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MTARTIDDAAKVFAMPSAYTDEAKFHEALTHLRVNAPVSWVDVPPYRPFWAITRYADIMAIERANDLFTN SPRPVLMTAEEDEQQAAVGISTLIHMDDPQHRVIRAIGADWFRPKAMRALKIRVDELAKIHVDKMVAAGG ECDFVQEITVNYPLYVIMSLLGIPEADFPLMLKLTQELFGNKDDEYQRSADEGDSMAALLEMFQYFTELT ASRRANPTDDLASAIANATVNGEPLNDIETVSYYAIVAAAGHDTTSATISGGMLALLEHPDQLERLRNDP SLMGTATEEMIRWVTPVKAFMRTAATDTVVRDVPIAAGESLLLAYPSGNRDEEVFTDPFRFDVGRDPNKH VAFGYGVHFCLGAALARMEINSFFAELIPRLESIELTGSPRHTATTFVGGLKHLPVRYALR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2257 | - | - | 100% (411) | cytochrome P450-terp |
| M. smegmatis MC2 155 | MSMEG_1429 | - | e-168 | 68.51% (416) | cytochrome P450-terp |
| M. smegmatis MC2 155 | MSMEG_1431 | - | e-163 | 68.75% (416) | cytochrome P450-terp |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3575c | cyp125 | 8e-62 | 34.07% (408) | cytochrome P450 125 |
| M. gilvum PYR-GCK | Mflv_4325 | - | 1e-180 | 74.39% (410) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3545c | cyp125 | 9e-62 | 34.07% (408) | cytochrome P450 125 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-38 | 28.35% (321) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 1e-158 | 64.72% (411) | cytochrome P450 |
| M. marinum M | MMAR_3999 | cyp108B4 | 1e-174 | 72.93% (410) | cytochrome P450 108B4 Cyp108B4 |
| M. avium 104 | MAV_1609 | - | 0.0 | 75.37% (410) | cytochrome P450 family protein |
| M. thermoresistible (build 8) | TH_2733 | - | 0.0 | 77.37% (411) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3863 | cyp108B4 | 1e-174 | 73.17% (410) | cytochrome P450 108B4 Cyp108B4 |
| M. vanbaalenii PYR-1 | Mvan_2021 | - | 1e-179 | 73.90% (410) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3575c|M.bovis_AF2122/97 MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFAELRSAA
Rv3545c|M.tuberculosis_H37Rv MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFAELRSAA
MSMEG_2257|M.smegmatis_MC2_155 ---------MTARTIDDAAKVFAMPSAYTD-----EAKFHEALTHLRVNA
TH_2733|M.thermoresistible__bu ---------MSTPIIDEAARVFATPKAYTD-----ERALHAALTHLRAHA
MMAR_3999|M.marinum_M ---------MSAPTMDEAA-LLADPLAYTD-----ETRLHAALTRLRAQA
MUL_3863|M.ulcerans_Agy99 ---------MSAPTMDEAA-LLADPLAYTD-----ETRLHAALTRLRAQA
MAV_1609|M.avium_104 ---------MSTTTMDEAAKLLADPMAYTD-----EQRLHAALTHLRANA
Mflv_4325|M.gilvum_PYR-GCK ---------MSVRVADEAGKVFADPTAYAD-----EQRLHAAMTHLRANA
Mvan_2021|M.vanbaalenii_PYR-1 ---------MSVRIADEAARVFADPSAYAD-----EARLHAAMTHLRANA
MAB_3825|M.abscessus_ATCC_1997 -------MATALSEIEEAGRVLADPAAYAD-----ELRLHAAMTLLRREQ
MLBr_02088|M.leprae_Br4923 -------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLID
: : **
Mb3575c|M.bovis_AF2122/97 PIWWNG-QDPGKGGGFH---DGGFWAITKLNDVKEISRHSDVFSSYENGV
Rv3545c|M.tuberculosis_H37Rv PIWWNG-QDPGKGGGFH---DGGFWAITKLNDVKEISRHSDVFSSYENGV
MSMEG_2257|M.smegmatis_MC2_155 PVSWVD-VPPYR----------PFWAITRYADIMAIERANDLFTNSPRPV
TH_2733|M.thermoresistible__bu PVSWVE-VDGYR----------PFWAITKHADIMAIERDNELFTNSPRPV
MMAR_3999|M.marinum_M PVALVD-VPNYR----------RFWAITRHADVMDIERDNTLFTNWPRPV
MUL_3863|M.ulcerans_Agy99 PVALVD-VPNYR----------RFWAITRHADVMDIERDNTLFTNWPRPV
MAV_1609|M.avium_104 PVSWVE-VPNYK----------PFWAITKHADVMDIERENMLFTNWPRPV
Mflv_4325|M.gilvum_PYR-GCK PVSWVD-VEGYN----------PFWAITKHADIMAIERDNTVFTNSPRPV
Mvan_2021|M.vanbaalenii_PYR-1 PVSWVE-VPGYN----------PFWAITKHADIMAVERDNLVFTNSPRPV
MAB_3825|M.abscessus_ATCC_1997 PVTKVI-TDDYR----------PFWAVTKHDDIMAVERDNALWINEPRPL
MLBr_02088|M.leprae_Br4923 PGTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRL
* . .:* .. .. . :
Mb3575c|M.bovis_AF2122/97 IPRFKND---IAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRL
Rv3545c|M.tuberculosis_H37Rv IPRFKND---IAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRL
MSMEG_2257|M.smegmatis_MC2_155 LMTAEED---EQQAAVGIS--TLIHMDDPQHRVIRAIGADWFRPKAMRAL
TH_2733|M.thermoresistible__bu LITAEAD---ELQAGVGIR--TLIHLDDPEHRDLRAIGADWFRPKAMRAL
MMAR_3999|M.marinum_M LATVAGD---ELQAAAGVR--TLIHLDDPQHRVARAIGADWFRPKAMRAL
MUL_3863|M.ulcerans_Agy99 LATVAGD---ELQAAAGVR--TLIHLDDPQHRVARAIGADWFRPKAMRAL
MAV_1609|M.avium_104 LTTAEGD---EMQAAAGVR--TLIHMDDPQHRVVRAIGSDWFRPKAMRAL
Mflv_4325|M.gilvum_PYR-GCK LTTAEGD---AQHASMGVS--TLIHMDDPQHRKVRAIGADWFRPKAMRAL
Mvan_2021|M.vanbaalenii_PYR-1 LTTAEGD---AQHEAMGIS--TLIHLDDPQHRKVRAIGADWFRPKAMRAL
MAB_3825|M.abscessus_ATCC_1997 LMNLEQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAMRDM
MLBr_02088|M.leprae_Br4923 KATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQAL
: . :: :* *.* * : : * *:.: :
Mb3575c|M.bovis_AF2122/97 HDELQERAQKIAAEAAAAG-SGDFVEQVSCELPLQAIAGLLGVPQEDRGK
Rv3545c|M.tuberculosis_H37Rv HDELQERAQKIAAEAAAAG-SGDFVEQVSCELPLQAIAGLLGVPQEDRGK
MSMEG_2257|M.smegmatis_MC2_155 KIRVDELAKIHVDKMVAAGGECDFVQEITVNYPLYVIMSLLGIPEADFPL
TH_2733|M.thermoresistible__bu KIRVDELARIHVDKMLELGPECDFVQEVAVNYPLYVIMSLLGVPEADFPL
MMAR_3999|M.marinum_M KVRVDELAKNYVDAMMAAGPECDFVQQIAVNYPLYVIMSLLGLPEADFPR
MUL_3863|M.ulcerans_Agy99 KVRVDELAKNYVDAMMAAGPECDFVQQIAVNYPLYVIMSLLGLPEADFPR
MAV_1609|M.avium_104 KVRVDELAKIYVDKMLAAGPECDFVQEVAVNYPLYVIMSLLGLPEADFPR
Mflv_4325|M.gilvum_PYR-GCK KVRVDELAKTFVDQMYDRGGECDFVQEVAVNFPLYVIMSLLGIPESDFGR
Mvan_2021|M.vanbaalenii_PYR-1 KVRVDELAKTFVDQMYERGGECDFVQEVAVNFPLYVIMSLLGIPESDFQR
MAB_3825|M.abscessus_ATCC_1997 KLRTDELANRYVNKLLEAGGSCDFAQDIAVHFPLYVIMSLLGIPESDFDR
MLBr_02088|M.leprae_Br4923 EGDIAALVDSLLDKGAAAG-QFDVIADLAFPLAVAVICRLLGVPYEDAPE
. . * . *. ::: .: .* ***:* *
Mb3575c|M.bovis_AF2122/97 LFHWSNEMTGNEDPEYAHI----DPKASS----AELIGYAMKMAEEKAKN
Rv3545c|M.tuberculosis_H37Rv LFHWSNEMTGNEDPEYAHI----DPKASS----AELIGYAMKMAEEKAKN
MSMEG_2257|M.smegmatis_MC2_155 MLKLTQELFGNKDDEYQRS----ADEGDSMAALLEMFQYFTELTASRRAN
TH_2733|M.thermoresistible__bu MLKLTQELFGSDDEEFKRG----ASQEDQMTALLEMFEYFTKLTASRREN
MMAR_3999|M.marinum_M MLKLTQELFGSDDSEFKRG----STSEDQLPALLDMFGYFNAVTTARREH
MUL_3863|M.ulcerans_Agy99 MLKLTQELFGSDDSEFKRG----STSEDQLPALLDMFGYFNAVTTARRAH
MAV_1609|M.avium_104 MLKLTQELFGSDDSEFKRG----SSNEDQLPALLDMFGYFNGVTAARREH
Mflv_4325|M.gilvum_PYR-GCK MLTYTQELFGSDDAELQRG----TTMEERGLALFDMFTYFNELTASRRAQ
Mvan_2021|M.vanbaalenii_PYR-1 MLTYTQELFGNDDAELQRG----ESMEERGLALFDMFTYFNEITAARRAR
MAB_3825|M.abscessus_ATCC_1997 MLKLTQELFGGDDSEFQRG----TTPEEQLMALLDFFGYFSGLTASRRQH
MLBr_02088|M.leprae_Br4923 FGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT
: : : . * . : * :. :
Mb3575c|M.bovis_AF2122/97 PADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAF
Rv3545c|M.tuberculosis_H37Rv PADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAF
MSMEG_2257|M.smegmatis_MC2_155 PTDDLASAIANATVNGEPLNDIETVSYYAIVAAAGHDTTSATISGGMLAL
TH_2733|M.thermoresistible__bu PTEDLASAIANAKIDGEPLSDIDTMSYYAIVAAAGHDTTSATISGGLLAL
MMAR_3999|M.marinum_M PTEDLASAIANARIDGEPLSDIDTVSYYLIVATAGHDTTSATISGGLHAL
MUL_3863|M.ulcerans_Agy99 PTADLASAIANARIDGEPLSDIDTVSYYLIVATAGHDTTSATISGGLHAL
MAV_1609|M.avium_104 PTEDLASAIANARVDGEPLSDIDTVSYYLIVATAGHDTTSATISGGLQAL
Mflv_4325|M.gilvum_PYR-GCK PTEDLASAIANARINGEPLSDIDTVSYYLIVATAGHDTTSATISGGLQAL
Mvan_2021|M.vanbaalenii_PYR-1 PTEDLASAIANARIDGAPLSDIDTVSYYLIVATAGHDTTSATISGGLQAL
MAB_3825|M.abscessus_ATCC_1997 PTDDLASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAGGLEAL
MLBr_02088|M.leprae_Br4923 PGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAM
* *: : : : .* *.: : :: .**::** *: .: *:
Mb3575c|M.bovis_AF2122/97 AEHPDQWELYKKVR--PETAADEIVRWATPVTAFQRTALRDYELSGVQIK
Rv3545c|M.tuberculosis_H37Rv AEHPDQWELYKKVR--PETAADEIVRWATPVTAFQRTALRDYELSGVQIK
MSMEG_2257|M.smegmatis_MC2_155 LEHPDQLERLRNDPSLMGTATEEMIRWVTPVKAFMRTAATDTVVRDVPIA
TH_2733|M.thermoresistible__bu LEHPDQHERLLADPELMPLAVEEMIRWVTPVKAFMRTAQRDTTVRDVPIK
MMAR_3999|M.marinum_M IEHPDQLARLQADPALIPLATEEMIRWVTPVKQFMRTASRDTVVRGIPIA
MUL_3863|M.ulcerans_Agy99 IEHPDQLARLQADPALMSLATEEMIRWVTPVKQFMRTASSDTVVRGIPIA
MAV_1609|M.avium_104 IENPDQLQRLRDNLDLMPLATEEMIRWVTPVKEFMRTAAKDTVVRGVPIA
Mflv_4325|M.gilvum_PYR-GCK IENPDQLARLQQAPELLPLAVEEMIRWVTPVKEFMRTAQQDTEVRGVPIA
Mvan_2021|M.vanbaalenii_PYR-1 IENPDQLQRLQQNPGLMPLAVEEMIRWVTPVKEFMRTAQQDAEVRGVKIA
MAB_3825|M.abscessus_ATCC_1997 LEHPDQLARLRENPGLMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPIT
MLBr_02088|M.leprae_Br4923 LRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLT
.:*.* ..:* :*: ..: : *.* * : :
Mb3575c|M.bovis_AF2122/97 KGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAHYCIGANL
Rv3545c|M.tuberculosis_H37Rv KGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAHYCIGANL
MSMEG_2257|M.smegmatis_MC2_155 AGESLLLAYPSGNRDEEVFTDPFRFDVGRDPNKHVAFG-YGVHFCLGAAL
TH_2733|M.thermoresistible__bu AGESVLLSYVSGNRDEEVFDDPFGFDVGRDPNKHISFG-YGVHFCLGAAL
MMAR_3999|M.marinum_M AGESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFG-YGVHFCMGAAL
MUL_3863|M.ulcerans_Agy99 AGESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFG-YGVHFCMGAAL
MAV_1609|M.avium_104 AGESVLLSYVSANRDEDVFDEPFRFDVGRDPNKHLAFG-YGVHFCMGAAL
Mflv_4325|M.gilvum_PYR-GCK AGESVLLSYPSGNRDEDVFTDPFRFDIGRDPNKHVAFG-YGVHFCLGAAL
Mvan_2021|M.vanbaalenii_PYR-1 AGESVLLSYPSGNRDEDVFTDPFRFDVGRDPNKHVAFG-YGVHFCLGAAL
MAB_3825|M.abscessus_ATCC_1997 EGESVLLSYPSGNRDEDIFTDPFTFDIARDPNKHLAFG-FGVHFCLGAAL
MLBr_02088|M.leprae_Br4923 EGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFA-VGSHFCLGAAL
*: ::: :.* * :: * *: * .. *:.*. * *:*:** *
Mb3575c|M.bovis_AF2122/97 ARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTGRCPVA
Rv3545c|M.tuberculosis_H37Rv ARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTGRCPVA
MSMEG_2257|M.smegmatis_MC2_155 ARMEINSFFAELIPRLESIELTGSPRHTATTFVGGLKHLPVRYALR----
TH_2733|M.thermoresistible__bu ARMEVNSFFTELLPRLKSVEPAGPAEFVATTFVGGPKHLPIRYELR----
MMAR_3999|M.marinum_M ARMEVGSFFTELLPRLKSIELSGDPQFTATTFVGGLKHLPVSYSLV----
MUL_3863|M.ulcerans_Agy99 ARMEVASFFTELLPRLKSIELSGDPQFTATTFVGGLKRLPVSYSLM----
MAV_1609|M.avium_104 ARMEVNSFFTELLPRLKSIELTGDPELVATTFVGGLKHLPVRYSLA----
Mflv_4325|M.gilvum_PYR-GCK ARMEINSFFSELLPRLTSVELAGRPEHIATIFVGGLKHLPIRYSLTR---
Mvan_2021|M.vanbaalenii_PYR-1 ARMEINSFFTELLPRLKSVELAGRPEHIATIFVGGLKHLPIRYSLTR---
MAB_3825|M.abscessus_ATCC_1997 ARMEVNSFFSALLPRLESIEVDGNIERTSTIFVGGIKHLPIRYTLR----
MLBr_02088|M.leprae_Br4923 ARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV-------
**: : : :: .:: . . : * . :
Mb3575c|M.bovis_AF2122/97 H
Rv3545c|M.tuberculosis_H37Rv H
MSMEG_2257|M.smegmatis_MC2_155 -
TH_2733|M.thermoresistible__bu -
MMAR_3999|M.marinum_M -
MUL_3863|M.ulcerans_Agy99 -
MAV_1609|M.avium_104 -
Mflv_4325|M.gilvum_PYR-GCK -
Mvan_2021|M.vanbaalenii_PYR-1 -
MAB_3825|M.abscessus_ATCC_1997 -
MLBr_02088|M.leprae_Br4923 -