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MRASWRITPRLTRILLVALVALTAAGGGVVLYQKNFGPKTIVAHFTSATAIYPGDEVRVAGVKVGNIKTI DAAGTTAKMTLEVQRDVPIPADAKAIIVAQNLVSARYVQLTPPYGVDGADGPVMADGAEIGVDRTAVPVE WDEVKEQLTRLATDLGPANGVSETSLGRFIDSTANAMAGNGDKLRTTIAQMSEVGRILGEGSGNIVGTLQ NLQTFVTALRDSNAQIVQFQGSLADVTSVIDGSRSDLDAAVKDLSEAVGLVQGFISGTRDQTAEQIQRLA EVTQVLSDNSTVVKNVLHAAPNALVNGYNIYNPDTGGPRGSFAMNNFANPVAVICSAIGAVENATSEESA KACAQYLGPALRLMNFNYLPMPFNAYLGPAPKNVIYSEPGLAPGGGGTPSAPAELPPAVSAYTGAGDVPP PAGWADPPQPPGAYTPNGLPAERHPALYPGAPVPPATSPPPASTLEDLLLPAEMAAAPPAPEGTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2858 | - | - | 100% (485) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_4787 | - | e-150 | 59.28% (474) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_5897 | - | 2e-83 | 39.52% (458) | virulence factor mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 8e-81 | 39.86% (444) | MCE-family protein MCE4D |
| M. gilvum PYR-GCK | Mflv_4535 | - | 0.0 | 71.63% (490) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3496c | mce4D | 8e-81 | 39.86% (444) | MCE-family protein MCE4D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 5e-71 | 34.11% (513) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 1e-79 | 38.53% (462) | MCE-family protein |
| M. marinum M | MMAR_4707 | - | 1e-142 | 57.76% (483) | MCE-family protein |
| M. avium 104 | MAV_0951 | - | 1e-145 | 59.03% (476) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_2817 | - | 0.0 | 74.13% (491) | PUTATIVE virulence factor mce family protein |
| M. ulcerans Agy99 | MUL_4059 | mce4D | 2e-81 | 40.17% (478) | MCE-family protein Mce4D |
| M. vanbaalenii PYR-1 | Mvan_2854 | - | 0.0 | 75.73% (478) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3526c|M.bovis_AF2122/97 ------MMGRVAMLTGSRGLRYATVIALVAALVGGVYVLSSTGNK-RTIV
Rv3496c|M.tuberculosis_H37Rv ------MMGRVAMLTGSRGLRYATVIALVAALVGGVYVLSSTGNK-RTIV
MUL_4059|M.ulcerans_Agy99 ------MMK---QRLSSRGMRTVTIVALVAALVGGLYVLFSGGESGRKVV
MAB_4150c|M.abscessus_ATCC_199 ------------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGTYKIV
MSMEG_2858|M.smegmatis_MC2_155 --------MRASWRITPRLTRILLVALVALTAAGGGVVLYQKNFGPKTIV
TH_2817|M.thermoresistible__bu --------MIATWRTAPRITRTLLIVLVALMLASSGYLLYQNRFGPITIS
Mflv_4535|M.gilvum_PYR-GCK --------MTARVRQSSAARMVLLVTLGALAVAGAAVVVYQQFFSPYTVV
Mvan_2854|M.vanbaalenii_PYR-1 --------MTVRGGSLRPARALLVVALTVLAVAGSGVLVYQHFFSPKTIV
MMAR_4707|M.marinum_M -------MMRLEGAARSKVKAVLAVALVGLVVVGTGVALRNTFFRPTTIT
MAV_0951|M.avium_104 --------MSPR-VPRNRLAALAAVVLVGLILAGTAVLVRNTFFGQKTIT
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
. .. .:
Mb3526c|M.bovis_AF2122/97 GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
Rv3496c|M.tuberculosis_H37Rv GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
MUL_4059|M.ulcerans_Agy99 AYFTSAVGIYPGDEVRILGVPVGRIDSIEPRPADVKITMSVSNDVKIPRD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
MSMEG_2858|M.smegmatis_MC2_155 AHFTSATAIYPGDEVRVAGVKVGNIKTIDAAGTTAKMTLEVQRDVPIPAD
TH_2817|M.thermoresistible__bu AYFRSATAVYPGDDVRVAGVRVGTIKSIEPMGTRAKVVLQVRRDVPIPAD
Mflv_4535|M.gilvum_PYR-GCK AYFRSATAIYAGDEVRVAGVRVGTIESIEPQGTRAKMTMAIDHDVPVPAD
Mvan_2854|M.vanbaalenii_PYR-1 AYFRSATAIYAGDEVRVAGVRVGTIEAIEPQGTRAKMTLAVDRGVPIPAD
MMAR_4707|M.marinum_M AYFPTATAIYPGDDVRVSGMKVGTIAAIRPDGTKAKMILHVDHNVPIPAD
MAV_0951|M.avium_104 AYFTTATAIYPNDEVRVSGVKVGNIKSIEPQGTQAKMTLKVDHDVPIPAD
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
:* :*..:*..*.*:: *: .* * : . *: : :* .
Mb3526c|M.bovis_AF2122/97 VQAVIMSPNLVAARFIQLTPVYT-----GGAVLPDNGRIDLDRTAVPVEW
Rv3496c|M.tuberculosis_H37Rv VQAVIMSPNLVAARFIQLTPVYT-----GGAVLPDNGRIDLDRTAVPVEW
MUL_4059|M.ulcerans_Agy99 AQALIVSPNLVAARFIQLTPVYT-----GGAVVPDGASIDLSRTAIPVEW
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYT-----DGKALQDGASLGLDKTAVPIEW
MSMEG_2858|M.smegmatis_MC2_155 AKAIIVAQNLVSARYVQLTPPYG-VDGADGPVMADGAEIGVDRTAVPVEW
TH_2817|M.thermoresistible__bu AEAIIVAQNLVSARYVQLTPPYGSAAAPDGPTMPDGGEIGLERTAVPIEW
Mflv_4535|M.gilvum_PYR-GCK AEAIIVAPNLVSARYVQLTPAWGATPETSGPTMVDGAEIGQDRTAVPVEW
Mvan_2854|M.vanbaalenii_PYR-1 AEAIIVAPNLVSARYVQLTPAWGASPETSGPTMADGGEIGQDRTAVPVEW
MMAR_4707|M.marinum_M AKAVIVAQNLVAARYVQLTPAYR----SSGPVMADGAVIPIERTAVPVEW
MAV_0951|M.avium_104 AKAVIVASNLVSARYVQLSPAYR----DSGPVMPDGAVIPVERTAVPVEW
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYK-----GGPALGDNAVIPLERTQVPVEW
..*:*: .**::* :** * : .* .: *.. : .:* :*:**
Mb3526c|M.bovis_AF2122/97 DEVKEGLTRLAADLSPAAGELQGPLGAAINQAADTLD-GNGDSLHNALRE
Rv3496c|M.tuberculosis_H37Rv DEVKEGLTRLAADLSPAAGELQGPLGAAINQAADTLD-GNGDSLHNALRE
MUL_4059|M.ulcerans_Agy99 DEVKESLTQLAVQLSPAAGELQGPLGAAINQAADTLN-GNGDSFHNALRE
MAB_4150c|M.abscessus_ATCC_199 DEVKTELAKLSDSLGPQ-GQSKGPVSDFINQAATTFD-GNGDSFRNAVRE
MSMEG_2858|M.smegmatis_MC2_155 DEVKEQLTRLATDLGPANGVSETSLGRFIDSTANAMA-GNGDKLRTTIAQ
TH_2817|M.thermoresistible__bu DEVKEQLTRLATELGPDGGVSDTALGRFIDSAADAMA-GNGGKLRQTISE
Mflv_4535|M.gilvum_PYR-GCK DEIKQQLTRLATELGPSGGVSETSLGRFIDTTAAAMD-GNGNKLRETISQ
Mvan_2854|M.vanbaalenii_PYR-1 DEIKEQLTRLAAELGPASGVSGTSLGRFIDTTADAMA-GNGEKLRETIAQ
MMAR_4707|M.marinum_M DEVKDQLMRLATELGPNSKVSSPSISRFIDSAADALGNGNGDKLRQTLAE
MAV_0951|M.avium_104 DEVKTQLMRLATDLGPKSGVSGTSVGRFIDSAANALD-GNGDKLRQTLAQ
MLBr_02592|M.leprae_Br4923 DELRDSITKIISKLGPTKEQPKGPFGDVIESFADGLA-GKGKQINATLDS
**:: : :: .*.* ... *: * : *:* .:. :: .
Mb3526c|M.bovis_AF2122/97 LAQVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVL
Rv3496c|M.tuberculosis_H37Rv LAQVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVL
MUL_4059|M.ulcerans_Agy99 LSQVAGRLGDSRNDIFSTVKNLQVLVDALSQSNEQIVQFAGHVASVSQVL
MAB_4150c|M.abscessus_ATCC_199 LSQAAGRLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVL
MSMEG_2858|M.smegmatis_MC2_155 MSEVGRILGEGSGNIVGTLQNLQTFVTALRDSNAQIVQFQGSLADVTSVI
TH_2817|M.thermoresistible__bu LSAVGRVLGEGSGNIVEILENLQTFVTALRDSNIQIVQFQDRLADVTSVV
Mflv_4535|M.gilvum_PYR-GCK LSGVARVLGEGSGDIVEVITHLETFVTALRDSNVQIVQFQDRLADVTQVV
Mvan_2854|M.vanbaalenii_PYR-1 LSGVGRILGEGSGDIVEVIQNLQIFVTALRDSNTQIVQFQDRLADVTSVV
MMAR_4707|M.marinum_M LSGVGRILANGSGNIVDIIKNLQTFIGALRDSNVQIVQFNDRLASLTSVL
MAV_0951|M.avium_104 LSGVGRILANGSGNIVDIIKNLQTFVGALRDSNVQIVQFNDRLATLTSVV
MLBr_02592|M.leprae_Br4923 LSRALTALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRL
:: . * :. ::. : * :: ** .: *:* : :* .: :
Mb3526c|M.bovis_AF2122/97 ADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLSDQS
Rv3496c|M.tuberculosis_H37Rv ADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLSDQS
MUL_4059|M.ulcerans_Agy99 ADSSRNLDNTLGTLNQALSDIKGFLRENNSTLIETVNQLGDLTQTLSDQS
MAB_4150c|M.abscessus_ATCC_199 AASTENLGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFSDQS
MSMEG_2858|M.smegmatis_MC2_155 DGSRSDLDAAVKDLSEAVGLVQGFISGTRDQTAEQIQRLAEVTQVLSDNS
TH_2817|M.thermoresistible__bu DGSRAELDAAIRDVADAVGVVERFIDGTRDQTAEQIQRLAALTRVLSDNS
Mflv_4535|M.gilvum_PYR-GCK DGSRSELNSAITTLSEAVGEVQRFVEGSRSQTAEQVQRLANVTQVLADDS
Mvan_2854|M.vanbaalenii_PYR-1 DGSRSDLDSAITTLSEAVGEVRRFVQGSRGQTVEQVQRLANVTQVLSDDS
MMAR_4707|M.marinum_M DDNKSDLDAALTDLSSAVGEVQRFIAGSRDATAEQITRLADLTQILVDNK
MAV_0951|M.avium_104 NDSKSDLDAALTDLSTAVGEVQRFIAGTRNQTSEQIARLADVTQILVDHH
MLBr_02592|M.leprae_Br4923 AHSDTDLSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPE
. :*. :: . : :. *: .. : .* . . . :
Mb3526c|M.bovis_AF2122/97 --ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQF-----
Rv3496c|M.tuberculosis_H37Rv --ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQF-----
MUL_4059|M.ulcerans_Agy99 --DNIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQF-----
MAB_4150c|M.abscessus_ATCC_199 --DDLEQILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQF-----
MSMEG_2858|M.smegmatis_MC2_155 --TVVKNVLHAAPNALVNGYNIYNPDTGGPRGSFAMNNFANPVAV-----
TH_2817|M.thermoresistible__bu --MTVKNVLHAAPTALANGYNIYNPDTGGPRGSFAMNNFANPVTL-----
Mflv_4535|M.gilvum_PYR-GCK --LVLKNILHAAPNALVNGYNIYNPDTGGPRGSFAMNNFSNPVTL-----
Mvan_2854|M.vanbaalenii_PYR-1 --MVLKNILHAAPNALVNGYNIYNPDTGGPRGSFAMNNFANPVTM-----
MMAR_4707|M.marinum_M --MALKNVLHVTPNALANAYNDYDPDVGNVRGGVGIQNLTNPVFS-----
MAV_0951|M.avium_104 --MDLENILHVAPNALGNFFNDYNADTGTIVGGFGIMNFANPTFSGLMVP
MLBr_02592|M.leprae_Br4923 PLNGVETFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQF-----
:: .**.: . * : *.. * * : *::**
Mb3526c|M.bovis_AF2122/97 ----ICGGSFDTAAGPSAPDYYRRAEICRERLGPVLRRLT------VNYP
Rv3496c|M.tuberculosis_H37Rv ----ICGGSFDTAAGPSAPDYYRRAEICRERLGPVLRRLT------VNYP
MUL_4059|M.ulcerans_Agy99 ----ICGGSFDTAAGKSAPDYYRRAELCRERLGPVLRRLT------ANYP
MAB_4150c|M.abscessus_ATCC_199 ----ICGGVFETGT---KTEYLKRAEICRERMGPVLRRAT------FNYA
MSMEG_2858|M.smegmatis_MC2_155 ----ICSAIGAVEN----ATSEESAKACAQYLGPALRLMN------FNYL
TH_2817|M.thermoresistible__bu ----ICAAIGAVEN----VTAEASAKACAEYLGPALRLIN------FNYL
Mflv_4535|M.gilvum_PYR-GCK ----ICSAIAAVEN----VTAEESGKACAQYLGPALRLMN------FNYL
Mvan_2854|M.vanbaalenii_PYR-1 ----ICSAIAAVEN----VTAEESGKACAQYLGPALRLMN------FNYL
MMAR_4707|M.marinum_M ----ICSQLGAMEN----VTSVESGKLCGLYLSPALKVFNPLMYFNFNYF
MAV_0951|M.avium_104 LPVPGCTAVGAIEN----ITAVESGKLCSLFLGPGLRVLN------FNNL
MLBr_02592|M.leprae_Br4923 ----ICSAIQAGSR----LGYQESAELCAQYLSPVLDAIK------FNYF
* .: * :.* * . *
Mb3526c|M.bovis_AF2122/97 PIMFHPLNTITAYKGQIIYDTPATEA------------------------
Rv3496c|M.tuberculosis_H37Rv PIMFHPLNTITAYKGQIIYDTPATEA------------------------
MUL_4059|M.ulcerans_Agy99 PFLFHPLNTITAYKGQIIYDTPATQA------------------------
MAB_4150c|M.abscessus_ATCC_199 PILLHPINQISAYKGQIIYDTPETEA------------------------
MSMEG_2858|M.smegmatis_MC2_155 PMPFNAYLGPAP--KNVIYSEPGLAP------------------------
TH_2817|M.thermoresistible__bu PLPFNAYLGPAP--QNVIYSEPGLAP------------------------
Mflv_4535|M.gilvum_PYR-GCK PMPFNAYLGPAP--QNVIYSEPGLAP------------------------
Mvan_2854|M.vanbaalenii_PYR-1 PLPFNAYLGPAP--QNVIYSEPGLAP------------------------
MMAR_4707|M.marinum_M PIPINPILAPAFDLQNVVYTEQRLAP------------------------
MAV_0951|M.avium_104 PIPINIFLQKSVDPSKILYSEPRLAP------------------------
MLBr_02592|M.leprae_Br4923 PFGLNLFSTAEVLPKEVAYSEARLQPPSGYKDTTVPGIWVPDTPLSHRNT
*: :: :: * .
Mb3526c|M.bovis_AF2122/97 ----------KSETPVPELTWVPAGGG--APVGNPADLQSLLV-------
Rv3496c|M.tuberculosis_H37Rv ----------KSETPVPELTWVPAGGG--APVGNPADLQSLLV-------
MUL_4059|M.ulcerans_Agy99 ----------KAETPVPELTWIPAHPAPQPAPGNTTDLQSLFV-------
MAB_4150c|M.abscessus_ATCC_199 ----------KSQAPREDLVWVRPNGAPPPPKPSPQDLSALMLGPDEVNA
MSMEG_2858|M.smegmatis_MC2_155 ----------GGGGTPSAPAELPPAVS--AYTG-AGDVPPPAGWADPPQP
TH_2817|M.thermoresistible__bu ----------GGGQRPPGPDEPPPAVS--AYTG-AGDVAPPAGWHDPPHP
Mflv_4535|M.gilvum_PYR-GCK ----------GGGGTPPAPAEIPPAVS--AYTG-AGDIAPPPGWSDPPQP
Mvan_2854|M.vanbaalenii_PYR-1 ----------GGGGTAPAPAETPPAVS--AYTG-VGDVPPPPGWSDPAHP
MMAR_4707|M.marinum_M ----------GGEGPKPIAPELPPAVS--AYTGLPGDT--------PEAP
MAV_0951|M.avium_104 ----------GGEGPKPGPPEIPPAVS--AYTGLPGD---------PVGP
MLBr_02592|M.leprae_Br4923 QPGWIVAPGMQGQQVGPITAALMTPDSLAELMGGPDIEPIQSNLQTPPGP
. . .
Mb3526c|M.bovis_AF2122/97 PPAPG----------------PAPAP------PAPGAG----------PG
Rv3496c|M.tuberculosis_H37Rv PPAPG----------------PAPAP------PAPGAG----------PG
MUL_4059|M.ulcerans_Agy99 PQAPGPTPGSPPGYGPAPGPPPAPAP------AGPDAGLSSPAPGAPLPA
MAB_4150c|M.abscessus_ATCC_199 PPPPGTEVRPAE---------PGPVP------PGFPVTADDAPP----PA
MSMEG_2858|M.smegmatis_MC2_155 PGAYTPNGLPAERHPALYPGAPVPP--------ATSPPPASTLEDLLLPA
TH_2817|M.thermoresistible__bu PGAYTPDGLPAIPQPALFPGAPVPPGLPA---PAPSGPGPADLQDLLLPA
Mflv_4535|M.gilvum_PYR-GCK PGAFAPHGLPANPSGALYPGAPVPPGVPS---PPPA-AGPAGIAEMLLPA
Mvan_2854|M.vanbaalenii_PYR-1 PGAYAPHGLPANPHPALYPDAPIPPGVPP---PPPARPAPSSIGDMLLPA
MMAR_4707|M.marinum_M PPPPPPARIPG----AAMP-EPPPPSVP----AEPSPPP-ANLSDMLLPA
MAV_0951|M.avium_104 PGAEPPARIPG----AAMP-LPPPPSTP----MPPPPPPEPGVSGMLLPA
MLBr_02592|M.leprae_Br4923 PTAYDEHPVPPPIGLQASVPIPSPRPDVVPGPVAPTPSPAANVGDPPLPA
* . * * *.
Mb3526c|M.bovis_AF2122/97 EHGGGG-------
Rv3496c|M.tuberculosis_H37Rv EHGGGG-------
MUL_4059|M.ulcerans_Agy99 EQGAGG-------
MAB_4150c|M.abscessus_ATCC_199 IPGAPR-------
MSMEG_2858|M.smegmatis_MC2_155 EMAAAPPAPEGTP
TH_2817|M.thermoresistible__bu ERHSDQ-QPGGTP
Mflv_4535|M.gilvum_PYR-GCK EAAPSP---GGNP
Mvan_2854|M.vanbaalenii_PYR-1 EAAPAPPSTEGTP
MMAR_4707|M.marinum_M EGPQP--------
MAV_0951|M.avium_104 QGPQQ--------
MLBr_02592|M.leprae_Br4923 ELGAGQ-------