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RIRKRIRLAVAAGTCVALTASGCAFQGVNSLPLPGAEGRGADSVVYHVEIANVATLEPNSPVMMNDVVVG SVRRLAVRDWHADVEFSVEPGVVVPANAVATIGQTSLLGSMHLALNPPLGQEPQGRLTPGGTIPLNSAST YPTTEQTLSSLAAVVNGGGLGQIGEVIHNFSVALDGREADFRDLLTRLDNFVGTLDAQRDNIVSSIDSLN RLASTFAGQSEEITRALNKIPPAMDVLIQERPRFTTALQKLGTFGSTAHQLVNESQDDLVRNLRNLEPAI KALADVGPDLAGVLEYAGHFPFTQSFIDRAIRGDYWNLFATIDLTIPRLKRSLMLGTRWEQEGAQLVPAP GDPYYLNYTYDPLKAGVETPGPASFPPPFADPPVPAAPVDQTTLPLPEAPPGPPPAYAGPVLPVAPPAPM TLPGVPAPVTTPGDPTQIFAGPYGDQPNPPTEAPAPAQPTTGGGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4786 | - | - | 100% (466) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_2859 | - | e-140 | 62.63% (388) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0350 | - | 6e-74 | 40.52% (343) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3525c | lprN | 1e-58 | 36.41% (357) | MCE-family lipoprotein LprN |
| M. gilvum PYR-GCK | Mflv_2512 | - | 1e-154 | 60.48% (463) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1970 | lprM | 3e-71 | 42.30% (331) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 4e-49 | 31.78% (321) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 4e-67 | 36.92% (390) | MCE-family protein LprN |
| M. marinum M | MMAR_4706 | - | 1e-137 | 60.93% (407) | MCE family lipoprotein |
| M. avium 104 | MAV_2536 | - | 3e-79 | 43.95% (339) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4487 | - | 1e-172 | 66.31% (472) | PUTATIVE virulence factor mce family protein |
| M. ulcerans Agy99 | MUL_2866 | lprM | 4e-79 | 45.38% (346) | MCE family lipoprotein LprM |
| M. vanbaalenii PYR-1 | Mvan_4146 | - | 1e-155 | 59.13% (460) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1970|M.tuberculosis_H37Rv -----MRIG------------LTLVMIAAVVASCGWRGLNSLPLPGTQGN
MUL_2866|M.ulcerans_Agy99 -----MRVRQRRRVAPRLATVLVTMVTLAAVSGCGWRGLNSLPLPGTEGN
MAV_2536|M.avium_104 -----MSQSPLRR---RVMAALLAAVALATLSGCGFRGLNSFNLPGTKGG
Mb3525c|M.bovis_AF2122/97 -----MNRIWLR-------AIIL-TASSALLAGCQFGGLNSLPLPGTAGH
MAB_4149c|M.abscessus_ATCC_199 -----MSRNVLR-------AAVMGVGVAVVVSGCQFNGLNSLNLPGTAGH
MSMEG_4786|M.smegmatis_MC2_155 ---MRIRKRIRL-------AVAAGTCVALTASGCAFQGVNSLPLPGAEGR
TH_4487|M.thermoresistible__bu --------MMRG-------VVAVGACVALTVSGCGFQGVNSLPLPGAVGR
MMAR_4706|M.marinum_M MTASTATPALRR-------LFVIGCCVMLAVTGCAFNGLNSLPLPGAVGR
Mflv_2512|M.gilvum_PYR-GCK -----MMRSVKS-------WAAVGCAVAVTLSGCAFEGVNSLPLPGAEGR
Mvan_4146|M.vanbaalenii_PYR-1 -----MIRGVKQ-------LTVLGCSAALSLSGCAFQGVNSLPLPGAVGR
MLBr_02593|M.leprae_Br4923 -MRRAMSVVHTSRVRHQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
:.* : *:... :** *
Rv1970|M.tuberculosis_H37Rv GPGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQG-----WHALV
MUL_2866|M.ulcerans_Agy99 GPGSFVIQAQMPDVNNIQPNSRVRVADVTVGHVARIERQG-----WHALV
MAV_2536|M.avium_104 GPGAYTIRAQMPDVQNLQRNSRVRVNDVTVGNVIDIELQG-----WNALV
Mb3525c|M.bovis_AF2122/97 GEGAYSVTVEMADVATLPQNSPVMVDDVTVGSVAGIVAVQRPDGSFYAAV
MAB_4149c|M.abscessus_ATCC_199 GSRSYTVTVELPDVTTLPQNSPVMVDDVTVGSVSGIDAFQKPDGSWYAGV
MSMEG_4786|M.smegmatis_MC2_155 GADSVVYHVEIANVATLEPNSPVMMNDVVVGSVRRLAVRD-----WHADV
TH_4487|M.thermoresistible__bu GPGAETYTVEIENVATLEPNSPVMIGDVVVGSVRSMTVQD-----WHAKV
MMAR_4706|M.marinum_M GPGASVYHVEIANVGTLEANSPVMLNDVIVGSISKMTVRG-----WHADV
Mflv_2512|M.gilvum_PYR-GCK GGDAVTYHIQVPNVATLESNSPVMIDDVVVGSVGKMTVQN-----WHADV
Mvan_4146|M.vanbaalenii_PYR-1 GPDAVSYNVQVPNVATLESNSPVMIDDVVVGSVGKMTVQN-----WHADV
MLBr_02593|M.leprae_Br4923 GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLKN-----WVATL
* : :: :. : ** * : ** ** : : : * :
Rv1970|M.tuberculosis_H37Rv TMRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLRDGSLIA
MUL_2866|M.ulcerans_Agy99 TIRLDAGVALPANATARIGTTSLLGSYHIELAAPKHDAPQGRLRKGSLIP
MAV_2536|M.avium_104 TMTIDGDVDLPANATATLGQTSLLGSVHVELAPPAGVAPQGKLKNGSLIP
Mb3525c|M.bovis_AF2122/97 KLDLDKNVLLPANAVAKVSQTSLLGSLHVELAPPTDRPPTGRLVDGSRIT
MAB_4149c|M.abscessus_ATCC_199 KVSLEPEVHLPANAVAKVAQTSLLGSQHIELAAPVGEPAVGKLTGGATIP
MSMEG_4786|M.smegmatis_MC2_155 EFSVEPGVVVPANAVATIGQTSLLGSMHLALNPPLGQEPQGRLTPGGTIP
TH_4487|M.thermoresistible__bu EISVEPGVEVPANAVASVGQTSLLGSMHLALDPPPGERPQGRLAPGSVIR
MMAR_4706|M.marinum_M EISVRRGAVIPDNAVASVGQTSLLGSMHLALNSPLGQVSDQRLQPGSTIP
Mflv_2512|M.gilvum_PYR-GCK EVSIKPDVVIPANAVATVGQTSLLGSMHLALNPPLGESPSGRLQPGSTLP
Mvan_4146|M.vanbaalenii_PYR-1 EISVKPDVVIPANAVATVGQTSLLGSMHLALNPPLGDEPKGRLQPGSTLP
MLBr_02593|M.leprae_Br4923 TLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN-PSLELLKNGDTIP
. : . :* *:.* :. ****** *: * .* * * :
Rv1970|M.tuberculosis_H37Rv LSHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGL
MUL_2866|M.ulcerans_Agy99 LSRGGAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFRGREHEVRSL
MAV_2536|M.avium_104 LSSAGAYPSTERTLAAVSLLLNGGGLGQVQDITKTLSTAFSGREQDLRNL
Mb3525c|M.bovis_AF2122/97 EANTDRFPTTEEVFSALGVVVNKGNVGALEEIIDETHQAVAGRQAQFVNL
MAB_4149c|M.abscessus_ATCC_199 LSRTGKYPSTEEVLSALSVVVNKGNLGALQDITDETYNLFKGRTGNLTQV
MSMEG_4786|M.smegmatis_MC2_155 LNSASTYPTTEQTLSSLAAVVNGGGLGQIGEVIHNFSVALDGREADFRDL
TH_4487|M.thermoresistible__bu LDDSSTYPTTEQTLASLAAVVNGGGLGQIGDVIHNMSGALNGREQQIRDL
MMAR_4706|M.marinum_M LSRSSTYPSTEQTLSSLSVILNAGGLGQIGDIIHNFTAALSGRTSDIRDL
Mflv_2512|M.gilvum_PYR-GCK LNESSTYPTTEQTLSSLSTVANGGGLGQIGDIIHNMSTGLAGREDDAREL
Mvan_4146|M.vanbaalenii_PYR-1 LNASSTYPTTEQTLASLSTVANGGGLGQIGDIVHNMNTALSGREPEVREL
MLBr_02593|M.leprae_Br4923 LKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAF
. :*:**..::::. : . *.: : : . . ** : .
Rv1970|M.tuberculosis_H37Rv IGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDAL
MUL_2866|M.ulcerans_Agy99 IAQLDSFTATLDDQSDDIIEATESLNRLVGKFAEQQPVLDRALATIPDAL
MAV_2536|M.avium_104 LNQLDTFVGYLNDQKSDIIAATDHLNNLVGQFADQKPIIDKALKTIPQAL
Mb3525c|M.bovis_AF2122/97 VPRLAELTAGLNRQVHDIIDALDGLNRVSAILARDKDNLGRALDTLPDAV
MAB_4149c|M.abscessus_ATCC_199 LPKLATLISSLNSQRDDIISAIEGIDKFSRVLAEHKESLGRAIDSIEPAL
MSMEG_4786|M.smegmatis_MC2_155 LTRLDNFVGTLDAQRDNIVSSIDSLNRLASTFAGQSEEITRALNKIPPAM
TH_4487|M.thermoresistible__bu LNRLDTFVGTLDAQRDNIVSSIESLNRLAARFAGERDDITRALERVPPAI
MMAR_4706|M.marinum_M LVRLDRFVGTFDEQRDNLVASIQALNRLAGTLAGQRDVITQALQKIPPAL
Mflv_2512|M.gilvum_PYR-GCK LQRLDNFVGVLAEQREDIVASIQQLRRVAGTFANQQQVIDRALTEIPPAI
Mvan_4146|M.vanbaalenii_PYR-1 LTRLDNFVGVLAEQRENIIASIQQLRRVAGTFANQREVIDRALKEIPPAI
MLBr_02593|M.leprae_Br4923 LTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLI
: :* : . : * :: : : .. .. : : : : :
Rv1970|M.tuberculosis_H37Rv AVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESLA
MUL_2866|M.ulcerans_Agy99 AVLNDERDKLVTAADQLSKFSALTADSVNKTKANLVSELRQLGPVLESLA
MAV_2536|M.avium_104 TVLKDERENLANALGEVGQLSALAADSVNKTKENLIKELKDLGPVLQSLA
Mb3525c|M.bovis_AF2122/97 RVLNQNRDHIVDAFAALKRLTMVTSHVLAETKVDFGEDLKDLYSIVKALN
MAB_4149c|M.abscessus_ATCC_199 KVLNENRANIIEAFRSVGNLAKITDRVLRTTKDDIVADLKGLYPVVRALA
MSMEG_4786|M.smegmatis_MC2_155 DVLIQERPRFTTALQKLGTFGSTAHQLVNESQDDLVRNLRNLEPAIKALA
TH_4487|M.thermoresistible__bu EVLVRERPRLTAALERLGTFSDTTTRFVNDSQADLVRNLENLEPALKALA
MMAR_4706|M.marinum_M DVLIRERPRITAALDKLGTFSDTATRLVNDAGSDLVQNLQNLGPTISALA
Mflv_2512|M.gilvum_PYR-GCK DVLIQERPQFTTALDRLGTFSDTATQLVNDAGDDLVKNLENLGPILGALA
Mvan_4146|M.vanbaalenii_PYR-1 DVLIRERPNFTTALDRLGQFSNTATQLVNDAGDDLVKNLENLGPVLGALA
MLBr_02593|M.leprae_Br4923 KHFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLRELG
: : : * : : . : : : :*. * : *
Rv1970|M.tuberculosis_H37Rv NSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLL
MUL_2866|M.ulcerans_Agy99 NAGPSLTRSLSLLATFPFPNETFQNFQRGDYANLTAIVDLTLSRIDQGLL
MAV_2536|M.avium_104 DAGPALTRSLGFLGTFPFPAETLSKWIRGDYANLTAVIDLTLSRLDASFL
Mb3525c|M.bovis_AF2122/97 DDRKDFVTSLQLLLTFPFPNFGIKQAVRGDYLNVFTTFDLTLRRIGETFF
MAB_4149c|M.abscessus_ATCC_199 ENRDVLIDSLDLLPTFPFSTKYLRNAVRGDYLNVFVTFDLTARRLGETLF
MSMEG_4786|M.smegmatis_MC2_155 DVGPDLAGVLEYAGHFPFTQSFIDRAIRGDYWNLFATIDLTIPRLKRSLM
TH_4487|M.thermoresistible__bu DVGPSLNSVLEFAVHFPFTQNFIDRAIRGDYYNLFAIVDFTIPRLKRTLF
MMAR_4706|M.marinum_M DIGPDLDAAIAYAPTFPFTQGFIDRYIRGDYVNGYFIIDLTNAGLRKSIL
Mflv_2512|M.gilvum_PYR-GCK DVGPDLNLALLWTSAFPYGPTFADRVTKGDYINLYAIFDITYPRLKKTLL
Mvan_4146|M.vanbaalenii_PYR-1 DIGPDLNEAVLWASAFPYGPTFADRITRGDYINLYAIFDLTYPRLKKTLL
MLBr_02593|M.leprae_Br4923 RGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNAVL
: : *: . :*:* * .*.* : .:
Rv1970|M.tuberculosis_H37Rv TGTRWECHLTQLELQWG---RTIGQFPS----------------------
MUL_2866|M.ulcerans_Agy99 TGTRWECHLTELELQWG---RTIGQFPS----------------------
MAV_2536|M.avium_104 TGTRFECNLTELELQWG---RTIGQLPS----------------------
Mb3525c|M.bovis_AF2122/97 TTAYFDPNMAHMDEILNPPDFLIGELAN----------------------
MAB_4149c|M.abscessus_ATCC_199 TTSFFDPNMQHFNDVVNPPEWLIGSMAN----------------------
MSMEG_4786|M.smegmatis_MC2_155 LGTRWEQEGAQLVPAPGDPYYLNYTYDPLKAGVETPGPASFPPPFAD---
TH_4487|M.thermoresistible__bu LGTRWAQEGAQLVPAPGDPQYLQYTYDPLRLGVDPP-PPQFVPPLGDEVF
MMAR_4706|M.marinum_M LGTHWGRLGAEGVPAPGDPEYLQFKFG-----------------------
Mflv_2512|M.gilvum_PYR-GCK LGTRWGDENAKLIPAPGDPYYLNYSYDPLKIGVAP---------------
Mvan_4146|M.vanbaalenii_PYR-1 AGTRWGDQNAKLIPAPGDPYYLNYAYNPMMVGITP---------------
MLBr_02593|M.leprae_Br4923 TGTGLSGALRALEQSFGRDPETMIPDVR----------------------
: .
Rv1970|M.tuberculosis_H37Rv ----------------------PCTAGYRGTPGNPLTIAYRWDQGP----
MUL_2866|M.ulcerans_Agy99 ----------------------PCTAGYRGTPGNPLTVPYHWDQGP----
MAV_2536|M.avium_104 ----------------------PCTGGGPYNPGNPLVVPYHFDQGR----
Mb3525c|M.bovis_AF2122/97 ----------------------LSGQAADPFKIPPGTAS---GQ------
MAB_4149c|M.abscessus_ATCC_199 ----------------------LNGKETSPFDLPAPAAPQGGGR------
MSMEG_4786|M.smegmatis_MC2_155 -PPVPAAPVDQTTLPLPEAPPGPPPAYAGPVLPVAPPAPMTLPGVPAPVT
TH_4487|M.thermoresistible__bu PPAVPPEPPQAATAEQEALPLPPITEDVGPLLPAAPPAVVNFPGGPVTVR
MMAR_4706|M.marinum_M -APIPPGPPPADAPPPGDPAPGPPPDSAVPIPGATPAEAAPTDGGP----
Mflv_2512|M.gilvum_PYR-GCK -PPAEAIPAPAEG-AAATPALPPMSEPLLPVTPPPPAAPWLPQSQPITSG
Mvan_4146|M.vanbaalenii_PYR-1 -PPEEALPPPAQG-GAPSSLTGVPAQPILPVVPPPPAAPWLPQAQPMAGD
MLBr_02593|M.leprae_Br4923 -----------------------YTTNPNDAPGGPLVERADRRC------
.
Rv1970|M.tuberculosis_H37Rv ---------------------------------------
MUL_2866|M.ulcerans_Agy99 ---------------------------------------
MAV_2536|M.avium_104 ---------------------------------------
Mb3525c|M.bovis_AF2122/97 ---------------------------------------
MAB_4149c|M.abscessus_ATCC_199 ---------------------------------------
MSMEG_4786|M.smegmatis_MC2_155 -TPGDP---TQIFAGPYGDQPNPPTEAPAPAQPTTGGGG
TH_4487|M.thermoresistible__bu PTPPAPDGSTPIFAG-HPAQPPSPETAPS-----SGGGG
MMAR_4706|M.marinum_M ---------------------------------------
Mflv_2512|M.gilvum_PYR-GCK ----------NIFAGPYGAEAAP--APVPPAAPTPGGGG
Mvan_4146|M.vanbaalenii_PYR-1 ----------QIFAGPFGAPTPPPVAPPAPSVPTPGGGG
MLBr_02593|M.leprae_Br4923 ---------------------------------------