii_PYR-1 ----MTGTMKDFRRVADEVRNWGRWGDDDEVGTLNFITPAKVAEAAGLVK
TH_0900|M.thermoresistible__bu VKPMSTASMTEFRRVADQVRNWGRWGTDDELGTLNFITAEKVTEAAGLVR
MMAR_4772|M.marinum_M -----MADMTEFRRVARELSNWGRWGDADELGTLNFITAEKVQRAASLVR
MUL_0343|M.ulcerans_Agy99 ----MMADMTEFRRVARELSNWGRWGDADELGTLNFITAEKVQRAASLVR
MAV_0883|M.avium_104 -----MASVTDFRRAARDVSNWGRWGDDDELGTLNFITEEKIAQAASLVQ
MAB_3566c|M.abscessus_ATCC_199 ----MGDDLAVLESYIQRCSNWGRWGSQDQLGTVNLITQEKIREAATLVK
Mb1744|M.bovis_AF2122/97 ---------------------------------MTFAWPLGAAEST----
Rv1716|M.tuberculosis_H37Rv ---------------------------------MTFAWPLGAAEST----
MSMEG_3991|M.smegmatis_MC2_155 ---------------------------------MNASLLDALAAAR----
:. :
Mflv_2406|M.gilvum_PYR-GCK QGKVISLGGDFSSGGPQGAFKFRQNPVHVMTVDGGDASTLVEYGPKWLRN
Mvan_4240|M.vanbaalenii_PYR-1 QGKVISLGGDFSSGGPQGAFKFRQNPVHVMTVDGGDASTLVEYGPQWLRN
TH_0900|M.thermoresistible__bu QGKVFALGGDFGSAGPQGAFQFRQNPVHVMTVDGGDINTLAQYGPQWLRN
MMAR_4772|M.marinum_M HGKVFALGVDFGSSGPQGAFGFRHNPIHLMTIDGGDASSLAQYGPGWEQN
MUL_0343|M.ulcerans_Agy99 HGKVFALGVDFGSSGPQGAFGFRHNPIHLMTIDGGDASSLAQYGPGWEQN
MAV_0883|M.avium_104 HGKVFPLGVDFGSSGPQGAFGFRHNPIHVMTVDGGDAATLAQYGPGWDRN
MAB_3566c|M.abscessus_ATCC_199 VGKTISLTMAYDADGPQNGYLGRANP-QLYQLTSGPGYLVGEQ--QQVET
Mb1744|M.bovis_AF2122/97 -LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSR--VLTQKITTVMHS
Rv1716|M.tuberculosis_H37Rv -LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSR--VLTQKITTVMHS
MSMEG_3991|M.smegmatis_MC2_155 -PRIIDLAQPLQEGMPCSPTHP------------------------GFRM
. * * .
Mflv_2406|M.gilvum_PYR-GCK AVAADMSAFFADNPFRFNDDIIVMPLQAATQWDAMSHVYYEDKLYNGFPA
Mvan_4240|M.vanbaalenii_PYR-1 AVAADMSAFFADNPFRFNDDIIVMPLQAATQWDAMSHVYYEDKLYNGFPA
TH_0900|M.thermoresistible__bu SVAHQVSEFFVDNPFRFNDDMIVMPLQAATQWDALSHVYYDDQLYNGFPA
MMAR_4772|M.marinum_M PTAREMGKYVVDNPFRFNDDMIIMPLQAATQWDALSHVYYDDQLYNGFPA
MUL_0343|M.ulcerans_Agy99 PTAREMGKYLVDNPFRFNDDMIIMPLQAATQWDALSHVYYDDQLYNGFPA
MAV_0883|M.avium_104 PTAAQMGPYFVDNLFRFNDDMIIMPLQAATQWDALSHVYYDDLLYNGVPA
MAB_3566c|M.abscessus_ATCC_199 QTLTELRKTSGEPTAGYYDDVLVMPTQSGTQWDALCHFFWRGKMYNGHRV
Mb1744|M.bovis_AF2122/97 GTHIDAPAHVVEGTP-FLDEIPLS-------------AFFGTGVVVSIPK
Rv1716|M.tuberculosis_H37Rv GTHIDAPAHVVEGTP-FLDEIPLS-------------AFFGTGVVVSIPK
MSMEG_3991|M.smegmatis_MC2_155 ALSRRHGDVARPDGMTGSHEMLVLGGHVGTHMDALAHVAVDGYFHGGTP-
.:: : . .
Mflv_2406|M.gilvum_PYR-GCK DSVTSFGAFHLGIEKVDRKGITSRGVLLDVVAHRGADVFCEPGEPITPDE
Mvan_4240|M.vanbaalenii_PYR-1 DSVTSFGAFHLGIEKVDNKGITSRGVLLDVVAHRGVDTFCQPGAPITPDE
TH_0900|M.thermoresistible__bu GSVTSFGAFHCGIDKVDHKGITSRGVLLDVVRHRGAEVFLEPGQPVTPEE
MMAR_4772|M.marinum_M DSVTSLGAYHCGIDKVDVKGITSRGVLLDLVRHRGAEVFLEHGNPITPEE
MUL_0343|M.ulcerans_Agy99 DSVTSLGAYHCGIDKVDVKGITSRGVLLDLVRHRGAEVFLEHGNPITPEE
MAV_0883|M.avium_104 GSVTSLGARRLGIEKVDGKGITSRGVLLDLVRHRGAAVFLEHGNPITPEE
MAB_3566c|M.abscessus_ATCC_199 ADAGTGGSRSNGVQNYTGR-IITRGVFVDLAEYWGVET-LDPGYPITTAD
Mb1744|M.bovis_AF2122/97 GKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYAYSPGFDKK
Rv1716|M.tuberculosis_H37Rv GKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYAYSPGFDKK
MSMEG_3991|M.smegmatis_MC2_155 --VTVTDGRYASHGIDEVPPLVCRGVLVDVPKLRGVDR-LPPGEPVTAAD
. * . . * .
Mflv_2406|M.gilvum_PYR-GCK LDEIVARQQVEIRSGDIVVVHTGWWTRFL-ATR--DGGEAGSGLHWTCAK
Mvan_4240|M.vanbaalenii_PYR-1 LDEIVARQNVEIRSGDIVVVHTGWWTRFL-STG--DGGEAGSGLHWTCAS
TH_0900|M.thermoresistible__bu LDEVAAAQGVTIRSGDIVVVHTGWWTRFL-STG--DGAEPGSGLHWRCAI
MMAR_4772|M.marinum_M LDDVARSQGVTIESGDIVLIRTGWWTRFL-MTA--NKTEPYSGLDWRCAQ
MUL_0343|M.ulcerans_Agy99 LDDVARSQGVTIESGDIVLIRTGWWTRFL-MTA--NKTEPYSGLDWRCAQ
MAV_0883|M.avium_104 LDDVVRAQGVTIERGDILLIRTGWWTRYL-ETG--NKTEPYSGLDWRCAQ
MAB_3566c|M.abscessus_ATCC_199 LDDYLAAKKLEIRSGDALIIRTGFMAARR-GNWRDYAGGAAPGLSLHTAP
Mb1744|M.bovis_AF2122/97 AGEWFAAKGVKAVGTDTQALDHPLATAIA-PHG----PAEAQGGLLPWAV
Rv1716|M.tuberculosis_H37Rv AGEWFAAKGVKAVGTDTQALDHPLATAIA-PHS----PAEAQGGLLPWAV
MSMEG_3991|M.smegmatis_MC2_155 L------RDADIRHGDVVLIRTGWAQLWHNPDAYIGTDSGVPGLTTDGAR
: * : * *
Mflv_2406|M.gilvum_PYR-GCK WLHRHEVAAVASDNLMVEDPNPANGVEGTFLPMHMLCLRDMGLMLGEYWD
Mvan_4240|M.vanbaalenii_PYR-1 WLHEHEVAAVAADNLMVEDPDPGNGVEGTFLPMHMLCLRDMGLMLGEYWD
TH_0900|M.thermoresistible__bu WLHEHEVAAVAADNLMVEDPDPANGVEGTFLPMHMLCLRDMGLMLGEYWD
MMAR_4772|M.marinum_M WLHDHEVAAVASDNLQVEDP--VSGVDGLFLPLHLLCLRDMGLMLGEYWD
MUL_0343|M.ulcerans_Agy99 WLHDHEVAAVASDNLQVEDP--VSGVDGLFLPLHLLCLRDMGLMLGEYWD
MAV_0883|M.avium_104 WLHDHEVAAVASDNLQVEDP--VSGVDGVFLPFHLLTLRDMGLMLGEYWD
MAB_3566c|M.abscessus_ATCC_199 WLRDHDIAAVATDTWGIEVLP--NEID-VWQPLHVVSLVHTGLAFGEMFD
Mb1744|M.bovis_AF2122/97 REYEAQTGRKVLDDFPDWEP-----CHRAILSQGIYGFENVGGDLDKVTG
Rv1716|M.tuberculosis_H37Rv REYEAQTGRKVLDDFPDWEP-----CHRAILSQGIYGFENVGGDLDKVTG
MSMEG_3991|M.smegmatis_MC2_155 HLVAAGARVVGADTLALEHIP--PGAGFANLPVHRILLQDSGMNIIEAMN
* . : . * : : .
Mflv_2406|M.gilvum_PYR-GCK LGPLAADCAADGVYEFQLVAPPLKVVGAVGAPVSPIAIK-----------
Mvan_4240|M.vanbaalenii_PYR-1 LGPLAADCAADGVYEFQLVAPPLKVVGAVGAPVSPIAIK-----------
TH_0900|M.thermoresistible__bu LTDLAADCAADGVYEFQLIAPPLRVIGAVGSPVNPIAIK-----------
MMAR_4772|M.marinum_M LTALAADCAADGVYEFQLVAPPLRFVGAVGSPVNPIAIK-----------
MUL_0343|M.ulcerans_Agy99 LTALAADCAADGVYEFQLVAPPLRFVGAVGSPVNPIAIK-----------
MAV_0883|M.avium_104 LSALAADCAADGVYEFQLVAPPLRFVGAVGSPVNPIAIK-----------
MAB_3566c|M.abscessus_ATCC_199 LDGLSEDTKTDGVYEFMFVASPLPLTGASGSPVSALAIK-----------
Mb1744|M.bovis_AF2122/97 KRVTFAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKAA----------
Rv1716|M.tuberculosis_H37Rv KRVTFAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKAV----------
MSMEG_3991|M.smegmatis_MC2_155 LEALAHT----GAREFVFVGAPLPVVGATGAPIRPLALVEEQHVGSGGQT
. : : . .. *: .