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TQLHTSTADLGGDAVKLVDELCLKYRNWGRWGEDDERGTLNFITPAAIAEAAALVRTGTVVSCALPFNGD GPQAGGFGGRTNPIHSMLQDGGDIALGAQDHLDILRYCDDAVSMPLQCGTQWDALAHIFYRGQMYNGHGL ESVTSSGATANSIDKVADGIAGRGVLLDVARHHDVPWLEAGHAINSADLTACADQQGVSICSGDIVLIRT GQLAQVRAEGTWGAYDSGPAPGLGVDSAHWFVEHEIAALATDTWGAEVQPNDTPGVFQPLHLILLANAGM TIGEIFDLERLADVCRQQERYEFFFVAPPLPITAAVGSPVNPLAIF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4048 | - | - | 100% (327) | cyclase |
| M. smegmatis MC2 155 | MSMEG_4861 | - | 4e-64 | 45.20% (323) | cyclase |
| M. smegmatis MC2 155 | MSMEG_3991 | - | 6e-22 | 35.75% (207) | cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2406 | - | 2e-60 | 42.69% (335) | hypothetical protein Mflv_2406 |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3566c | - | 1e-69 | 42.38% (328) | putative cyclase |
| M. marinum M | MMAR_4772 | - | 9e-65 | 45.60% (318) | hypothetical protein MMAR_4772 |
| M. avium 104 | MAV_0883 | - | 2e-64 | 45.62% (320) | putative cyclase superfamily protein |
| M. thermoresistible (build 8) | TH_0900 | - | 2e-63 | 45.17% (321) | cyclase |
| M. ulcerans Agy99 | MUL_0343 | - | 5e-65 | 46.23% (318) | hypothetical protein MUL_0343 |
| M. vanbaalenii PYR-1 | Mvan_4240 | - | 2e-62 | 42.51% (334) | hypothetical protein Mvan_4240 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2406|M.gilvum_PYR-GCK ----MTGTMADFR--------KAADEVRNWGRWGDDDEVGTLNFITPEKV
Mvan_4240|M.vanbaalenii_PYR-1 ----MTGTMKDFR--------RVADEVRNWGRWGDDDEVGTLNFITPAKV
TH_0900|M.thermoresistible__bu VKPMSTASMTEFR--------RVADQVRNWGRWGTDDELGTLNFITAEKV
MMAR_4772|M.marinum_M -----MADMTEFR--------RVARELSNWGRWGDADELGTLNFITAEKV
MUL_0343|M.ulcerans_Agy99 ----MMADMTEFR--------RVARELSNWGRWGDADELGTLNFITAEKV
MAV_0883|M.avium_104 -----MASVTDFR--------RAARDVSNWGRWGDDDELGTLNFITEEKI
MSMEG_4048|M.smegmatis_MC2_155 -MTQLHTSTADLGGDAVKLVDELCLKYRNWGRWGEDDERGTLNFITPAAI
MAB_3566c|M.abscessus_ATCC_199 ----MGDDLAVLE--------SYIQRCSNWGRWGSQDQLGTVNLITQEKI
: ****** *: **:*:** :
Mflv_2406|M.gilvum_PYR-GCK AEAARLVTQGKVISLGGDFSSGGPQ-GAFKFRQNPVHVMTVDGGDASTLV
Mvan_4240|M.vanbaalenii_PYR-1 AEAAGLVKQGKVISLGGDFSSGGPQ-GAFKFRQNPVHVMTVDGGDASTLV
TH_0900|M.thermoresistible__bu TEAAGLVRQGKVFALGGDFGSAGPQ-GAFQFRQNPVHVMTVDGGDINTLA
MMAR_4772|M.marinum_M QRAASLVRHGKVFALGVDFGSSGPQ-GAFGFRHNPIHLMTIDGGDASSLA
MUL_0343|M.ulcerans_Agy99 QRAASLVRHGKVFALGVDFGSSGPQ-GAFGFRHNPIHLMTIDGGDASSLA
MAV_0883|M.avium_104 AQAASLVQHGKVFPLGVDFGSSGPQ-GAFGFRHNPIHVMTVDGGDAATLA
MSMEG_4048|M.smegmatis_MC2_155 AEAAALVRTGTVVSCALPFNGDGPQAGGFGGRTNPIHSMLQDGGDIALGA
MAB_3566c|M.abscessus_ATCC_199 REAATLVKVGKTISLTMAYDADGPQ-NGYLGRANPQLYQLTSGPGYLVGE
.** ** *.... :.. *** ..: * ** .* .
Mflv_2406|M.gilvum_PYR-GCK EYGPKWLRNAVAADMSAFFADNPFRFNDDIIVMPLQAATQWDAMSHVYYE
Mvan_4240|M.vanbaalenii_PYR-1 EYGPQWLRNAVAADMSAFFADNPFRFNDDIIVMPLQAATQWDAMSHVYYE
TH_0900|M.thermoresistible__bu QYGPQWLRNSVAHQVSEFFVDNPFRFNDDMIVMPLQAATQWDALSHVYYD
MMAR_4772|M.marinum_M QYGPGWEQNPTAREMGKYVVDNPFRFNDDMIIMPLQAATQWDALSHVYYD
MUL_0343|M.ulcerans_Agy99 QYGPGWEQNPTAREMGKYLVDNPFRFNDDMIIMPLQAATQWDALSHVYYD
MAV_0883|M.avium_104 QYGPGWDRNPTAAQMGPYFVDNLFRFNDDMIIMPLQAATQWDALSHVYYD
MSMEG_4048|M.smegmatis_MC2_155 QDHLDILR-----------------YCDDAVSMPLQCGTQWDALAHIFYR
MAB_3566c|M.abscessus_ATCC_199 QQQ---VETQTLTELRKTSGEPTAGYYDDVLVMPTQSGTQWDALCHFFWR
: . : ** : ** *..*****:.*.::
Mflv_2406|M.gilvum_PYR-GCK DKLYNGFPADSVTSFGAFHLGIEKVDRKGITSRGVLLDVVAHRGADVFCE
Mvan_4240|M.vanbaalenii_PYR-1 DKLYNGFPADSVTSFGAFHLGIEKVDNKGITSRGVLLDVVAHRGVDTFCQ
TH_0900|M.thermoresistible__bu DQLYNGFPAGSVTSFGAFHCGIDKVDHKGITSRGVLLDVVRHRGAEVFLE
MMAR_4772|M.marinum_M DQLYNGFPADSVTSLGAYHCGIDKVDVKGITSRGVLLDLVRHRGAEVFLE
MUL_0343|M.ulcerans_Agy99 DQLYNGFPADSVTSLGAYHCGIDKVDVKGITSRGVLLDLVRHRGAEVFLE
MAV_0883|M.avium_104 DLLYNGVPAGSVTSLGARRLGIEKVDGKGITSRGVLLDLVRHRGAAVFLE
MSMEG_4048|M.smegmatis_MC2_155 GQMYNGHGLESVTSSGATANSIDKVAD-GIAGRGVLLDVARHHDVP-WLE
MAB_3566c|M.abscessus_ATCC_199 GKMYNGHRVADAGTGGSRSNGVQNYTG-RIITRGVFVDLAEYWGVE-TLD
. :*** .. : *: .::: * ***::*:. : .. :
Mflv_2406|M.gilvum_PYR-GCK PGEPITPDELDEIVARQQVEIRSGDIVVVHTGWWTRFLATRDG----GEA
Mvan_4240|M.vanbaalenii_PYR-1 PGAPITPDELDEIVARQNVEIRSGDIVVVHTGWWTRFLSTGDG----GEA
TH_0900|M.thermoresistible__bu PGQPVTPEELDEVAAAQGVTIRSGDIVVVHTGWWTRFLSTGDG----AEP
MMAR_4772|M.marinum_M HGNPITPEELDDVARSQGVTIESGDIVLIRTGWWTRFLMTANK----TEP
MUL_0343|M.ulcerans_Agy99 HGNPITPEELDDVARSQGVTIESGDIVLIRTGWWTRFLMTANK----TEP
MAV_0883|M.avium_104 HGNPITPEELDDVVRAQGVTIERGDILLIRTGWWTRYLETGNK----TEP
MSMEG_4048|M.smegmatis_MC2_155 AGHAINSADLTACADQQGVSICSGDIVLIRTGQLAQVRAEGTWGAYDSGP
MAB_3566c|M.abscessus_ATCC_199 PGYPITTADLDDYLAAKKLEIRSGDALIIRTGFMAARRGNWRD--YAGGA
* .:.. :* : : * ** ::::** : .
Mflv_2406|M.gilvum_PYR-GCK GSGLHWTCAKWLHRHEVAAVASDNLMVEDPNPANGVEGTFLPMHMLCLRD
Mvan_4240|M.vanbaalenii_PYR-1 GSGLHWTCASWLHEHEVAAVAADNLMVEDPDPGNGVEGTFLPMHMLCLRD
TH_0900|M.thermoresistible__bu GSGLHWRCAIWLHEHEVAAVAADNLMVEDPDPANGVEGTFLPMHMLCLRD
MMAR_4772|M.marinum_M YSGLDWRCAQWLHDHEVAAVASDNLQVEDP--VSGVDGLFLPLHLLCLRD
MUL_0343|M.ulcerans_Agy99 YSGLDWRCAQWLHDHEVAAVASDNLQVEDP--VSGVDGLFLPLHLLCLRD
MAV_0883|M.avium_104 YSGLDWRCAQWLHDHEVAAVASDNLQVEDP--VSGVDGVFLPFHLLTLRD
MSMEG_4048|M.smegmatis_MC2_155 APGLGVDSAHWFVEHEIAALATDTWGAEVQ--PNDTPGVFQPLHLILLAN
MAB_3566c|M.abscessus_ATCC_199 APGLSLHTAPWLRDHDIAAVATDTWGIEVL--PNEID-VWQPLHVVSLVH
.** * *: *::**:*:*. * . : *:*:: * .
Mflv_2406|M.gilvum_PYR-GCK MGLMLGEYWDLGPLAADCAADGVYEFQLVAPPLKVVGAVGAPVSPIAIK
Mvan_4240|M.vanbaalenii_PYR-1 MGLMLGEYWDLGPLAADCAADGVYEFQLVAPPLKVVGAVGAPVSPIAIK
TH_0900|M.thermoresistible__bu MGLMLGEYWDLTDLAADCAADGVYEFQLIAPPLRVIGAVGSPVNPIAIK
MMAR_4772|M.marinum_M MGLMLGEYWDLTALAADCAADGVYEFQLVAPPLRFVGAVGSPVNPIAIK
MUL_0343|M.ulcerans_Agy99 MGLMLGEYWDLTALAADCAADGVYEFQLVAPPLRFVGAVGSPVNPIAIK
MAV_0883|M.avium_104 MGLMLGEYWDLSALAADCAADGVYEFQLVAPPLRFVGAVGSPVNPIAIK
MSMEG_4048|M.smegmatis_MC2_155 AGMTIGEIFDLERLADVCRQQERYEFFFVAPPLPITAAVGSPVNPLAIF
MAB_3566c|M.abscessus_ATCC_199 TGLAFGEMFDLDGLSEDTKTDGVYEFMFVASPLPLTGASGSPVSALAIK
*: :** :** *: : *** ::*.** . .* *:**..:**